Neuronal autophagy and aggresomes constitute a consistent part of neurodegeneration in experimental scrapie

Folia Neuropathologica

Volumn 45, Issue 4, 2007, Pages 170-178

  Sikorska, Beata ^a   Liberski, Paweł P ^a   Brown, Paul ^b  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

^b NONE

Author keywords

Aggresomes; Autophagic vacuoles; Autophagy; Prion diseases; Scrapie; Transmissible spongiform encephalopathies

Indexed keywords

AGGRESOME; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CELL INCLUSION; CELL STRUCTURE; CELL VACUOLE; CONTROLLED STUDY; CYTOPATHOLOGY; CYTOPLASM; ELECTRON MICROSCOPY; HAMSTER; NERVE CELL MEMBRANE; NERVE DEGENERATION; NEURITE; NEUROPATHOLOGY; NONHUMAN; PERIKARYON; PRION DISEASE; SCRAPIE;

EID: 38549160084     PISSN: 16414640     EISSN: 1509572X     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Beck E. Lesions akin to transmissible spongiform encephalopathy in the brains of rats inoculated with immature cerebellum. Their significance in the aetiology of these diseases. Acta Neuropathol (Berl) 1988; 76: 295-305.
2. Belichenko PV, Brown D, Jeffrey M, Fraser JR. Dendritic and synaptic alterations of hippocampal pyramidal neurones in scrapie-infected mice. Neuropathol Appl Neurobiol 2000; 26: 143-149.
3. Boellaard JW, Kao M, Schlote W, Diringer H. Neuronal autophagy in experimental scrapie. Acta Neuropathol (Berl) 1991; 82: 225-228.
4. Boellaard JW Schlote W, Tateishi J. Neuronal autophagy in experimental Creutzfeldt-Jakob's disease. Acta Neuropathol (Berl) 1989; 78: 410-418.
5. Budka H, Head MW, Ironside JW, Gambetti P, Parchi P, Zeidler M, Tagliavini F. Prion Disorders: CJD: Sporadic Creutzfeldt-Jakob disease. In: Dickson D (ed.). Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders. ISN Neuropath Press, Basel 2003; pp. 287-297.
6. Bursch W, Ellinger A, Gerner C, Schulte-Hermann R. Autophagocytosis and programmed cell death. In: Klionsky DJ (ed.). Autophagy. Landes Bioscience, Georgetown, Texas, USA 2004; pp. 290-306.
7. Cohen E, Taraboulos A. Scrapie-like prion protein accumulates in aggresomes of cyclosporin A-treated cells. EMBO J 2003; 22: 404-417.
8. Ersdal C, Simmons MM, Goodsir C, Martin S, Jeffrey M. Sub-cellular pathology of scrapie: coated pits are increased in PrP codon 136 alanine homozygous scrapie-affected sheep. Acta Neuropathol (Berl) 2003; 106: 17-28.
9. Fraser JR. What is the basis of transmissible spongiform encephalopathy induced neurodegeneration and can it be repaired? Neuropathol Appl Neurobiol 2002; 28: 1-11.
10. Gajdusek DC. Transmissible and nontransmissible dementias: distinction between primary cause and pathogenetic mechanisms in Alzheimer's disease and aging. Mt Sinai J Med 1988; 55: 3-5.
11. Jeffrey M, Goodbrand IA, Goodsir CM. Pathology of the transmissible spongiform encephalopathies with special emphasis on ultrastructure. Micron 1995; 26: 277-298.
12. Jeffrey M, Halliday WG, Bell J, Johnston AR, MacLeod NK, Ingham C, Sayers AR, Brown DA, Fraser JR. Synapse loss associated with abnormal PrP precedes neuronal degeneration in the scrapie-infected murine hippocampus. Neuropathol Appl Neurobiol 2000; 26: 41-54.
