Telithromycin resistance in Streptococcus pneumoniae is conferred by a deletion in the leader sequence of erm(B) that increases rRNA methylation

Antimicrobial Agents and Chemotherapy

Volumn 52, Issue 2, 2008, Pages 435-440

  Wolter, Nicole ^a,f   Smith, Anthony M ^a   Farrell, David J ^b   Northwood, John Blackman ^b   Douthwaite, Stephen ^c   Klugman, Keith P ^a,d,e  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^b GR Micro Ltd   (United Kingdom)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^d EMORY UNIVERSITY   (United States)

^e EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f NATIONAL INSTITUTE FOR COMMUNICABLE DISEASES   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROMYCIN; RIBOSOME RNA; TELITHROMYCIN;

ALLELE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM ISOLATE; CONTROLLED STUDY; ERMB GENE; GENE DELETION; GENE EXPRESSION; GENE INDUCTION; GENE SEQUENCE; MINIMUM INHIBITORY CONCENTRATION; MUTAGENESIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA METHYLATION; STREPTOCOCCUS PNEUMONIAE; WILD TYPE;

5' UNTRANSLATED REGIONS; AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, BACTERIAL; HUMANS; KETOLIDES; METHYLATION; METHYLTRANSFERASES; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; RNA, RIBOSOMAL; SEQUENCE DELETION; STREPTOCOCCUS PNEUMONIAE;

EID: 38649112301     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.01074-07     Document Type: Article

References (41)

