Potassium channel KCNH2 K897T polymorphism and cardiac repolarization during exercise test: The Finnish Cardiovascular Study

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 68, Issue 1, 2008, Pages 31-38

  Koskela, J ^a,c   Laiho, J ^a   Kahonen M ^a   Rontu, R ^a   Lehtinen, R ^a,b   Viik, J ^c   Niemi, M ^a   Niemela K ^a   Koobi T ^a   Turjanmaa, V ^a   Porsti I ^a   Lehtimaki T ^a   Nieminen, T ^d  

^a TAMPERE UNIVERSITY HOSPITAL   (Finland)

^b Hospital District of Pirkanmaa

^c TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^d UNIVERSITY OF TAMPERE MEDICAL SCHOOL   (Finland)

Author keywords

Arrhythmia; Beta adrenergic blockers; Electrocardiography; Ion channels; Polymorphism

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; POTASSIUM CHANNEL;

ACUTE HEART INFARCTION; ARTICLE; DNA POLYMORPHISM; ELECTROCARDIOGRAPHY; EXERCISE TEST; FEMALE; GENETIC VARIABILITY; HEART ARRHYTHMIA; HEART REPOLARIZATION; HUMAN; HYPERTENSION; ISCHEMIC HEART DISEASE; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QT INTERVAL; T WAVE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; BLOOD PRESSURE; COHORT STUDIES; ELECTROCARDIOGRAPHY; ETHER-A-GO-GO POTASSIUM CHANNELS; EXERCISE TEST; FEMALE; FINLAND; GENE FREQUENCY; GENOTYPE; HEART; HEART RATE; HUMANS; MALE; MIDDLE AGED; MYOCARDIUM; POLYMORPHISM, SINGLE NUCLEOTIDE; SEX FACTORS;

EID: 38549168027     PISSN: 00365513     EISSN: 15027686     Source Type: Journal    
DOI: 10.1080/00365510701496488     Document Type: Article

References (38)