13. Jeffrey M, Scott JR, Williams A, Fraser H. Ultrastructural features of spongiform encephalopathy transmitted to mice from three species of bovidae. Acta Neuropathol (Berl) 1992; 84: 559-569.
14. Johnston AR, Fraser JR, Jeffrey M, MacLeod N. Synaptic plasticity in the CA1 area of the hippocampus of scrapie-infected mice. Neurobiol Dis 1998; 5: 188-195.
15. Junn E, Lee SS, Suhr UT, Mouradian MM. Parkin accumulation in aggresomes due to proteasome impairment. J Biol Chem 2002; 277: 47870-47877.
16. Lansbury PT Jr, Caughey B. The chemistry of scrapie infection: implications of the 'ice 9' metaphor. Chem Biol 1995; 2: 1-5.
17. Liberski PP, Asher DM, Yanagihara R, Gibbs CJ Jr, Gajdusek DC. Serial ultrastructural studies of scrapie in hamsters. J Comp Pathol 1989; 101: 429-442.
18. Liberski PP, Bucka H. Neuroaxonal pathology in Creutzfeldt-Jakob disease. Acta Neuropathol (Berl) 1999; 97: 329-334.
19. Liberski PP, Budka H, Yanagihara R, Gajdusek DC. Neuroaxonal dystrophy in experimental Creutzfeidt-Jakob disease: electron microscopical and immunohistochemical demonstration of neurofilament accumulations within affected neurites. J Comp Pathol 1995; 112: 243-255.
20. Liberski PP, Gajdusek DC, Brown P. How do neurons degenerate in prion diseases or transmissible spongiform encephalopathies (TSEs): neuronal autophagy revisited. Acta Neurobiol Exp (Wars) 2002; 62: 141-147.
21. Liberski PP, Mori S. The Echigo-1: a panencephalopathic strain of Creutzfeldt-Jakob disease: a passage to hamsters and ultrastructural studies. Folia Neuropathol 1997; 35: 250-254.
22. Liberski PP, Sikorska B, Bratosiewicz-Wasik J, Gajdusek DC, Brown P. Neuronal cell death in transmissible spongiform encephalopathies (prion diseases) revisited: from apoptosis to autophagy. Int J Biochem Cell Biol 2004; 36: 2473-2790.
23. Liberski PP, Streichenberger N, Giraud P, Soutrenon M, Meyronnet D, Sikorska B, Kopp N. Ultrastructural pathology of prion diseases revisited: brain biopsy studies. Neuropathol Appl Neurobiol 2005; 31: 88-96.
24. Liberski PP, Yanagihara R, Gibbs CJ Jr, Gajdusek DC. Neuronal autophagic vacuoles in experimental scrapie and Creutzfeldt-Jakob disease. Acta Neuropathol (Berl) 1992; 83: 134-139.
25. Ma J, Lindquist S. Wild-type PrP and a mutant associated with prion disease are subject to retrograde transport and proteasome degradation. Proc Natl Acad Sci U S A 2001; 98: 14955-14960.
26. Mallucci GR, Ratté S, Asante EA, Linehan J, Gowland I, Jefferys JG, Collinge J. Post-natal knockout of prion protein alters hippocampal CA1 properties, but does not result in neurodegeneration. EMBO J 2002; 21: 202-210.
27. Mishra RS, Bose S, Gu Y, Li R, Singh N. Aggresome formation by mutant prion proteins: the unfolding role of proteasomes in familial prion disorders. J Alzheimer's Dis 2003; 5: 15-23.
28. Myohara M. Real-time observation of autophagic programmed cell death of Drosophila salivary glands in vitro. Dev Genes Evol 2004; 214: 99-104.
29. Sikorska B, Liberski PP, Giraud P, Kopp N, Brown P. Autophagy is a part of ultrastructural synaptic pathology in Creutzfeldt-Jakob disease: a brain biopsy study. Int J Biochem Cell Biol 2004; 36: 2563-2573.
30. Wójcik C, DeMartino GN. Intracellular localization of proteasomes. Int J Biochem Cell Biol 2003; 35: 579-589.