Asynchronous DNA replication detected by fluorescence in situ hybridisation as a possible indicator of genetic damage in human lymphocytes

Oncology Reports

Volumn 19, Issue 2, 2008, Pages 369-375

  Bras A ^a   Cotrim, C Z ^a   Vasconcelos, I ^a   Mexia, J ^b   Leonard A ^c   Sanzhar, I ^d   Akhmatullina, N ^d   Rueff, J ^a  

^a UNIVERSIDADE NOVA DE LISBOA   (Portugal)

^b UNIVERSIDADE NOVA DE LISBOA   (Portugal)

^c UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^d INSTITUTE OF IONOSPHERE   (Kazakhstan)

Author keywords

D22S163; DNA replication timing; Fluorescence in situ hybridisation; Genetic damage; RB1; TP53

Indexed keywords

DNA; GENE PRODUCT; HYDROGEN PEROXIDE; MITOMYCIN C; PROTEIN P53;

ACCURACY; ANALYTIC METHOD; ARTICLE; CANCER MORTALITY; CARCINOGENESIS; CONTROLLED STUDY; DNA DAMAGE; DNA REPLICATION; FLUORESCENCE IN SITU HYBRIDIZATION; GENE LOCUS; GENETIC CORRELATION; GENETIC DAMAGE; GENETIC DIFFERENCE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; IONIZING RADIATION; KAZAKHSTAN; LYMPHOCYTE; POPULATION RESEARCH; PRIORITY JOURNAL;

EID: 38749087897     PISSN: 1021335X     EISSN: None     Source Type: Journal    
DOI: 10.3892/or.19.2.369     Document Type: Article

References (29)

