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Volumn 17, Issue 3, 1996, Pages 551-554

Induction of micronuclei and initiation of enzyme-altered foci in the liver of female rats treated with cyproterone acetate, chlormadinone acetate or megestrol acetate

Author keywords

[No Author keywords available]

Indexed keywords

CHLORMADINONE ACETATE; CYPROTERONE ACETATE; GAMMA GLUTAMYLTRANSFERASE; MEGESTROL ACETATE;

EID: 0029866687     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/17.3.551     Document Type: Article
Times cited : (30)

References (27)
  • 1
    • 0018370444 scopus 로고
    • Liver tumors and steroid hormones in rats and mice
    • Schuppler,J. and Günzel,P. (1979) Liver tumors and steroid hormones in rats and mice. Arch. Toxicol., 2, 181-195.
    • (1979) Arch. Toxicol. , vol.2 , pp. 181-195
    • Schuppler, J.1    Günzel, P.2
  • 2
    • 0018817695 scopus 로고
    • Adaptive responses of rat liver to the gestagen and anti-androgen cyproterone acetate and other inducers. II. Induction of growth
    • Schulte-Hermann,R., Hoffman,V, Parzefall,W., Kallenbach,M., Gerhardt,A. and Schuppler,J. (1980) Adaptive responses of rat liver to the gestagen and anti-androgen cyproterone acetate and other inducers. II. Induction of growth. Chem.-Biol. Interactions, 31, 287-300.
    • (1980) Chem.-Biol. Interactions , vol.31 , pp. 287-300
    • Schulte-Hermann, R.1    Hoffman, V.2    Parzefall, W.3    Kallenbach, M.4    Gerhardt, A.5    Schuppler, J.6
  • 3
    • 0019475270 scopus 로고
    • Enhanced proliferation of putative preneoplastic cells in rat liver following treatment with the tumor promoters phenobarbital, hexachlorocyclohexane, steroid compounds, and nafenopin
    • Schulte-Hermann,R., Ohde,G., Schuppler,J. and Timmermann-Trosiener,I. (1981) Enhanced proliferation of putative preneoplastic cells in rat liver following treatment with the tumor promoters phenobarbital, hexachlorocyclohexane, steroid compounds, and nafenopin, Cancer Res., 41, 2556-2562.
    • (1981) Cancer Res. , vol.41 , pp. 2556-2562
    • Schulte-Hermann, R.1    Ohde, G.2    Schuppler, J.3    Timmermann-Trosiener, I.4
  • 4
    • 0020664892 scopus 로고
    • Promotion of spontaneous preneoplastic cells in rat liver as possible explanation of tumor production by nonmutagenic compounds
    • Schulte-Hermann,R., Timmermann-Trosiener,I. and Schuppler,J. (1983) Promotion of spontaneous preneoplastic cells in rat liver as possible explanation of tumor production by nonmutagenic compounds. Cancer Res., 43, 839-844.
    • (1983) Cancer Res. , vol.43 , pp. 839-844
    • Schulte-Hermann, R.1    Timmermann-Trosiener, I.2    Schuppler, J.3
  • 5
    • 0027522963 scopus 로고
    • Studies for a genotoxic potential of some endogenous sex steroids. I. Communication: Examination for the induction of gene mutations using the Ames Salmonella/microsome test and the HGPRT test in V79 cells
    • Lang,R. and Reimann,R. (1993) Studies for a genotoxic potential of some endogenous sex steroids. I. Communication: examination for the induction of gene mutations using the Ames Salmonella/microsome test and the HGPRT test in V79 cells. Environ. Mol. Mutagenesis, 21, 272-304.
    • (1993) Environ. Mol. Mutagenesis , vol.21 , pp. 272-304
    • Lang, R.1    Reimann, R.2
