Age-at-onset linkage analysis in Caribbean Hispanics with familial late-onset Alzheimer's disease

Neurogenetics

Volumn 9, Issue 1, 2008, Pages 51-60

  Lee, Joseph H ^a,b   Barral, Sandra ^a   Cheng, Rong ^a,b   Chacon, Inara ^b   Santana, Vincent ^a,b   Williamson, Jennifer ^a,b   Lantigua, Rafael ^a,c   Medrano, Martin ^d   Jimenez Velazquez, Ivonne Z ^e   Stern, Yaakov ^a,b,c   Tycko, Benjamin ^a,c   Rogaeva, Ekaterina ^f   Wakutani, Yosuke ^f   Kawarai, Toshitaka ^f   St George Hyslop, Peter ^f   Mayeux, Richard ^a,b,c  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b Taub Institute for Research on Alzheimer's Disease and the Aging Brain and the Gertrude H Sergievsky Center   (United States)

^c University of Puerto Rico School of Medicine ^*  (United States)

^d UNIVERSIDAD TECNOLÓGICA DE SANTIAGO   (Dominican Republic)

^e UNIVERSITY OF PUERTO RICO SCHOOL OF MEDICINE   (Puerto Rico)

^f TORONTO WESTERN HOSPITAL   (Canada)

Author keywords

Age at onset; Alzheimer's disease; APOE; Family based association analysis; Linkage analysis

Indexed keywords

APOLIPOPROTEIN E;

ADULT; AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; CHROMOSOME 12Q; CHROMOSOME 13Q; CHROMOSOME 14Q; CHROMOSOME 17P; CHROMOSOME 17Q; CHROMOSOME 5Q; CHROMOSOME 7Q; CONTROLLED STUDY; FEMALE; GENE LOCUS; GENETIC VARIABILITY; GENOME; GENOTYPE; HUMAN; LINKAGE ANALYSIS; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE MARKER; ONSET AGE; PRIORITY JOURNAL; QUANTITATIVE TRAIT; VARIANCE;

ADULT; AGE OF ONSET; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; APOLIPOPROTEIN E4; CARIBBEAN REGION; FEMALE; HISPANIC AMERICANS; HUMANS; LINKAGE (GENETICS); LOD SCORE; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; PRESENILIN-1;

EID: 38649102180     PISSN: 13646745     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10048-007-0103-3     Document Type: Article

References (54)

