Carbonic anhydrase 9 (CA9) expression in tumor cells enhances sensitivity to tirapazamine

Journal of Cancer Research and Clinical Oncology

Volumn 134, Issue 3, 2008, Pages 397-404

  Shin, Hye Jin ^a   Kim, Joo Young ^a   Yoo, Chong Woo ^a   Roberts, Stephen A ^b   Lee, Sun ^a   Choi, Soo Jin ^a   Lee, Hee Young ^a   Lee, Doo Hyun ^a   Kim, Tae Hyun ^a   Cho, Kwan Ho ^a  

^a National Cancer Center   (South Korea)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Carbonic Anhydrase IX (CA9); Hypoxia; Tirapazamine (TPZ)

Indexed keywords

CARBONATE DEHYDRATASE IX; COMPLEMENTARY DNA; TIRAPAZAMINE;

ARTICLE; CLONOGENIC ASSAY; COMET ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DRUG MECHANISM; DRUG SENSITIVITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYPOXIC CELL; IONIZING RADIATION; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOSENSITIVITY; SINGLE STRANDED DNA BREAK; TUMOR CELL;

ANTIGENS, NEOPLASM; CARBONIC ANHYDRASES; CARCINOMA, SMALL CELL; CELL HYPOXIA; DNA DAMAGE; DNA, NEOPLASM; DOSE-RESPONSE RELATIONSHIP, RADIATION; GENE EXPRESSION; HELA CELLS; HUMANS; RADIATION-SENSITIZING AGENTS; TRANSFECTION; TRIAZINES; TUMOR CELLS, CULTURED;

EID: 38649126586     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00432-007-0298-6     Document Type: Article

References (29)

