Helicobacter pylori Infection, a paradigm for chronic mucosal inflammation: Pathogenesis and implications for eradication and prevention

Advances in Internal Medicine

Volumn 41, Issue , 1996, Pages 85-117

  Cover, Timothy L ^a,b   Blaser, Martin J ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHRONIC DISEASE; GASTRITIS; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; ISOLATION AND PURIFICATION; MICROBIOLOGY; PATHOLOGY; REVIEW; STOMACH MUCOSA;

CHRONIC DISEASE; GASTRIC MUCOSA; GASTRITIS; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS;

EID: 0030344912     PISSN: 00652822     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (214)

1. Doenges JL: Spirochaetes in the gastric glands of Macacus rhesus and humans without definite history of related disease. Proc Soc Exp Med BioJ 38:536-538, 1938.
2. Warren JR: Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 1:1273, 1983.
3. Marshall BJ: Unidentified curved bacillus on gastric epithelium in active chronic gastritis. Lancet 1:1273-1275, 1983.
4. Marshall BJ, Warren JR: Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulcération. Lancet 1:1311-1313, 1984.
5. Goodwin CS, Armstrong JA, Chilvers T, et al: Transfer of Campylobacter pylori and Campylobacter mustelae to HeJicobacter gen. nov. as Helicobacter pylori comb. nov. and Helicobacter mustelae comb, nov., respectively. Int J Syst Bacterial 39:397-405, 1989.
6. Taylor DE, Eaton M, Chang N, et al: Construction of a Helicobacter pylori genome map and demonstration of diversity at the genome level. J Bacteriol 174:6800-6806, 1992.
7. Bukanov NO, Berg DE: Ordered cosmid library and high-resolution physical-genetic map of Helicobacter pylori strain NCTC 11638. Mol Microbiol 11:509-523, 1994.
8. Kleanthous H, Clayton CL, Tabaqchali S: Characterization of a plasmid from Helicobacter pylori encoding a replication protein common to plasmids in gram-positive bacteria. Mol Microbiol 5:2377-2389, 1991.
9. Majewski SI, Goodwin CS: Restriction endonuclease analysis of the genome of Campylobacter pylori with a rapid extraction method: Evidence for considerable genomic variation. J Infect Dis 157:465-471, 1988.
10. Akopyanz N, Bukanov NO, Westblom TU, et al: DNA diversity among clinical isolates of Helicobacter pylori detected by PCR-based RAPD fingerprinting. Nucleic Acids Res 20:5137-5142, 1992.
11. Fujimoto S, Marshall B, Blaser MJ: PCR-based restriction fragment length polymorphism typing of Helicobacter pylori. J Clin Microbiol 34:331-334, 1994.
12. Moran AP, Heiander IM, Kosunen TU: Compositional analysis of Helicobacter pylori rough-form lipopolysaccharides. J Bacteriol 174:1370-1377, 1992.
13. Mills SD, Kurjanczyk LA, Penner JL: Antigeniticity of Helicobacter pylori lipopolysaccharides. J Clin Microbiol 30:3175-3180, 1992.
14. Lee A, Fox J, Hazell S: Pathogenicity of Helicobacter pylori: A perspective. Infect Immun 61:1601-1610, 1993.
15. Solnick JV, O'Rourke J, Lee A, et al: An uncultured gastric spiral organism is a newly identified Helicobacter in humans. J Infect Dis 168:379-385, 1993.
16. Taylor DN, Blaser MJ: The epidemiology of Helicobacter pylori infections. Epidermiol Rev 13:42-59, 1991.
17. Glupczynski Y, Bourdeaux L, Verhas M, et al: Use of a urea breath test versus invasive methods to determine the prevalence of Helicobacter pylori in Zaire. Eur J Clin Microbiol Infect Dis 11:322-327, 1992.
18. Mitchell HM, Li YY, Hu PJ, et al: Epidemiology of Helicobacter pylori in Southern China: Identification of early childhood as the critical period for acquisition. J Infect Dis 166:149-153, 1992.
19. Perez-Perez GI, Taylor DN, Bodhidatta L, et al: Seroprevalence of Helicobacter pylori infections in Thailand. J Infect Dis 161:1237-1241, 1990.
20. Megraud F, Brassens-Rabbe M-P, Denis F, et al: Seroepidemiology of Campylobacter pylori infection in various populations. J Clin Microbiol 27:1870-1873, 1989.
21. Dooley CP, Cohen H, Fitzgibbons PL, et al: Prevalence of Helicobacter pylori infection and histologie gastritis in asymptomatic persons. N EngJ J Med 321:1562-1566, 1989.
22. Ferez GI, Dworkin BM, Chodos JE, et al: Campylobacter pylori antibodies in humans. Ann Intern Med 109:11-17, 1988.
23. van Zanten SJOV, Pollak PT, Best LM, et al: Increasing prevalence of Helicobacter pylori infection with age: Continuous risk of infection in adults rather than cohort effect. }Infect Dis 169:434-437, 1994.
24. Kuipers EJ, Pena AS, van Kamp G, et al: Seroconversion for Helicobacter pylori. Lancet 342:328-331, 1993.
25. Parsonnet J, Blaser MJ, Perez-Perez GI, et al: Symptoms and risk factors of Helicobacter pyJori infection in a cohort of epidemiologists. Gastroenterology 102:41-46, 1992.
