Peptide design of a competitive inhibitor for HMG-CoA reductase based on statin structure

Biopolymers - Peptide Science Section

Volumn 84, Issue 6, 2006, Pages 586-594

  Pak, Valeriy V ^a,b   Kim, Sung Hee ^a   Koo, Minseon ^a   Lee, Nari ^a   Shakhidoyatov, K M ^b   Kwon, Dae Young ^a  

^a Korea Food Research Institute   (South Korea)

^b S Yu Yunusov Institute of the Chemistry of Plant Substances Uzbekistan Academy of Sciences   (Uzbekistan)

Author keywords

Competitive inhibitor; HMG CoA reductase; Hypocholesterolemic peptide; Peptide design; Statin

Indexed keywords

CONFORMATIONS; ENZYME INHIBITION; MOLECULAR STRUCTURE; ORGANIC COMPOUNDS; PROBABILITY; SYNTHESIS (CHEMICAL);

COMPETITIVE INHIBITOR; HMG-COA REDUCTASE; HYPOCHOLESTEROLEMIC PEPTIDE; PEPTIDE DESIGN; STATIN STRUCTURE;

ENZYMES;

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ORGANIC COMPOUND; PEPTIDE; PEPTIDE LIBRARY;

ARTICLE; DRUG INHIBITION; IC 50; IN VITRO STUDY; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS;

AMINO ACID SEQUENCE; BINDING, COMPETITIVE; DRUG DESIGN; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; OLIGOPEPTIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33845583653     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.20580     Document Type: Article

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