Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer's disease

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 135 B, Issue 1, 2005, Pages 24-32

  Holmans, Peter ^a   Hamshere, Marian ^a   Hollingworth, Paul ^a   Rice, Frances ^a   Tunstall, Nigel ^b   Jones, Sue ^a   Moore, Pamela ^a   Wavrant DeVrieze, Fabienne ^c   Hyers, Amanda ^c   Crook, Richard ^e   Compton, Danielle ^e   Marshall, Helen ^d   Meyer, David ^d   Shears, Shantia ^d   Booth, Jeremy ^d   Ramic, Bzanan ^d   Williams, Nigel ^a   Norton, Nadine ^a   Abraham, Richard ^a   Kehoe, Pat ^a   Williams, Hywel ^a   Rudrasingham, Varuni ^a   O'Donovan, Mick ^a   Jones, Lesley ^a   Hardy, John ^c   Goate, Alison ^d   Lovestone, Simon ^b   Owen, Michael ^a   Williams, Julie ^a   more..

^a CARDIFF UNIVERSITY   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c NATIONAL INSTITUTE ON AGING   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e MAYO CLINIC   (United States)

Author keywords

Age at onset; Alzheimer's Disease; Genome screen; Linkage; Rate of decline

Indexed keywords

APOLIPOPROTEIN E;

AGE; AGED; ALZHEIMER DISEASE; ARTICLE; CHROMOSOME 19Q; CHROMOSOME 1P; CHROMOSOME 2Q; CHROMOSOME 6P; COVARIANCE; DISEASE COURSE; GENE LOCUS; GENETIC LINKAGE; GENETIC SCREENING; GENOME; GENOTYPE; HOMOZYGOTE; HUMAN; LINKAGE ANALYSIS; MAJOR CLINICAL STUDY; ONSET AGE; PRIORITY JOURNAL; PROGENY; SIBLING; UNITED KINGDOM;

AGE OF ONSET; ALZHEIMER DISEASE; APOLIPOPROTEINS E; CHROMOSOME MAPPING; GENETIC PREDISPOSITION TO DISEASE; GENOME, HUMAN; GENOTYPE; HUMANS; LINKAGE (GENETICS); LOD SCORE; SIBLINGS;

EID: 20244364113     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30114     Document Type: Article

References (38)