26. Mendall MA, Goggin PM, Molineaux N, et al: Childhood living conditions and Helicobacter pylori seropositivity in adult life. Lancet 339:896-897, 1992.
27. Banatvala N, Mayo K, Megraud F, et al: The cohort effect and Helicobacter pylori. J Infect Dis 168:219-221, 1993.
28. Johnston BJ, Reed PI, Ali MH: Campylobacter like organisms in duodenal and antral endoscopie biopsies: Relationship to inflammation. Gut 27:1132-1137, 1986.
29. Wyatt JI, Rathbone BJ, Dixon MF, et al: Campylobacter pyloridis and acid induced gastric metaplasia in the pathogenesis of duodenitis. J Clin Pathol 40:841-848, 1987.
30. Ferguson DA Jr, Li C, Patel NR, et al: Isolation of Helicobacter pylori from saliva. J Clin Microbiol 31:2802-2804, 1993.
31. Shames B, Krajden S, Fuksa M, et al: Evidence for the occurrence of the same strain of Campylobacter pylori in the stomach and dental plaque. J Clin Microbiol 27:2849-2850, 1989.
32. Krajden S, Fuksa M, Anderson J, et al: Examination of human stomach biopsies, saliva, and dental plaque for Campylobacter pylori. J Clin Microbiol 27:1397-1398, 1989.
33. Banatvala N, Lopez CR, Owen R, et al: H. pylori in dental plaque. Lancet 341:380, 1993.
34. Nguyen A-MH, Engstrand L, Genta RM, et al: Detection of Helicobacter pylori in dental plaque by reverse transcription-polymerase chain reaction. J Clin Microbiol 31:783-787, 1993.
35. Thomas JE, Gibson GR, Darboe MK, et al: Isolation of Helicobacter pylori from human faeces. Lancet 340:1194-1195, 1992.
36. Drazek ES, Dubois A, Holmes RK: Characterization and presumptive identification of Helicobacter pylori isolates from rhesus monkeys. J Clin Microbiol 32:1799-1804, 1994.
37. Handt LK, Fox JG, Dewhirst FE, et al: H. pylori isolated from the do-mestic cat: Public health implications. Infect Immun 62:2367-2374, 1994.
38. Drumm B, Perez-Perez GI, Blaser MJ, et al: Intrafamilial clustering of Helicobacter pylori infection. N EngJ J Med 322:359-363, 1990.
39. Fox JG, Bianca MC, Yan L, et al: Role of gastric pH in isolation of Helicobacter mustelae from the feces of ferrets. Gastroenterology 104:8692, 1993.
40. Marshall BJ, Armstrong JA, McGechie DB, et al: Attempt to fulfill Koch's postulates for pyloric Campylobacter. Med J Aust 142:436-439, 1985.
41. Morris A, Nicholson G: Ingestion of Campylobacter pyJoridis causes gastritis and raised fasting gastric pH. Am J GastroenteroJ 82:192-199, 1987.
42. Morris AJ, Ali MR, Nicholson GI, et al: Long-term follow-up of voluntary ingestion of Helicobacter pylori. Ann Intern Med 114:662-663, 1991.
43. Graham DY, Alpert LC, Smith JL, et al: latrogenic Campylobacter pylori infection is a cause of epidemic achlorhydria. Am J Gastroenterol 83:974-980, 1988.
44. Ramsey EJ, Carey KV, Peterson WL, et al: Epidemic gastritis with hypochlorhydria. GastroenteroJogy 76:1449-1457, 1979.
45. Gledhill T, Leicester RJ, Addis B, et al: Epidemic hypochlorhydria. BMJ 290:1383-1386, 1985.
46. Forbes GM, Glaser ME, Cullen DJE, et al: Duodenal ulcer treated with HeJicobacter pylori eradication: Seven-year follow-up. Lancet 343:258-260, 1994.
47. Rauws EAJ, Langenberg W, Houthoff HJ, et al: Campylobacter pyloridis-associated chronic active antral gastritis. Gastroenterology 94:3340, 1988.
48. Carrick J, Lee A, Hazell S, et al: Campylobacter pylori, duodenal ulcer, and gastric metaplasia: Possible role of functional heterotopic tissue in ulcerogenesis. Gut 30:790-797, 1989.
49. Coghlan JG, Humphries H, Dooley C, et al: Campylobacter pylori and recurrence of duodenal ulcers-a 12-month follow-up study. Lancet 1:1109-1111, 1987.
50. Marshall BJ, Goodwin CS, Warren JR, et al: Prospective double-blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori. Lancet 2:1437-1441, 1988.
51. Nomura A, Stemmermann GN, Chyour P-H, et al: Helicobacter pylori infection and the risk for duodenal and gastric ulcération. Ann Intern Med 120:977-981, 1994.
52. Cullen DJE, Collins BJ, Christiansen KJ, et al: Long term risk of peptic ulcer disease in people with Helicobacter pylori infection-a community based study (abstract F284). Gut 34(suppl 1):72, 1993.
53. Sipponen P, Varis K, Fraki O, et al: Cumulative 10-year risk of symptomatic duodenal and gastric ulcer in patients with or without chronic gastritis-a clinical follow-up study of 454 outpatients. Scand J GastroenteroJ 25:966-973, 1990.
54. Vaira D, Miglioli M, Mule P, et al: Prevalence of peptic ulcer in Helicobacter pylori positive blood donors. Gut 35:309-312, 1994.
