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Volumn 58, Issue 4, 2007, Pages 397-409

Anti-genotoxic effect of Ocimum sanctum L. extract against cyproterone acetate induced genotoxic damage in cultured mammalian cells

Author keywords

Anti genotoxicity; Aqueous extract; Cyproterone acetate; Human lymphocytes; Ocimum sanctum

Indexed keywords

CYPROTERONE ACETATE; PLANT EXTRACT;

EID: 38549169980     PISSN: 02365383     EISSN: 1588256X     Source Type: Journal    
DOI: 10.1556/ABiol.58.2007.4.7     Document Type: Article
Times cited : (22)

References (46)
  • 1
    • 0029835128 scopus 로고    scopus 로고
    • Randomized placebo controlled, single blind trial of holy basil leaves in patients with non-insulin dependent diabetes mellitus
    • Agrawal, P., Rai, V., Singh, R. B. (1996) Randomized placebo controlled, single blind trial of holy basil leaves in patients with non-insulin dependent diabetes mellitus. Int. J. Clin. Pharmacol. Therap. 34, 406-409.
    • (1996) Int. J. Clin. Pharmacol. Therap. , vol.34 , pp. 406-409
    • Agrawal, P.1    Rai, V.2    Singh, R.B.3
  • 2
    • 0036024055 scopus 로고    scopus 로고
    • Additive action of vitamins C and e against hydrocortisone induced genotoxicity in human lymphocytes chromosomes
    • Ahmad, S., Hoda, A., Afzal, M. (2002) Additive action of vitamins C and E against hydrocortisone induced genotoxicity in human lymphocytes chromosomes. Int. J. Vitam. Nutr. 72, 204-209.
    • (2002) Int. J. Vitam. Nutr. , vol.72 , pp. 204-209
    • Ahmad, S.1    Hoda, A.2    Afzal, M.3
  • 3
    • 0027067948 scopus 로고
    • Anticarcinogenic effect of some Indian plant products
    • Aruna, K., Sivaramakrishnan, V. M. (1992) Anticarcinogenic effect of some Indian plant products. Food Chem. Toxicol. 30, 953-956.
    • (1992) Food Chem. Toxicol. , vol.30 , pp. 953-956
    • Aruna, K.1    Sivaramakrishnan, V.M.2
  • 4
    • 0025942340 scopus 로고
    • Protective effect of oleanolic acid and ursolic acid against lipid peroxidation
    • Balanehru, S., Nagarajan, B. (1991) Protective effect of oleanolic acid and ursolic acid against lipid peroxidation. Biochem. Inter. 24, 981-990.
    • (1991) Biochem. Inter. , vol.24 , pp. 981-990
    • Balanehru, S.1    Nagarajan, B.2
  • 5
    • 0027255164 scopus 로고
    • Cellular stress by light and Rose Bengal in human lymphocytes
    • Carballo, M. A., Alvarez, S., Boveris, S. (1993) Cellular stress by light and Rose Bengal in human lymphocytes. Mutat. Res. 288, 215-222.
    • (1993) Mutat. Res. , vol.288 , pp. 215-222
    • Carballo, M.A.1    Alvarez, S.2    Boveris, S.3
  • 7
    • 0027284739 scopus 로고
    • Initiation of enzyme altered foci by the synthetic steroid cyproterone acetate in rat liver foci bioassay
    • Deml, E., Schwarz, L. R., Oesterle, D. (1993) Initiation of enzyme altered foci by the synthetic steroid cyproterone acetate in rat liver foci bioassay. Carcinogenesis 14, 1229-1231.
    • (1993) Carcinogenesis , vol.14 , pp. 1229-1231
    • Deml, E.1    Schwarz, L.R.2    Oesterle, D.3
  • 8
    • 2642681646 scopus 로고    scopus 로고
    • A comparative study of radioprotection by flavonoids and synthetic aminothiol protectors in the mouse
    • Devi, P. U., Bisht, K. S., Vinitha, M. (1998) A comparative study of radioprotection by flavonoids and synthetic aminothiol protectors in the mouse. British J. Radiol. 71, 782-784.
