Radiation protection of human lymphocyte chromosomes in vitro by orientin and vicenin

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 498, Issue 1-2, 2001, Pages 39-46

  Vrinda, B ^a   Uma Devi, P ^a,b  

^a KASTURBA MEDICAL COLLEGE   (India)

^b Jawaharlal Nehru Cancer Hospital & Research Centre Bhopal   (India)

Author keywords

Chromosome protection; MN assay; Ocimum flavonoids; Orientin; Vicenin

Indexed keywords

COBALT 60; CYTOCHALASIN; DIMETHYL SULFOXIDE; FLAVONOID; OCIMUM SANCTUM EXTRACT; ORIENTIN; UNCLASSIFIED DRUG; VICENIN;

ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD SAMPLING; CANCER THERAPY; CHROMOSOME DAMAGE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINESIS; DRUG EFFECT; GAMMA RADIATION; HUMAN; HUMAN CELL; INCUBATION TIME; LYMPHOCYTE CULTURE; MICRONUCLEUS TEST; PERIPHERAL LYMPHOCYTE; PLANT LEAF; PRIORITY JOURNAL; RADIATION EXPOSURE; RADIATION PROTECTION; RADIATION RESPONSE; REDUCTION;

ADULT; ANTIOXIDANTS; APIGENIN; CELL DIVISION; CELL NUCLEUS; CELLS, CULTURED; CHROMOSOMES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; FLAVONOIDS; GLUCOSIDES; HUMANS; LYMPHOCYTES; RADIATION-PROTECTIVE AGENTS; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

OCIMUM; OCIMUM BASILICUM; OCIMUM TENUIFLORUM;

EID: 0035889594     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(01)00263-7     Document Type: Article

References (28)

1. In vivo radioprotection by Ocimum flavonoids: Survival of mice
2. A comparative study of radioprotection by Ocimum flavonoids and synthetic aminothiol protectors
3. Radiation protection by the Ocimum flavonoids orientin and vicenin: Mechanisms of action
4. Measurement of micronuclei in lymphocytes
5. The cytokinesis-block micronucleus technique: A detailed description of the method and its application to genotoxicity studies in human population
6. Oxygen radical scavenging activity of curcumin
7. Radiation protection by 2-mercaptopropionylglycine (MPG) in mice
8. Modulation of radiation-induced chromosome aberrations by DMSO, an OH radical scavenger. 1. Dose-response studies in human lymphocytes exposed to 220 kV X-rays
9. Free radical scavenging in protection of human lymphocytes against chromosome aberration formation by gamma-ray irradiation
10. Concentration-dependent protection against X-ray-induced chromosome aberrations in human lymphocytes by the aminothiol WR-1065
11. Marked reduction of radiation-induced micronuclei in human blood lymphocytes pretreated with melatonin
12. Protection against radiation-induced chromosome damage in mouse bone marrow by Ocimum sanctum
13. A comment on the quantitative relationship between micronuclei and chromosomal aberrations
14. Formation of 8-hydroxyguanosine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair
15. Free radicals in biology: Oxidative stress and the effects of ionizing radiation
16. Protection of DNA molecules of cultured mammalian cells from radiation-induced single-strand scissions by various alcohols and SH compounds
17. Radioprotection of intracellular genetic material
18. Protective effects of chlorogenic acid, curcumin and β-carotene against γ-radiation-induced in vivo chromosomal damage
19. Protective effects of vitamins C and E against γ-ray-induced chromosomal damage in mouse
20. Beta-carotene prevents X-ray induction of micronuclei in human lymphocytes
21. Hydroxyl radical scavenging activity of flavonoids
22. Reduction and release of ferritin iron by plant phenoloics
23. Flavonoids are scavengers of superoxide anion
24. Radioprotective effects of antioxidative plant flavonoids in mice
25. Modulation of glutathione and antioxidant enzymes by Ocimum sanctum and its role in protection against radiation injury
26. Effect of Ocimum sanctum Linn. on humoral immune response