Regulation of L-lactate utilization by the FadR-type regulator LldR of Corynebacterium glutamicum

Journal of Bacteriology

Volumn 190, Issue 3, 2008, Pages 963-971

  Georgi, Tobias ^a   Engels, Verena ^a   Wendisch, Volker F ^b  

^a FORSCHUNGSZENTRUM JÜLICH   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; COMPLEMENTARY DNA; FLAVINE ADENINE NUCLEOTIDE; GLUCOSE; LACTATE DEHYDROGENASE; LACTIC ACID; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE; PYRUVIC ACID; QUINONE DEPENDENT LACTATE DEHYDROGENASE; RIBOSE; UNCLASSIFIED DRUG;

AFFINITY CHROMATOGRAPHY; ARTICLE; BACTERIAL GROWTH; BACTERIAL METABOLISM; CORYNEBACTERIUM GLUTAMICUM; DELETION MUTANT; DNA MICROARRAY; ENZYME ASSAY; GENETIC TRANSCRIPTION; LLDD GENE; LLDDRP GENE; LLDR GENE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; REGULATOR GENE; TRANSCRIPTION REGULATION;

BACTERIAL PROTEINS; BENZOQUINONES; CORYNEBACTERIUM GLUTAMICUM; GENE DELETION; GENE EXPRESSION REGULATION, BACTERIAL; L-LACTATE DEHYDROGENASE; LACTIC ACID; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OPERON; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTEOME; TRANSCRIPTION, GENETIC;

CORYNEBACTERIUM GLUTAMICUM;

EID: 38649116935     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.01147-07     Document Type: Article

References (59)

