HLA DRB1*13 as a risk factor for type 1 autoimmune hepatitis in North American patients

Digestive Diseases and Sciences

Volumn 53, Issue 2, 2008, Pages 522-528

  Czaja, Albert J ^a   Carpenter, Herschel A ^a   Moore, S Breanndan ^a  

^a MAYO CLINIC   (United States)

Author keywords

Distinctions; Genetic predisposition; Susceptibility factor

Indexed keywords

HLA DR ANTIGEN; HLA DRB1*13 ANTIGEN, HUMAN; HLA-DRB1*13 ANTIGEN, HUMAN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; AUTOIMMUNE HEPATITIS; CHRONIC LIVER DISEASE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; NORTH AMERICA; PHENOTYPE; PRIMARY SCLEROSING CHOLANGITIS; PRIORITY JOURNAL; RISK FACTOR; CAUCASIAN; CHRONIC DISEASE; GENETIC PREDISPOSITION; GENETICS; HAPLOTYPE; IMMUNOLOGY; LIVER DISEASE; MIDDLE AGED; UNITED STATES; VIRUS HEPATITIS;

ADULT; CHRONIC DISEASE; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HEPATITIS, AUTOIMMUNE; HEPATITIS, VIRAL, HUMAN; HLA-DR ANTIGENS; HUMANS; LIVER DISEASES; MALE; MIDDLE AGED; UNITED STATES;

EID: 38649132622     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-007-9859-4     Document Type: Article

References (35)