55. Hentschel I, Brandstatter G, Dragosics B, et al: Effect of ranitidine and amoxicillin plus metronidazole on the eradication of Helicobacter pyJori and the recurrence of duodenal ulcer. N EngJ J Med 328:308-312, 1993.
56. Rauws EAJ, Tytgat GNJ: Cure of duodenal ulcer associated with eradication of Helicobacter pylori. Lancet 335:1233-1235, 1990.
57. Graham DY, Lew GM, Klein PD, et al: Effect of treatment of Helicobacter pylori infection on the long-term recurrence of gastric or duodenal ulcer: A randomized, controlled study. Ann Intern Med 116:705-708, 1992.
58. Hosking SW, Ling TKW, Chung SCS, et al: Duodenal ulcer healing by eradication of Helicobacter pylori without anti-acid treatment: Randomised controlled trial. Lancet 343:508-510, 1994.
59. Wyatt JI, Rathbone BJ, Sobala GM, et al: Gastric epithelium in the duodenum: Its association with Helicobacter pylori and inflammation. J Clin Pathol 43:981-986, 1990.
60. Sipponen P, Aarynen M, Kaariainen I, et al: Chronic antral gastritis, Lewis""1" phenotype, and male sex as factors in predicting coexisting duodenal ulcer. Scand J Gastroenterol 24:581-588, 1989.
61. Beardshall K, Moss S, Gill J, et al: Suppression of Helicobacter pylori reduces gastrin releasing peptide stimulated gastrin release in duodenal ulcer patients. Gut 33:601-603, 1992.
62. El-Omar E, Penman I, Dorrian ÇA, et al: Eradicating H. plori infection lowers gastrin mediated acid secretion by two thirds in patients with duodenal ulcer. Gut 34:1060-1065, 1993.
63. Graham DY, Opekun A, Lew GM, et al: Helicobacter pylori-associated exaggerated gastrin release in duodenal ulcer patients: The effect of bombesin infusion and urea ingestion. Gastroenterology 100:15711575, 1991.
64. Moss SF, Calam J: Acid secretion and sensitivity to gastrin in patients with duodenal ulcer: Effect of eradication of Helicobacter pylori. Gut 34:888-892, 1993.
65. Mossi S, Meyer-Wyss B, Renner EL, et al: Influence of Helicobacter pylori, sex, and age on serum gastrin and pepsinogen concentrations in subjects without symptoms and patients with duodenal ulcers. Gut 34:752-756, 1993.
66. Mulholland G, Ardill JES, Fillmore D, et al: Helicobacter pylori related hypergastrinaemia is the result of a selective increase in gastrin 17. Gut 34:757-761, 1993.
67. Moss SF, Legon S, Bioshop AE, et al: Effect of Helicobacter pylori on gastric somatostatin in duodenal ulcer disease. Lancet 340:930-932, 1992.
68. Queiroz D, Moura SB, Mendes EN, et al: Effect of Helicobacter pylori eradication on G-cell and D-cell density in children. Lancet 343:11911193, 1994.
69. Wagner S, Gladziwa U, Haruma K, et al: Effect of Helicobacter pylori infection on 24 hour intragastric acidity in patients with gastritis and duodenal ulcer. Gut 33:1024-1028, 1992.
70. Katelaris PH, Seow F, Lin BPC, et al: Effect of age, Helicobacter pylori infection, and gastritis with atrophy on serum gastrin and gastric acid secretion in healthy men. Gut 34:1032-1037, 1993.
71. Peterson WL, Barnett CC, Evans DJ Jr, et al: Acid secretion and serum gastrin in normal subjects and patients with duodenal ulcer: The role of Helicobacter pylori. Am J Gastroenterol 88:2038-2043, 1993.
72. Ihamaki T, Saukkonen M, Siurala M: Long-term observation of subjects with normal mucosa and with superficial gastritis: Results of 23-27 years' follow-up examinations. Scand J Gastroenterol 13:771-775, 1978.
73. Ihamaki T, Kekki M, Sipponen P, et al: The sequelae and course of chronic gastritis during a 30- to 34-year bioptic follow-up study. Scand J Gastroenterol 20:485-491, 1985.
74. Sakaki N, Momma K, Egawa N, et al: Influence of Helicobacter pylori infection on the progress of gastric mucosal atrophy and the occurrence of gastric cancer (abstract 462). Am J Gastroenterol 89:1400, 1994.
75. Karnes WE Jr, Samloff IM, Siurala M, et al: Positive serum antibody and negative tissue staining for Helicobacter pylori in subjects with atrophie body gastritis. Gastroenterology 101:167-174, 1991.
76. Siurala M, Lehtola J, Ihamaki T: Atrophie gastritis and its sequelae: Results of 19-23 years' follow-up examinations. Scand J Gastroenterol 9:441-446, 1974.
77. Nomura A, Stemmermann GN, Chyou P-H, et al: Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii. N Engl J Med 325:1132-1136, 1991.
78. Parsonnet J, Friedman GD, Vandersteen DP, et al: Helicobacter pylori infection and the risk of gastric carcinoma. N Engl }Med 325:11271131, 1991.
79. Parsonnet J, Vandersteen D, Goates J, et al: Helicobacter pylori infection in intestinal-and diffuse-type gastric adenocarcinomas. J Natl Cancer Inst 83:640-643, 1991.
80. Talley NJ, Zinsmeister AR, Weaver A, et al: Gastric adenocarcinoma and Helicobacter pylori infection. J Natl Cancer Inst 83:1734-1739, 1991.