1. Berisio, R., J. Harms, F. Schluenzen, R. Zarivach, H. A. Hansen, P. Fucini, and A. Yonath. 2003. Structural insight into the antibiotic action of telithromycin against resistant mutants. J. Bacteriol. 185:4276-4279.
2. Canu, A., B. Malbruny, M. Coquemont, T. Davies, P. C. Appelbaum, and R. Leclercq. 2002. Diversity of ribosomal mutations conferring resistance to macrolides, clindamycin, streptogramin, and telithromycin in Streptococcus pneumoniae. Antimicrob. Agents Chemother. 46:125-131.
3. Capobianco, J. O., Z. Cao, V. D. Shortridge, Z. Ma, R. K. Flamm, and P. Zhong. 2000. Studies of the novel ketolide ABT-773: transport, binding to ribosomes, and inhibition of protein synthesis in Streptococcus pneumoniae. Antimicrob. Agents Chemother. 44:1562-1567.
4. Champney, W. S. 2001. Bacterial ribosomal subunit synthesis: a novel antibiotic target. Curr. Drug Targets Infect. Disord. 1:19-36.
5. Clinical and Laboratory Standards Institute. 2006. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 7th ed. Approved standard M7-A7. Clinical and Laboratory Standards Institute, Wayne, PA.
6. Clinical and Laboratory Standards Institute. 2006. Performance standards for antimicrobial susceptibility testing; 16th informational supplement. CLSI document M100-S16. Clinical and Laboratory Standards Institute, Wayne, PA.
7. Douthwaite, S., L. H. Hansen, and P. Mauvais. 2000. Macrolide-ketolide inhibition of MLS-resistant ribosomes is improved by alternative drug interaction with domain II of 23S rRNA. Mol. Microbiol. 36:183-193.
8. Douthwaite, S., and W. S. Champney. 2001. Structures of ketolides and macrolides determine their mode of interaction with the ribosomal target site. J. Antimicrob. Chemother. 48:1-8.
9. Douthwaite, S., J. Jalava, and L. Jakobsen. 2005. Ketolide resistance in Streptococcus pyogenes correlates with the degree of rRNA dimethylation by Erm. Mol. Microbiol. 58:613-622.
10. Faccone, D., P. Andres, M. Galas, M. Tokumoto, A. Rosato, and A. Corso. 2005. Emergence of a Streptococcus pneumoniae clinical isolate highly resistant to telithromycin and fluoroquinolones. J. Clin. Microbiol. 43:5800-5803.
11. Farrell, D. J., S. Douthwaite, I. Morrissey, S. Bakker, J. Poehlsgaard, L. Jakobsen, and D. Felmingham. 2003. Macrolide resistance by ribosomal mutation in clinical isolates of Streptococcus pneumoniae from the PROTEKT 1999-2000 study. Antimicrob. Agents Chemother. 47:1777-1783.
12. Farrell, D. J., I. Morrissey, S. Bakker, S. Buckridge, and D. Felmingham. 2004. In vitro activities of telithromycin, linezolid, and quinupristin-dalfopristin against Streptococcus pneumoniae with macrolide resistance due to ribosomal mutations. Antimicrob. Agents Chemother. 48:3169-3171.
13. Hansen, L. H., P. Mauvais, and S. Douthwaite. 1999. The macrolide-ketolide antibiotic binding site is formed by structures in domains II and V of 23S ribosomal RNA. Mol. Microbiol. 31:623-631.
14. Jalava, J., J. Kataja, H. Seppala, and P. Huovinen. 2001. In vitro activities of the novel ketolide telithromycin (HMR 3647) against erythromycin-resistant Streptococcus species. Antimicrob. Agents Chemother. 45:789-793.
15. Liu, M., and S. Douthwaite. 2002. Activity of the ketolide telithromycin is refractory to erm monomethylation of bacterial rRNA. Antimicrob. Agents Chemother. 46:1629-1633.
16. McGee, L., K. P. Klugman, A. Wasas, T. Capper, A. Brink, and The Antibiotics Surveillance Forum of South Africa. 2001. Serotype 19F multiresistant pneumococcal clone harboring two erythromycin resistance determinants [erm(B) and mef(A)] in South Africa. Antimicrob. Agents Chemother. 45:1595-1598.
17. McGee, L., L. McDougal, J. Zhou, B. G. Spratt, F. C. Tenover, R. George, R. Hakenbeck, W. Hryniewicz, J. C. Lefévre, A. Tomasz, and K. P. Klugman. 2001. Nomenclature of major antimicrobial-resistant clones of Streptococcus pneumoniae defined by the Pneumococcal Molecular Epidemiology Network. J. Clin. Microbiol. 39:2565-2571.
18. Nagai, K., P. C. Appelbaum, T. Davies, L. M. Kelly, D. B. Hoellman, A. T. Andrasevic, L. Drukalska, W. Hryniewicz, M. R. Jacobs, J. Kolman, J. Miciuleviciene, M. Pana, L. Setchanova, M. K. Thege, H. Hupkova, J. Trupl, and P. Urbaskova. 2002. Susceptibilities to telithromycin and six other agents and prevalence of macrolide resistance due to L4 ribosomal protein mutation among 992 pneumococci from 10 central and eastern European countries. Antimicrob. Agents Chemother. 46:371-377.
19. Okitsu, N., S. Kaieda, H. Yano, R. Nakano, Y. Hosaka, R. Okamoto, T. Kobayashi, and M. Inoue. 2005. Characterization of erm(B) gene transposition by Tn1545 and Tn917 in macrolide-resistant Streptococcus pneumoniae isolates. J. Clin. Microbiol. 43:168-173.
