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Volumn 143, Issue 1, 2008, Pages 59-68

Enzymatic characterization and inhibitor discovery of a new cystathionine γ-synthase from Helicobacter pylori

Author keywords

Cystathionine synthase; Helicobacter pylori; Inhibitor; Inhibitor type; Minimum inhibition concentration; Transsulfuration

Indexed keywords

9 HYDROXY ALPHA LAPACHONE; ALPHA LAPACHONE; ANTIINFECTIVE AGENT; BACTERIAL ENZYME; CYSTATHIONINE GAMMA SYNTHASE; HYDROXYAMINO ACID; NPLC 518; NPLC 519; NPLC 604; NPLC 605; PAULOWNIN; UNCLASSIFIED DRUG; YANGAMBIN;

EID: 38849186664     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvm194     Document Type: Article
Times cited : (14)

References (27)
  • 1
    • 0032402991 scopus 로고    scopus 로고
    • Crystal structure of Escherichia coli cystathionine gamma-synthase at 1.5 A° resolution
    • Clausen, T., Huber, R., Prade, L., Wahl, M.C., and Messerschmidt, A. (1998) Crystal structure of Escherichia coli cystathionine gamma-synthase at 1.5 A° resolution. Embo. J. 17, 6827-6838
    • (1998) Embo. J , vol.17 , pp. 6827-6838
    • Clausen, T.1    Huber, R.2    Prade, L.3    Wahl, M.C.4    Messerschmidt, A.5
  • 2
    • 0141456354 scopus 로고    scopus 로고
    • Escherichia coli cystathionine gamma-synthase does not obey ping-pong kinetics. Novel continuous assays for the elimination and substitution reactions
    • Aitken, S.M., Kim, D.H., and Kirsch, J.F. (2003) Escherichia coli cystathionine gamma-synthase does not obey ping-pong kinetics. Novel continuous assays for the elimination and substitution reactions. Biochemistry 42, 11297-11306
    • (2003) Biochemistry , vol.42 , pp. 11297-11306
    • Aitken, S.M.1    Kim, D.H.2    Kirsch, J.F.3
  • 3
    • 0023066723 scopus 로고
    • Microbial sulfur amino acids: An overview
    • Soda, K. (1987) Microbial sulfur amino acids: an overview. Methods Enzymol. 143, 453-459
    • (1987) Methods Enzymol , vol.143 , pp. 453-459
    • Soda, K.1
  • 4
    • 0030768603 scopus 로고    scopus 로고
    • Wahl, M.C., Huber, R., Prade, L., Marinkovic, S., Messerschmidt, A., and Clausen, T. (1997) Cloning, purification, crystallization, and preliminary X-ray diffraction analysis of cystathionine gamma-synthase from E. coli. FEBS Lett. 414, 492-496
    • Wahl, M.C., Huber, R., Prade, L., Marinkovic, S., Messerschmidt, A., and Clausen, T. (1997) Cloning, purification, crystallization, and preliminary X-ray diffraction analysis of cystathionine gamma-synthase from E. coli. FEBS Lett. 414, 492-496
  • 6
    • 0014198939 scopus 로고
    • Acetylhomoserine. An intermediate in the fungal biosynthesis of methionine
    • Nagai, S. and Flavin, M. (1967) Acetylhomoserine. An intermediate in the fungal biosynthesis of methionine. J. Biol. Chem. 242, 3884-3895
    • (1967) J. Biol. Chem , vol.242 , pp. 3884-3895
    • Nagai, S.1    Flavin, M.2
  • 7
    • 0032522761 scopus 로고    scopus 로고
    • Cystathionine gamma-synthase from Arabidopsis thaliana: Purification and biochemical characterization of the recombinant enzyme overexpressed in Escherichia coli
    • Ravanel, S., Gakiere, B., Job, D., and Douce, R. (1998) Cystathionine gamma-synthase from Arabidopsis thaliana: purification and biochemical characterization of the recombinant enzyme overexpressed in Escherichia coli. Biochem. J. 331(Pt 2), 639-648
