Geriatric depression and cognitive impairment

Psychological Medicine

Volumn 38, Issue 2, 2008, Pages 163-175

  Steffens, D C ^a   Potter, G G ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Cognition; Cognitive impairment; Depression; Elderly

Indexed keywords

DONEPEZIL; GALANTAMINE; MEMANTINE; RIVASTIGMINE;

CINGULATE GYRUS; COGNITION; COGNITIVE DEFECT; COMORBIDITY; DEMENTIA; DEPRESSION; GERIATRIC PATIENT; HIPPOCAMPUS; HUMAN; MEDICAL RESEARCH; NEUROSCIENCE; ORBITAL CORTEX; OUTCOME ASSESSMENT; PREFRONTAL CORTEX; PREVALENCE; PSYCHOTHERAPY; REVIEW; VASCULAR DISEASE;

AGED; CEREBROVASCULAR DISORDERS; CHOLINESTERASE INHIBITORS; COGNITION DISORDERS; DEPRESSIVE DISORDER, MAJOR; HUMANS; NEUROPSYCHOLOGICAL TESTS; PREVALENCE;

EID: 38549122267     PISSN: 00332917     EISSN: 14698978     Source Type: Journal    
DOI: 10.1017/S003329170700102X     Document Type: Review

References (128)

1. Adler G, Chwalek K, Jajcevic A (2004). Six-month course of mild cognitive impairment and affective symptoms in late-life depression. European Psychiatry 19, 502-505.
2. Adler G, Jajcevic A (2001). Post-dexamethasone cortisol level and memory performance in elderly depressed patients. Neuroscience Letters 298, 142-144.
3. Alexopoulos GS, Meyers BS, Young RC, Kalayam B, Kakuma T, Gabrielle M, Sirey J, Hull J (2000). Executive dysfunction and long-term outcomes of geriatric depression. Archives of General Psychiatry 57, 285-290.
4. Alexopoulos GS, Raue P, Arean P (2003). Problem-solving therapy versus supportive therapy in geriatric major depression with executive dysfunction. American Journal of Geriatric Psychiatry 11, 46-52.
5. APA (2000). Diagnostic and Statistical Manual of Mental Disorders: DSM-IV-TR, 4th edn, text revision. American Psychiatric Association: Washington, DC.
6. Arve S, Tilvis RS, Lehtonen A, Valvanne J, Sairanen S (1999). Coexistence of lowered mood and cognitive impairment of elderly people in five birth cohorts. Aging (Milano) 11, 90-95.
7. Austin MP, Mitchell P, Wilhelm K, Parker G, Hickie I, Brodaty H, Chan J, Eyers K, Milic M, Hadzi-Pavlovic D (1999). Cognitive function in depression: a distinct pattern of frontal impairment in melancholia? Psychological Medicine 29, 73-85.
8. Ballard C, Holmes C, McKeith I, Neill D, O'Brien J, Cairns N, Lantos P, Perry E, Ince P, Perry R (1999). Psychiatric morbidity in dementia with Lewy bodies: a prospective clinical and neuropathological comparative study with Alzheimer's disease. American Journal of Psychiatry 156, 1039-1045.
9. Ballmaier M, Toga AW, Blanton RE, Sowell ER, Lavretsky H, Peterson J, Pham D, Kumar A (2004). Anterior cingulate, gyrus rectus, and orbitofrontal abnormalities in elderly depressed patients: an MRI-based parcellation of the prefrontal cortex. American Journal of Psychiatry 161, 99-108.
10. Bartolini M, Coccia M, Luzzi S, Provinciali L, Ceravolo MG (2005). Motivational symptoms of depression mask preclinical Alzheimer's disease in elderly subjects. Dementia and Geriatric Cognitive Disorders 19, 31-36.
11. Beats BC, Sahakian BJ, Levy R (1996). Cognitive performance in tests sensitive to frontal lobe dysfunction in the elderly depressed. Psychological Medicine 26, 591-603.
12. Biver F, Goldman S, Delvenne V, Luxen A, De Maertelaer V, Hubain P, Mendlewicz J, Lotstra F (1994). Frontal and parietal metabolic disturbances in unipolar major depression. Biological Psychiatry 36, 381-388.
13. Blakemore SJ, Rees G, Frith CD (1998). How do we predict the consequences of our actions? A functional imaging study. Neuropsychologia 36, 521-529.
14. Boone K, Lesser B, Miller B, Wohl M, Berman N, Lee A, Palmer B (1995). Cognitive functioning in a geriatric depressed population: relationship of presence and severity of depression to neuropsychological scores. Neuropsychology 9, 390-398.
