Polymorphisms in glutathione S-transferase omega-1 and AD, vascular dementia, and stroke

Neurology

Volumn 63, Issue 12, 2004, Pages 2255-2260

  Kölsch, Heike ^a,c   Linnebank, M ^a   Lutjohann D ^a   Jessen, F ^a   Wullner U ^a   Harbrecht, U ^a   Thelen, K M ^a   Kreis, M ^b   Hentschel, F ^b   Schulz, A ^a   Von Bergmann, K ^a   Maier, W ^a   Heun, R ^a  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c Department of Psychiatry ^*  (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ASPARTIC ACID; CHOLESTEROL; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE OMEGA 1; HOMOCYSTEINE; UNCLASSIFIED DRUG;

ADULT; AGED; ALLELE; ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD LEVEL; CEREBROSPINAL FLUID LEVEL; CEREBROVASCULAR DISEASE; CONTROLLED STUDY; EXON; FEMALE; GENE; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; GSTO1 GENE; HUMAN; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; MULTIINFARCT DEMENTIA; ONSET AGE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; RISK FACTOR; STROKE;

EID: 19944424114     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/01.WNL.0000147294.29309.47     Document Type: Article

References (33)

1. Roman GC. Vascular dementia: distinguishing characteristics, treatment, and prevention. J Am Geriatr Soc 2003;51:296-304.
2. Miller AL. The methionine-homocysteine cycle and its effects on cognitive diseases. Altern Med Rev 2003;8:7-19.
3. Siow RCM, Sato H, Leake DS, Pearson JD, Bannai S, Mann GE. Vitamin C protects human arterial smooth muscle cells against atherogenic lipoproteins-effects of antioxidant vitamins C and E on oxidized LDL-induced adaptive increases in cystine transport and glutathione. Arterioscler Thromb Vasc Biol 1998;18:1662-1670.
4. Ihara Y, Hayabara T, Sasaki K, et al. Free radicals and superoxide dismutase in blood of patients with Alzheimer's disease and vascular dementia. J Neurol Sci 1997;153:76-81.
5. Floyd RA, Hensley K. Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases. Neurobiol Aging 2002;23:795-807.
6. Chan PH. Role of oxidants in ischemic brain damage. Stroke 1996;27:1124-1129.
7. Goodrum JF. Cholesterol from degenerating nerve myelin becomes associated with lipoproteins containing apolipoprotein E. J Neurochem 1991;56:2082-2086.
8. Björkhem I, Lütjohann D, Diczfalusy U, Stahle L, Ahlborg G, Wahren J. Cholesterol homeostasis in human brain: turnover of 24S-hydroperoxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation. J Lipid Res 1998;39:1594-1600.
9. Lund EG, Guileyardo JM, Russell DW. cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain. Proc Natl Acad Sci USA 1999;96:7238-7243.
10. Lütjohann D, Breuer O, Ahlborg G, et al. Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation. Proc Natl Acad Sci USA 1996;93:9799-9804.
11. Papassotiropoulos A, Lütjohann D, Bagli M, et al. Plasma 24S-hydroxycholesterol: a peripheral indicator of neuronal degeneration and potential state marker for Alzheimer's disease. Neuroreport 2000;11:1959-1962.
12. Strittmatter WJ, Saunders AM, Schmechel D, et al. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci USA 1993;90:1977-1981.
13. Li YJ, Scott WK, Hedges DJ, et al. Age at onset in two common neurodegenerative diseases is genetically controlled. Am J Hum Genet 2002;70:985-993.
14. Alberts MJ. Stroke genetics update. Stroke 2003;34:342-344.
15. Board PG, Coggan M, Chelvanayagam G, et al. Identification, characterization, and crystal structure of the Omega class glutathione transferases. J Biol Chem 2000;275:24798-24806.
16. Rouimi P, Anglade P, Benzekri A, et al. Purification and characterization of a glutathione S-transferase Omega in pig: evidence for two distinct organ-specific transcripts. Biochem J 2001;358:257-262.
17. Yin ZL, Dahlstrom JE, Le Couteur DG, Board PG. Immunohistochemistry of omega class glutathione S-transferase in human tissues. J Histochem Cytochem 2001;49:983-987.
18. Simon T, Becquemont L, Mary-Krause M, et al. Combined glutathione-S-transferase M1 and T1 genetic polymorphism and tacrine hepatotoxicity. Clin Pharmacol Ther 2000;67:432-437.
19. Green VJ, Pirmohamed M, Kitteringham NR, Knapp MJ, Park BK. Glutathione S-transferase mu genotype (GSTM1*0) in Alzheimer's patients with tacrine transaminitis. Br J Clin Pharmacol 1995;39:411-415.
20. Lovell MA, Xie C, Markesbery WR. Decreased glutathione transferase activity in brain and ventricular fluid in Alzheimer's disease. Neurology 1998;51:1562-1566.
21. Tanaka-Kagawa T, Jinno H, Hasegawa T, et al. Functional characterization of two variant human GSTO 1-1s (Ala140Asp and Thr217Asn). Biochem Biophys Res Commun 2003;301:516-520.
22. Li YJ, Oliveira SA, Xu P, et al. Glutathione S-transferase omega 1 modifies age-at-onset of Alzheimer disease and Parkinson disease. Hum Mol Genet 2003;12:3259-3267.
23. World Health Organization. Composite International Diagnostic Interview. Geneva: World Health Organization, Division of Mental Health, 1900.
24. Zaudig M, Mittelhammer J, Hiller W, et al. SIDAM-A structured interview for the diagnosis of dementia of the Alzheimer type, multi-infarct dementia and dementias of other aetiology according to ICD-10 and DSM-III-R. Psychol Med 1991;21:225-236.
25. Folstein MF, Folstein SE, McHugh PR. "Mini-mental state." A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-198.
26. Hamajima N, Saito T, Matsuo K, Kozaki K, Takahashi T, Tajima K. Polymerase chain reaction with confronting two-pair primers for polymorphism genotyping. Jpn J Cancer Res 2000;91:865-868.
27. Hixson JE, Vernier DT. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J Lipid Res 1990;31:545-548.
28. Lütjohann D, Brzezinka A, Barth E, et al. Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain. J Lipid Res 2002;43:1078-1085.
29. Whitbread AK, Tetlow N, Eyre HJ, Sutherland GR, Board PG. Characterization of the human Omega class glutathione transferase genes and associated polymorphisms. Pharmacogenetics 2003;13:131-144.
30. Tan SL, Wood M, Maher P. Oxidative stress induces a form of programmed cell death with characteristics of both apoptosis and necrosis in neuronal cells. J Neurochem 1998;71:95-105.
31. Maler JM, Seifert W, Huther G, et al. Homocysteine induces cell death of rat astrocytes in vitro. Neurosci Lett 2003;347:85-88.
32. Adams HP, Jr., Adams RJ, Brott T, et al. Guidelines for the early management of patients with ischemic stroke: a scientific statement from the Stroke Council of the American Stroke Association. Stroke 2003;34:1056-1083.
33. Breuer O, Dzeletovic S, Lund E, Diczfalusy U. The oxysterols cholest-5-ene-3β,4α-diol, cholest-5-ene-3β, 4β-diol and cholestane-3β,5α,6α-triol are formed during in vitro oxidation of low density lipoprotein, and are present in human atherosclerotic plaques. Biochim Biophys Acta Lipids Lipid Metab 1996;1302:145-152.