1. Abe, S., K.-I. Takayama, and S. Kinoshita. 1967. Taxonomical studies on glutamic acid-producing bacteria. J. Gen. Appl. Microbiol. 13:279-301.
2. Arndt, A., M. Auchter, T. Ishige, V. F. Wendisch, and B. J. Eikmanns. Ethanol catabolism in Corynebacterium glutamicum. J. Mol. Microbiol. Biotechnol., in press.
3. Bott, M., and A. Niebisch. 2003. The respiratory chain of Corynebacterium glutamicum. J. Biotechnol. 104:129-153.
4. Brocker, M., and M. Bott. 2006. Evidence for activator and repressor functions of the response regulator MtrA from Corynebacterium glutamicum. FEMS Microbiol. Lett. 264:205-212.
5. Claes, W. A., A. Puhler, and J. Kalinowski. 2002. Identification of two prpDBC gene clusters in Corynebacterium glutamicum and their involvement in propionate degradation via the 2-methylcitrate cycle. J. Bacteriol. 184:2728-2739.
6. Cramer, A., R. Gerstmeir, S. Schaffer, M. Bott, and B. J. Eikmanns. 2006. Identification of RamA, a novel LuxR-type transcriptional regulator of genes involved in acetate metabolism of Corynebacterium glutamicum. J. Bacteriol. 188:2554-2567.
7. Cronan, J. E., Jr., and S. Subrahmanyam. 1998. FadR, transcriptional coordination of metabolic expediency. Mol. Microbiol. 29:937-943.
8. Dominguez, H., M. Cocaign-Bousquet, and N. D. Lindley. 1997. Simultaneous consumption of glucose and fructose from sugar mixtures during batch growth of Corynebacterium glutamicum. Appl. Microbiol. Biotechnol. 47:600-603.
9. Dominguez, H., C. Rollin, A. Guyonvarch, J. L. Guerquin-Kern, M. Cocaign-Bousquet, and N. D. Lindley. 1998. Carbon-flux distribution in the central metabolic pathways of Corynebacterium glutamicum during growth on fructose. Eur. J. Biochem. 254:96-102.
10. Dong, J. M., J. S. Taylor, D. J. Latour, S. Iuchi, and E. C. Lin. 1993. Three overlapping lct genes involved in L-lactate utilization by Escherichia coli. J. Bacteriol. 175:6671-6678.
11. Duncan, S. H., P. Louis, and H. J. Flint. 2004. Lactate-utilizing bacteria, isolated from human feces, that produce butyrate as a major fermentation product. Appl. Environ Microbiol. 70:5810-5817.
12. Reference deleted.
13. H. Mol. Microbiol. 52:285-302.
14. Engels, V., and V. F. Wendisch. 2007. The DeoR-type regulator SugR represses expression of ptsG in Corynebacterium glutamicum. J. Bacteriol. 189:2955-2966.
15. Fujita, Y., and T. Fujita. 1987. The gluconate operon gnt of Bacillus subtilis encodes its own transcriptional negative regulator. Proc. Natl. Acad. Sci. USA 84:4524-4528.
16. Gerstmeir, R., A. Cramer, P. Dangel, S. Schaffer, and B. J. Eikmanns. 2004. RamB, a novel transcriptional regulator of genes involved in acetate metabolism of Corynebacterium glutamicum. J. Bacteriol. 186:2798-2809.
17. Gerstmeir, R., V. F. Wendisch, S. Schnicke, H. Ruan, M. Farwick, D. Reinscheid, and B. J. Eikmanns. 2003. Acetate metabolism and its regulation in Corynebacterium glutamicum. J. Biotechnol. 104:99-122.
18. Goffin, P., F. Lorquet, M. Kleerebezem, and P. Hols. 2004. Major role of NAD-dependent lactate dehydrogenases in aerobic lactate utilization in Lactobacillus plantarum during early stationary phase. J. Bacteriol. 186:6661-6666.
19. Hanahan, D. 1985. Techniques for transformation of E. coli, p. 109-135. In D. M. Glover (ed.), DNA cloning, vol. 1. IRL Press, Washington, DC.
20. Hanahan, D. 1983. Studies on transformation of Escherichia coli with Plasmids. J. Mol. Biol. 166:557-580.
21. Hansmeier, N., A. Albersmeier, A. Tauch, T. Damberg, R. Ros, D. Anselmetti, A. Puhler, and J. Kalinowski. 2006. The surface (S)-layer gene cspB of Corynebacterium glutamicum is transcriptionally activated by a LuxR-type regulator and located on a 6 kb genomic island absent from the type strain ATCC 13032. Microbiology 152:923-935.
22. Inui, M., S. Murakami, S. Okino, H. Kawaguchi, A. A. Vertes, and H. Yukawa. 2004. Metabolic analysis of Corynebacterium glutamicum during lactate and succinate production under oxygen deprivation conditions. J. Mol. Microbiol. Biotechnol. 7:182-196.
