Reduced podocyte expression of α3β1 integrins and podocyte depletion in patients with primary focal segmental glomerulosclerosis and chronic PAN-treated rats

Journal of Laboratory and Clinical Medicine

Volumn 147, Issue 2, 2006, Pages 74-82

  Chen, Chien An ^b   Hwang, Jyh Chang ^b   Guh, Jinn Yuh ^b   Chang, Jer Ming ^b   Lai, Yung Hsiung ^b   Chen, Hung Chun ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA3 INTEGRIN; BETA1 INTEGRIN; PEROXIDASE; PUROMYCIN AMINONUCLEOSIDE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL ARTICLE; CORRELATION ANALYSIS; FEMALE; FOCAL GLOMERULOSCLEROSIS; HUMAN; HUMAN TISSUE; IMMUNOELECTRON MICROSCOPY; IMMUNOHISTOCHEMISTRY; MALE; MICROPHOTOGRAPHY; MORPHOMETRICS; NONHUMAN; PODOCYTE; PROTEIN BLOOD LEVEL; PROTEIN DEPLETION; PROTEIN EXPRESSION; RAT; SCORING SYSTEM;

ADULT; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; CELL COUNT; CHRONIC DISEASE; FEMALE; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; HUMANS; IMMUNOENZYME TECHNIQUES; INTEGRIN ALPHA3BETA1; MALE; MICROSCOPY, IMMUNOELECTRON; PODOCYTES; PUROMYCIN AMINONUCLEOSIDE; RATS; RATS, WISTAR;

EID: 31944440132     PISSN: 00222143     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lab.2005.08.011     Document Type: Article

References (62)

