Structural basis of specificity and degeneracy of T cell recognition: Pluriallelic restriction of T cell responses to a peptide antigen involves both specific and promiscuous interactions between the T cell receptor, peptide, and HLA-DR

Journal of Immunology

Volumn 161, Issue 7, 1998, Pages 3527-3535

  Doherty, Derek G ^a,d   Penzotti, Julie E ^a,b   Koelle, David M ^b,c   Kwok, William W ^a   Lybrand, Terry P ^b   Masewicz, Susan ^a   Nepom, Gerald T ^a,b  

^a BENAROYA RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

^d ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

HLA DR3 ANTIGEN; T LYMPHOCYTE RECEPTOR;

ALLELE; ALLOIMMUNITY; AMINO ACID SEQUENCE; ANTIGEN SPECIFICITY; ARTICLE; BINDING AFFINITY; CYTOTOXICITY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LYMPHOCYTE FUNCTION; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; VIRION;

EID: 0032194159     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (4)

1. Rothbard, J. B., and M. L. Gefter. 1991. Interactions between immunogenic peptides and MHC proteins. Annu. Rev. Immunol. 9:527.
2. O'Sullivan, D., J. Sidney, E. Appella, L. Walker, L. Phillips, S. M. Colón. C. Miles, R. W. Chesnut, and A. Sette. 1990. Characterization of the specificity of peptide binding to four DR haplotypes. J. Immunol. 145:1799.
3. Falk, K., O. Rötzschke, S. Stevanovic, O. Jung, and H. G. Rammensee. 1991. Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature 351:290.
4. Rudensky A. Y., P. Preston-Hurlburt, S. C. Hong, A. Barlow, and C. A. Janeway, Jr. 1991. Sequence analysis of peptides bound to MHC class II molecules. Nature 353:622.