  • 6
    • 0027217590 scopus 로고
    • Cyproterone acetate generates DNA adduces in rat liver and in primary rat hepatocyte cultures
    • Topinka,J., Andrae,U., Schwarz,L.R. and Wolff,T. (1993) Cyproterone acetate generates DNA adduces in rat liver and in primary rat hepatocyte cultures. Carcinogenesis, 14, 423-427.
    • (1993) Carcinogenesis , vol.14 , pp. 423-427
    • Topinka, J.1    Andrae, U.2    Schwarz, L.R.3    Wolff, T.4
  • 7
    • 0026598408 scopus 로고
    • Cyproterone acetate induces DNA damage in cultured rat hepatocytes and preferentially stimulates DNA synthesis in γ-glutamyltranspeptidasepositive cells
    • Neumann,I., Thierau,D., Andrae,U., Greim,H and Schwarz,L.R. (1992) Cyproterone acetate induces DNA damage in cultured rat hepatocytes and preferentially stimulates DNA synthesis in γ-glutamyltranspeptidasepositive cells. Carcinogenesis. 13, 373-378.
    • (1992) Carcinogenesis , vol.13 , pp. 373-378
    • Neumann, I.1    Thierau, D.2    Andrae, U.3    Greim, H.4    Schwarz, L.R.5
  • 8
    • 0027284739 scopus 로고
    • Initiation of enzyme-altered foci by the synthetic steroid cyproterone acetate in rat liver foci bioassay
    • Deml,E., Schwarz,L R. and Oesterle,D. (1993) Initiation of enzyme-altered foci by the synthetic steroid cyproterone acetate in rat liver foci bioassay. Carcinogenesis, 14, 1229-1231.
    • (1993) Carcinogenesis , vol.14 , pp. 1229-1231
    • Deml, E.1    Schwarz, L.R.2    Oesterle, D.3
  • 9
    • 0029059097 scopus 로고
    • DNA repair synthesis and DNA fragmentation in primary cultures of human and rat hepatocytes exposed to cyproterone acetate
    • Martelli,A., Mattioli,F., Fazio,S., Andrae,U. and Brambilla,G. (1995) DNA repair synthesis and DNA fragmentation in primary cultures of human and rat hepatocytes exposed to cyproterone acetate. Carcinogenesis, 16, 1265-1269.
    • (1995) Carcinogenesis , vol.16 , pp. 1265-1269
    • Martelli, A.1    Mattioli, F.2    Fazio, S.3    Andrae, U.4    Brambilla, G.5
  • 10
    • 0018831167 scopus 로고
    • A micronucleus technique for detecting clastogenic effects of mutagens/ carcinogens (DEN, DMN) in hepatocytes of rat liver in vivo
    • Tates,A.D. Neuteboom,I., Hofker,M. and den Engelse,L. (1980) A micronucleus technique for detecting clastogenic effects of mutagens/ carcinogens (DEN, DMN) in hepatocytes of rat liver in vivo. Mutat. Res., 74, 11-20.
    • (1980) Mutat. Res. , vol.74 , pp. 11-20
    • Tates, A.D.1    Neuteboom, I.2    Hofker, M.3    Den Engelse, L.4
  • 11
    • 0020672031 scopus 로고
    • The induction of chromosomal damage in rat hepatocytes and lymphocytes. I. Tissue-dependent changes of the clastogenic effects of diethylnitrosamine, dimethylnitrosamine and ethyl methanesulfonate
    • Tates,A.D., Neuteboom,I., de Vogel,N. and den Engelse,L. (1983) The induction of chromosomal damage in rat hepatocytes and lymphocytes. I. Tissue-dependent changes of the clastogenic effects of diethylnitrosamine, dimethylnitrosamine and ethyl methanesulfonate. Mutat. Res., 107, 131-151.
    • (1983) Mutat. Res. , vol.107 , pp. 131-151
    • Tates, A.D.1    Neuteboom, I.2    De Vogel, N.3    Den Engelse, L.4
  • 12
    • 0024558686 scopus 로고
