Binding effect and design of a competitive inhibitory peptide for HMG-CoA reductase through modeling of an active peptide backbone

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 3, 2008, Pages 1309-1318

  Pak, Valeriy Viktorovich ^a   Koo, Minseon ^a   Kim, Min Jung ^a   Yun, Lyubov ^b   Kwon, Dae Young ^a  

^a Korea Food Research Institute   (South Korea)

^b S Yu Yunusov Institute of the Chemistry of Plant Substances Uzbekistan Academy of Sciences   (Uzbekistan)

Author keywords

Active conformation; Enzymes; Inhibition mechanism; Inhibitors; Peptides

Indexed keywords

AMINO ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE;

ARTICLE; CIRCULAR DICHROISM; ENZYME BINDING; ENZYME INHIBITION; ENZYME MECHANISM; HYDROPHOBICITY; IN VITRO STUDY; PROTEIN AGGREGATION; PROTEIN STRUCTURE;

BINDING, COMPETITIVE; CIRCULAR DICHROISM; DATABASES, PROTEIN; DRUG DESIGN; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; PEPTIDES; PROTEIN BINDING; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE;

GLYCINE MAX;

EID: 38849098428     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.10.064     Document Type: Article

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