    • (1998) British J. Radiol. , vol.71 , pp. 782-784
    • Devi, P.U.1    Bisht, K.S.2    Vinitha, M.3
  • 9
    • 0032472944 scopus 로고    scopus 로고
    • Enhancement of bone marrow radioprotection and reduction of WR-2721 toxicity by Ocimum sanctum
    • Ganasoundari, A., Devi, P. U., Rao, B. S. S. (1998) Enhancement of bone marrow radioprotection and reduction of WR-2721 toxicity by Ocimum sanctum. Mutat. Res. 394, 303-312.
    • (1998) Mutat. Res. , vol.394 , pp. 303-312
    • Ganasoundari, A.1    Devi, P.U.2    Rao, B.S.S.3
  • 10
    • 0242531810 scopus 로고    scopus 로고
    • Protection against radiation-induced chromosome damage in mouse bone marrow by Ocimum sanctum
    • Ganasoundari, A., Devi, P. U., Rao, M. N. A. (1997) Protection against radiation-induced chromosome damage in mouse bone marrow by Ocimum sanctum. Mutat. Res. 373, 271-276.
    • (1997) Mutat. Res. , vol.373 , pp. 271-276
    • Ganasoundari, A.1    Devi, P.U.2    Rao, M.N.A.3
  • 11
    • 1842377451 scopus 로고    scopus 로고
    • Modification of bone marrow radiosensitivity by medicinal plant extract
    • Ganasoundari, A., Zare, S. M., Devi, P. U. (1997) Modification of bone marrow radiosensitivity by medicinal plant extract. British J. Radiol. 70, 599.
    • (1997) British J. Radiol. , vol.70 , pp. 599
    • Ganasoundari, A.1    Zare, S.M.2    Devi, P.U.3
  • 12
    • 0019411446 scopus 로고
    • Sister chromatid exchange (SCE) and structural chromosome aberrations in mutagenicity testing
    • Gebhart, E. (1981) Sister chromatid exchange (SCE) and structural chromosome aberrations in mutagenicity testing. Hum. Genet. 58, 235-254.
    • (1981) Hum. Genet. , vol.58 , pp. 235-254
    • Gebhart, E.1
  • 13
    • 34249094490 scopus 로고    scopus 로고
    • Characterization of atrazine induced gonodal malformations in African clawed frogs (Xenopus laevis) and comparisons with effects of an androgen antagonist (cyproterone acetate) and exogenous estrogen (17 beta estradiol): Support for the demasculization/feminization hypothesis
    • Hayes, T. B., Stuart, A. A., Mendoza, M., Collins, A., Norieg, N., Vonk, A., Johmston., G., Liu, R., Kpodzo, D. (2006) Characterization of atrazine induced gonodal malformations in African clawed frogs (Xenopus laevis) and comparisons with effects of an androgen antagonist (cyproterone acetate) and exogenous estrogen (17 beta estradiol): support for the demasculization/ feminization hypothesis. Environ. Health Perspect. 114, 134-141.
    • (2006) Environ. Health Perspect. , vol.114 , pp. 134-141
    • Hayes, T.B.1    Stuart, A.A.2    Mendoza, M.3    Collins, A.4    Norieg, N.5    Vonk, A.6    Johmston, G.7    Liu, R.8    Kpodzo, D.9
  • 14
    • 0032620470 scopus 로고    scopus 로고
    • Oral Contraceptive, Combined (Group 1)
    • IARC Lyon, France
    • IARC (1999) International Agency for Research on Cancer. Oral Contraceptive, Combined (Group 1) Vol. 72, Lyon, France, pp. 49.
    • (1999) International Agency for Research on Cancer , vol.72 , pp. 49
  • 15
    • 33845193520 scopus 로고    scopus 로고
    • Monographs on the hormonal contraceptives, progestogens only (Group 2B)
    • IARC
    • IARC (1999) Monographs on the hormonal contraceptives, progestogens only (Group 2B). International Agency for Research on Cancer, Vol. 72. Lyon, France p. 399.