    • The role of short-lived lesions in the induction of micronuclei in rat liver by ethylnitrosourea and methyl methanesulphonate, the importance of experimental design
    • Tates,A.D. and den Engelse,L. (1989) The role of short-lived lesions in the induction of micronuclei in rat liver by ethylnitrosourea and methyl methanesulphonate, the importance of experimental design. Mutat. Res., 210, 271-279
    • (1989) Mutat. Res. , vol.210 , pp. 271-279
    • Tates, A.D.1    Den Engelse, L.2
  • 13
    • 0025017421 scopus 로고
    • Correlation between clastogenicity and promotion activity in liver carcinogenesis by N-hydroxy-2-acetylaminofluorene, N-hydroxy-4́fluoro4-acetylaminobiphenyl and N-hydroxy-4-acetylaminobiphenyl
    • van de Poll,L.M., van der Hulst,D.A.M., Tates,A.D and Meerman,J.H.N. (1990) Correlation between clastogenicity and promotion activity in liver carcinogenesis by N-hydroxy-2-acetylaminofluorene, N-hydroxy-4́fluoro4-acetylaminobiphenyl and N-hydroxy-4-acetylaminobiphenyl. Carcinogenesis, 11, 333-339.
    • (1990) Carcinogenesis , vol.11 , pp. 333-339
    • Van De Poll, L.M.1    Van Der Hulst, D.A.M.2    Tates, A.D.3    Meerman, J.H.N.4
  • 14
    • 10144253260 scopus 로고
    • Persistence and accumulation of DNA adducts induced by the synthetic steroid cyproterone acetate in rat liver in vivo
    • Barcelona, 27 September-2 October
    • Topinka,J., Andrae,U., Schwarz,L,R., Wermer,S., Sram,R.J. and Wolff,T. (1993) Persistence and accumulation of DNA adducts induced by the synthetic steroid cyproterone acetate in rat liver in vivo. Proc. 23rd Annual Meeting of the EEMS. Barcelona, 27 September-2 October, pp. 2-38.
    • (1993) Proc. 23rd Annual Meeting of the EEMS , pp. 2-38
    • Topinka, J.1    Andrae, U.2    Schwarz, L.3    Wermer, S.4    Sram, R.J.5    Wolff, T.6
  • 15
    • 0017402672 scopus 로고
    • Detection of chemical carcinogens by unscheduled DNA synthesis in rat liver primary cell cultures
    • Williams,G.M. (1977) Detection of chemical carcinogens by unscheduled DNA synthesis in rat liver primary cell cultures. Cancer Res.. 37, 1845-1851.
    • (1977) Cancer Res. , vol.37 , pp. 1845-1851
    • Williams, G.M.1
  • 17
    • 0020964668 scopus 로고
    • Survey of various chemicals for initiating and promoting activities in a short-term in vivo system based on generation of hyperplastic liver nodules in rats
    • Tatematsu,M., Hasegawa,R., Imaida,K , Tsuda,H. and Ito,N. (1983) Survey of various chemicals for initiating and promoting activities in a short-term in vivo system based on generation of hyperplastic liver nodules in rats. Carcinogenesis, 4, 381-386.
    • (1983) Carcinogenesis , vol.4 , pp. 381-386
    • Tatematsu, M.1    Hasegawa, R.2    Imaida, K.3    Tsuda, H.4    Ito, N.5
  • 18
    • 0018840528 scopus 로고
    • Phenotypic diversity as an early property of putative preneoplastic hepatocyte population in liver carcinogenesis
    • Ogawa,K., Solt,D. and Farber,E. (1980) Phenotypic diversity as an early property of putative preneoplastic hepatocyte population in liver carcinogenesis. Cancer Res., 40, 725-733
    • (1980) Cancer Res. , vol.40 , pp. 725-733
    • Ogawa, K.1    Solt, D.2    Farber, E.3
  • 20
    • 0020070809 scopus 로고
    • Application of quantitative stereology to the evaluation of enzyme-altered foci in rat liver