81. Hansen S, Vollset SE, Melby K, et al: Strong association of previous Helicobacter pylori infection to distal gastric adenocarcinoma (abstract 292).Am J Gastroenterol 89:1358, 1994.
82. The Eurogast Study Group: An international association between Helicobacter pylori infection and gastric cancer. Lancet 341:1359-1362, 1993.
83. Correa P, Fox J, Fontham E, et al: Helicobacter pylori and gastric carcinoma: Serum antibody prevalence in populations with contrasting cancer risks. Cancer 66:2569-2574, 1990.
84. Forman D, Sitas F, Newell DG, et al: Geographic association of Helicobacter pylori antibody prevalence and gastric cancer mortality in rural China. Int J Cancer 46:608-611, 1990.
85. Howson CP, Hiyama T, Wynder EL: The decline in gastric cancer: Epidemiology of an unplanned triumph. Epidemiol Rev 8:1-27, 1986.
86. Correa P: Human gastric carcinogenesis: A multistep and multifactorial process-First American Cancer Society Award Lecture on cancer epidemiology and prevention. Cancer Res 52:6735-6740, 1992.
87. Sobala GM, Schorah CJ, Shires S, et al: Effect of eradication of Helicobacter pylori on gastric juice ascorbic acid concentrations. Gut 34:1038-1041, 1993.
88. Benerjee S, Hawksby C, Miller S, et al: Effect of Helicobacter pylori and its eradication on gastric juice ascorbic acid.Gut 35:317-322, 1994.
89. Tsuji M, Kawano S, Tsuji S, et al: Cell kinetics of mucosal atrophy in rat stomach induced by long-term administration of ammonia. Gastroenterology 104:796-801, 1993.
90. Brenes F, Ruiz B, Correa P, et al: HeJicobacter pylori causes hyperproliferation of the gastric epithelium: Pre- and post-eradication indices of proliferating cell nuclear antigen. Am J Gastroenterol 88:18701875, 1993.
91. Lynch DAF, Mapstone NP, Clarke AMT, et al: Cell proliferation in Helicobacter pylori associated gastritis and the long term effect of eradication (abstract 298). Am J Gastroenterol 89:1359, 1994.
92. Johnson LR, Guthrie PD: Stimulation of DNA synthesis by big and little gastrin (G-34 and G-17). Gastroenterology 71:599-602, 1976.
93. Jackson JH, Gajewski E, Schraufstatter IU, et al: Damage to the bases in DNA induced by stimulated human neutrophils. J Clin Invest 84:1644-1649, 1989.
94. Wotherspoon AC, Ortiz-Hidalgo C, Falzon MR, et al: HeJicobacter pylori-associated gastritis and primary B-cell gastric lymphoma. Lancet 338:1175-1176, 1991.
95. Hussell T, Isaacson PG, Crabtree JE, et al: The response of cells from low-grade B-cell gastric lymphomas of mucosa-associated lymphoid tissue to Helicobacter pylori. Lancet 342:571-574, 1993.
96. Wotherspoon AC, Doglioni C, Diss TC, et al: Regression of primary low-grade B cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori. Lancet 342:575-577, 1993.
97. Parsonnet J, Hansen S, Rodriguez L, et al: Helicobacer pylori infection and gastric lymphoma. N Eng! J Med 330:1267-1271, 1994.
98. Fox JG, Otto G, Taylor NS, et al: Helicobacter pylori-induced gastritis and elevated gastric pH in the ferret (Mustela putorius furoj. Infect Immun 59:1875-1880, 1991.
99. Cave DR, Vargas M: Effect of a Campylobacter pylori protein on acid secretion by parietal cells. Lancet 2:187-189, 1989.
100. Suèrbaum S, Josenhans C, Labigne A: Cloning and genetic characterization of the Helicobacter pylori and Helicobacter mustelae flaB flagellin genes and construction of Helicobacter pylori flaA- and flaBnegative mutants by electroporation-mediated allelic exchange. J Bacteriol 175:3278-3288, 1993.
101. Kostrzynska M, Betts JD, Austin JW, et al: Identification, characterization, and spatial localization of two flagellin species in Helicobacter pylori flagella. J Bacteriol 173:937-946,1991.
102. Hazell SL, Lee A, Brady L, et al: Campylobacter pyloridis and gastritis: Association with intercellular spaces and adaptation to an environment of mucus as important factors in colonization of the gastric epithelium. J Infect Dis 153:658-663, 1986.
103. Eaton KA, Morgan DR, Krakowka S: Motility as a factor in the colonisation of gnotobiotic piglets by Helicobacter pylori. J Med Microbiol 37:123-127, 1992.
104. Dunn BE, Campbell GP, Perez-Perez GI, et al: Purification and characterization of urease from Helicobacter pylori. J Biol Chem 265:94649469, 1990.
105. Hu LT, Mobley HL: Purification and N-terminal analysis of urease from Helicobacter pylori. Infect Immun 58:992-998, 1990.
106. Labigne A, Cussac V, Courcoux P: Shuttle cloning and nucleotide sequences of Helicobacter pylori genes responsible for urease activity. J Bacteriol 173:1920-1931, 1991.
107. Cussac V, Ferrero RL, Labigne A: Expression of Helicobacter pylori urease genes in Escherichia coli grown under nitrogen-limiting conditions. J Bacteriol 174:2466-2473, 1992.