1. Nussbaum RL, Ellis CE (2003) Alzheimer's disease and Parkinson's disease. N Engl J Med 348:1356-1364
2. St George-Hyslop PH, Petit A (2005) Molecular biology and genetics of Alzheimer's disease. C R Biol 328:119-130
3. Tanzi RE, Bertram L (2005) Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective. Cell 120:545-555
4. Pastor P, Goate AM (2004) Molecular genetics of Alzheimer's disease. Curr Psychiatry Rep 6:125-133
5. Lander ES, Schork NJ (1994) Genetic dissection of complex traits, vol 265. Science, New York, NY, pp 2037-2048
6. Kamboh MI (2004) Molecular genetics of late-onset Alzheimer's disease. Ann Hum Genet 68:381-404
7. Blacker D, Haines JL, Rodes L, Terwedow H, Go RC, Harrell LE et al (1997) ApoE-4 and age at onset of Alzheimer's disease: the NIMH genetics initiative. Neurology 48:139-147
8. Breitner JC, Jarvik GP, Plassman BL, Saunders AM, Welsh KA (1998) Risk of Alzheimer disease with the epsilon4 allele for apolipoprotein E in a population-based study of men aged 62-73 years. Alzheimer Dis Assoc Disord 12:40-44
9. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW et al (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families, vol 261. Science, New York, NY, pp 921-923
10. Harwood DG, Barker WW, Ownby RL, St George-Hyslop P, Mullan M, Duara R (2004) Apolipoprotein E polymorphism and age of onset for Alzheimer's disease in a bi-ethnic sample. Int Psychogeriatr 16:317-326
11. Nicodemus KK, Stenger JE, Schmechel DE, Welsh-Bohmer KA, Saunders AM, Roses AD et al (2004) Comprehensive association analysis of APOE regulatory region polymorphisms in Alzheimer disease. Neurogenetics 5:201-208
12. Wijsman EM, Daw EW, Yu X, Steinbart EJ, Nochlin D, Bird TD et al (2005) APOE and other loci affect age-at-onset in Alzheimer's disease families with PS2 mutation. Am J Med Genet B Neuropsychiatr Genet 132:14-20
13. Daw EW, Payami H, Nemens EJ, Nochlin D, Bird TD, Schellenberg GD et al (2000) The number of trait loci in late-onset Alzheimer disease. Am J Hum Genet 66:196-204
14. Holmans P, Hamshere M, Hollingworth P, Rice F, Tunstall N, Jones S et al (2005) Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer's disease. Am J Med Genet B Neuropsychiatr Genet 135:24-32
15. Li YJ, Scott WK, Hedges DJ, Zhang F, Gaskell PC, Nance MA et al (2002) Age at onset in two common neurodegenerative diseases is genetically controlled. Am J Hum Genet 70:985-993
16. Nacmias B, Latorraca S, Piersanti P, Forleo P, Piacentini S, Bracco L et al (1995) ApoE genotype and familial Alzheimer's disease: a possible influence on age of onset in APP717 Val->Ile mutated families. Neurosci Lett 183:1-3
17. Olson JM, Goddard KA, Dudek DM (2002) A second locus for very-late-onset Alzheimer disease: a genome scan reveals linkage to 20 p and epistasis between 20 p and the amyloid precursor protein region. Am J Hum Genet 71:154-161
18. Rademakers R, Cruts M, Sleegers K, Dermaut B, Theuns J, Aulchenko Y et al (2005) Linkage and association studies identify a novel locus for Alzheimer disease at 7q36 in a Dutch population-based sample. Am J Hum Genet 77:643-652
19. Wavrant-De Vrieze F, Crook R, Holmans P, Kehoe P, Owen MJ, Williams J et al (1999) Genetic variability at the amyloid-beta precursor protein locus may contribute to the risk of late-onset Alzheimer's disease. Neurosci Lett 269:67-70
20. Wijsman EM, Daw EW, Yu CE, Payami H, Steinbart EJ, Nochlin D et al (2004) Evidence for a novel late-onset Alzheimer disease locus on chromosome 19p13.2. Am J Hum Genet 75:398-409
21. Lee JH, Cheng R, Santana V, Williamson J, Lantigua R, Medrano M et al (2006) Expanded genomewide scan implicates a novel locus at 3q28 among Caribbean hispanics with familial Alzheimer disease. Arch Neurol 63:1591-1598
22. Lee JH, Mayeux R, Mayo D, Mo J, Santana V, Williamson J et al (2004) Fine mapping of 10q and 18q for familial Alzheimer's disease in Caribbean Hispanics. Mol Psychiatry 9:1042-1051
23. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34:939-944
24. Hughes CP, Berg L, Danziger WL, Coben LA, Martin RL (1982) A new clinical scale for the staging of dementia. Br J Psychiatry 140:566-572
25. Pittman J, Andrews H, Tatemichi T, Link B, Struening E, Stern Y et al (1992) Diagnosis of dementia in a heterogeneous population. A comparison of paradigm-based diagnosis and physician's diagnosis. Arch Neurol 49:461-467
26. Stern Y, Andrews H, Pittman J, Sano M, Tatemichi T, Lantigua R et al (1992) Diagnosis of dementia in a heterogeneous population. Development of a neuropsychological paradigm-based diagnosis of dementia and quantified correction for the effects of education. Arch Neurol 49:453-460