1. Fainboim L, Marcos Y, Pando M, Capucchio M, Reyes GB, Galoppo C, Badia I, Remondino G, Ciocca M, Ramonet M, Fainboim H, Satz ML (1994) Chronic active autoimmune hepatitis in children. Strong association with a particular HLA DR6 (DRB1*1301) haplotype. Hum Immunol 41:146-150
2. Pando M, Larriba J, Fernandez GC, Fainboim H, Ciocca M, Ramonet M, Badia I, Daruich J, Findor J, Tanno H, Canero-Velasco C, Fainboim L (1999) Pediatric and adult forms of type 1 autoimmune hepatitis in Argentina: evidence for differential genetic predisposition. Hepatology 30:1374-1380
3. Bittencourt PL, Goldberg AC, Cancado ELR, Porta G, Carrilho FJ, Farias AQ, Palacios SA, Chiarella JM, Abrantes-Lemos CP, Baggio VL, Laudanna AA, Kalil J (1999) Genetic heterogeneity in susceptibility to autoimmune hepatitis types 1 and 2. Am J Gastroenterol 94:1906-1913
4. Goldberg AC, Bittencourt PL, Mougin B, Cancado ELR, Porta G, Carrilho F, Kalil J (2001) Analysis of HLA haplotypes in autoimmune hepatitis type 1: identifying the major susceptibility locus. Hum Immunol 62:165-169
5. Donaldson PT, Doherty DG, Hayllar KM, McFarlane IG, Johnson PJ, Williams R (1991) Susceptibility to autoimmune chronic active hepatitis: human leukocyte antigens DR4 and A1-B8-DR3 are independent risk factors. Hepatology 13:701-706
6. Czaja AJ, Carpenter HA, Santrach PJ, Moore SB (1993) Significance of HLA DR4 in type 1 autoimmune hepatitis. Gastroenterology 105:1502-1507
7. Doherty DG, Donaldson PT, Underhill JA, Farrant JM, Duthie A, Mieli-Vergani G, McFarlane IG, Johnson PJ, Eddleston ALWF, Mowat AP, Williams R (1994) Allelic sequence variation in the HLA class II genes and proteins in patients with autoimmune hepatitis. Hepatology 19:609-615
8. Fainboim L, Velasco VCC, Marcos CY, Ciocca M, Roy A, Theiler G, Capucchio M, Nuncifora S, Sala L, Zelazko M (2001) Protracted, but not acute, hepatitis A virus infection is strongly associated with HLA-DRB1*1301, a marker for pediatric autoimmune hepatitis. Hepatology 33:1512-1517
9. Lango-Warensjo A, Cardell K, Lindblom B (1998) Haplotypes comprising subtypes of the HLA-DQB1*06 allele direct the antibody response after immunization with hepatitis B surface antigen. Tissue Antigens 52:374-380
10. Czaja AJ, Souto EO, Bittencourt PL, Cancado ELR, Porto G, Goldberg AC, Donaldson PT (2002) Clinical distinctions and pathogenic implications of type 1 autoimmune hepatitis in Brazil and the United States. J Hepatol 37:302-308
11. Czaja AJ, Carpenter HA, Moore SB (2006) Clinical and HLA phenotypes of type 1 autoimmune hepatitis in North American patients outside DR3 and DR4. Liver Int 26:552-558
12. Czaja AJ, Freese DK (2002) Diagnosis and treatment of autoimmune hepatitis. Hepatology 36:479-497
13. Alvarez F, Berg PA, Bianchi FB, Bianchi L, Burroughs AK, Cancado EL, Chapman RW, Cooksley WGE, Czaja AJ, Desmet VJ, Donaldson PT, Eddleston ALWF, Fainboim L, Heathcote J, Homberg J-C, Hoofnagle JH, Kakumu S, Krawitt EL, Mackay IR, MacSween RNM, Maddrey WC, Manns MP, McFarlane IG, Meyer zum Buschenfelde K-H, Mieli-Vergani G, Nakanuma Y, Nishioka M, Penner E, Porta G, Portmann BC, Reed WD, Rodes J, Schalm SW, Scheuer PJ, Schrumpf E, Seki T, Toda G, Tsuji T, Tygstrup N, Vergani D, Zeniya M (1999) International Autoimmune Hepatitis Group report: review of criteria for diagnosis of autoimmune hepatitis. J Hepatol 31:929-938
14. Czaja AJ (2005) Autoantibodies in autoimmune liver disease. Adv Clin Chem 40:127-164
15. Czaja AJ (2005) Current concepts in autoimmune hepatitis. Ann Hepatol 4:6-24
16. Czaja AJ, Carpenter HA (1993) Sensitivity, specificity and predictability of biopsy interpretations in chronic hepatitis. Gastroenterology 105:1824-1832
17. Czaja AJ, Santrach PJ, Moore SB (2001) Shared genetic risk factors in autoimmune liver disease. Dig Dis Sci 46:140-147
18. Czaja AJ, Carpenter HA, Santrach PJ, Moore SB (1996) Genetic predispositions for immunological features in chronic liver diseases other than autoimmune hepatitis. J Hepatol 24:52-59
19. Czaja AJ, Carpenter HA, Santrach PJ, Moore SB, Homburger HA (1993) The nature and prognosis of severe cryptogenic chronic active hepatitis. Gastroenterology 104:1755-1761
20. Czaja AJ, Donaldson PT (2000) Genetic susceptibilities for immune expression and liver cell injury in autoimmune hepatitis. Immunol Rev 174:250-259
21. Czaja AJ, Doherty DG, Donaldson PT (2002) Genetic bases of autoimmune hepatitis. Dig Dis Sci 47:2139-2150
22. Donaldson PT, Czaja AJ (2002) Genetic effects on susceptibility, clinical expression, and treatment outcome of type 1 autoimmune hepatitis. Clin Liver Dis 6:707-725
23. Donaldson PT (2002) Genetics in autoimmune hepatitis. Semin Liver Dis 22:353-364
24. Doherty DG, Penzotti JE, Koelle DM, Kwok WW, Lybrand TP, Masewicz S, Nepom GT (1998) Structural basis of specificity and degeneracy of T cell recognition: pluriallelic restriction of T cell responses to a peptide antigen involves both specific and promiscuous interactions between the T cell receptor, peptide, and HLA-DR. J Immunol 161:3527-3535
25. Singal DP, Li J, Zhu Y (1999) Genetic basis for rheumatoid arthritis. Arch Immunol Ther Exp 47:307-311
26. Tapia-Conyer R, Santos JI, Cavalcanti AM, Urdaneta E, Rivera L, Manterola A, Potin M, Ruttiman R, Tanaka-Kido J (1999) Hepatitis A in Latin America: a changing epidemiologic pattern. Am J Trop Med Hyg 61:825-829
27. Vento S, Garofano T, Di Perri G, Dolci L, Concia E, Bassetti D (1991) Identification of hepatitis A virus as a trigger for autoimmune chronic hepatitis type 1 in susceptible individuals. Lancet 337:1183-1187
28. Huppertz H-K, Treichel U, Gassel AM, Jeschke R, Meyer zum Buschenfelde K-H (1995) Autoimmune hepatitis following hepatitis A virus infection. J Hepatol 23:204-208
29. Tanaka H, Tujioka H, Ueda H, Hamagami H, Kida Y, Ichinose M (2005) Autoimmune hepatitis triggered by acute hepatitis A. World J Gastroenterol 11:6069-6071
30. Schreuder GM, Hurley CK, Marsh SG, Lau M, Maiers M, Kollman C, Noreen HJ (2001) The HLA dictionary 2001: a summary of HLA-A, -B, -C, -DRB1/3/4/5, -DQB1 alleles and their association with serologically defined HLA-A, -B, -C, -DR, and -DQ antigens. Hum Immunol 62:826-849
31. Hill A, Allsopp C, Kwiatkowski D, Anstey N, Twumasi P, Rowe P, Bennet S, Brewster D, McMichael AJ, Greenwood BM (1991) Common West African HLA antigens are associated with protection from severe malaria. Nature 352:595-600
32. Farrant JM, Doherty DG, Donaldson PT, Vaughan RW, Hayllar KM, Welsh KI, Eddleston ALWF, Williams R (1992) Amino acid substitutions at position 38 of the DRβ polypeptide confer susceptibility to and protection from primary sclerosing cholangitis. Hepatology 16:390-395
33. Boberg KM, Spurkland A, Rocca G, Egeland T, Saarinen S, Mitchell S, Broome U, Chapman R, Olerup O, Pares A, Rosina F, Schrumpf E (2001) The HLA-DR3, Dq2 heterozygous genotype is associated with an accelerated progression of primary sclerosing cholangitis. Scand J Gastroenterol 36:886-890
34. Donaldson PT, Norris S (2001) Immunogenetics in PSC. Best Practice Res Clin Gastroenterol 15:611-627
35. Donaldson PT, Norris S (2002) Evaluation of the role of MHC class II alleles, haplotypes and selected amino acid sequences in primary sclerosing cholangitis. Autoimmunity 35:555-564