1. Blagden S, de Bono J (2005) Drugging cell cycle kinases in cancer therapy. Curr Drug Targets 6:325-335
2. Delahoussaye YM, Evans JW, Brown JM (2001) Metabolism of tirapazamine by multiple reductases in the nucleus. Biochem Pharmacol 62:1201-1209
3. Durand RE, Olive PL (1997) Physiologic and cytotoxic effects of tirapazamine in tumor-bearing mice. Radiat Oncol Investig 5:213-219
4. Fukuoka K, Usuda J, Iwamoto Y, Fukumoto H, Nakamura T, Yoneda T, Narita N, Saijo N, Nishio K (2001) Mechanisms of action of the novel sulfonamide anticancer agent E7070 on cell cycle progression in human non-small cell lung cancer cells. Invest New Drugs 19:219-227
5. Haddad RI, Weinstein LJ, Wieczorek TJ, Bhattacharya N, Raftopoulos H, Oster MW, Zhang X, Latham VM Jr, Costello R, Faucher J, DeRosa C, Yule M, Miller LP, Loda M, Posner MR, Shapiro GI (2004) A phase II clinical and pharmacodynamic study of E7070 in patients with metastatic, recurrent, or refractory squamous cell carcinoma of the head and neck: modulation of retinoblastoma protein phosphorylation by a novel chloroindolyl sulfonamide cell cycle inhibitor. Clin Cancer Res 10:4680-4687
6. Hellauer K, Lesage G, Sdicu AM, Turcotte B (2005) Large-scale analysis of genes that alter sensitivity to the anticancer drug tirapazamine in Saccharomyces cerevisiae. Mol Pharmacol 68:1365-1375
7. Ivanov S, Liao SY, Ivanova A, Danilkovitch-Miagkova A, Tarasova N, Weirich G, Merrill MJ, Proescholdt MA, Oldfield EH, Lee J, Zavada J, Waheed A, Sly W, Lerman MI, Stanbridge EJ (2001) Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer. Am J Pathol 158:905-919
8. Kim JY, Shin HJ, Kim TH, Cho KH, Shin KH, Kim BK, Roh JW, Lee S, Park SY, Hwang YJ, Han IO (2006) Tumor-associated carbonic anhydrases are linked to metastases in primary cervical cancer. J Cancer Res Clin Oncol 132:302-308
9. Kim JY, West CM, Valentine H, Ward TH, Patterson AV, Stratford IJ, Roberts SA, Hendry JH (2004) Cytotoxicity of the bioreductive agent RH1 and its lack of interaction with radiation. Radiother Oncol 70:311-317
10. Lal A, Peters H, St Croix B, Haroon ZA, Dewhirst MW, Strausberg RL, Kaanders JH, van der Kogel AJ, Riggins GJ (2001) Transcriptional response to hypoxia in human tumors. J Natl Cancer Inst 93:1337-1343
11. Lee S, Shin HJ, Han IO, Hong EK, Park SY, Roh JW, Shin KH, Kim TH, Kim JY (2007) Tumor carbonic anhydrase 9 expression is associated with the presence of lymph node metastases in uterine cervical cancer. Cancer Sci 98:329-333
12. Lee HS, Park HJ, Lyons JC, Griffin RJ, Auger EA, Song CW (1997) Radiation-induced apoptosis in different pH environments in vitro. Int J Radiat Oncol Biol Phys 38:1079-1087
13. Loncaster JA, Harris AL, Davidson SE, Logue JP, Hunter RD, Wycoff CC, Pastorek J, Ratcliffe PJ, Stratford IJ, West CM (2001) Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Res 61:6394-6399
14. Olive PL, Vikse CM, Banath JP (1996) Use of the comet assay to identify cells sensitive to tirapazamine in multicell spheroids and tumors in mice. Cancer Res 56:4460-4463
15. Olive PL, Aquino-Parsons C, MacPhail SH, Liao SY, Raleigh JA, Lerman MI, Stanbridge EJ (2001) Carbonic anhydrase 9 as an endogenous marker for hypoxic cells in cervical cancer. Cancer Res 61:8924-8929
16. Pastorekova S, Parkkila S, Pastorek J, Supuran CT (2004) Carbonic anhydrases: current state of the art, therapeutic applications and future prospects. J Enzyme Inhib Med Chem 19:199-229
17. Rischin D, Hicks RJ, Fisher R, Binns D, Corry J, Porceddu S, Peters LJ (2006) Prognostic significance of [18F]-misonidazole positron emission tomography-detected tumor hypoxia in patients with advanced head and neck cancer randomly assigned to chemoradiation with or without tirapazamine: a substudy of Trans-Tasman Radiation Oncology Group Study 98.02. J Clin Oncol 24:2098-2104
18. Rischin D, Peters L, Fisher R, Macann A, Denham J, Poulsen M, Jackson M, Kenny L, Penniment M, Corry J, Lamb D, McClure B (2005) Tirapazamine, cisplatin, and radiation versus fluorouracil, cisplatin, and Radiation in patients with locally advanced head and neck cancer: a randomized phase II trial of the trans-Tasman radiation oncology group (TROG 98.02). J Clin Oncol 23:79-87
19. Siim BG, Pruijn FB, Sturman JR, Hogg A, Hay MP, Brown JM, Wilson WR (2004) Selective potentiation of the hypoxic cytotoxicity of tirapazamine by its 1-N-oxide metabolite SR 4317. Cancer Res 64:736-742
20. Siim BG, van Zijl PL, Brown JM (1996) Tirapazamine-induced DNA damage measured using the comet assay correlates with cytotoxicity towards hypoxic tumour cells in vitro. Br J Cancer 73:952-960
21. Tocher JH, Virk NS, Edwards DI (1990a) DNA damaging effects and voltammetric studies on the hypoxic cell toxin 3-amino-1,2,4-benzotriazine-1,4- dioxide, SR4233, as a function of pH. Biochem Pharmacol 40:1405-1410
22. Tocher JH, Virk NS, Edwards DI (1990b) Electrochemical studies and DNA damaging effects of the benzotriazine-N-oxides. Biochem Pharmacol 39:781-786
23. Tocher JH, Virk NS, Edwards DI (1990c) Electrochemical properties as a function of pH for the benzotriazine di-N-oxides. Free Radic Res Commun 10:295-302
24. Roberts SA (1990) DRFIT: a program for fitting radiation survival models. Int J Radiat Biol 57:1243-1246
25. Van Kesteren C, Beijnen JH, Schellens JH (2002) E7070: a novel synthetic sulfonamide targeting the cell cycle progression for the treatment of cancer. Anticancer Drugs 13:989-997
26. Vaupel P (2004) Tumor microenvironmental physiology and its implications for radiation oncology. Semin Radiat Oncol 14:198-206
27. Wahl ML, Owen CS, Grant DS (2002) Angiostatin induces intracellular acidosis and anoikis in endothelial cells at a tumor-like low pH. Endothelium 9:205-216
28. Williamson SK, Crowley JJ, Lara PN Jr, McCoy J, Lau DH, Tucker RW, Mills GM, Gandara DR (2005) Phase III trial of paclitaxel plus carboplatin with or without tirapazamine in advanced non-small-cell lung cancer: southwest oncology group trial S0003. J Clin Oncol 23:9097-9104
29. Yokoi A, Kuromitsu J, Kawai T, Nagasu T, Sugi NH, Yoshimatsu K, Yoshino H, Owa T (2002) Profiling novel sulfonamide antitumor agents with cell-based phenotypic screens and array-based gene expression analysis. Mol Cancer Ther 1:275-286