    • (1999) International Agency for Research on Cancer , vol.72 , pp. 399
  • 18
    • 0032747708 scopus 로고    scopus 로고
    • Sex specific induction of apoptosis by cyproterone acetate in primary rat hepatocytes
    • Kasper, P., Mueller, L. (1999) Sex specific induction of apoptosis by cyproterone acetate in primary rat hepatocytes. Carcinogenesis 20, 2185-2188.
    • (1999) Carcinogenesis , vol.20 , pp. 2185-2188
    • Kasper, P.1    Mueller, L.2
  • 19
    • 0028800239 scopus 로고
    • In vitro mutagenicity studies on cyproterone studies on cyproterone acetate using female rat hepatocytes for metabolic activation and as indicator cells
    • Kasper, P., Tegethoff, K., Mueller, L. (1995) In vitro mutagenicity studies on cyproterone studies on cyproterone acetate using female rat hepatocytes for metabolic activation and as indicator cells. Carcinogenesis 16, 2309-2314.
    • (1995) Carcinogenesis , vol.16 , pp. 2309-2314
    • Kasper, P.1    Tegethoff, K.2    Mueller, L.3
  • 20
    • 6344256415 scopus 로고    scopus 로고
    • Inhibition of lipid peroxidation by botanical extracts of Ocimum sanctum: In vivo and in vitro
    • Kedlaya, G. R., Vasedevan, D. M. (2004) Inhibition of lipid peroxidation by botanical extracts of Ocimum sanctum: In vivo and in vitro. Life Sci. 76, 21-28.
    • (2004) Life Sci. , vol.76 , pp. 21-28
    • Kedlaya, G.R.1    Vasedevan, D.M.2
  • 21
    • 0034068409 scopus 로고    scopus 로고
    • Antioxidant and cyclooxygenase inhibitory phenolic compounds from Ocimum sanctum Linn
    • Keml, M. A., Nair, M. G., Strassburg, G. M., Dewitt, D. L. (2000) Antioxidant and cyclooxygenase inhibitory phenolic compounds from Ocimum sanctum Linn. Phytomedicine 7, 7-13.
    • (2000) Phytomedicine , vol.7 , pp. 7-13
    • Keml, M.A.1    Nair, M.G.2    Strassburg, G.M.3    Dewitt, D.L.4
  • 22
    • 0020535194 scopus 로고
    • Cell kinetics and sister chromatid exchange frequency in human lymphocytes
    • Lamberti, L., Bigatti-Ponzetto, P., Ardito, G. (1983) Cell kinetics and sister chromatid exchange frequency in human lymphocytes. Mutat. Res. 193-199.
    • (1983) Mutat. Res. , pp. 193-199
    • Lamberti, L.1    Bigatti-Ponzetto, P.2    Ardito, G.3
  • 23
    • 0029866687 scopus 로고    scopus 로고
    • Induction of micronuclei and initiation of enzyme altered foci in the liver of female rats treated with cyproterone acetate, chlormadinone acetate or megestrol acetate
    • Martelli, A., Campart, G. B., Ghia, M., Allavena, A., Mereto, E., Brambilla, G. (1996) Induction of micronuclei and initiation of enzyme altered foci in the liver of female rats treated with cyproterone acetate, chlormadinone acetate or megestrol acetate. Carcinogenesis 17, 551-554.
    • (1996) Carcinogenesis , vol.17 , pp. 551-554
    • Martelli, A.1    Campart, G.B.2    Ghia, M.3    Allavena, A.4    Mereto, E.5    Brambilla, G.6
  • 24
    • 0037457572 scopus 로고    scopus 로고
    • Species, sex and inter-individual differences in DNA repair induced by nine sex steroids in primary cultures of rat and human hepatocytes
    • Martelli, A., Mattioli, F., Angiola, M., Reimann, R., Brambilla, G. (2003) Species, sex and inter-individual differences in DNA repair induced by nine sex steroids in primary cultures of rat and human hepatocytes. Mutat. Res. 536, 69-78.