    • (1998) Biochem. J , vol.331 , Issue.PART 2 , pp. 639-648
    • Ravanel, S.1    Gakiere, B.2    Job, D.3    Douce, R.4
  • 8
    • 0035943386 scopus 로고    scopus 로고
    • Crystal structures of cystathionine gamma-synthase inhibitor complexes rationalize the increased affinity of a novel inhibitor
    • Steegborn, C., Laber, B., Messerschmidt, A., Huber, R., and Clausen, T. (2001) Crystal structures of cystathionine gamma-synthase inhibitor complexes rationalize the increased affinity of a novel inhibitor. J. Mol. Biol. 311, 789-801
    • (2001) J. Mol. Biol , vol.311 , pp. 789-801
    • Steegborn, C.1    Laber, B.2    Messerschmidt, A.3    Huber, R.4    Clausen, T.5
  • 9
    • 0025070021 scopus 로고
    • Reaction mechanism of Escherichia coli cystathionine gamma-synthase: Direct evidence for a pyridoxamine derivative of vinylglyoxylate as a key intermediate in pyridoxal phosphate dependent gamma-elimination and gamma-replacement reactions
    • Brzovic, P., Holbrook, E.L., Greene, R.C., and Dunn, M.F. (1990) Reaction mechanism of Escherichia coli cystathionine gamma-synthase: direct evidence for a pyridoxamine derivative of vinylglyoxylate as a key intermediate in pyridoxal phosphate dependent gamma-elimination and gamma-replacement reactions. Biochemistry 29, 442-451
    • (1990) Biochemistry , vol.29 , pp. 442-451
    • Brzovic, P.1    Holbrook, E.L.2    Greene, R.C.3    Dunn, M.F.4
  • 10
    • 0036899645 scopus 로고    scopus 로고
    • Helicobacter pylori interactions with host serum and extracellular matrix proteins: Potential role in the infectious process
    • table of contents
    • Dubreuil, J.D., Giudice, G.D., and Rappuoli, R. (2002) Helicobacter pylori interactions with host serum and extracellular matrix proteins: potential role in the infectious process. Microbiol. Mol. Biol. Rev. 66, 617-629 table of contents
    • (2002) Microbiol. Mol. Biol. Rev , vol.66 , pp. 617-629
    • Dubreuil, J.D.1    Giudice, G.D.2    Rappuoli, R.3
  • 11
    • 0030344912 scopus 로고    scopus 로고
    • Helicobacter pylori infection, a paradigm for chronic mucosal inflammation: Pathogenesis and implications for eradication and prevention
    • Cover, T.L. and Blaser, M.J. (1996) Helicobacter pylori infection, a paradigm for chronic mucosal inflammation: pathogenesis and implications for eradication and prevention. Adv. Intern. Med. 41, 85-117
    • (1996) Adv. Intern. Med , vol.41 , pp. 85-117
    • Cover, T.L.1    Blaser, M.J.2
  • 12
    • 3042585907 scopus 로고    scopus 로고
    • Helicobacter pylori: Antibiotic resistance and eradication rates in Suffolk. UK, 1991-2001
    • Cameron, E.A., Powell, K.U., Baldwin, L., Jones, P., Bell, G.D., and Williams, S.G. (2004) Helicobacter pylori: antibiotic resistance and eradication rates in Suffolk. UK, 1991-2001. J. Med. Microbiol. 53, 535-538
    • (2004) J. Med. Microbiol , vol.53 , pp. 535-538
    • Cameron, E.A.1    Powell, K.U.2    Baldwin, L.3    Jones, P.4    Bell, G.D.5    Williams, S.G.6
  • 14
    • 0030835739 scopus 로고    scopus 로고