108. Perez-Perez GI, Olivares AZ, Cover TL, et al: Characteristics of Helicobacter pylori variants selected for urease deficiency. Infect Immun 60:3658-3663, 1992.
109. Eaton KA, Krakowka S: Effect of gastric pH on urease-dependent colonization of gnotobiotic piglets by Helicobacter pylori. Infect Immun 62:3604-3607, 1994.
110. Ferrero RL, Lee A: The importance of urease in acid protection for the gastric-colonising bacteria Helicobacter pylori and Helicobacter /élis sp. nov. Microb Ecol Health Dis 4:121-134, 1991.
111. McColm A, Bagshaw I, O'Malley C, et al: Is urease a lethal target for therapy of Helicobacter pylori? Microb Ecol Health Dis 4(suppl):145, 1991.
112. el Nujumi AM, Dorrian ÇA, Chittajallu RS, et al: Effect of inhibition of Helicobacter pylori urease activity by acetohydroxamic acid on serum gastrin in duodenal ulcer subjects. Gut 32:866-870, 1991.
113. McColm AA, Bagshaw JA, O'Malley CF: Development of a 14C-urea breath test in ferrets colonised with Helicobacter mustelae: Effects of treatment with bismuth, antibiotics, and urease inhibitors. Gut 34:181-186, 1993.
114. Hui PK, Chan WY, Cheung PS, et al: Pathologie changes of gastric mucosa colonized by Helicobacter pylori. Hum Pathol 23:548-556,1992.
115. Hessey SJ, Spencer J, Wyatt JI, et al: Bacterial adhesion and disease activity in Helicobacter pylori associated chronic gastritis. Gut 31:134-138, 1990.
116. Denizot Y, Sobhani I, Rambaud J-C, et al: Paf-acether synthesis by Helicobacter pylori. Gut 31:1242-1245, 1990.
117. Salmela KS, Roine RP, Koivisto T, et al: Characteristics of Helicobacter pylori alcohol dehydrogenase. Gastroenterology 105:325-330, 1993.
118. Weitkamp J-H, Perez-Perez GI, Bode G, et al: Identification and characterization of Helicobacter pylori phospholipase C activity. Zentralbl Bakteriol 280:11-27, 1993.
119. Ottlecz A, Romero }J, Hazell SL, et al: Phospholipase activity of Helicobacter pylori and its inhibition by bismuth salts. Dig Dis Sei 38:2071-2080, 1993.
120. Langton SR, Cesareo SD: Helicobacter pylori associated phospholipase A2 activity: A factor in peptic ulcer production? J Clin Pathol 45:221-224, 1992.
121. Mooney C, Keenan J, Munster D, et al: Neutrophil activation by Helicobacter pylori. Gut 32:853-857, 1991.
122. Davies GR, Simmonds NJ, Stevens TRJ, et al: Helicobacter pylori stimulates antral mucosal reactive oxygen metabolite production in vivo. Gut 35:179-185, 1994.
123. Cover TL, Vaughn SG, Cao P, et al: Potentiation of Helicobacter pylori vacuolating toxin activity by nicotine and other weak bases. J Infect Dis 166:1073-1078, 1992.
124. Suzuki M, Miura S, Suematsu M, et al: Helicobacter pylori-associated ammonia production enhances neutrophil-dependent gastric mucosal cell injury. Am J Physiol 263:G719-G725, 1992.
125. Sarosiek J, Marshall BJ, Peura DA, et al: Gastroduodenal mucus gel thickness in patients with Helicobacter pylori: A method for assessment of biopsy specimens. Am J Gastroenterol 86:729-734, 1981.
126. Spychal RT, Goggin PM, Marrero JM, et al: Surface hydrophobicity of gastric mucosa in peptic ulcer disease: Relationship to gastritis and Campylobacter pylori infection. Gastroenterology 98:1250-1254, 1990.
127. Mauch F, Bode G, Ditschuneit H, et al: Demonstration of a phospholipid-rich zone in the human gastric epithelium damaged by Helicobacter pylori. Gastroenterology 105:1698-1704, 1993.
128. Slomiany BL, Bilsky J, Sarosiek J, et al: Campylobacter pyloridis degrades mucin and undermines gastric mucosal integrity. Biochem Biophys Res Commun 144:307-312, 1987.
129. Smith AW, Chahal B, French GL: The human gastric pathogen Helicobacter pylori has a gene encoding an enzyme first classified as a mucinase in Vibrio cholerae. Mol Microbiol 13:153-160, 1994.
130. Micots I, Augeron C, Laboisses CL, et al: Mucin exocytosis: A major target for Helicobacter pylori. J Clin Pathol 46:241-245, 1993.
131. Evans DG, Karjalainen TK, Evans DJ Jr, et al: Cloning, nucleotide sequence, and expression of a gene encoding an adhesin subunit protein of Helicobacter pylori. J BacterioJ 175:674-683, 1993.
132. Lingwood ÇA, Wasfy G, Han H, et al: Receptor affinity purification of a lipid-binding adhesin from Helicobacter pylori. Infect Immun 61:2474-2478, 1993.
133. Lingwood ÇA, Huesca M, Kuksis A: The glycerolipid receptor for Helicobacter pylori (and exoenzyme S) is phosphatidylethanolamine. Infect Immun 60:2470-2474, 1992.
134. Gold BD, Hesca M, Sherman PM, et al: Helicobacter mustelae and Helicobacter pylori bind to common lipid receptors in vitro. Infect Immun 61:2632-2638, 1993.