1. S.M. Korbet, M.M. Schwartz, E.J. Lewis Primary focal segmental glomerulosclerosis clinical course and response to therapy Am J Kidney Dis 23 1994 773 783
2. M.M. Schwartz, S.M. Korbet Primary focal segmental glomerulosclerosis pathology, histological variants, and pathogenesis Am J Kidney Dis 22 1993 874 883
3. A. Tejani, D.H. Stablein Recurrence of focal segmental glomerulosclerosis posttransplantation a special report of the North American Pediatric Renal Transplant Cooperative Study J Am Soc Nephrol 2 1992 S258 S263
4. J.W. Fries, D.J. Sandstrom, T.W. Meyer, H.G. Rennke Glomerular hypertrophy and epithelial cell injury modulate progressive glomerulosclerosis in the rat Lab Invest 60 1989 205 218
5. M. Nagata, W. Kriz Glomerular damage after uninephrectomy in young rats. II. Mechanical stress on podocytes as a pathway to sclerosis Kidney Int 42 1992 148 160
6. M. Kretzler, I. Koeppen-Hagemann, W. Kriz Podocyte damage is a critical step in the development of glomerulosclerosis in the uninephrectomised- desoxycorticosterone rat Virchows Arch [A] 452 1994 181 193
7. W. Kriz, B. Hahnel, S. Rosener, M. Elger Long-term treatment of rats with FGF-2 results in focal segmental glomerulosclerosis Kidney Int 48 1995 1435 1450
8. I. Shirato, T. Sakai, K. Kimura, Y. Tomino, W. Kriz Cytoskeletal changes in podocytes associated with foot process effacement in Masugi nephritis Am J Pathol 148 1996 1283 1296
9. E. Grishman, J. Churg Focal glomerular sclerosis in nephrotic patients an electron microscopic study of glomerular podocytes Kidney Int 7 1975 111 122
10. P. Mundel, S.T. Shankland Podocyte biology and response to injury J Am Soc Nephrol 13 2002 3005 3015
11. T. Benzing Signaling at slit diaphragm J Am Soc Nephrol 16 2004 1382 1391
12. J. Patrakka, M. Kestila, J. Wartiovaara, V. Ruotsalainen, P. Tissari, U. Lenkkeri Congenital nephrotic syndrome (NPHS1) features resulting from different mutations in Finnish patients Kidney Int 58 2000 972 980
13. M.R. Pollak Inherited podocytopathies FSGS and nephrotic syndrome from a genetic viewpoint J Am Soc Nephrol 13 2002 3016 3023
14. N. Boute, O. Gribouval, S. Roselli, F. Benessy, H. Lee, A. Fuchshuber NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome Nat Genet 24 2000 349 354
15. C. Li, V. Ruotsalainen, K. Tryggvason, A.S. Shaw, J.H. Miner CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere Am J Physiol 279 2000 F785 F792
16. G. Wolf, R.A. Stahl CD2-associated protein and glomerular disease Lancet 362 2003 1746 1748
17. M.P. Winn, P.J. Conlon, K.L. Lynn, M.K. Farrington, T. Creazzo, A.F. Hawkins A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis Science 308 2005 1801 1804
18. J. Reiser, K.R. Polu, C.C. Moller, P. Kenlan, M.M. Altintas, C. Wei TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function Nat Genet 37 2005 663 664
19. J.M. Kaplan, S.H. Kim, K.N. North, H. Rennke, L.A. Correia, H.Q. Tong Mutations in ACTN4, encoding α-actinin-4 cause familial focal segmental glomerulosclerosis Nat Genet 24 2000 251 256
20. J.L. Michaud, L.I. Lemieux, M. Dube, B.C. Vanderhyden, S.J. Robertson, C.R. Kennedy Focal and segmental glomerulosclerosis in mice with podocyte-specific expression of mutant α-actinin-4 J Am Soc Nephrol 14 2003 1200 1211
21. R.O. Hynes Integrins Versatility, modulation, and signaling in cell adhesion Cell 69 1992 11 25
22. E. Ruoslahti, N.A. Noble, S. Kagami, W.A. Border Integrins Kidney Int 45 suppl 44 1994 S17 S22
23. M. Korhonen, J. Ylanne, L. Laitinen, I. Virtanen Distribution of β1 and β3 integrins in human fetal and adult kidney Lab Invest 62 1990 616 625
24. S. Adler Characterization of glomerular epithelial cell matrix receptors Am J Pathol 141 1992 571 578
25. H.C. Chen, C.A. Chen, J.Y. Guh, J.M. Chang, S.J. Shin, Y.H. Lai Altering expression of α3β1 integrin on podocytes of human and rats with diabetes Life Sci 67 2000 2345 2353
26. T. Nakamura, C. Ushiyama, S. Suzuki, M. Hara, N. Shimada, I. Ebihara The urinary podocyte as a marker for the differential diagnosis of idiopathic focal glomerulosclerosis and minimal-change nephrotic syndrome Am J Nephrol 20 2000 175 179
27. J.R. Diamond, M.J. Karnovsky Focal and segmental glomerulosclerosis following a single intravenous dose of puromycin aminonucleoside Am J Pathol 122 1986 481 487
28. J. Grond, E.W. Muller, H. van Goor, J.J. Weening, J.D. Elema Mesangial function and glomerular sclerosis in rats with aminonucleoside nephrosis Kidney Int 33 1988 405 410
29. H.C. Chen, J.Y. Guh, J.M. Chang, J.C. Tsai, S.J. Hwang, Y.H. Lai Plasma and urinary endothelin-1 in focal segmental glomerulosclerosis J Clin Lab Anal 15 2001 59 63
30. T. Saito, E. Sumithran, E.F. Glasgow, R.C. Atkins The enhancement of aminonucleoside nephrosis by the co-administration of protamin Kidney Int 32 1987 691 699
31. E.R. Weibel Stereological methods. Practical methods for biological morphometry 1979 Academic Press London
32. M. Nagata, W. Kriz Glomerular damage after uninephrectomy in young rats. II: mechanical stress on podocytes as a pathway to sclerosis Kidney Int 42 1992 148 160
33. J. Kreidberg, H. Sariola, J. Loring, M. Maeda, J. Pelletier, D. Housman WT-1 is required for early kidney development Cell 74 1993 679 691