1. Chiang CE, Roden DM. The long QT syndromes: genetic basis and clinical implications. J Am Coll Cardiol 2000;36:1-12.
2. Moss AJ, Schwartz PJ, Crampton RS, Tzivoni D, Locati EH, MacCluer J, et al. The long QT syndrome. Prospective longitudinal study of 328 families. Circulation 1991;84:1136-44.
3. Schwartz PJ, Zaza A, Locati E, Moss AJ. Stress and sudden death. The case of the long QT syndrome. Circulation 1991;83:II71-80.
4. Schwartz PJ, Priori SG, Spazzolini C, Moss AJ, Vincent GM, Napolitano C, et al. Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias. Circulation 2001;103:89-95.
5. Roden DM, Balser JR, George AL Jr, Anderson ME. Cardiac ion channels. Annu Rev Physiol 2002;64:431-75.
6. Tamargo J, Caballero R, Gomez R, Valenzuela C, Delpon E. Pharmacology of cardiac potassium channels. Cardiovasc Res 2004;62:9-33.
7. Laitinen P, Fodstad H, Piippo K, Swan H, Toivonen L, Viitasalo M, et al. Survey of the coding region of the HERG gene in long QT syndrome reveals six novel mutations and an amino acid polymorphism with possible phenotypic effects. Hum Mutat 2000;15:580-1.
8. Bezzina CR, Verkerk AO, Busjahn A, Jeron A, Erdmann J, Koopmann TT, et al. A common polymorphism in KCNH2 (HERG) hastens cardiac repolarization. Cardiovasc Res 2003;59:27-36.
9. Abbott GW, Sesti F, Splawski I, Buck ME, Lehmann MH, Timothy KW, et al. MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell 1999;97:175-87.
10. McDonald TV, Yu Z, Ming Z, Palma E, Meyers MB, Wang KW, et al. A minK-HERG complex regulates the cardiac potassium current I(Kr). Nature 1997;388:289-92.
11. Sesti F, Abbott GW, Wei J, Murray KT, Saksena S, Schwartz PJ, et al. A common polymorphism associated with antibiotic-induced cardiac arrhythmia. Proc Natl Acad Sci USA 2000;97:10613-8.
12. Anson BD, Ackerman MJ, Tester DJ, Will ML, Delisle BP, Anderson CL, et al. Molecular and functional characterization of common polymorphisms in HERG (KCNH2) potassium channels. Am J Physiol Heart Circ Physiol 2004;286:H2434-41.
13. Paavonen KJ, Chapman H, Laitinen PJ, Fodstad H, Piippo K, Swan H, et al. Functional characterization of the common amino acid 897 polymorphism of the cardiac potassium channel KCNH2 (HERG). Cardiovasc Res 2003;59:603-11.
14. Pfeufer A, Jalilzadeh S, Perz S, Mueller JC, Hinterseer M, Illig T, et al. Common variants in myocardial ion channel genes modify the QT interval in the general population: results from the KORA study. Circ Res 2005;96:693-701.
15. Pietila E, Fodstad H, Niskasaari E, Laitinen PP, Swan H, Savolainen M, et al. Association between HERG K897T polymorphism and QT interval in middle-aged Finnish women. J Am Coll Cardiol 2002;40:511-14.
16. Scherer CR, Lerche C, Decher N, Dennis AT, Maier P, Ficker E, et al. The antihistamine fexofenadine does not affect I(Kr) currents in a case report of drug-induced cardiac arrhythmia. Br J Pharmacol 2002;137:892-900.
17. Crotti L, Lundquist AL, Insolia R, Pedrazzini M, Ferrandi C, De Ferrari GM, et al. KCNH2-K897T is a genetic modifier of latent congenital long-QT syndrome. Circulation 2005;112:1251-8.
18. Walker BD, Krahn AD, Klein GJ, Skanes AC, Yee R, Wang J, et al. Effect of change in posture and exercise on repolarization in patients with long QT syndrome with HERG channel mutations. Can J Cardiol 2005;21:33-8.
19. Rosenbaum DS, Jackson LE, Smith JM, Garan H, Ruskin JN, Cohen RJ. Electrical alternans and vulnerability to ventricular arrhythmias. N Engl J Med 1994;330:235-41.
20. Schwartz PJ, Moss AJ, Vincent GM, Crampton RS. Diagnostic criteria for the long QT syndrome. An update. Circulation 1993;88:782-4.
21. Nieminen T, Lehtinen R, Viik J, Lehtimaki T, Niemela K, Nikus K, et al. The Finnish Cardiovascular Study (FINCAVAS): characterising patients with high risk of cardiovascular morbidity and mortality. BMC Cardiovasc Disord 2006;6:9.
22. Mason RE, Likar I. A new system of multiple-lead exercise electrocardiography. Am Heart J 1966;71:196-205.
23. Luo S, Michler K, Johnston P, Macfarlane PW. A comparison of commonly used QT correction formulae: the effect of heart rate on the QTc of normal ECGs. J Electrocardiol 2004;37:81-90.
24. Nearing BD, Verrier RL. Modified moving average analysis of T-wave alternans to predict ventricular fibrillation with high accuracy. J Appl Physiol 2002;92:541-9.
25. Bloomfield DM, Hohnloser SH, Cohen RJ. Interpretation and classification of microvolt T wave alternans tests. J Cardiovasc Electrophysiol 2002;13:502-12.
26. Livak KJ. Allelic discrimination using fluorogenic probes and the 5( nuclease assay. Genet Anal 1999;14:143-9.
27. Priori SG, Schwartz PJ, Napolitano C, Bloise R, Ronchetti E, Grillo M, et al. Risk stratification in the long-QT syndrome. N Engl J Med 2003;348:1866-74.
28. Rautaharju PM, Zhou SH, Wong S, Calhoun HP, Berenson GS, Prineas R, et al. Sex differences in the evolution of the electrocardiographic QT interval with age. Can J Cardiol 1992;8:690-5.
29. Conrath CE, Wilde AA, Jongbloed RJ, Alders M, van Langen IM, van Tintelen JP, et al. Gender differences in the long QT syndrome: effects of beta-adrenoceptor blockade. Cardiovasc Res 2002;53:770-6.
30. Ebbehoj E, Arildsen H, Hansen KW, Mogensen CE, Molgaard H, Poulsen PL. Effects of metoprolol on QT interval and QT dispersion in Type 1 diabetic patients with abnormal albuminuria. Diabetologia 2004;47:1009-15.
31. Moss AJ, Zareba W, Hall WJ, Schwartz PJ, Crampton RS, Benhorin J, et al. Effectiveness and limitations of beta-blocker therapy in congenital long-QT syndrome. Circulation 2000;101:616-23.
32. Priori SG, Napolitano C, Diehl L, Schwartz PJ. Dispersion of the QT interval. A marker of therapeutic efficacy in the idiopathic long QT syndrome. Circulation 1994;89:1681-9.
33. Dovgalevskii P, Rybak OK, Furman NV, Sham'iunov MR, Morozov IA. [Relationship of the duration of QT interval and corrected QT interval in patients with coronary heart disease and the cause of the bicycle ergometer test cessation]. Ter Arkh 2002;74:18-20.
34. Nearing BD, Huang AH, Verrier RL. Dynamic tracking of cardiac vulnerability by complex demodulation of the T wave. Science 1991;252:437-40.
35. Karjalainen J, Viitasalo M, Manttari M, Manninen V. Relation between QT intervals and heart rates from 40 to 120 beats/min in rest electrocardiograms of men and a simple method to adjust QT interval values. J Am Coll Cardiol 1994;23:1547-53.
36. Yi G, Crook R, Guo XH, Staunton A, Camm AJ, Malik M. Exercise-induced changes in the QT interval duration and dispersion in patients with sudden cardiac death after myocardial infarction. Int J Cardiol 1998;63:271-9.
37. Malik M, Farbom P, Batchvarov V, Hnatkova K, Camm AJ. Relation between QT and RR intervals is highly individual among healthy subjects: implications for heart rate correction of the QT interval. Heart (British Cardiac Society) 2002;87:220-8.
38. Zacks ES, Morin DP, Ageno S, Janik M, Mauer AC, Markowitz SM, et al. Effect of oral beta-blocker therapy on microvolt T-wave alternans and electrophysiology testing in patients with ischemic cardiomyopathy. Am Heart J 2007;153:392-7.