    • Tomb, J.F., White, O., Kerlavage, A.R., Clayton, R.A., Sutton, G.G., Fleischmann, R.D., Ketchum, K.A., Klenk, H.P., Gill, S., Dougherty, B.A., Nelson, K., Quackenbush, J., Zhou, L., Kirkness, E.F., Peterson, S., Loftus, B., Richardson, D., Dodson, R., Khalak, H.G., Glodek, A., McKenney, K., Fitzegerald, L.M., Lee, N., Adams, M.D., Hickey, E.K., Berg, D.E., Gocayne, J.D., Utterback, T.R., Peterson, J.D., Kelley, J.M., Cotton, M.D., Weidman, J.M., Fujii, C., Bowman, C., Watthey, L., Wallin, E., Hayes, W.S., Borodovsky, M., Karp, P.D., Smith, H.O., Fraser, C.M., and Venter, J.C. (1997) The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature 388, 539-547
    • Tomb, J.F., White, O., Kerlavage, A.R., Clayton, R.A., Sutton, G.G., Fleischmann, R.D., Ketchum, K.A., Klenk, H.P., Gill, S., Dougherty, B.A., Nelson, K., Quackenbush, J., Zhou, L., Kirkness, E.F., Peterson, S., Loftus, B., Richardson, D., Dodson, R., Khalak, H.G., Glodek, A., McKenney, K., Fitzegerald, L.M., Lee, N., Adams, M.D., Hickey, E.K., Berg, D.E., Gocayne, J.D., Utterback, T.R., Peterson, J.D., Kelley, J.M., Cotton, M.D., Weidman, J.M., Fujii, C., Bowman, C., Watthey, L., Wallin, E., Hayes, W.S., Borodovsky, M., Karp, P.D., Smith, H.O., Fraser, C.M., and Venter, J.C. (1997) The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature 388, 539-547
  • 15
    • 0035426577 scopus 로고    scopus 로고
    • Industrial-scale, genomics-based drug design and discovery
    • Dean, P.M., Zanders, E.D., and Bailey, D.S. (2001) Industrial-scale, genomics-based drug design and discovery. Trends Biotechnol. 19, 288-292
    • (2001) Trends Biotechnol , vol.19 , pp. 288-292
    • Dean, P.M.1    Zanders, E.D.2    Bailey, D.S.3
  • 16
    • 0035581737 scopus 로고    scopus 로고
    • Exploiting genomics to discover new antibiotics
    • McDevitt, D. and Rosenberg, M. (2001) Exploiting genomics to discover new antibiotics. Trends Microbiol. 9, 611-617
    • (2001) Trends Microbiol , vol.9 , pp. 611-617
    • McDevitt, D.1    Rosenberg, M.2
  • 17
    • 9244239747 scopus 로고    scopus 로고
    • Global transposon mutagenesis and essential gene analysis of Helicobacter pylori
    • Salama, N.R., Shepherd, B., and Falkow, S. (2004) Global transposon mutagenesis and essential gene analysis of Helicobacter pylori. J. Bacteriol. 186, 7926-7935
    • (2004) J. Bacteriol , vol.186 , pp. 7926-7935
    • Salama, N.R.1    Shepherd, B.2    Falkow, S.3
  • 18
    • 0031281419 scopus 로고    scopus 로고
    • A continuous coupled spectrophotometric assay for tyrosine aminotransferase activity with aromatic and other nonpolar amino acids
    • Luong, T.N. and Kirsch, J.F. (1997) A continuous coupled spectrophotometric assay for tyrosine aminotransferase activity with aromatic and other nonpolar amino acids. Anal. Biochem. 253, 46-49
    • (1997) Anal. Biochem , vol.253 , pp. 46-49
    • Luong, T.N.1    Kirsch, J.F.2
  • 19
    • 0033618350 scopus 로고    scopus 로고
    • The crystal structure of cystathionine gamma-synthase from Nicotiana tabacum reveals its substrate and reaction specificity
    • Steegborn, C., Messerschmidt, A., Laber, B., Streber, W., Huber, R., and Clausen, T. (1999) The crystal structure of cystathionine gamma-synthase from Nicotiana tabacum reveals its substrate and reaction specificity. J. Mol. Biol. 290, 983-996