1. Alexopoulos GS, Abrams RC, Young RC, Shamoian CA. 1988. Cornell scale for depression in dementia. Biol Psychiatry 23(3):271-284.
2. Allen NHP, Gordon S, Hope T, Burns A. 1996. Manchester and Oxford Universities scale for psychological assessment of dementia (MOUSEPAD). Br J Psychiatry 169:239-307.
3. Bachman DL, Wolf PA, Linn R, Knoefel JE, Cobb J, Belanger A, D'Agostino RB, White LR. 1992. Prevalence of dementia and probable senile dementia of the Alzheimer type in the Framingham Study. Neurology 42:115-119.
4. Bergem AL, Engedal K, Kringlen E. 1997. The role of heredity in late-onset Alzheimer disease and vascular dementia. A twin study. Arch Gen Psychiatry 54(3):264-270.
5. Blacker D, Haines J, Rodes L, Terwedow H, Go RCP, Harrell LE, Perry RT, Bassett SS, Chase G, Meyers D, Albert MS, Tanzi RE. 1997. ApoE 4 and age at onset Alzheimer's disease: The NIMH genetics initiative. Neurology 48:139-147.
6. Blessed G, Tomlinson BE, Roth M. 1968. The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. Br J Psychiatry 114(512):797-811.
7. Bucks RS, Ashworth DL, Wilcock GK, Siegfried K. 1996. Assessment of activities of daily living in dementia: Development of the Bristol activities of daily living scale. Age Ageing 25(2):113-120.
8. Corder EH, Saunders AM, Strittmatter WJ, Schmedchel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA. 1993. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261:921-923.
9. Daw EW, Payami H, Nemens E, Nochlin D, Bird TD. 2000. The number of trait loci in late-onset Alzheimer's disease. Am J Hum Genet 66:196-204.
10. Farrer LA, Cupples LA, Haines JL. 1997. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer's disease. A meta-analysis. APOE and Alzheimer's disease meta analysis consortium. JAMA 278:1349-1356.
11. Farrer LA, Bowirrat A, Friedland R, Waraska K, Korczyn A, Baldwin C. 2002. Identification of multiple loci for AD in an inbred Israeli-Arab community. Paper presented at 8th International Conference on Alzheimer's Disease and related disorders: Stockholm, July 20-25.
12. Folstein MF, Folstein SE, McHugh PR. 1975. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12(3):189-198.
13. Gatz M, Pedersen NL, Berg S, Johansson B, Johansson K, Mortimer JA, Posner SF, Viitainen M, Winblad B, Ahlborn A. 1997. Heritability for Alzheimer's disease: the study of dementia in Swedish twins. J Gerontol A Biol Sci Med Sci 52:M117-M125.
14. Goate A, Chartier-Harlin MC, Mullan M, Brown J, Crawford F, Fidani L, Giuffra L, Haynes A, Irving N, James L, Mant R, Newton P, Rooke K, Roques P, Talbot C, Pericak-Vance MA, Roses A, Williamson R, Rossor M, Owen M, Hardy J. 1991. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349:704-706.
15. Holmes C, Cairns N, Lantos P, Mann A. 1999. Validity of current clinical criteria for Alzheimer's disease, vascular dementia and dementia with Lewy bodies. Br J Psychiatry 174:45-50.
16. Hughes CP, Berg L, Danziger WL, Coben LA, Martin RL. 1997. A new clinical scale for the staging of dementia. Br J Psychiatry 140:566-572.
17. Kehoe P, Wavrant-De Vrieze F, Crook R, Wu WS, Holmans P, Fenton I, Spurlock G, Norton N, Williams H, Williams N, Lovestone S, Perez-Tur J, Hutton M, Chartier-Harlin MC, Shears S, Rochl K, Booth J, Van Voorst W, Ramic D, Williams J, Goate A, Hardy J, Owen MJ. 1999. A full genome scan for late onset Alzheimer's disease. Hum Mol Genet 8(2): 237-245.
18. Levy Lahad E, Wasco W, Poorkaj P, Romano DM, Oshima J, Pettingell WH, Yu CE, Jondro PD, Schmidt SD, Wang K, Crowley AC, Fu YH, Guenette SY, Galas D, Nemens E, Wijsman EM, Bird TD, Schellenberg GD, Tanzi RE. 1995. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269:973-977.
19. Li Y-J, Scott WK, Hedges DJ, Zhang F, Gaskell PC, Nance MA, Watts RL, Hubble JP, Koller WC, Pahwa R, Stern MB, Hiner BC, Jankovic J, Allen FH Jr, Goetz CG, Mastaglia F, Stajich JM, Gibson RA, Middleton LT, Saunderg AM, Scott BL, Small GW, Nicodemus KK, Reed AD, Schmechel DE, Welsh-Bohmer KA, Conneally PM, Roses AD, Gilbert JR, Vance JM, Haines JL, Pericak-Vance MA. 2002. Age at onset in two common neurodegenerative diseases is genetically controlled. Am J Hum Genet 70:985-993.