34. S.K. Sanden, J.E. Wiggins, M. Goyal, L.K. Riggs, R.C. Wiggins Evaluation of a thick and thin section method for estimation of podocytes number, glomerular volume, and glomerular volume per podocytes in rat kidney with Wilms' tumor-1 protein used as a podocytes nuclear marker J Am Soc Nephrol 14 2003 2484 2493
35. S. Mundlos, J. Pelletier, A. Darveau, M. Bachmann, A. Winterpacht, B. Zabel Nuclear localization of the protein encoded by Wilms' tumor gene WT1 in embryonic and adult tissue Development 119 1993 1329 1341
36. L. Barisoni, W. Kriz, P. Mundel, V. D'Agati The dysregulated podocytes phenotype a novel concept in the pathogenesis and HIV-associated nephropathy J Am Soc Nephrol 10 1999 51 61
37. J. Bariety, D. Nochy, C. Mandet, C. Jacquot, D. Glotz, A. Meyrier Podocyte undergo phenotypic changes and express macrophagic-associated markers in idiopathic collapsing glomerulopathy Kidney Int 53 1998 918 925
38. H.C. Chen, J.Y. Guh, Y.H. Lai Alterations of glomerular and extracellular glutathione peroxidase levels in patients and rats with focal segmental glomerulosclerosis J Lab Clin Med 137 2001 279 283
39. C. Whiteside, K. Prutis, R. Cameron, J. Thompson Glomerular epithelial detachment, not reduced charge density, correlates with proteinuria in adriamycin and puromycin nephrosis Lab Invest 61 1989 650 660
40. M. Hara, T. Yanagihara, I. Kihara Urinary podocytes in primary focal segmental glomerusclerosis Nephron 89 2001 342 347
41. A.T. Petermann, R. Krofft, M. Blonski, K. Hiromura, M. Vaughn, R. Pichler Podocytes that detach in experimental membranous nephropathy are viable Kidney Int 64 2003 1222 1231
42. S.U. Vogelmann, W.J. Nelson, B.D. Myers, K.V. Lemley Urinary excretion of viable podocytes in health and renal disease Am J Physiol 285 2003 F40 F48
43. P.V. Kitsiou, A.K. Tzinia, W.G. Stetler-Sterenson, A.F. Michael, W.W. Fan, B. Zhou Glucose-induced changes in integrins and matrix-related functions in cultured human glomerular epithelial cells Am J Physiol 284 2003 F671 F679
44. H. Sugiyama, N. Kashihara, H. Makino, Y. Yamasaki, Z. Ota Apoptosis in glomerular sclerosis Kidney Int 49 1996 103 111
45. Y.H. Kim, M. Goyal, D. Kurnit, B. Wharram, J. Wiggins, L. Holzman Podocyte depletion and glomerulosclerosis have a direct relationship in the PAN-treated rat Kidney Int 60 2001 957 968
46. S. Adler, X. Chen Anti-Fx1A antibody recognizes a β1-integrin on glomerular epithelial cells and inhibits adhesion and growth Am J Physiol 262 1992 F770 F776
47. 2 and Fab' antibodies to rat renal tubular epithelial antigen Kidney Int 21 1982 36 43
48. T.J. Tsai, J.R. Sheu, Y.M. Chen, C.J. Yen, C.F. Chen, T.F. Huang Disintegrin modulates rat glomerular mesangial cell behavior Nephron 70 1995 83 90
49. G.B. Ryan, M.J. Karnovsky An ultrastructural study of the mechanisms of proteinuria in aminonucleoside nephrosis Kidney Int 8 1975 219 232
50. M.M. Schwartz, E.J. Lewis Focal segmental glomerular sclerosis the cellular lesion Kidney Int 28 1985 968 974
51. M. Regoli, M. Bendayan Alterations in the expression of the α3β1 integrin in certain membrane domains of the glomerular epithelial cells (podocytes) in diabetes mellitus Diabetologia 40 1997 15 22
52. A. Baraldi, L. Furci, G. Zambruno, E. Rubbiani, G. Annessi, E. Lusvarghi Very late activation-3 integrin is the dominant beta 1-integrin on the glomerular capillary wall an immunofluorescence study in nephrotic syndrome Nephron 62 1992 382 388
53. R. Bains, P.N. Furness, D.R. Critchley A quantitative immunofluorescence study of glomerular cell adhesion proteins in proteinuric states J Pathol 183 1997 272 280
54. E. Kemeny, M.J. Mihatsch, U. Durmuller, F. Gudat Podocytes lose their adhesive phenotype in focal segmental glomerulosclerosis Clin Nephrol 43 1995 71 83
55. H.M. Regele, E. Filliporic, B. Langer, H. Poczewki, I. Kraxberger, R.E. Bittner Glomerular expression of dystroglycans is reduced in minimal change nephrosis but not in focal segmental glomerulosclerosis J Am Soc Nephrol 11 2000 403 412
56. W.E. Smoyer, P. Mubdel, A. Gupta, M.J. Welsh Podocyte α-actinin induction precedes foot process effacement in experimental nephritic syndrome Am J Physiol 363 1997 F150 F157
57. K. Kojima, K. Matsui, M. Nagase Protection of α3 mediated podocytes shape by superoxide dismutase in the puromycin aminonucleoside nephrosis rat Am J Kidney Dis 35 2000 1175 1185
58. U. Krishnamurti, B. Zhou, W.W. Fan, E. Tsilibary, E. Wayner, Y. Kim Puromycin aminonucleoside suppresses integrin expression in cultured glomerular epithelial cells J Am Soc Nephrol 12 2001 758 766
59. J. Reiser, J. Oh, I. Shirato, K. Asanuma, A. Hug, T.M. Mundel Podocyte migration during nephrotic syndrome requires a coordinated interplay between cathepsin L and α3 integrin J Biol Chem 279 2004 34827 34832
60. J.A. Kreidberg, M.J. Donovan, S.L. Goldstein, H. Rennke, K. Shepherd, R.C. Jones Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis Development 122 1996 3537 3547
61. K. Yoshioka, T. Takemura, K. Murakami, M. Okada, S. Hino, H. Miyamoto Transforming growth factor-β protein and mRNA in glomeruli in normal and diseased human kidneys Lab Invest 68 1993 154 163
62. S. Kagami, W.A. Border, E. Rouslahti, N.A. Noble Coordinated expression of β1 integrins and transforming growth factor-β induced matrix protein in glomerulonephritis Lab Invest 69 1993 68 76