23. Ishige, T., M. Krause, M. Bott, V. F. Wendisch, and H. Sahm. 2003. The phosphate starvation stimulon of Corynebacterium glutamicum determined by DNA microarray analyses. J. Bacteriol. 185:4519-4529.
24. Iuchi, S., and E. C. Lin. 1988. arcA (dye), a global regulatory gene in Escherichia coli mediating repression of enzymes in aerobic pathways. Proc. Natl. Acad. Sci. USA 85:1888-1892.
25. Jakob, K., P. Satorhelyi, C. Lange, V. F. Wendisch, B. Silakowski, S. Scherer, and K. Neuhaus. 2007. Gene expression analysis of Corynebacterium glutamicum subjected to long-term lactic acid adaptation. J. Bacteriol. 189:5582-5590.
26. Keilhauer, C., L. Eggeling, and H. Sahm. 1993. Isoleucine synthesis in Corynebacterium glutamicum: molecular analysis of the ilvB-ilvN-ilvC operon. J. Bacteriol. 175:5595-5603.
27. Kiefer, P., E. Heinzle, and C. Wittmann. 2002. Influence of glucose, fructose and sucrose as carbon sources on kinetics and stoichiometry of lysine production by Corynebacterium glutamicum. J. Industrial Microbiol. Biotechnol. 28:338-343.
28. Kiefer, P., E. Heinzle, O. Zelder, and C. Wittmann. 2004. Comparative metabolic flux analysis of lysine-producing Corynebacterium glutamicum cultured on glucose or fructose. Appl. Environ Microbiol. 70:229-239.
29. Kim, H. J., T. H. Kim, Y. Kim, and H. S. Lee. 2004. Identification and characterization of glxR, a gene involved in regulation of glyoxylate bypass in Corynebacterium glutamicum. J. Bacteriol. 186:3453-3460.
30. Kinoshita, S., S. Udaka, and M. Shimono. 1957. Studies on the amino acid fermentation. I. Production of L-glutamic acid by various microorganisms. J. Gen. Appl. Microbiol. 3:193-205.
31. Krämer, R., C. Lambert, C. Hoischen, and H. Ebbighausen. 1990. Uptake of glutamate in Corynebacterium glutamicum. 1. Kinetic properties and regulation by internal pH and potassium. Eur. J. Biochem. 194:929-935.
32. Krug, A., V. F. Wendisch, and M. Bott. 2005. Identification of AcnR, a TetR-type repressor of the aconitase gene acn in Corynebacterium glutamicum. J. Biol. Chem. 280:585-595.
33. Lange, C., D. Rittmann, V. F. Wendisch, M. Bott, and H. Sahm. 2003. Global expression profiling and physiological characterization of Corynebacterium glutamicum grown in the presence of L-valine. Appl. Environ. Microbiol. 69:2521-2532.
34. Lynch, A. S., and E. C. C. Lin. 1996. Transcriptional control mediated by the ArcA two-component response regulator protein of Escherichia coli: characterization of DNA binding to target promoters. J. Bacteriol. 178:6238-6249.
35. Merkens, H., G. Beckers, A. Wirtz, and A. Burkovski. 2005. Vanillate metabolism in Corynebacterium glutamicum. Curr. Microbiol. 51:59-65.
36. Moon, M. W., H. J. Kim, T. K. Oh, C. S. Shin, J. S. Lee, S. J. Kim, and J. K. Lee. 2005. Analyses of enzyme II gene mutants for sugar transport and heterologous expression of fructokinase gene in Corynebacterium glutamicum ATCC 13032. FEMS Microbiol. Lett. 244:259-266.
37. Netzer, R., P. Peters-Wendisch, L. Eggeling, and H. Sahm. 2004. Cometabolism of a nongrowth substrate: L-serine utilization by Corynebacterium glutamicum. Appl. Environ. Microbiol. 70:7148-7155.
38. 3 branch of the Corynebacterium glutamicum respiratory chain containing an unusual diheme cytochrome c1. Arch. Microbiol. 175:282-294.
39. Nunez, M. F., O. Kwon, T. H. Wilson, J. Aguilar, L. Baldoma, and E. C. Lin. 2002. Transport of L-lactate, D-lactate, and glycolate by the LldP and GlcA membrane carriers of Escherichia coli. Biochem. Biophys. Res. Commun. 290:824-829.
40. Nunn, W. D., and R. W. Simons. 1978. Transport of long-chain fatty acids by Escherichia coli: mapping and characterization of mutants in the fadL gene. Proc. Natl. Acad. Sci. USA 75:3377-3381.
41. Patek, M., J. Nesvera, A. Guyonvarch, O. Reyes, and G. Leblon. 2003. Promoters of Corynebacterium glutamicum. J. Biotechnol. 104:311-323.