1. UNECE - United Nations Economic Commission for Europe. Economic and Social Council. Committee on Environment Policy. Environmental Performance review of Kazakhstan (http://www.unece.org/env/epr/studies/ kazakhstan).
2. Au W: Usefulness of biomarkers in population studies: from exposure to susceptibility and prediction of cancer. Int J Hyg Environ Health 210: 239-246, 2007.
3. Léonard A, Rueff J, Gerber GB and Leonard ED: Usefulness and limits of biological dosimetry based on cytogenetic methods. Radiat Prot Dosimetry 115: 448-454, 2005.
4. Smith L, Plug A and Thayer M: Delayed replication timing leads to delayed mitotic chromosome condensation and chromosomal instability of chromosome translocations. Proc Natl Acad Sci USA 98: 13300-13305, 2001.
5. Breger KS, Smith L, Turker MS and Thayer MJ: Ionizing radiation induces frequent translocations with delayed replication and condensation. Cancer Res 64: 8231-8238, 2004.
6. Cinti R, Schema F, Passalacqua M, Ceccherini I and Ravazzolo R: Replication pattern of the pericentromeric region of chromosome 10q and expression of the RET protooncogene. Exp Cell Res 298: 602-610, 2004.
7. Sun Y, Wyatt RT, Bigley A and Krontiris TG: Expression and replication timing patterns of wild-type and translocated BCL2 genes. Genomics 73: 161-170, 2001.
8. Andreassen PR, Ho G and D' Andrea AD: DNA damage responses and their many interactions with the replication fork. Carcinogenesis 27: 883-892, 2006.
9. Merrick CJ, Jackson D and Diffley JFX: Visualization of altered replication dynamics after DNA damage in human cells. J Biol Chem 279: 20067-20075, 2004.
10. Selig S, Okumura K, Ward DC and Cedar H: Delineation of DNA replication time zones by fluorescence in situ hybridization. EMBO J 11: 1217-1225, 1992.
11. Boggs BA and Chinault AC: Analysis of DNA replication by fluorescence in situ hybridization. Methods 13: 259-270, 1997.
12. Goren A and Cedar H: Replicating by the clock. Nat Rev Mol Cell Biol 4: 25-32, 2003.
13. Woodfine K, Fiegler H, Beare DM, Collins J, McCann O, Young B, Debernardi S, Mott R, Dunham I and Carter N: Replication timing of the human genome. Hum Mol Genet 13: 191-202, 2004.
14. Amiel A, Elis A, Sherker S, Gaber E, Manor Y and Fejgin MD: The influence of cytogenetic aberrations on gene replication in chronic lymphocytic leukemia patients. Cancer Genet Cytogenet 125: 81-86, 2001.
15. Dotan ZA, Dotan A, Litmanovitch T, Ravia Y, Oniashvili N, Leibovitch I, Ramon J and Avivi L: Modification in the inherent mode of allelic replication in lymphocytes of patients suffering from renal cell carcinoma: a novel genetic alteration associated with malignancy. Genes Chromosomes Cancer 27: 270-277, 2000.
16. Reish O, Orlovski A, Mashevitz M, Sher C, Libman V, Rosenblat M and Avivi L: Modified allelic replication in lymphocytes of patients with neurofibromatosis type 1. Cancer Genet Cytogenet 143: 133-139, 2003.
17. 60Co gamma-radiation. Mutat Res 289: 197-204, 1993.
18. Ofir R, Wong ACC, McDermid HE, Skorecki KL and Selig S: Position effect of human telomeric repeats on replication timing. Proc Natl Acad Sci USA 96: 11434-11439, 1999.
19. Malins DC, Polissar NL, Ostrander GK and Vinson MA: Single 8-oxo-guanine and 8-oxo-adenine lesions induce marked changes in the backbone structure of a 25-base DNA strand. Proc Natl Acad Sci USA 97: 12442-12445, 2000.
20. Gilbert DM: Replication timing and transcriptional control: beyond cause and effect. Curr Opin Cell Biol 14: 377-383, 2002.
21. White EJ, Emanuelsson O, Scalzo D, Royce T, Kosak S, Oakeley EJ, Weissman S, Gerstein M, Groudine M, Snyder M and Schubeler D: DNA replication-timing analysis of human chromosome 22 at high resolution and different developmental states. Proc Natl Acad Sci USA 101: 17771-17776, 2004.
22. Schimke RT, Sherwood SW, Hill AB and Johnston RN: Over-replication and recombination of DNA in higher eukaryotes: potential consequences and biological implications. Proc Natl Acad Sci USA 83: 2157-2161, 1986.
23. Campisi J: Cancer and aging: rival demons? Nat Rev Cancer 3: 339-349, 2003.
24. Levine AJ: p53, the cellular gatekeeper for growth and division. Cell 88: 323-331, 1997.
25. Yang J and Duerksen-Hughes P: A new approach to identifying genotoxic carcinogens: p53 induction as an indicator of genotoxic damage. Carcinogenesis 19: 1117-1125, 1998.
26. Islaih M, Halstead BW, Kadura IA, Li B, Reid-Hubbard JL, Flick L, Altizer JL, Thom Deahl J, Monteith DK, Newton RK and Watson DE: Relationships between genomic, cell cycle and mutagenic responses of TK6 cells exposed to DNA damaging chemicals. Mutat Res 578: 100-116, 2005.
27. Elkon R, Rashi-Elkeles S, Lerenthal Y, Linhart C, Tenne T, Amariglio N, Rechavi G, Shamir R and Shiloh Y: Dissection of a DNA-damage-induced transcriptional network using a combination of microarrays, RNA interference and computational promoter analysis. Genome Biol 6: R43.1-R43.8, 2005.
28. Amundson SA, Bittner M, Meltzer P, Trent J, Fornace AJ Jr: Physiological function as regulation of large transcriptional programs: the cellular response to genotoxic stress. Comp Biochem Physiol B 129: 703-710, 2001.
29. Singh N, Ebrahimi FA, Gimelbrant AA, Ensminger AW, Tackett MR, Qi P, Gribnau J and Chess A: Coordination of the random asynchronous replication of autosomal loci. Nat Genet 33: 339-341, 2003