    • (1999) J. Mol. Biol , vol.290 , pp. 983-996
    • Steegborn, C.1    Messerschmidt, A.2    Laber, B.3    Streber, W.4    Huber, R.5    Clausen, T.6
  • 20
    • 0028800634 scopus 로고
    • Methionine biosynthesis in higher plants. I. Purification and characterization of cystathionine gamma-synthase from spinach chloroplasts
    • Ravanel, S., Droux, M., and Douce, R. (1995) Methionine biosynthesis in higher plants. I. Purification and characterization of cystathionine gamma-synthase from spinach chloroplasts. Arch Biochem. Biophys. 316, 572-584
    • (1995) Arch Biochem. Biophys , vol.316 , pp. 572-584
    • Ravanel, S.1    Droux, M.2    Douce, R.3
  • 21
    • 0014011385 scopus 로고
    • Cystathionine gamma-synthetase of Salmonella. Catalytic properties of a new enzyme in bacterial methionine biosynthesis
    • Kaplan, M.M. and Flavin, M. (1966) Cystathionine gamma-synthetase of Salmonella. Catalytic properties of a new enzyme in bacterial methionine biosynthesis. J. Biol. Chem. 241, 4463-4471
    • (1966) J. Biol. Chem , vol.241 , pp. 4463-4471
    • Kaplan, M.M.1    Flavin, M.2
  • 22
    • 14044273636 scopus 로고    scopus 로고
    • Catalytic mechanism of Chlamydia trachomatis flavin-dependent thymidylate synthase
    • Griffin, J., Roshick, C., Iliffe-Lee, E., and McClarty, G. (2005) Catalytic mechanism of Chlamydia trachomatis flavin-dependent thymidylate synthase. J. Biol. Chem. 280, 5456-5467
    • (2005) J. Biol. Chem , vol.280 , pp. 5456-5467
    • Griffin, J.1    Roshick, C.2    Iliffe-Lee, E.3    McClarty, G.4
  • 25
    • 0001359125 scopus 로고
    • Methiomine synthesis in Lemna. Inhibition of cystathionine γ-synthase by propargylglycine
    • Thompson, G.A., Datko, A.H., and Mudd, S.H. (1982) Methiomine synthesis in Lemna. Inhibition of cystathionine γ-synthase by propargylglycine. Plant Physiol. 70, 1347-1352
    • (1982) Plant Physiol , vol.70 , pp. 1347-1352
    • Thompson, G.A.1    Datko, A.H.2    Mudd, S.H.3
  • 26
    • 0024601543 scopus 로고
    • Synthesis and pharmacology of a series of 3- and 4-(phosphonoalkyl)pyridine- and -piperidine-2-carboxylic acids. Potent N-methyl-D-aspartate receptor antagonists
    • Ornstein, P.L., Schaus, J.M., Chambers, J.W., Huser, D.L., Leander, J.D., Wong, D.T., Paschal, J.W., Jones, N.D., and Deeter, J.B. (1989) Synthesis and pharmacology of a series of 3- and 4-(phosphonoalkyl)pyridine- and -piperidine-2-carboxylic acids. Potent N-methyl-D-aspartate receptor antagonists,. J. Med. Chem. 32, 827-833
    • (1989) J. Med. Chem , vol.32 , pp. 827-833
    • Ornstein, P.L.1    Schaus, J.M.2    Chambers, J.W.3    Huser, D.L.4    Leander, J.D.5    Wong, D.T.6    Paschal, J.W.7    Jones, N.D.8    Deeter, J.B.9
  • 27
    • 0028100244 scopus 로고
    • Purification and properties of cystathionine γ-synthase from wheat (Triticum aestivum L.)
    • Kreft, B.D., Townsend, A., Pohlenz, H.D., and Laber, B. (1994) Purification and properties of cystathionine γ-synthase from wheat (Triticum aestivum L.). Plant Physiol. 104, 1215-1220
    • (1994) Plant Physiol , vol.104 , pp. 1215-1220
    • Kreft, B.D.1    Townsend, A.2    Pohlenz, H.D.3    Laber, B.4


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