135. Fauchere J-L, Blaser MJ: Adherence of Helicobacter pylori cells and their surface components to HeLa cell membranes. Microb Pathog 9:427-439, 1990.
136. Trust TJ, Doig P, Emody L, et al: High-affinity binding of the basement membrane proteins collagen type IV and laminin to the gastric pathogen Helicobacter pylori. Infect Immun 59:4398-4404, 1991.
137. Valkonen KH, Ringner M, Ljungh A, et al: High-affinity binding of laminin by Helicobacter pylori: Evidence for a lectin-like interaction. FEMS Immunol Med Microbiol 7:29-38, 1993.
138. Ascencio F, Fransson LA, Wadstron T: Affinity of the gastric pathogen Helicobacter pylori for the N-sulphated glycosaminoglycan heparan sulphate. /Med Microbiol 38:240-244, 1993.
139. Saitoh T, Natomi H, Zhao W, et al: Identification of glycolipid receptors for Helicobacter pylori by TLC-immunostaining. FEBS Lett 282:385-387, 1991.
140. Falk P, Roth KA, Boren T, et al: An in vitro adherence assay reveals that Helicobacter pylori exhibits cell lineage-specific tropism in the human gastric epithelium. Proc Natl Acad Sei U S A 90:2035-2039, 1993.
141. Deleted in proof.
142. Krakowka S, Morgan DR, Kraft WG, et al: Establishment of gastric Campylobacter pylori infection in the neonatal gnotobiotic piglet. Infect Immun 55:2789-2796, 1987.
143. Lee A, Fox JG, Ottot G, et al: A small animal model of human Helicobacter pylori active chronic gastritis. Gastroenterology 99:1315-1323, 1990.
144. Fox JG, Lee A, Otto G, et al: Helicobacter/élis gastritis in gnotobiotic rats: An animal model of Helicobacter pylori gastritis. Infect Immun 59:785-791, 1991.
145. Sakagami T, Shimoyama T, O'Rourke J, et al: Back to the host: Severity of inflammation induced by Helicobacter felis in different strains of mice (abstract 241). Am J Gastroenterol 89:1345, 1994.
146. Mai UEH, Perez-Perez GI, Wahl LM, et al: Soluble surface proteins from Helicobacter pylori activate monocytes/macrophages by lipopolysaccharide-independent mechanism. J Clin Invest 87:894-900, 1991.
147. Mai UEH, Perez-Perez GI, Alien JB, et al: Surface proteins from Helicobacter pylori exhibit chemotactic activity for human leukocytes and are present in gastric mucosa. J Exp Med 175:517-525, 1992.
148. Tufano MA, Rossano F, Catalanotti P, et al: Immunobiological activities of Helicobacter pylori porins. Infect Immun 62:1392-1399,1994.
149. Reymunde A, Deren J, Nachamkin I, et al: Production of chemoattractant by Helicobacter pylori. Dig Dis Sei 38:1697-1701, 1993.
150. Craig PM, Territo MC, Karnes WE, et al: Helicobacter pylori secretes a chemotactic factor for monocytes and neutrophils. Gut 33:1020-1023, 1992.
151. Kozol R, McCurdy B, Czanko R: A neutrophil chemotactic factor present in H. pylori but absent in H. mustelae. Dig Dis Sei 38:137-141, 1993.
152. Nielsen H, Andersen LP: Chemotactic activity of Helicobacter pylori sonicate for human polymorphonuclear leucocytes and monocytes. Gut 33:738-742, 1992.
153. Crabtree JE, Shallcross TM, Heatley RV, et al: Mucosal tumour necrosis factor alpha and interleukin-6 in patients with Helicobacter pylori associated gastritis. Gut 32:1473-1477, 1991.
154. Crabtree JE, Wyatt JI, Trejdosiewicz LK, et al: Interleukin-8 expression in Helicobacter pylori infected, normal, and neoplastic gastroduodenal mucosa. J Clin Pathol 47:61-66, 1994.
155. Crabtree JE, Peichl P, Wyatt JI, et al: Gastric interleukin-8 and IgA IL-8 autoantibodies in Helicobacter pylori infection. Scand J Immunol 37:65-70, 1993.
156. Yoshida N, Granger DN, Evans DJ Jr, et al: Mechanisms involved in Helicobacter pylori-induced inflammation. Gastroenterology 105: 1431-1440, 1993.
157. Evans DJ Jr, Evans DG, Takemura T, et al: Identification of Helicobacter pylori neutrophil activating protein: A ring-forming protein of Helicobacter pylori which promotes neutrophil adhesion to endothelial cells (abstract 212). Am J Gastroenterol 89:1338, 1994.
158. Nielsen H, Anderson LP: Activation of human phagocyte oxidative metabolism by Helicobacter pylori. Gastroenterology 103:1747-1753, 1992.
159. Nielsen H, Birkhoz S, Anderson LP, et al: Neutrophil activation by Helicobacter pylori lipopolysaccharides. J Infect Dis 170:135-139, 1994.
160. Spiegelhalder C, Gerstenecker B, Kersten A, et al: Purification of Helicobacter pylori Superoxide dismutase and cloning and sequencing of the gene. Infect Immun 61:5315-5325, 1993.
161. Westblom TU, Phadnis S, Langenberg W, et al: Catalase negative mutants of Helicobacter pylori. Eur J Clin Microbiol Infect Dis 11:522526, 1992.