27. Stricks L, Pittman J, Jacobs DM, Sano M, Stern Y (1998) Normative data for a brief neuropsychological battery administered to English- and Spanish-speaking community-dwelling elders. J Int Neuropsychol Soc 4:311-318
28. Ganguli M, Dodge HH, Chen P, Belle S, DeKosky ST (2000) Ten-year incidence of dementia in a rural elderly US community population: the MoVIES Project. Neurology 54:1109-1116
29. Hixson JE, Vernier DT (1990) Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J Lipid Res 31:545-548
30. Maestre G, Ottman R, Stern Y, Gurland B, Chun M, Tang MX et al (1995) Apolipoprotein E and Alzheimer's disease: ethnic variation in genotypic risks. Ann Neurol 37:254-259
31. Athan ES, Williamson J, Ciappa A, Santana V, Romas SN, Lee JH et al (2001) A founder mutation in presenilin 1 causing early-onset Alzheimer disease in unrelated Caribbean Hispanic families. JAMA 286:2257-2263
32. Preisser JS, Koch GG (1997) Categorical data analysis in public health. Annu Rev Public Health 18:51-82
33. Zeger SL, Liang KY (1992) An overview of methods for the analysis of longitudinal data. Stat Med 11:1825-1839
34. Amos CI (1994) Robust variance-components approach for assessing genetic linkage in pedigrees. Am J Hum Genet 54:535-543
35. Almasy L, Blangero J (1998) Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62:1198-1211
36. Comuzzie AG, Williams JT (1999) Correcting for ascertainment bias in the COGA data set. Genet Epidemiol 17(Suppl 1):S109-S114
37. Churchill GA, Doerge RW (1994) Empirical threshold values for quantitative trait mapping. Genetics 138:963-971
38. Doerge RW, Churchill GA (1996) Permutation tests for multiple loci affecting a quantitative character. Genetics 142:285-294
39. Horvath S, Xu X, Laird NM (2001) The family based association test method: strategies for studying general genotype-phenotype associations. Eur J Hum Genet 9:301-306
40. Rabinowitz D, Laird N (2000) A unified approach to adjusting association tests for population admixture with arbitrary pedigree structure and arbitrary missing marker information. Hum Hered 50:211-223
41. Li YJ, Oliveira SA, Xu P, Martin ER, Stenger JE, Scherzer CR et al (2003) Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease. Hum Mol Genet 12:3259-3267
42. Avramopoulos D, Fallin MD, Bassett SS (2005) Linkage to chromosome 14q in Alzheimer's disease (AD) patients without psychotic symptoms. Am J Med Genet B Neuropsychiatr Genet 132:9-13
43. Kamboh MI, Minster RL, Kenney M, Ozturk A, Desai PP, Kammerer CM et al (2006) Alpha-1-antichymotrypsin (ACT or SERPINA3) polymorphism may affect age-at-onset and disease duration of Alzheimer's disease. Neurobiol Aging 27:1435-1439
44. Risch NJ (2000) Searching for genetic determinants in the new millennium. Nature 405:847-856
45. Tunstall N, Owen MJ, Williams J, Rice F, Carty S, Lillystone S et al (2000) Familial influence on variation in age of onset and behavioural phenotype in Alzheimer's disease. Br J Psychiatry 176:156-159
46. Coon KD, Myers AJ, Craig DW, Webster JA, Pearson JV, Lince DH et al (2007) A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease. J Clin Psychiatry 68:613-618
47. Goddard KA, Olson JM, Payami H, van der Voet M, Kuivaniemi H, Tromp G (2004) Evidence of linkage and association on chromosome 20 for late-onset Alzheimer disease. Neurogenetics 5:121-128
48. Kolsch H, Linnebank M, Lutjohann D, Jessen F, Wullner U, Harbrecht U et al (2004) Polymorphisms in glutathione S-transferase omega-1 and AD, vascular dementia, and stroke. Neurology 63:2255-2260
49. Nishimura M, Sakamoto T, Kaji R, Kawakami H (2004) Influence of polymorphisms in the genes for cytokines and glutathione S-transferase omega on sporadic Alzheimer's disease. Neurosci Lett 368:140-143
50. Ozturk A, Desai PP, Minster RL, Dekosky ST, Kamboh MI (2005) Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease. Neurobiol Aging 26:1161-1165
51. Higuchi M, Iwata N, Saido TC (2005) Understanding molecular mechanisms of proteolysis in Alzheimer's disease: progress toward therapeutic interventions. Biochim Biophys Acta 1751:60-67
52. Higuchi M, Tomioka M, Takano J, Shirotani K, Iwata N, Masumoto H et al (2005) Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors. J Biol Chem 280:15229-15237
53. Fathi Z, Battaglino PM, Iben LG, Li H, Baker E, Zhang D et al (1998) Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor. Brain Res Mol Brain Res 58:156-169
54. Taguchi K, Yamagata HD, Zhong W, Kamino K, Akatsu H, Hata R et al (2005) Identification of hippocampus-related candidate genes for Alzheimer's disease. Ann Neurol 57:585-588