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Volumn 77, Issue 3, 2008, Pages 560-569

FXR-mediated regulation of angiotensin type 2 receptor expression in vascular smooth muscle cells

Author keywords

Angiotensin II; Angiotensin II type 2 receptor; FXR; Regulation; Smooth muscle cells

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; ALPHA BROMO 4 HYDROXYACEPHENONE 4 HYDROXYPHENACYL BROMIDE; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ANGIOTENSIN II; ANGIOTENSINOGEN; FARNESOID X RECEPTOR; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE INHIBITOR; PROTEIN TYROSINE PHOSPHATASE SHP 1; UNCLASSIFIED DRUG;

EID: 38849135894     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvm068     Document Type: Article
Times cited : (50)

References (51)
  • 1
    • 0033215367 scopus 로고    scopus 로고
    • The cardiac Renin-Angiotensin system: Conceptual, or a regulator of cardiac function
    • Dostal DE, Baker KM. The cardiac Renin-Angiotensin system: conceptual, or a regulator of cardiac function. Circ Res 1999;85:643-650.
    • (1999) Circ Res , vol.85 , pp. 643-650
    • Dostal, D.E.1    Baker, K.M.2
  • 2
    • 0033635110 scopus 로고    scopus 로고
    • Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells
    • Touyz RM, Schiffrin EL. Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells. Pharmacol Rev 2000;52:639-672.
    • (2000) Pharmacol Rev , vol.52 , pp. 639-672
    • Touyz, R.M.1    Schiffrin, E.L.2
  • 3
    • 14844338481 scopus 로고    scopus 로고
    • Beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation
    • Barnes WG, Reiter E, Violin JD, Ren XR, Milligan G, Lefkowitz RJ. Beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. J Biol Chem 2005;280:8041-8050.
    • (2005) J Biol Chem , vol.280 , pp. 8041-8050
    • Barnes, W.G.1    Reiter, E.2    Violin, J.D.3    Ren, X.R.4    Milligan, G.5    Lefkowitz, R.J.6
  • 4
    • 20144387642 scopus 로고    scopus 로고
    • Angiotensin II type 2 receptors contribute to vascular responses in spontaneously hypertensive rats treated with angiotensin II type 1 receptor antagonists
    • Cosentino F, Savoia C, De Paolis P, Francia P, Russo A, Maffei A et al. Angiotensin II type 2 receptors contribute to vascular responses in spontaneously hypertensive rats treated with angiotensin II type 1 receptor antagonists. Am J Hypertens 2005;18:493-499.
    • (2005) Am J Hypertens , vol.18 , pp. 493-499
    • Cosentino, F.1    Savoia, C.2    De Paolis, P.3    Francia, P.4    Russo, A.5    Maffei, A.6
  • 5
    • 33750575906 scopus 로고    scopus 로고
    • Angiotensin II/AT2 receptor-induced vasodilation in stroke-prone spontaneously hypertensive rats involves nitric oxide and cGMP-dependent protein kinase
    • Savoia C, Ebrahimian T, He Y, Gratton JP, Schiffrin EL, Touyz RM. Angiotensin II/AT2 receptor-induced vasodilation in stroke-prone spontaneously hypertensive rats involves nitric oxide and cGMP-dependent protein kinase. J Hypertens 2006;24:2417-2422.
    • (2006) J Hypertens , vol.24 , pp. 2417-2422
    • Savoia, C.1    Ebrahimian, T.2    He, Y.3    Gratton, J.P.4    Schiffrin, E.L.5    Touyz, R.M.6
  • 6
    • 0033824138 scopus 로고    scopus 로고
    • International Union of Pharmacology. XXIII. The angiotensin II receptors
    • de Gasparo M, Catt KJ, Inagami T, Wright JW, Unger T. International Union of Pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev 2000;52:415-472.