162. Hazell SL, Evans DJ, Graham DY: Helicobacter pylori catalase. J Gen Microbiol 137:57-61, 1991.
163. Tarkkanen J, Kosunen TU, Saksela E: Contact of lymphocytes with Helicobacter pylori augments natural killer cell ativity and induces production of gamma Interferon. Infect Immun 61:3012-3016, 1993.
164. Kartunen R, Andersson G, Poikonen K, et al: Helicobacter pylori induces lymphocyte activation in peripheral blood cultures. Clin Exp Immunol 82:485-488, 1990.
165. Sharma SA, Miller GG, Perez-Perez GI, et al: Humoral and cellular immune recognition of Helicobacter pylori proteins are not concordant. Clin Exp Immunol 97:126-132, 1994.
166. Mattsby-Baltzer I, Mielniczuk Z, Larsson L, et al: Lipid A in Helicobacter pylori. Infect Immun 60:4383-4387, 1992.
167. Birkholz S, Knipp U, Netzki C, et al: Immunological activity of lipopolysaccharide of Helicobacter pylori on human peripheral mononuclear blood cells in comparison to lipopolysaccharides of other intestinal bacteria. FEMS Immunol Med Microbiol 6:317-324, 1993.
168. Leunk RD, Johnson PT, David BC, et al: Cytotoxic activity in broth culture filtrates of Campylobacter pylori. J Med Microbiol 26:93-99, 1988.
169. Cover TL, Dooley CP, Blaser MJ: Characterization of and human sérologie response to proteins in Helicobacter pylori broth culture supernatants with vacuolizing cytotoxin activity. Infect Immun 58: 603-610, 1990.
170. Tummuru MKR, Cover TL, Blaser MJ: Cloning and expression of a high-molecular mass major antigen of Helicobacter pylori: Evidence of linkage to cytotoxin production. Infect Immun 61:1799-1809,1993.
171. Covacci A, Censini S, Bugnoli M, et al: Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. Proc Natl Acad Sei U S A 90:5791-5795, 1993.
172. Crabtree JE, Taylor JD, Wyatt JI, et al: Mucosal IgA recognition of Helicobacter pylori 120 kDa protein, peptic ulcération, and gastric pathology. Lancet 338:332-335, 1991.
173. Rautelein H, Blomberg B, Jarnerot G, et al: Nonopsonic activation of neutrophils and cytotoxin production by Helicobacter pylori: Ulcerogenic markers. Scand J Gastroenterol 29:128-132, 1994.
174. Crabtree JE, Farmery SM, Lindley IJD, et al: CagA/cytotoxic strains of Helicobacter pylori and interleukin-8 in gastric epithelial cell lines. J Clin Pathol 47:945-950, 1994.
175. Doig P, Trust TJ: Identification of surface-exposed outer membrane antigens of Helicobacter pylori. Infect Immun 62:4526-4533, 1994.
176. Figura N, Guglielmetti P, Rossolini A, et al: Cytotoxin production by Campylobacter pylori strains isolated from patients with peptic ulcers and from patients with chronic gastritis only. J Clin Microbiol 27:225-226, 1989.
177. Cover TL, Blaser MJ: Purification and characterization of the vacuolating toxin from Helicobacter pylori. J Biol Chem 267:10570-10575, 1992.
178. Cover TL, Cao P, Murthy UK, et al: Serum neutralizing antibody response to the vacuolating cytotoxin of Helicobacter pylori. J Clin Invest 90:913-918, 1992.
179. Cover TL, Tummuru MKR, Cao P, et al: Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains. J Biol Chem 269:10566-10573, 1994.
180. Telford JL, Ghiara P, Dell'Orco M, et al: Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease. JExp Med 179:1653-1658, 1994.
181. Schmitt W, Haas R: Genetic analysis of the Helicobacter pylori vacuolating cytotoxin: Structural similarties with the IgA protease type of exported protein. Mol Microbiol 12:307-319, 1994.
182. Phadnis SH, liver D, Janzon L, et al: Pathological significance and molecular characterization of the vacuolating toxin gene of Helicobacter pylori. Infect Immun 62:1557-1565, 1994.
183. Tummuru MKR, Cover TL, Blaser MJ: Mutation of the cytotoxinassociated cagA gene does not affect the vacuolating cytotoxin activity of Helicobacter pylori. Infect Immun 62:2609-2613, 1994.
184. Cover TL, Glupczynski Y, Lage AP, et al: Sérologie detection of infection with CagA+ Helicobacter pylori strains. J Clin Microbiol 33:14961500, 1995.
185. Cover TL, Cao P, Lind CD, et al: Correlation between vacuolating cytotoxin production by Helicobacter pylori isolates in vitro and in vivo. Infect Immun 61:5008-5012, 1993.
186. Goossens H, Glupczynski Y, Burette A, et al: Role of the vacuolating toxin from Helicobacter pylori in the pathogenesis of duodenal and gastric ulcer. Med Microbiol Lett 1:153-159, 1992.
187. Tee W, Lambert JR, Dwyer B: Cytotoxin production by Helicobacter pylori more common in peptic ulcer disease. J Clin Microbiol 33:1203-1205, 1995.
188. Xiang Z, Bugnoli M, Ponzetto A, et al: Detection in an enzyme immunoassay of an immune response to a recombinant fragment of the 128 kilodalton protein (CagA) of Helicobacter pylori. Eur J Clin Microbiol Infect Dis 12:739-745, 1993.
