Evaluation of genotoxic potential of synthetic progestin chlormadinone acetate

Toxicology Letters

Volumn 153, Issue 2, 2004, Pages 221-225

  Siddique, Yasir Hasan ^a   Afzal, Mohammad ^a  

^a ALIGARH MUSLIM UNIVERSITY   (India)

Author keywords

Chlormadinone acetate; Chromosomal aberrations; Genotoxicity; Mouse bone marrow cells; Sister chromatid exchanges

Indexed keywords

CHLORMADINONE ACETATE; GESTAGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; BONE MARROW CELL; CHROMOSOME ABERRATION; CONTROLLED STUDY; CYTOTOXICITY; EXPERIMENTAL MOUSE; FEMALE; GENOTOXICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SISTER CHROMATID EXCHANGE; STATISTICAL SIGNIFICANCE;

ANIMALS; BONE MARROW CELLS; CHLORMADINONE ACETATE; CHROMOSOME ABERRATIONS; DNA ADDUCTS; DNA DAMAGE; FEMALE; MICE; SISTER CHROMATID EXCHANGE;

EID: 4644222754     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2004.03.026     Document Type: Article

References (26)

1. Ahmad M.E., Shadab G.G.H.A., Azfer M.A., Afzal M. Evaluation of genotoxic potential of synthetic progestins-norethindrone and norgestrel in human lymphocytes in vitro. Mutat. Res. 494:2001;13-20
2. Biri A., Civelek E., Karahalil B., Sardas S. Assessment of DNA damage in women using oral contraceptives. Mutat. Res. 521:2002;113-119
3. Chen Y., Shen L., Zhang F., Lau S.S., Van Breemen R.B., Nikolic D., Bolton J.L. The equine estrogen metabolite 4-hydroequilenin causes DNA single-strand breaks and oxidation of DNA bases in vitro. Chem. Res. Toxicol. 11:1998;1105-1111
4. Dhillon V.S., Singh J.R., Singh H., Kler R.S. In vitro and in vivo genotoxicity evaluation of hormonal drugs V, mestranol. Mutat. Res. 322:1994;173-183
5. El Etreby M.F., Gräf K.J. Effect of contraceptive steroids on mammary gland of beagle dog and its relevance to human carcinogenicity. Pharmacol. Ther. 5:1979;369-402
6. Fisher, R.A., Yates, Y., 1963. Statistical Table for Biological Agricultural and Medical Research, 6th ed. Oliver and Boyd, Edinburgh, p. 138.
7. Han X., Liehr J.G. Microsome-mediated 8-hydroxy-lation of guanine bases of DNA by steroid estrogens: correlation of DNA damage by free radicals with metabolic activation to quinones. Carcinogenesis. 16:1995;2571-2574
8. Herrera J.A., Coco R., Bergada C. Evaluation dela possible mutagenicidal del acetate de medroxiprogesterone por la prueda de micronucleus. Medicina. 40:1980;774
9. International Agency for Research on Cancer, 1987. IARC. Monograph on the Evaluation of Carcinogenic Risk of chemicals IARC, supplement, vol. 6. Lyon, France, pp. 148-149.
10. International Agency for Research on cancer, 1979. IARC. Monograph on the Evaluation of Carcinogenic Risk of chemicals to Humans Sex Hormones (II), vol. 21. IARC, Lyon, France, pp. 365-375.
11. Islam, S., Shafiullah, Ahmad, M., 1991. Mutagenic activity of certain synthetic steroids: structural requirement for mutagenic activity in Salmonellaand E. coli. Mutagen. 259, 177-187.
12. Lehmann, M., Putz, B., Poggel, M.A., Gunzel, P., 1989. Experimental toxicity studies with contraceptives of steroids and their relevances for human risk estimation. In: A.D. Dayan, A.J. Paine (Eds.), Advances in Applied Toxicology. Taylor and Frances, London, pp. 51-79.
13. Li Y., Trush M.A., Yager J.D. DNA damage caused by reactive oxygen species originating from a copper- dependent oxidation of the 2-hydroxy catechol of estradiol. Carcinogenesis. 15:1994;1421-1427
14. Lorke D. A new approach to practical acute toxicity testing. Arch. Toxicol. 54:1983;275-287
15. Martelli A., Mattioli F., Angiola M., Reimann R., Brambilla G. Species, sex and inter-individual differences in DNA repair induced by nine sex steroids in primary cultures of rats and human hepatocytes. Mutat. Res. 536:2003;69-78
16. Nutter L.M., Wu Y.Y., Ngo E.O., Sierra E.E., Gutierrez P.L., Abul-Hajj Y.J. An O-quinone form of estrogen produces free radicals in human breast cancer cells: correlation with DNA damage. Chem. Res. Toxicol. 7:1994;23-28
17. Perry P., Wolff S. New Giemsa method for differential staining of sister chromatids. Nature. 251:1974;156-158
18. Roy D., Floyd R.A., Liehr J.G. Elevated 8-hydroxy-deoxyguanosine levels in DNA of diethylstilbestrol treated Syrian hamsters: covalent DNA damage by free radicals generated by redox cycling of diethylstilbestrol. Cancer. Res. 51:1991;3882-3885
19. Singh H., Singh J.R., Dhillon V.S., Bali D., Sharma H.P. In vitro and in vivo genotoxicity evaluation of hormonal drugs II dexamethasone. Mutat. Res. 308:1994;89-97
20. Swierenga S.H.H., Heddle J.A., Sigal E.A., Gilman J.P.W., Brillinger R.L., Douglas G.R., Nestmann E.R. Recommended protocols based on a survey of current practice in genotoxicity testing laboratories, IV. Chromosome aberration and sister chromatid exchange in Chinese hamster ovary, V79 Chinese hamster lung and human lymphocytes cultures. Mutat. Res. 246:1991;301-322
21. Tanenbaum D.M., Wang Y., Williams S.P., Sigler P.B. Crystallographic comparison of the estrogen and progesterone receptors ligand binding domains. Proc. Natl. Acad. Sci. U.S.A. 95:1998;5998-6003
22. Thibodeau P.A., Paquette B. DNA damage induced by catecholestrogens in the presence of copper (II): generation of reactive oxygen species and enhancement by NADPH. Free Radic. Biol. Med. 27:1999;1367-1377
23. Tucker J.D., Preston R.J. Chromosome aberrations, micronuclei, aneuploidy, sister chromatid exchanges, and cancer risk assessment. Mutat. Res. 365:1996;147-159
24. Werner S., Kunz S., Beckurts T., Heidecke C.D., Wolff T., Schwarz L.R. Formation of DNA adducts by cyproterone acetate and some structural analogues in primary cultures of human hepatocytes. Mutat. Res. 395:1997;179-189
25. Yamamoto K.R. Steroid receptor regulated transcription of specific genes and gene networks. Annu. Rev. Genet. 19:1985;209-225
26. Yosida T.H., Amano K. Autosomal polymorphism in laboratory bred and wild Norway rats, Rattus norvegicus. Misima Chromosoma. 16:1965;658-667