20. Mayeux R, Lee JH, Romas SN, Mayo D, Santana V, Williamson J, Ciappa A, Rondon HZ, Estevez P, Lantigua R, Medrano M, Torres M, Stern Y, Tycko B, Knowles JA. 2002. Chromosome 12 mapping of late-onset Alzheimer disease among Caribbean Hispanics. Am J Hum Genet 70: 237-243.
21. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. 1984. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 34:939-944.
22. Myers A, Holmans P, Marshall H, Kwon J, Meyer D, Ramic D, Shears S, Booth J, Wavrant DeVrieze F, Crook R, Hamshere M, Abraham R, Tunstall N, Rice F, Carty S, Lillystone S, Kehoe P, Rudrasingham V, Jones L, Lovestone S, Perez-Tur J, Williams J, Owen MJ, Hardy J, Goate AM. 2000. Susceptibility locus for Alzheimer's disease on chromosome 10. Science 290(5500):2304-2305.
23. Myers A, Wavrant De-Vrieze F, Holmans P, Hamshere M, Crook R, Compton D, Marshall H, Meyer D, Shears S, Booth J, Ramic D, Knowles H, Morris JC, Williams N, Norton N, Abraham R, Kehoe P, Williams H, Rudrasingham V, Rice F, Giles P, Tunstall N, Jones L, Lovestone S, Williams J, Owen MJ, Hardy J, Goate A. 2002. Full genome screen for Alzheimer disease: Stage II analysis. Am J Med Genet (Neuropsych Genet) 114:235-244.
24. Olson JM. 1999. A general conditional-logistic model for affected relative-pair linkage studies. Am J Hum Genet 65:1760-1769.
25. Olson JM, Goddard KAB, Dudek DM. 2001. The amyloid precursor protein locus and very-late-onset Alzheimer disease. Am J Hum Genet 69:896-899.
26. Olson JM, Goddard KAB, Dudek DM. 2002. A second locus for very-late-onset Alzheimer's disease: A genome scan reveals linkage to 2Op and epistatsis between 20p and the amyloid precursor protein region. Am J Hum Genet 71:154-161.
27. Pedersen NL, Posner SF, Gatz M. 2001. Multiple-threshold models for genetic influences on age of onset for Alzheimer disease: Findings in Swedish twins. Am J Med Genet 105:724-728.
28. Pericak-Vance MA, Grubber J, Bailey LR, Hedges D, West S, Santoro L, Kemmerer B, Hall JL, Saunders AM, Roses AD, Small GW, Scott WK, Conneally PM, Vance JM, Haines JL. 2000. Identification of novel genes in late-onset Alzheimer's disease. Exp Gerontol 35:1343-1352.
29. Reisberg B, Ferris SH, de Leon MJ, Crook T. 1982. The Global Deterioration Scale for assessment of primary degenerative dementia. Am J Psychiatry 139:1136-1139.
30. Reisberg B, Borenstein J, Salob SP, Ferris SH, Franssen E, Georgotas A. 1987. Behavioral symptoms in Alzheimer's disease: Phenomenology and treatment. J Clin Psychiatry 48(Suppl):9-15.
31. Rice JP. 1997. The role of meta-analysis in linkage studies of complex traits. Am J Med Genet 74:112-114.
32. Rice JP, Rochberg N, Neuman RJ, Saccone NL, Liu KY, Zhang X, Culverhouse R. 1999. Covariates in linkage analysis. Genet Epidemiol 17(Suppl 1):S691-695.
33. Rogaev EI, Sherington R, Rogaeva EA, Levesque G, Ikeda M, Liang Y, Chi H, Lin C, Holman K, Tsuda T. 1995. Familial Alzheimer's disease in kindreds with missense mutations in a gene on the chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376: 775-778.
34. Rogaeva E, Premkumar S, Song Y, Sorbi S, Brindle N, Paterson A, Duara R, Levesque G, Yu G, Nishimura M, Ikeda M, O'Toole C, Kawarai T, Jorge R, Vilarino D, Bruni AC, Farrer LA, St George-Hyslop PH. 1998. Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity. JAMA 280:652-653.
35. Roth M, Tym E, Mountjoy CQ, Huppert FA, Hendrie H, Verma S, Goddard R. 1986. CAMDEX. A standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia. Br J Psychiatry 149:698-709.
36. Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, et al. 1995. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375:754-760.
37. Tunstall N, Owen MJ, Williams J, Rice F, Carty S, Lillystone S, Fraser L, Kehoe P, Neill D, Rudrasingham V, Sham P, Lovestone S. 2000. Familial influence on variation in age at onset and behavioural phenotype in Alzheimer's disease. Br J Psychiatry 176:156-159.
38. Webster DD. 1968. Critical analysis of the disability in Parkinson's disease. Mod Treat 257-282.