189. Crabtree JE, Wyatt JI, Sobala GM, et al: Systemic and mucosal humoral responses to Helicobacter pylori in gastric cancer. Gut 34:1339-1343, 1993.
190. Blaser MJ, Perez-Perez GI, Kleanthous H, et al: Infection with Helicobacter pylori strains possessing cagA is associated with increased risk of developing adenocarcinoma of the stomach. Cancer Res 55:2111-2115, 1995.
191. Fox JG, Correa P, Taylor NS, et al: Helicobacter mustelae-associated gastritis in ferrets. Gastroenterology 99:352-361, 1990.
192. Queiroz DMM, Rocha GA, Mendes EN, et al: Is "G. suis" the etiologic agent of gastric ulcer of swine (abstract 180)? Am J Gastroenterol 89:1330, 1994.
193. Fox JG, Dewhirst FE, Tully JG, et al: Helicobacter hepaticus sp. nov., a microaerophilic bacterium isolated from livers and intestinal mucosal scrapings from mice. J Clin Microbiol 32:1238-1245, 1994.
194. Blaser MJ, Parsonnet J: Parasitism by the "slow" bacterium Helicobacter pylori leads to altered gastric homeostasis and neoplasia. J Clin Invest 94:4-8, 1994.
195. Borody T, Anderew P, Mancuso N, et al: Helicobacter pylori reinfection 4 years post-eradication. Lancet 339:1295, 1992.
196. van Zwet AA, Thijs JC, Schievink-de Vries W, et al: In vitro studies on stability and development of metronidazole resistance in Helicobacter pylori. Antimicrob Agents Chemother 38:360-362, 1994.
197. McGowan CC, Cover TL, Blaser MJ: The proton pump inhibitor omeprazole inhibits acid survival of Helicobacter pylori by a ureaseindependent mechanism. Gastroenterology 107:1573-1578, 1994.
198. Iwahi T, Satoh H, Nakao M, et al: Lansoprazole, a novel benzimidazole proton pump inhibitor, and its related compounds have selective activity against Helicobacter pylori. Antimicrob Agents Chemother 35:490-496, 1991.
199. Nagata K, Satoh H, Iwahi T, et al: Potent inhibitory action of the gastric proton pump inhibitor lansoprazole against urease activity of Helicobacter pylori: Unique action selective for H. pylori cells. Antimicrob Agents Chemother 37:769-774, 1993.
200. Logan RPH, Gummett PA, Misiewicz JJ, et al: One week eradication for Helicobacter pylori. Lancet 338:1249-1252, 1991.
201. Bayerdorffer E, Miehlke S, Mannes GA, et al: Double-blind trial of omeprazole (120 mg) plus amoxycillin for Helicobacter pylori eradication in duodenal ulcer patients (abstract 315). Am J Gastroenterol 89:1364, 1994.
202. Logan RPH, Bardhan KD, Celestin LR, et al: Clarithromycin and omeprazole in the prevention of duodenal ulcer recurrence and eradication of H. pylori (abstract 372). Am J Gastroenterol 89:1378, 1994.
203. NIH Consensus Development Panel on Helicobacter pylori in peptic ulcer disease: Helicobacter pylori in peptic ulcer disease. JAMA 272:65-69, 1994.
204. Michetti P, Corthesy-Theulaz I, Vaney AC, et al: Prophylactic and therapeutic immunization against H. /élis infection with H. pylori urease B subunit (abstract 231). Am J Gastroenterol 89:1343, 1994.
205. Doidge C, Lee A, Buck F, et al: Therapeutic immunization against gastric Helicobacter infection (abstract 339). Am J Gastroenterol 89:1370, 1994.
206. Schurig GG, Hall CE, Corbeil LB, et al: Bovine venereal vibriosis: Cure of genital infection in females by systemic immunization. Infect Immun 1:245-251, 1975.
207. Eaton KA, Krakowka S: Chronic active gastritis due to Helicobacter pylori in immunized gnotobiotic piglets. Gastroenterology 103:1580-1586, 1992.
208. Chen M, Lee A, Hazell S: Immunization against gastric helicobacter infection in a mouse/Helicobacterfelis model. Lancet 339:1120-1121, 1992.
209. Czinn SJ, Gai A, Nedrud JG: Protection of germ-free mice from infection by Helicobacter felis after active oral or passive IgA immunization. Vaccine 11:637-642, 1993.
210. Lee A, Chen M: Successful immunization against gastric infection with Helicobacter species: Use of a cholera toxin B-subunit-wholecell vaccine. Infect Immun 62:3594-3597, 1994.
211. Ferrero RL, Thiberge J-M, Herre M, et al: Recombinant antigens prepared from the urease subunits of Helicobacter spp.: Evidence of protection in a mouse model of gastric infection. Infect Immun 62:4981-4989, 1994.
212. Prewett EJ, Bickley J, Owen RJ, et al: DNA patterns of Helicobacter pylori isolated from gastric antrum, body, and duodenum. Gastroenterology 102:829-833, 1992.
213. Fox JG, Batchelder M, Hayward A, et al: Prior Helicobacter mustelae infection does not confer protective immunity against experimental reinfection in ferrets (abstract 134). Am J Gastroenterol 89:1318,1994.
214. Czinn SJ, Nedrud JG: Oral immunization against Helicobacter pylori. Infect Immun 59:2359-2363, 1991.