20. Pérez-Trallero, E., J. M. Marimon, L. Iglesias, and J. Larruskain. 2003. Fluoroquinolone and macrolide treatment failure in pneumococcal pneumonia and selection of multidrug-resistant isolates. Emerg. Infect. Dis. 9:1159-1162.
21. Pihlajamaki, M., J. Jalava, P. Huovinen, and P. Kotilainen. 2003. Antimicrobial resistance of invasive pneumococci in Finland in 1999-2000. Antimicrob. Agents Chemother. 47:1832-1835.
22. Reinert, R. R., M. van der Linden, and A. Al-Lahham. 2005. Molecular characterization of the first telithromycin-resistant Streptococcus pneumoniae isolate in Germany. Antimicrob. Agents Chemother. 49:3520-3522.
23. Rosato, A., H. Vicarini, A. Bonnefoy, J. F. Chantot, and R. Leclercq. 1998. A new ketolide, HMR 3004, active against streptococci inducibly resistant to erythromycin. Antimicrob. Agents Chemother. 42:1392-1396.
24. Rosato, A., H. Vicarini, and R. Leclercq. 1999. Inducible or constitutive expression of resistance in clinical isolates of streptococci and enterococci cross-resistant to erythromycin and lincomycin. J. Antimicrob. Chemother. 43:559-562.
25. Sigmund, C. D., M. Ettayebi, A. Borden, and E. A. Morgan. 1988. Antibiotic resistance mutations in ribosomal RNA genes of Escherichia coli. Methods Enzymol. 164:673-690.
26. Smith, A. M., K. P. Klugman, T. J. Coffey, and B. G. Spratt. 1993. Genetic diversity of penicillin-binding protein 2B and 2X genes from Streptococcus pneumoniae in South Africa. Antimicrob. Agents Chemother. 37:1938-1944.
27. Smith, A. M., and K. P. Klugman. 2000. Non-penicillin-binding protein mediated high-level penicillin and cephalosporin resistance in a Hungarian clone of Streptococcus pneumoniae. Microb. Drug Resist. 6:105-110.
28. Sutcliffe, J., T. Grebe, A. Tait-Kamradt, and L. Wondrack. 1996. Detection of erythromycin-tesistant determinants by PCR. Antimicrob. Agents Chemother. 40:2562-2566.
29. Sutcliffe, J., A. Tait-Kamradt, and L. Wondrack. 1996. Streptococcus pneumoniae and Streptococcus pyogenes resistant to macrolides but sensitive to clindamycin: a common resistance pattern mediated by an efflux system. Antimicrob. Agents Chemother. 40:1817-1824.
30. Tait-Kamradt, A., T. Davies, M. Cronan, M. R. Jacobs, P. C. Appelbaum, and J. Sutcliffe. 2000. Mutations in 23S rRNA and ribosomal protein L4 account for resistance in pneumococcal strains selected in vitro by macrolide passage. Antimicrob. Agents Chemother. 44:2118-2125.
31. Tait-Kamradt, A., T. Davies, P. C. Appelbaum, F. Depardieu, P. Courvalin, J. Petitpas, L. Wondrack, A. Walker, M. R. Jacobs, and J. Sutcliffe. 2000. Two new mechanisms of macrolide resistance in clinical strains of Streptococcus pneumoniae from Eastern Europe and North America. Antimicrob. Agents Chemother. 44:3395-3401.
32. Tait-Kamradt, A., R. R. Reinert, A. Al-Lahham, D. E. Low, and J. Sutcliffe. 2001. High-level ketolide-resistant streptococci, p. 101. Abstr. 41st Intersci. Conf. Antimicrob. Agents Chemother. American Society for Microbiology, Washington, DC.
33. Tomasz, A., and R. D. Hotchkiss. 1964. Regulation of the transform ability of pneumococcal cultures by macromolecular cell products. Proc. Natl. Acad. Sci. USA 51:480-487.
34. Tu, D., G. Blaha, P. B. Moore, and T. A Steitz. 2005. Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance. Cell 121:257-270.
35. Walsh, F., J. Willcock, and S. Amyes. 2003. High-level telithromycin resistance in laboratory-generated mutants of Streptococcus pneumoniae. J. Antimicrob. Chemother. 52:345-353.
36. Weisblum, B. 1995. Erythromycin resistance by ribosome modification. Antimicrob. Agents Chemother. 39:577-585.
37. Weisblum, B. 1995. Insights into erythromycin action from studies of its activity as inducer of resistance. Antimicrob. Agents Chemother. 39:797-805.
38. Wolter, N., A. M. Smith, D. E. Low, and K. P. Klugman. 2007. High-level telithromycin resistance in a clinical isolate of Streptococcus pneumoniae. Antimicrob. Agents Chemother. 51:1092-1095.
39. Xiong, L., S. Shah, P. Mauvais, and A. S. Mankin. 1999. A ketolide resistance mutation in domain 11 of 23S rRNA reveals the proximity of hairpin 35 to the peptidyl transferase centre. Mol. Microbiol. 31:633-639.
40. Zhong, P., Z. Cao, R. Hammond, Y. Chen, J. Beyer, V. D. Shortridge, L. Y. Phan, S. Pratt, J. Capobianco, K. A. Reich, R. K. Flamm, Y. S. Or, and L. Katz. 1999. Induction of ribosome methylation in MLS-resistant Streptococcus pneumoniae by macrolides and ketolides. Microb. Drug Resist. 5:183-188.
41. Zuckerman, J. M. 2004. Macrolides and ketolides: azithromycin, clarithromycin, telithromycin. Infect. Dis. Clin. N. Am. 18:621-649, xi.