Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6

EMBO Reports

Volumn 8, Issue 8, 2007, Pages 784-789

  Wittler, Lars ^a   Shin, Eun Ha ^a   Grote, Phillip ^a,b   Kispert, Andreas ^c   Beckers, Anja ^c   Gossler, Achim ^c   Werber, Martin ^a   Herrmann, Bernhard G ^a,b  

^a MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; BETA GALACTOSIDASE; MESOGENIN 1; TRANSCRIPTION FACTOR TBX6; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL TISSUE; ARTICLE; CELL STRAIN HEK293; CHROMATIN IMMUNOPRECIPITATION; CONSENSUS SEQUENCE; CONTROLLED STUDY; ENZYME ACTIVITY; HISTOLOGY; HUMAN; HUMAN CELL; IN SITU HYBRIDIZATION; MESODERM; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BETA-GALACTOSIDASE; EMBRYONIC DEVELOPMENT; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MESODERM; MICE; MICE, TRANSGENIC; PROMOTER REGIONS (GENETICS); SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; WNT PROTEINS;

MOUSE MAMMARY TUMOR VIRUS; VERTEBRATA;

EID: 34547629799     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/sj.embor.7401030     Document Type: Article

References (23)

1. Arnold SJ, Stappert J, Bauer A, Kispert A, Herrmann BG, Kemler R (2000) Brachyury is a target gene of the Wnt-β-catenin signaling pathway. Mech Dev 91: 249-258
2. Aulehla A, Herrmann BG (2004) Segmentation in vertebrates: Clock and gradient finally joined. Genes Dev 18: 2060-2067
3. Aulehla A, Wehrle C, Brand-Saberi B, Kemler R, Gossler A, Kanzler B, Herrmann BG (2003) Wnt3a plays a major role in the segmentation clock controlling somitogenesis. Dev Cell 4: 395-406
4. Beckers J, Caron A, Hrabe de Angelis M, Hans S, Campos-Ortega JA, Gossler A (2000) Distinct regulatory elements direct delta expression in the nervous system and paraxial mesoderm of transgenic mice. Mech Dev 95: 23-34
5. Chapman DL, Papaioannou VE (1998) Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6. Nature 391: 695-697
6. Ciruna BG, Schwartz L, Harpal K, Yamaguchi TP, Rossant J (1997) Chimeric analysis of fibroblast growth factor receptor-1 (Fgfr1) function: a role for FGFR1 in morphogenetic movement through the primitive streak. Development 124: 2829-2841
7. Conlon RA, Reaume AG, Rossant J (1995) Notch1 is required for the coordinate segmentation of somites. Development 121: 1533-1545
8. Dubrulle J, Pourquie O (2004) fgf8 mRNA decay establishes a gradient that couples axial elongation to patterning in the vertebrate embryo. Nature 427: 419-422
9. -/- mice. Genes Dev 13: 709-717
10. Galceran J, Sustmann C, Hsu SC, Folberth S, Grosschedl R (2004) LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis. Genes Dev 18: 2718-2723
11. Gossler A, Tam PPL (2002) Somitogenesis: Segmentation of the paraxial mesoderm and the delineation of tissue compartments. In Mouse Development. Rossant J, Tam PPL (eds) pp 127-149. San Diego, CA: Academic Press
12. Greco TL, Takada S, Newhouse MM, McMahon JA, McMahon AP, Camper SA (1996) Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development. Genes Dev 10: 313-324
13. Herrmann BG (1995) The mouse Brachyury (T) gene. Semin Dev Biol 6: 385-394
14. Hofmann M, Schuster-Gossler K, Watabe-Rudolph M, Aulehla A, Herrmann BG, Gossler A (2004) WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating DII1 expression in the presomitic mesoderm of mouse embryos. Genes Dev 18: 2712-2717
15. Hrabe de Angelis M, McIntyre 2nd J, Gossler A (1997) Maintenance of somite borders in mice requires the Delta homologue DII1. Nature 386: 717-721
16. Sato Y, Yasuda K, Takahashi Y (2002) Morphological boundary forms by a novel inductive event mediated by Lunatic fringe and Notch during somitic segmentation. Development 129: 3633-3644
17. Theiler K (1989) The House Mouse: Atlas of Embryonic Development. Berlin, Heidelberg, New York: Springer
18. Wilkinson DG, Bhatt S, Herrmann BG (1990) Expression pattern of the mouse T gene and its role in mesoderm formation. Nature 343: 657-659
19. Wilson V, Beddington R (1997) Expression of T protein in the primitive streak is necessary and sufficient for posterior mesoderm movement and somite differentiation. Dev Biol 192: 45-58
20. Yamaguchi TP, Bradley A, McMahon AP, Jones S (1999a) A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. Development 126: 1211-1223
21. Yamaguchi TP, Takada S, Yoshikawa Y, Wu N, McMahon AP (1999b) T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification. Genes Dev 13: 3185-3190
22. Yoon JK, Wold B (2000) The bHLH regulator pMesogenin1 is required for maturation and segmentation of paraxial mesoderm. Genes Dev 14 3204-3214
23. Yoshikawa Y, Fujimori T, McMahon AP, Takada S (1997) Evidence that absence of Wnt-3a signaling promotes neuralization instead of paraxial mesoderm development in the mouse. Dev Biol 183: 234-242