    • (2000) Pharmacol Rev , vol.52 , pp. 415-472
    • de Gasparo, M.1    Catt, K.J.2    Inagami, T.3    Wright, J.W.4    Unger, T.5
  • 7
    • 22544448655 scopus 로고    scopus 로고
    • The AT2 receptor - a matter of love and hate
    • Steckelings UM, Kaschina E, Unger T. The AT2 receptor - a matter of love and hate. Peptides 2005;26:1401-1409.
    • (2005) Peptides , vol.26 , pp. 1401-1409
    • Steckelings, U.M.1    Kaschina, E.2    Unger, T.3
  • 8
    • 18244407290 scopus 로고    scopus 로고
    • Cardiovascular and renal regulation by the angiotensin type 2 receptor: The AT2 receptor comes of age
    • Carey RM. Cardiovascular and renal regulation by the angiotensin type 2 receptor: the AT2 receptor comes of age. Hypertension 2005;45:840-844.
    • (2005) Hypertension , vol.45 , pp. 840-844
    • Carey, R.M.1
  • 10
    • 3142677779 scopus 로고    scopus 로고
    • Blockade of the renin-angiotensin system by a combination of ACE inhibitors and AT1 receptor antagonists
    • Azizi M. Blockade of the renin-angiotensin system by a combination of ACE inhibitors and AT1 receptor antagonists. Rev Prat 2004;54:1167- 1174.
    • (2004) Rev Prat , vol.54 , pp. 1167-1174
    • Azizi, M.1
  • 11
    • 0035970623 scopus 로고    scopus 로고
    • Retinoids inhibit the actions of angiotensin II on vascular smooth muscle cells
    • Haxsen V, Adam-Stitah S, Ritz E, Wagner J. Retinoids inhibit the actions of angiotensin II on vascular smooth muscle cells. Circ Res 2001;88:637-644.
    • (2001) Circ Res , vol.88 , pp. 637-644
    • Haxsen, V.1    Adam-Stitah, S.2    Ritz, E.3    Wagner, J.4
  • 12
    • 1542547460 scopus 로고    scopus 로고
    • Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity
    • Benson SC, Pershadsingh HA, Ho CI, Chittiboyina A, Desai P, Pravenec M et al. Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity. Hypertension 2004;43:993-1002.
    • (2004) Hypertension , vol.43 , pp. 993-1002
    • Benson, S.C.1    Pershadsingh, H.A.2    Ho, C.I.3    Chittiboyina, A.4    Desai, P.5    Pravenec, M.6
  • 13
    • 13944283346 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors and cardiovascular remodeling
    • Schiffrin EL. Peroxisome proliferator-activated receptors and cardiovascular remodeling. Am J Physiol Heart Circ Physiol 2005;288:H1037-H1043.
    • (2005) Am J Physiol Heart Circ Physiol , vol.288
    • Schiffrin, E.L.1
  • 14
    • 0034633847 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma activators downregulate angiotensin II type 1 receptor in vascular smooth muscle cells
    • Takeda K, Ichiki T, Tokunou T, Funakoshi Y, Iino N, Hirano K et al. Peroxisome proliferator-activated receptor gamma activators downregulate angiotensin II type 1 receptor in vascular smooth muscle cells. Circulation 2000;102:1834-1839.
    • (2000) Circulation , vol.102 , pp. 1834-1839
    • Takeda, K.1    Ichiki, T.2    Tokunou, T.3    Funakoshi, Y.4    Iino, N.5    Hirano, K.6
  • 15
    • 0033978870 scopus 로고    scopus 로고
    • Downregulation of angiotensin II type 1 receptor by all-trans retinoic acid in vascular smooth muscle cells
    • Takeda K, Ichiki T, Funakoshi Y, Ito K, Takeshita A. Downregulation of angiotensin II type 1 receptor by all-trans retinoic acid in vascular smooth muscle cells. Hypertension 2000;35:297-302.