    • (2003) Mutat. Res. , vol.536 , pp. 69-78
    • Martelli, A.1    Mattioli, F.2    Angiola, M.3    Reimann, R.4    Brambilla, G.5
  • 25
    • 0029059097 scopus 로고
    • DNA repair synthesis and DNA fragmentation in primary cultures of human and rat hepatocytes exposed to cyproterone acetate
    • Martelli, A., Mattioli, F., Fazio, S., Andrae, U., Brambilla, G. (1995) DNA repair synthesis and DNA fragmentation in primary cultures of human and rat hepatocytes exposed to cyproterone acetate. Carcinogenesis 16, 1265-1269.
    • (1995) Carcinogenesis , vol.16 , pp. 1265-1269
    • Martelli, A.1    Mattioli, F.2    Fazio, S.3    Andrae, U.4    Brambilla, G.5
  • 26
    • 0026598408 scopus 로고
    • Cyproterone acetate induces DNA damage in cultured rat hepatocytes and preferentially stimulates DNA synthesis in α-glutamyl transpeptidase positive cells
    • Neumann, I., Thierau, D., Andrae, U., Greim, H., Schwarz, L. R. (1992) Cyproterone acetate induces DNA damage in cultured rat hepatocytes and preferentially stimulates DNA synthesis in α-glutamyl transpeptidase positive cells. Carcinogenesis 13, 373-378.
    • (1992) Carcinogenesis , vol.13 , pp. 373-378
    • Neumann, I.1    Thierau, D.2    Andrae, U.3    Greim, H.4    Schwarz, L.R.5
  • 27
    • 0016328318 scopus 로고
    • New Giemsa method for differential staining of sister chromatids
    • Perry, P., Wolff, S. (1974) New Giemsa method for differential staining of sister chromatids. Nature 261, 156-158.
    • (1974) Nature , vol.261 , pp. 156-158
    • Perry, P.1    Wolff, S.2
  • 28
    • 0029908259 scopus 로고    scopus 로고
    • Studies for a genotoxic potential of some endogenous and exogenous sex steroid. II. Communication: Examination for the induction of cytogenetic damage using the chromosomal aberration assay on human lymphocytes in vitro and the mouse bone marrow micronucleus test in vivo
    • Reimann, R., Kalweit, S., Lang, R. (1996) Studies for a genotoxic potential of some endogenous and exogenous sex steroid. II. Communication: examination for the induction of cytogenetic damage using the chromosomal aberration assay on human lymphocytes in vitro and the mouse bone marrow micronucleus test in vivo. Environ. Mol. Mutagen. 28, 133-144.
    • (1996) Environ. Mol. Mutagen. , vol.28 , pp. 133-144
    • Reimann, R.1    Kalweit, S.2    Lang, R.3
  • 29
    • 0029849422 scopus 로고    scopus 로고
    • Studies on peroxidation in rats ingesting copper sulphate and effect of subsequent treatment with Ocimum sanctum
    • Shymala, A. C., Devaki, T. (1996) Studies on peroxidation in rats ingesting copper sulphate and effect of subsequent treatment with Ocimum sanctum. J. Clinical Biochem. Nutr. 20, 113-119.
    • (1996) J. Clinical Biochem. Nutr. , vol.20 , pp. 113-119
    • Shymala, A.C.1    Devaki, T.2
  • 30
    • 4644222754 scopus 로고    scopus 로고
    • Evaluation of genotoxic potential of synthetic progestin chlormadinone acetate
    • Siddique, Y. H., Afzal, M. (2004) Evaluation of genotoxic potential of synthetic progestin chlormadinone acetate. Toxicol. Lett. 153, 221-225.
    • (2004) Toxicol. Lett. , vol.153 , pp. 221-225
    • Siddique, Y.H.1    Afzal, M.2
  • 31
    • 4444247716 scopus 로고    scopus 로고
    • Evaluation of genotoxic potential of synthetic progestins ethynodiol diacetate in human lymphocytes in vitro
    • Siddique, Y. H., Afzal, M. (2004) Evaluation of genotoxic potential of synthetic progestins ethynodiol diacetate in human lymphocytes in vitro. Curr. Sci. 86, 1161-1168.
