Transforming growth factor-β1 and Smad4 signaling pathway down-regulates renal extracellular matrix degradation in diabetic rats

Chinese Medical Sciences Journal

Volumn 22, Issue 4, 2007, Pages 243-249

  Yang, Qin ^a   Xie, Ru Jia ^a   Yang, Ting ^a   Fang, Li ^a   Han, Bing ^a   Zhang, Guo Zhong ^a   Cheng, Ming Liang ^a  

^a GUIZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Diabetes mellitus; Renal fibrosis; Smad4; Transforming growth factor 1

Indexed keywords

COLLAGEN TYPE 2; GLUCOSE; STREPTOZOCIN; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC NEUROPATHY; DOWN REGULATION; EXTRACELLULAR MATRIX; GLUCOSE BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; KIDNEY; KIDNEY FIBROSIS; MALE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; BASE SEQUENCE; DIABETES MELLITUS, EXPERIMENTAL; DNA PRIMERS; DOWN-REGULATION; EXTRACELLULAR MATRIX; KIDNEY; MALE; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 38749094498     PISSN: 10019294     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Nesbitt KN, Pharm D. An overview of diabetic nephropathy. J Pharm Pract 2004; 17:75-9.
2. Leask A, Abraham DJ. TGF-β signaling and the fibrotic response. FASEB J 2004; 18:816-27.
3. Liu C, Gaca MD, Swenson ES, et al. Smads 2 and 3 are differentially activated by transforming growth factor-β (TGF-β) in quiescent and activated hepatic stellate cells. J Biol Chem 2003; 278:11721-8.
4. Groneberg DA, Witt H, Adcock IM, et al. Smads as intracellular mediators of airway inflammation. Exp Lung Res 2004; 30:223-50.
5. Yang Q, Xie RJ, Han B, et al. Expression of TGF-β1 and Smad2/3 in kidney of STZ-induced diabetic nephropathy rats. Chin J Pathophysiol 2006; 22:1879-84.
6. Cheng J, Grande JP. Transforming growth factor-β signal transduction and progressive renal disease. Exp Biol Med 2002; 227:943-56.
7. Ikegami-Kawai M, Okuda R, Nemoto T, et al. Enhanced activity of serum and urinary hyaluronidases in streptozotocin-induced diabetic Wistar and GK rats. Glycobiology 2004; 14:65-72.
8. Ohnishi H, Miyata T, Yasuda H, et al. Distinct roles of Smad2-, Smad3-, and ERK-dependent pathways in transforming growth factor-β1 regulation of pancreatic stellate cellular functions. J Biol Chem 2004; 279:8873-8.
9. Pierreux CE, Nicolas FJ, Hill CS. Transforming growth factor-β-independent shuttling of Smad4 between the cytoplasm and nucleus. Mol Cell Biol 2000; 20:9041-54.
10. Ramachandra M, Atencio I, Rahman A, et al. Restoration of transforming growth factor-β signaling by functional expression of Smad4 induces anoikis. Cancer Res 2002; 62:6045-51.
11. Kelley TJ, Elmer HL, Corey DA. Reduced Smad3 protein expression and altered transforming growth factor-β1-mediated signaling in cystic fibrosis epithelial cells. Am J Respir Cell Mol Biol 2001; 25:732-8.
12. Roelen BA, Cohen OS, Raychowdhury MK, et al. Phosphorylation of threonine 276 in Smad4 is involved in transforming growth factor-β-induced nuclear accumulation. Am J Physiol Cell Physiol 2003; 285:C823-30.
13. Sirard C, Kim S, Mirtsos C, et al. Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling. J Biol Chem 2000; 275:2063-70.
14. Hayashida T, Schnaper HW. High ambient glucose enhances sensitivity to TGF-β1 via extracellular signal-regulated kinase and protein kinase Cδ activities in human mesangial cells. J Am Soc Nephrol 2004; 15:2032-41.
15. Ungefroren H, Lenschow W, Chen WB, et al. Regulation of biglycan gene expression by transforming growth factor-β requires MKK6-p38 mitogen-activated protein kinase signaling downstream of Smad signaling. J Biol Chem 2003; 278:11041-9.
16. Tsuchida K, Zhu Y, Siva S, et al. Role of Smad4 on TGF-β-induced extracellular matrix stimulation in mesangial cells. Kidney Int 2003; 63:2000-9.
17. Hou CC, Wang W, Huang XR, et al. Ultrasound-microbubble-mediated gene transfer of inducible Smad7 blocks transforming growth factor-beta signaling and fibrosis in rat remnant kidney. Am J Pathol 2005; 166:761-71.
18. Qi W, Twigg S, Chen X, et al. Integrated actions of transforming growth factor-beta1 and connective tissue growth factor in renal fibrosis. Am J Physiol Renal Physiol 2005; 288:F800-9.
19. Fukasawa H, Yamamoto T, Suzuki H, et al. Treatment with anti-TGF-beta antibody ameliorates chronic progressive nephritis by inhibiting Smad/TGF-beta signaling. Kidney Int 2004; 65:63-74.
20. Li JH, Zhu HJ, Huang XR, et al. Smad7 inhibits fibrotic effect of TGF-beta on renal tubular epithelial cells by blocking Smad2 activation. J Am Soc Nephrol 2002; 13:1464-72.
21. Hong SW, Isono M, Chen S, et al. Increased glomerular and tubular expression of transforming growth factor-beta1, its type II receptor, and activation of the Smad signaling pathway in the db/db mouse. Am J Pathol 2001; 158:1653-63.