    • (2000) Hypertension , vol.35 , pp. 297-302
    • Takeda, K.1    Ichiki, T.2    Funakoshi, Y.3    Ito, K.4    Takeshita, A.5
  • 16
    • 0029046931 scopus 로고
    • Identification of a nuclear receptor that is activated by farnesol metabolites
    • Forman BM, Goode E, Chen J, Oro AE, Bradley DJ, Perlmann T et al. Identification of a nuclear receptor that is activated by farnesol metabolites. Cell 1995;81:687-693.
    • (1995) Cell , vol.81 , pp. 687-693
    • Forman, B.M.1    Goode, E.2    Chen, J.3    Oro, A.E.4    Bradley, D.J.5    Perlmann, T.6
  • 18
    • 0036668184 scopus 로고    scopus 로고
    • Bile acid regulation of gene expression: Roles of nuclear hormone receptors
    • Chiang JY. Bile acid regulation of gene expression: roles of nuclear hormone receptors. Endocr Rev 2002;23:443-463.
    • (2002) Endocr Rev , vol.23 , pp. 443-463
    • Chiang, J.Y.1
  • 20
    • 9944247695 scopus 로고    scopus 로고
    • Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism
    • Eloranta JJ, Kullak-Ublick GA. Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism. Arch Biochem Biophys 2005;433:397-412.
    • (2005) Arch Biochem Biophys , vol.433 , pp. 397-412
    • Eloranta, J.J.1    Kullak-Ublick, G.A.2
  • 21
    • 6344243614 scopus 로고    scopus 로고
    • The Farnesoid X Receptor (FXR) as modulator of bile acid metabolism
    • Kuipers F, Claudel T, Sturm E, Staels B. The Farnesoid X Receptor (FXR) as modulator of bile acid metabolism. Rev Endocr Metab Disord 2004;5:319-326.
    • (2004) Rev Endocr Metab Disord , vol.5 , pp. 319-326
    • Kuipers, F.1    Claudel, T.2    Sturm, E.3    Staels, B.4
  • 22
    • 32244447570 scopus 로고    scopus 로고
    • Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice
    • Zhang Y, Lee FY, Barrera G, Lee H, Vales C, Gonzalez FJ et al. Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. Proc Natl Acad Sci USA 2006;103:1006-1011.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 1006-1011
    • Zhang, Y.1    Lee, F.Y.2    Barrera, G.3    Lee, H.4    Vales, C.5    Gonzalez, F.J.6
  • 23
    • 1542513682 scopus 로고    scopus 로고
    • Expression and activation of the farnesoid X receptor in the vasculature
    • Bishop-Bailey D, Walsh DT, Warner TD. Expression and activation of the farnesoid X receptor in the vasculature. Proc Natl Acad Sci USA 2004;101:3668-3673.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 3668-3673
    • Bishop-Bailey, D.1    Walsh, D.T.2    Warner, T.D.3
  • 24
    • 33644861794 scopus 로고    scopus 로고
    • Downregulation of endothelin-1 by farnesoid X receptor in vascular endothelial cells
    • He F, Li J, Mu Y, Kuruba R, Ma Z, Wilson A et al. Downregulation of endothelin-1 by farnesoid X receptor in vascular endothelial cells. Circ Res 2006;98:192-199.
    • (2006) Circ Res , vol.98 , pp. 192-199
    • He, F.1    Li, J.2    Mu, Y.3    Kuruba, R.4    Ma, Z.5    Wilson, A.6
  • 27
    • 0036589824 scopus 로고    scopus 로고
    • Use of dominant negative nuclear receptors to study xenobiotic-inducible gene expression in primary cultured hepatocytes
    • Kocarek TA, Shenoy SD, Mercer-Haines NA, Runge-Morris M. Use of dominant negative nuclear receptors to study xenobiotic-inducible gene expression in primary cultured hepatocytes. J Pharmacol Toxicol Methods 2002;47:177-187.