    • (2004) Curr. Sci. , vol.86 , pp. 1161-1168
    • Siddique, Y.H.1    Afzal, M.2
  • 32
    • 9944248640 scopus 로고    scopus 로고
    • Genotoxic potential of cyproterone acetate: A possible role of reactive oxygen species
    • Siddique, Y. H., Afzal, M. (2005) Genotoxic potential of cyproterone acetate: a possible role of reactive oxygen species. Toxicol. in vitro 19, 63-68.
    • (2005) Toxicol. in Vitro , vol.19 , pp. 63-68
    • Siddique, Y.H.1    Afzal, M.2
  • 33
    • 24644510210 scopus 로고    scopus 로고
    • Protective role of allicin and L-ascorbic acid against the genotoxic damage induced by chlormadinone acetate in cultured human lymphocytes
    • Siddique, Y. H., Afzal, M. (2005) Protective role of allicin and L-ascorbic acid against the genotoxic damage induced by chlormadinone acetate in cultured human lymphocytes. Indian J. Exp. Biol. 43, 769-772.
    • (2005) Indian J. Exp. Biol. , vol.43 , pp. 769-772
    • Siddique, Y.H.1    Afzal, M.2
  • 34
    • 18044383908 scopus 로고    scopus 로고
    • Antigenotoxic effects of ascorbic acid against megestrol acetate induced genotoxicity in mice
    • Siddique, Y. H., Beg, T., Afzal, M. (2005) Antigenotoxic effects of ascorbic acid against megestrol acetate induced genotoxicity in mice. Hum. Exp. Toxicol. 24, 121-127.
    • (2005) Hum. Exp. Toxicol. , vol.24 , pp. 121-127
    • Siddique, Y.H.1    Beg, T.2    Afzal, M.3
  • 35
    • 30644468710 scopus 로고    scopus 로고
    • Protective effect of nordihydroguaiaretic acid (NDGA) against norgestrel induced genotoxic damage
    • Siddique, Y. H., Beg, T., Afzal, M. (2006) Protective effect of nordihydroguaiaretic acid (NDGA) against norgestrel induced genotoxic damage. Toxicol. in vitro 20, 227-233.
    • (2006) Toxicol. in Vitro , vol.20 , pp. 227-233
    • Siddique, Y.H.1    Beg, T.2    Afzal, M.3
  • 36
    • 0026078331 scopus 로고
    • Recommended protocols on a survey of current practice in genotoxicity testing laboratories, IV. Chromosome aberrations and sister chromatid exchanges in Chinese Hamster Ovary V79, Chinese Hamster lung and human lymphocyte cultures
    • Swierenga, S. H. H., Heddle, J. A., Sigal, E. A., Gilman, J. P. W., Brillinger, R. L., Douglas, G. R., Nestmann, E. R. (1991) Recommended protocols on a survey of current practice in genotoxicity testing laboratories, IV. Chromosome aberrations and sister chromatid exchanges in Chinese Hamster Ovary V79, Chinese Hamster lung and human lymphocyte cultures. Mutat. Res. 246, 301-322.
    • (1991) Mutat. Res. , vol.246 , pp. 301-322
    • Swierenga, S.H.H.1    Heddle, J.A.2    Sigal, E.A.3    Gilman, J.P.W.4    Brillinger, R.L.5    Douglas, G.R.6    Nestmann, E.R.7
  • 37
    • 0035174110 scopus 로고    scopus 로고
    • Effects of endocrine disruptors on prosobranch snails (Mollusca: Gastropoda) in the laboratory part III: Cyproterone acetate and vinclozolin as anti androgens
    • Tillmann, M., Schulte-Oehlmann, U., Duft, M., Markert, B., Oehlmann, J. (2001) Effects of endocrine disruptors on prosobranch snails (Mollusca: Gastropoda) in the laboratory part III: Cyproterone acetate and vinclozolin as anti androgens. Ecotoxicology 10, 373-388.