42. Pequignot, C., C. G. Dussap, A. Pons, and J. B. Gros. 1997. Intra- and extracellular concentrations of glutamate, lactate and acetate during growth of Corynebacterium glutamicum on different media. J. Ind. Microbiol. Biotechnol. 18:312-318.
43. Peters-Wendisch, P. G., B. Schiel, V. F. Wendisch, E. Katsoulidis, B. Mockel, H. Sahm, and B. J. Eikmanns. 2001. Pyruvate carboxylase is a major bottleneck for glutamate and lysine production by Corynebacterium glutamicum. J. Mol. Microbiol. Biotechnol. 3:295-300.
44. Polen, T., and V. F. Wendisch. 2004. Genomewide expression analysis in amino acid-producing bacteria using DNA microarrays. Appl. Biochem. Biotechnol. 118:215-232.
45. Pons, A., C. G. Dussap, C. Pequinot, and J. B. Gros. 1996. Metabolic flux distribution in Corynebacterium melassecola ATCC 17965 for various carbon sources. Biotechnol. Bioeng. 51:177-189.
46. Quail, M. A., and J. R. Guest. 1995. Purification, characterization and mode of action of PdhR, the transcriptional repressor of the pdhR-aceEF-lpd operon of Escherichia coli. Mol. Microbiol. 15:519-529.
47. Rigali, S., A. Derouaux, F. Giannotta, and J. Dusart. 2002. Subdivision of the helix-turn-helix GntR family of bacterial regulators in the FadR, HutC, MocR, and YtrA subfamilies. J. Biol. Chem. 277:12507-12515.
48. Sambrook, J., and D. W. Russell. 2001. Molecular cloning: a laboratory manual, 3rd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
49. Schäfer, A., A. Tauch, W. Jäger, J. Kalinowski, G. Thierbach, and A. Pühler. 1994. Small mobilizable multi-purpose cloning vectors derived from the Escherichia coli plasmids pK18 and pK19: selection of defined deletions in the chromosome of Corynebacterium glutamicum. Gene 145:69-73.
50. Schaffer, S., B. Weil, V. D. Nguyen, G. Dongmann, K. Gunther, M. Nickolaus, T. Hermann, and M. Bott. 2001. A high-resolution reference map for cytoplasmic and membrane-associated proteins of Corynebacterium glutamicum. Electrophoresis 22:4404-4422.
51. Schluesener, D., F. Fischer, J. Kruip, M. Rogner, and A. Poetsch. 2005. Mapping the membrane proteome of Corynebacterium glutamicum. Proteomics 5:1317-1330.
52. Soual-Hoebeke, E., C. de Sousa-D'Auria, M. Chami, M. F. Baucher, A. Guyonvarch, N. Bayan, K. Salim, and G. Leblon. 1999. S-layer protein production by Corynebacterium strains is dependent on the carbon source. Microbiology 145:3399-3408.
53. Stansen, C., D. Uy, S. Delaunay, L. Eggeling, J. L. Goergen, and V. F. Wendisch. 2005. Characterization of a Corynebacterium glutamicum lactate utilization operon induced during temperature-triggered glutamate production. Appl. Environ. Microbiol. 71:5920-5928.
54. Studier, F. W., and B. A. Moffatt. 1986. Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. J. Mol. Biol. 189:113-130.
55. van der Rest, M. E., C. Lange, and D. Molenaar. 1999. A heat shock following electroporation induces highly efficient transformation of Corynebacterium glutamicum with xenogeneic plasmid DNA. Appl. Microbiol. Biotechnol. 52:541-545.
56. Wendisch, V. F. 2003. Genome-wide expression analysis in Corynebacterium glutamicum using DNA microarrays. J. Biotechnol. 104:273-285.
57. Wendisch, V. F., A. A. de Graaf, H. Sahm, and B. J. Eikmanns. 2000. Quantitative determination of metabolic fluxes during coutilization of two carbon sources: comparative analyses with Corynebacterium glutamicum during growth on acetate and/or glucose. J. Bacteriol. 182:3088-3096.
58. Wennerhold, J., A. Krug, and M. Bott. 2005. The AraC-type regulator RipA represses aconitase and other iron proteins from Corynebacterium under iron limitation and is itself repressed by DtxR. J. Biol. Chem. 280:40500-40508.
59. Yokota, A., and N. D. Lindley. 2005. Central metabolism: sugar uptake and conversion, p. 215-240. In L. Eggeling and M. Bott (ed.), Handbook of Corynebacterium glutamicum, vol. 10. CRC Press, Boca Raton, FL.