    • (2002) J Pharmacol Toxicol Methods , vol.47 , pp. 177-187
    • Kocarek, T.A.1    Shenoy, S.D.2    Mercer-Haines, N.A.3    Runge-Morris, M.4
  • 28
    • 0030950128 scopus 로고    scopus 로고
    • Characterization of the induction of nitric oxide synthase and cyclo-oxygenase in rat aorta in organ culture
    • Bishop-Bailey D, Larkin SW, Warner TD, Chen G, Mitchell JA. Characterization of the induction of nitric oxide synthase and cyclo-oxygenase in rat aorta in organ culture. Br J Pharmacol 1997;121:125-133.
    • (1997) Br J Pharmacol , vol.121 , pp. 125-133
    • Bishop-Bailey, D.1    Larkin, S.W.2    Warner, T.D.3    Chen, G.4    Mitchell, J.A.5
  • 29
    • 9144231188 scopus 로고    scopus 로고
    • A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification
    • Saini SP, Sonoda J, Xu L, Toma D, Uppal H, Mu Y et al. A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification. Mol Pharmacol 2004;65:292-300.
    • (2004) Mol Pharmacol , vol.65 , pp. 292-300
    • Saini, S.P.1    Sonoda, J.2    Xu, L.3    Toma, D.4    Uppal, H.5    Mu, Y.6
  • 31
    • 10744228017 scopus 로고    scopus 로고
    • Inhibitory effect of the small heterodimer partner on hepatocyte nuclear factor-4 mediates bile acid-induced repression of the human angiotensinogen gene
    • Shimamoto Y, Ishida J, Yamagata K, Saito T, Kato H, Matsuoka T et al. Inhibitory effect of the small heterodimer partner on hepatocyte nuclear factor-4 mediates bile acid-induced repression of the human angiotensinogen gene. J Biol Chem 2004;279:7770-7776.
    • (2004) J Biol Chem , vol.279 , pp. 7770-7776
    • Shimamoto, Y.1    Ishida, J.2    Yamagata, K.3    Saito, T.4    Kato, H.5    Matsuoka, T.6
  • 32
    • 85047682066 scopus 로고    scopus 로고
    • NUBIScan, an in silico approach for prediction of nuclear receptor response elements
    • Podvinec M, Kaufmann MR, Handschin C, Meyer UA. NUBIScan, an in silico approach for prediction of nuclear receptor response elements. Mol Endocrinol 2002;16:1269-1279.
    • (2002) Mol Endocrinol , vol.16 , pp. 1269-1279
    • Podvinec, M.1    Kaufmann, M.R.2    Handschin, C.3    Meyer, U.A.4
  • 33
    • 0346096545 scopus 로고    scopus 로고
    • Angiotensin II induces endothelin-1 gene expression via extracellular signal-regulated kinase pathway in rat aortic smooth muscle cells
    • Hong HJ, Chan P, Liu JC, Juan SH, Huang MT, Lin JG et al. Angiotensin II induces endothelin-1 gene expression via extracellular signal-regulated kinase pathway in rat aortic smooth muscle cells. Cardiovasc Res 2004;61:159-168.
    • (2004) Cardiovasc Res , vol.61 , pp. 159-168
    • Hong, H.J.1    Chan, P.2    Liu, J.C.3    Juan, S.H.4    Huang, M.T.5    Lin, J.G.6
  • 34
    • 0035874635 scopus 로고    scopus 로고
    • Angiotensin and its AT2 receptor: New insights into an old system
    • Stoll M, Unger T. Angiotensin and its AT2 receptor: new insights into an old system. Regul Pept 2001;99:175-182.
    • (2001) Regul Pept , vol.99 , pp. 175-182
    • Stoll, M.1    Unger, T.2
  • 35
    • 0034616147 scopus 로고    scopus 로고
    • Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor
    • Laffitte BA, Kast HR, Nguyen CM, Zavacki AM, Moore DD, Edwards PA. Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor. J Biol Chem 2000;275:10638-10647.