    • (2001) Ecotoxicology , vol.10 , pp. 373-388
    • Tillmann, M.1    Schulte-Oehlmann, U.2    Duft, M.3    Markert, B.4    Oehlmann, J.5
  • 38
    • 0027217590 scopus 로고
    • Cyproterone acetate generates DNA adducts in rat liver and in primary rat hepatocyte cultures
    • Topinka, J., Andrae, U., Schwartz, L. R., Wolff, T. (1993) Cyproterone acetate generates DNA adducts in rat liver and in primary rat hepatocyte cultures. Carcinogenesis 14, 423-427.
    • (1993) Carcinogenesis , vol.14 , pp. 423-427
    • Topinka, J.1    Andrae, U.2    Schwartz, L.R.3    Wolff, T.4
  • 39
    • 0029037437 scopus 로고
    • DNA damaging activity of cyproterone acetate analogues of chlormadinone acetate and megestrol acetate in rat liver
    • Topinka, J., Binkova, B., Zhu, H. K., Andrae, U., Neumann, I., Schwartz, L. R., Werner, S., Wolff, T. (1995) DNA damaging activity of cyproterone acetate analogues of chlormadinone acetate and megestrol acetate in rat liver. Carcinogenesis 16, 1483-1487.
    • (1995) Carcinogenesis , vol.16 , pp. 1483-1487
    • Topinka, J.1    Binkova, B.2    Zhu, H.K.3    Andrae, U.4    Neumann, I.5    Schwartz, L.R.6    Werner, S.7    Wolff, T.8
  • 40
    • 28344456094 scopus 로고    scopus 로고
    • Cyproterone acetate in the therapy of prostatic carcinoma
    • Torri, V., Floriani, I. (2005) Cyproterone acetate in the therapy of prostatic carcinoma. Arch. Ital. Urol. Androl. 77, 157-163.
    • (2005) Arch. Ital. Urol. Androl. , vol.77 , pp. 157-163
    • Torri, V.1    Floriani, I.2
  • 41
    • 0030250252 scopus 로고    scopus 로고
    • Chromosomes aberrations, micronuclei, aneuploidy, sister chromatid exchanges and cancer risk assessment
    • Tucker, J. D., Preston, R. J. (1996) Chromosomes aberrations, micronuclei, aneuploidy, sister chromatid exchanges and cancer risk assessment. Mutat. Res. 365, 147-159.
    • (1996) Mutat. Res. , vol.365 , pp. 147-159
    • Tucker, J.D.1    Preston, R.J.2
  • 42
    • 0035889594 scopus 로고    scopus 로고
    • Radiation protection of human lymphocyte chromosomes in vitro by orientin and vicenin
    • Vrinda, B., Devi, P. U. (2001) Radiation protection of human lymphocyte chromosomes in vitro by orientin and vicenin. Mutat. Res. 498, 37-46.
    • (2001) Mutat. Res. , vol.498 , pp. 37-46
    • Vrinda, B.1    Devi, P.U.2
  • 44
    • 0031566025 scopus 로고    scopus 로고
    • Formation of DNA adducts by cyproterone acetate and some structural analogues in primary cultures of human hepatocytes
    • Werner, S., Kuntz, S., Beckurts, T., Heidecke, C. D., Wolff, T., Schwarz, L. R. (1997) Formation of DNA adducts by cyproterone acetate and some structural analogues in primary cultures of human hepatocytes. Mutat. Res. 395, 179-187.
    • (1997) Mutat. Res. , vol.395 , pp. 179-187
    • Werner, S.1    Kuntz, S.2    Beckurts, T.3    Heidecke, C.D.4    Wolff, T.5    Schwarz, L.R.6
  • 46
    • 4544272940 scopus 로고    scopus 로고
    • Evaluation of antioxidant and neuroprotective effect of Ocimum sanctum transient cerebral ischemia and long term cerebral hypoperfusion
    • Yanpallewar, S. U., Rai, S., Kumar, M., Acharya, S. B. (2004) Evaluation of antioxidant and neuroprotective effect of Ocimum sanctum transient cerebral ischemia and long term cerebral hypoperfusion. Pharmacol. Biochem. Behav. 79, 155-164.
    • (2004) Pharmacol. Biochem. Behav. , vol.79 , pp. 155-164
    • Yanpallewar, S.U.1    Rai, S.2    Kumar, M.3    Acharya, S.B.4


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