The Serotonin Transporter Gene in Aggressive Children with and without ADHD and Nonaggressive Matched Controls

Annals of the New York Academy of Sciences

Volumn 1008, Issue , 2003, Pages 248-251

  Beitchman, Joseph H ^a,b   Davidge, Kristen M ^a,b   Kennedy, James L ^b   Atkinson, Leslie ^b   Lee, Vivien ^b   Shapiro, Solomon ^b   Douglas, Lori ^b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

Author keywords

Aggression; Attention deficit hyperactivity disorder (ADHD); Children; Serotonin transporter gene

Indexed keywords

SEROTONIN TRANSPORTER;

AGGRESSION; ATTENTION DEFICIT DISORDER; CHILD; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENETIC ANALYSIS; HUMAN; MALE; PROTEIN ANALYSIS; PROTEIN FUNCTION; SAMPLING; VARIABLE NUMBER OF TANDEM REPEAT;

EID: 1342284140     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1301.025     Document Type: Conference Paper

References (16)

1. GINGRICH, J.A. & R. HEN. 2001. Dissecting the role of the serotonin system in neuropsychiatric disorders using knockout mice. Psychopharmacology 155: 1-10.
2. MEHLMAN, P.T. et al. 1994. Low CSF 5-HIAA concentrations and severe aggression and impaired impulse control in nonhuman primates. Am. J. Psychiatry 151: 1485-1491.
3. DAVIDSON, R.J., K.M. PUTNAM & C.L. LARSON. 2000. Dysfunction in the neural circuitry of emotion regulation: a possible prelude to violence. Science 289: 591-594.
4. LEE, R. & E. COCCARO. 2001. The neuropsychopharmacology of criminality and aggression. Can. J. Psychiatry 46: 35-44.
5. HALPERIN, J.M. et al. 1994. Serotonergic function in aggressive and nonaggressive boys with attention deificit hyperactivity disorder. Am. J. Psychiatry 151: 243-248.
6. PINE, D.S. et al. 1997. Neuroendocrine response to fenfluramine challenge in boys. Arch. Gen. Psychiatry 54: 839-846.
7. KRUESI, M.J.P. et al. 1992. A 2-year prospective follow-up study of children and adolescents with disruptive behavior disorders. Arch. Gen. Psychiatry 49: 429-435.
8. STOFF, D.M. et al. 1992. Neuroendocrine responses to challenge with D,L-fenfluramine and aggression in disruptive behavior disorders of children and adolescents. Psychiatry Res. 43: 263-276.
9. HALPERIN, J.M. et al. 1997. Serotonin, aggression and parental psychopathology in children with attention-deficit hyperactivity disorder. Am. J. Psychiatry 151: 243-248.
10. NEWCORN, J.H. et al. 1996. Emotionality and serotonergic function in aggressive and non-aggressive ADHD children. Sci. Proc. Ann. Meet. Am. Acad. Child Adolesc. Psychiatry 12: 94.
11. SCHULZ, K.P. et al. 2001. Relationship between central serotonergic function and aggression in prepubertal boys: effect of age and attention-deficit/hyperactivity disorder. Psychiatry Res. 101: 1-10.
12. MACKENZIE, A. & J. QUINN. 1999. A serotonin transporter gene intron 2 polymorphic region, correlated with affective disorders, has allele-dependent differential enhancer-like properties in the mouse embryo. Proc. Natl. Acad. Sci. USA 96: 15251-15255.
13. HEILS, A. et al. 1996. Allelic variation of human serotonin transporter gene expression. J. Neurochem. 66: 2621-2624.
14. MANOR, I. et al. 2001. Family-based association study of the serotonin transporter promoter region polymorphism (5-HTTLPR) in attention deficit hyperactivity disorder. Am. J. Med. Genet. 105: 91-95.
15. KENT, L. et al. 2002. Evidence that variation at the serotonin transporter gene influences susceptibility to attention deficit hyperactivity disorder (ADHD): analysis and pooled analysis. Mol. Psychiatry 7: 908-912.
16. ZOROGLU, S.S. et al. 2002. Significance of serotonin transporter gene 5-HTTLPR and variable number of tandem repeat polymorphism in attention deficit hyperactivity disorder. Neuropsychobiology 45: 176-181.