    • (2000) J Biol Chem , vol.275 , pp. 10638-10647
    • Laffitte, B.A.1    Kast, H.R.2    Nguyen, C.M.3    Zavacki, A.M.4    Moore, D.D.5    Edwards, P.A.6
  • 36
    • 0035834769 scopus 로고    scopus 로고
    • Dehydroepiandrosterone sulfotransferase gene induction by bile acid activated farnesoid X receptor
    • Song CS, Echchgadda I, Baek BS, Ahn SC, Oh T, Roy AK et al. Dehydroepiandrosterone sulfotransferase gene induction by bile acid activated farnesoid X receptor. J Biol Chem 2001;276:42549-42556.
    • (2001) J Biol Chem , vol.276 , pp. 42549-42556
    • Song, C.S.1    Echchgadda, I.2    Baek, B.S.3    Ahn, S.C.4    Oh, T.5    Roy, A.K.6
  • 37
    • 0037169551 scopus 로고    scopus 로고
    • Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor
    • Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM et al. Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J Biol Chem 2002;277:2908-2915.
    • (2002) J Biol Chem , vol.277 , pp. 2908-2915
    • Kast, H.R.1    Goodwin, B.2    Tarr, P.T.3    Jones, S.A.4    Anisfeld, A.M.5    Stoltz, C.M.6
  • 38
    • 0038491484 scopus 로고    scopus 로고
    • The human apolipoprotein AV gene is regulated by peroxisome proliferator-activated receptor-alpha and contains a novel farnesoid X-activated receptor response element
    • Prieur X, Coste H, Rodriguez JC. The human apolipoprotein AV gene is regulated by peroxisome proliferator-activated receptor-alpha and contains a novel farnesoid X-activated receptor response element. J Biol Chem 2003;278:25468-25480.
    • (2003) J Biol Chem , vol.278 , pp. 25468-25480
    • Prieur, X.1    Coste, H.2    Rodriguez, J.C.3
  • 39
    • 38849164313 scopus 로고    scopus 로고
    • FXR-mediated regulation of eNOS expression in vascular endothelial cells
    • Li J, Wilson A, Kuruba R, Zhang QH, Gao X, He FT et al. FXR-mediated regulation of eNOS expression in vascular endothelial cells. Cardiovasc Res 2007;77:169-177.
    • (2007) Cardiovasc Res , vol.77 , pp. 169-177
    • Li, J.1    Wilson, A.2    Kuruba, R.3    Zhang, Q.H.4    Gao, X.5    He, F.T.6
  • 40
    • 0030031398 scopus 로고    scopus 로고
    • Angiotensin II type 2 receptor mediates programmed cell death
    • Yamada T, Horiuchi M, Dzau VJ. Angiotensin II type 2 receptor mediates programmed cell death. Proc Natl Acad Sci USA 1996;93:156-160.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 156-160
    • Yamada, T.1    Horiuchi, M.2    Dzau, V.J.3
  • 41
    • 0029953974 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases in rat brain neuronal cultures are activated by angiotensin II type1 receptors and inhibited by angiotensin II type 2 receptors
    • Huang XC, Richards EM, Sumners C. Mitogen-activated protein kinases in rat brain neuronal cultures are activated by angiotensin II type1 receptors and inhibited by angiotensin II type 2 receptors. J Biol Chem 1996;271:15635-15641.
    • (1996) J Biol Chem , vol.271 , pp. 15635-15641
    • Huang, X.C.1    Richards, E.M.2    Sumners, C.3
  • 42
    • 0030851632 scopus 로고    scopus 로고
    • Angiotensin II type 2 receptors mediate inhibition of mitogen-activated protein kinase cascade and functional activation of SHP-1 tyrosine phosphatase
    • Bedecs K, Elbaz N, Sutren M, Masson M, Susini C, Strosberg AD et al. Angiotensin II type 2 receptors mediate inhibition of mitogen-activated protein kinase cascade and functional activation of SHP-1 tyrosine phosphatase. Biochem J 1997;325:449-454.