    • Campbell,H.A., Pitot,H.C., van Potter,R. and Laishes,B.A. (1982) Application of quantitative stereology to the evaluation of enzyme-altered foci in rat liver. Cancer Res., 42, 465-472.
    • (1982) Cancer Res. , vol.42 , pp. 465-472
    • Campbell, H.A.1    Pitot, H.C.2    Van Potter, R.3    Laishes, B.A.4
  • 21
    • 0022978110 scopus 로고
    • Potent mitogenic activity of 4-acetylaminofluorene to the rat liver
    • Ashby,J., Lefevre,P.A., Burlinson,B. and Beije,B. (1986) Potent mitogenic activity of 4-acetylaminofluorene to the rat liver. Mutat. Res., 172, 271-279.
    • (1986) Mutat. Res. , vol.172 , pp. 271-279
    • Ashby, J.1    Lefevre, P.A.2    Burlinson, B.3    Beije, B.4
  • 22
    • 0029037437 scopus 로고
    • DNA damaging activity of the cyproterone acetate analogues chlormadinone acetate and megestrol acetate in rat liver
    • Topmka,J., Binkova,B., Zhu,H.K., Andrae,U , Neumann,I., Schwarz,L.R., Werner,S. and Wolff,T. (1995) DNA damaging activity of the cyproterone acetate analogues chlormadinone acetate and megestrol acetate in rat liver. Carcinogenesis, 16, 1483-1487.
    • (1995) Carcinogenesis , vol.16 , pp. 1483-1487
    • Topmka, J.1    Binkova, B.2    Zhu, H.K.3    Andrae, U.4    Neumann, I.5    Schwarz, L.R.6    Werner, S.7    Wolff, T.8
  • 23
    • 0028006877 scopus 로고
    • Three cases of hepatocellular carcinoma among cyproterone users
    • Watanabe,S., Yamasaky,S., Tanae,A., Ibi,I., Ad Hoc Commitee on Androcur Users and Honna,T. (1994) Three cases of hepatocellular carcinoma among cyproterone users. Lancet, 344, 1567-1568.
    • (1994) Lancet , vol.344 , pp. 1567-1568
    • Watanabe, S.1    Yamasaky, S.2    Tanae, A.3    Ibi, I.4    Honna, T.5
  • 24
    • 0028897392 scopus 로고
    • Hepatocellular carcinoma after treatment with cyproterone acetate combined with ethinyl-oestradiol
    • Rüdiger,T., Beckmann,J. and Queisser,W. (1995) Hepatocellular carcinoma after treatment with cyproterone acetate combined with ethinyl-oestradiol. Lancet, 345, 452-453.
    • (1995) Lancet , vol.345 , pp. 452-453
    • Rüdiger, T.1    Beckmann, J.2    Queisser, W.3
  • 25
    • 0028046286 scopus 로고
    • Liver tumors in women on oral contraceptives
    • Rabe,T., Feldmann,K., Grunwald,K. and Runnebaum,B. (1994) Liver tumors in women on oral contraceptives. Lancet, 344, 1568-1569.
    • (1994) Lancet , vol.344 , pp. 1568-1569
    • Rabe, T.1    Feldmann, K.2    Grunwald, K.3    Runnebaum, B.4
  • 27
    • 0028979550 scopus 로고
    • Identification of 3α-hydroxy-cyproterone acetate as a metabolite of cyproterone acetate in the bile of female rats and the potential of this and other already known or putative metabolites to form DNA adducts in vitro
    • Kerdar,R.S., Baumann,A., Brudny-Klöppel,M., Biere,H., Blode,H. and Kuhnz,W. (1995) Identification of 3α-hydroxy-cyproterone acetate as a metabolite of cyproterone acetate in the bile of female rats and the potential of this and other already known or putative metabolites to form DNA adducts in vitro. Carcinogenesis, 16, 1835-1841.
    • (1995) Carcinogenesis , vol.16 , pp. 1835-1841
    • Kerdar, R.S.1    Baumann, A.2    Brudny-Klöppel, M.3    Biere, H.4    Blode, H.5    Kuhnz, W.6


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