    • (1997) Biochem J , vol.325 , pp. 449-454
    • Bedecs, K.1    Elbaz, N.2    Sutren, M.3    Masson, M.4    Susini, C.5    Strosberg, A.D.6
  • 43
    • 33846440099 scopus 로고    scopus 로고
    • Cross-talk between Angiotensin II receptor Types 1 and 2: Potential role in vascular remodeling in humans
    • Hernandez Schulman I, Zhou MS, Raij L. Cross-talk between Angiotensin II receptor Types 1 and 2: potential role in vascular remodeling in humans. Hypertension 2007;9:270-271.
    • (2007) Hypertension , vol.9 , pp. 270-271
    • Hernandez Schulman, I.1    Zhou, M.S.2    Raij, L.3
  • 44
    • 0028804906 scopus 로고
    • The angiotensin II type 2 receptor antagonizes the growth effects of the AT1 receptor: Gain of function study using in vivo gene transfer
    • Nakajima M, Morishita R, Zhang L, Horiuchi M, Pratt RE, Dzau VJ. The angiotensin II type 2 receptor antagonizes the growth effects of the AT1 receptor: gain of function study using in vivo gene transfer. Proc Natl Acad Sci USA 1995;92:10663-10667.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 10663-10667
    • Nakajima, M.1    Morishita, R.2    Zhang, L.3    Horiuchi, M.4    Pratt, R.E.5    Dzau, V.J.6
  • 45
    • 0347988111 scopus 로고    scopus 로고
    • Can angiotensin II type 2 receptors have deleterious effects in cardiovascular disease? Implications for therapeutic blockade of the renin-angiotensin system
    • Levy BI. Can angiotensin II type 2 receptors have deleterious effects in cardiovascular disease? Implications for therapeutic blockade of the renin-angiotensin system. Circulation 2004;109:8-13.
    • (2004) Circulation , vol.109 , pp. 8-13
    • Levy, B.I.1
  • 46
    • 33846427712 scopus 로고    scopus 로고
    • Angiotensin type 2 receptor in resistance arteries of type 2 diabetic hypertensive patients
    • Savoia C, Touyz RM, Volpe M, Schiffrin EL. Angiotensin type 2 receptor in resistance arteries of type 2 diabetic hypertensive patients. Hypertension 2007;49:341-346.
    • (2007) Hypertension , vol.49 , pp. 341-346
    • Savoia, C.1    Touyz, R.M.2    Volpe, M.3    Schiffrin, E.L.4
  • 47
    • 33746843082 scopus 로고    scopus 로고
    • Cardioprotective effects of rosiglitazone are associated with selective overexpression of type 2 angiotensin receptors and inhibition of p42/44 MAPK
    • Molavi B, Chen J, Mehta JL. Cardioprotective effects of rosiglitazone are associated with selective overexpression of type 2 angiotensin receptors and inhibition of p42/44 MAPK. Am J Physiol Heart Circ Physiol 2006;291:H687-H693.
    • (2006) Am J Physiol Heart Circ Physiol , vol.291
    • Molavi, B.1    Chen, J.2    Mehta, J.L.3
  • 48
    • 34247491040 scopus 로고    scopus 로고
    • FXR: A promising target for the metabolic syndrome?
    • Cariou B, Staels B. FXR: a promising target for the metabolic syndrome? Trends Pharmacol Sci 2007;28:236-243.
    • (2007) Trends Pharmacol Sci , vol.28 , pp. 236-243
    • Cariou, B.1    Staels, B.2
  • 49
    • 30844436795 scopus 로고    scopus 로고
    • Loss of functional farnesoid X receptor increases atherosclerotic lesions in apolipoprotein E-deficient mice
    • Hanniman EA, Lambert G, McCarthy TC, Sinal CJ. Loss of functional farnesoid X receptor increases atherosclerotic lesions in apolipoprotein E-deficient mice. J Lipid Res 2005;46:2595-2604.
    • (2005) J Lipid Res , vol.46 , pp. 2595-2604
    • Hanniman, E.A.1    Lambert, G.2    McCarthy, T.C.3    Sinal, C.J.4


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