15. Broe GA, Henderson AS, Creasey H, McCusker E, Korten AE, Jorm AF, Longley W, Anthony JC (1990). A case-control study of Alzheimer's disease in Australia. Neurology 40, 1698-1707.
16. Butters MA, Becker JT, Nebes RD, Zmuda MD, Mulsant BH, Pollock BG, Reynolds CF (2000). Changes in cognitive functioning following treatment of late-life depression. American Journal of Psychiatry 157, 1949-1954.
17. Butters MA, Bhalla RK, Mulsant BH, Mazumdar S, Houck PR, Begley AE, Dew MA, Pollock BG, Nebes RD, Becker JT, Reynolds CF (2004). Executive functioning, illness course, and relapse/recurrence in continuation and maintenance treatment of late-life depression: is there a relationship? American Journal of Geriatric Psychiatry 12, 387-394.
18. Butters MA, Salmon DP, Butters N (1994). Neuropsychological assessment of dementia. In Neuropsychological Assessment of Dementia and Depression in Older Adults: A Clinicians Guide (ed. M. Storandt and G. R. VandenBos), pp. 33-59. American Psychological Association: Washington, DC.
19. Carter CS, MacDonald AM, Botvinick M, Ross LL, Stenger VA, Noll D, Cohen JD (2000). Parsing executive processes: strategic vs. evaluative functions of the anterior cingulate cortex. Proceedings of the National Academy of Sciences USA 17, 1944-1948.
20. Chaves ML, Izquierdo I (1992). Differential diagnosis between dementia and depression: a study of efficiency increment. Acta Neurologica Scandinavica 85, 378-382.
21. Chen P, Ganguli M, Mulsant BH, DeKosky ST (1999). The temporal relationship between depressive symptoms and dementia: a community-based prospective study. Archives of General Psychiatry 56, 261-266.
22. Coffey CE, Figiel GS, Djang WT, Saunders WB, Weiner RD (1989). White matter hyperintensity on magnetic resonance imaging: clinical and neuroanatomic correlates in the depressed elderly. Journal of Neuropsychiatry 1, 135-144.
23. Copeland JR, Beekman AT, Braam AW, Dewey ME, Delespaul P, Fuhrer R, Hooijer C, Lawlor BA, Kivela SL, Lobo A, Magnusson H, Mann AH, Meller I, Prince MJ, Reischies F, Roelands M, Skoog I, Turrina C, deVries MW, Wilson KC (2004). Depression among older people in Europe: the EURODEP studies. World Psychiatry 3, 45-49.
24. Dagher A, Owen AM, Boecker H, Brooks DJ (1999). Mapping the network for planning: a correlational PET activation study with the Tower of London task. Brain 122, 1973-1987.
25. de Groot JC, de Leeuw FE, Oudkerk M, Hofman A, Jolles J, Breteler MM (2000). Cerebral white matter lesions and depressive symptoms in elderly adults. Archives of General Psychiatry 57, 1071-1076.
26. Devinsky O, Morrell MJ, Vogt BA (1995). Contributions of anterior cingulate cortex to behaviour. Brain 118, 279-306.
27. Dierckx E, Engelborghs S, De Raedt R, De Deyn PP, Ponjaert- Kristoffersen I (2007). Differentiation between mild cognitive impairment, Alzheimer's disease and depression by means of cued recall. Psychological Medicine 37, 747-755.
28. Dilling H, Mombour W, Schmidt MH (1991). International Classification of Mental and Behavioral Disorders, chapter V. Huber: Bern, Switzerland.
29. Drevets WC, Bogers W, Raichle ME (2002). Functional anatomical correlates of antidepressant drug treatment assessed using PET measures of regional glucose metabolism. European Neuropsychopharmacology 12, 527-544.
30. Duff K, McCaffrey RJ, Solomon GS (2002). The Pocket Smell Test: successfully discriminating probable Alzheimer's dementia from vascular dementia and major depression. Journal of Neuropsychiatry and Clinical Neurosciences 14, 197-201.
31. Elliott R, Baker SC, Rogers RD, O'Leary DA, Paykel ES, Frith CD, Dolan RJ, Sahakian BJ (1997). Prefrontal dysfunction in depressed patients performing a complex planning task: a study using positron emission tomography. Psychological Medicine 27, 931-942.
32. Elliott R, Rubinsztein JS, Sahakian BJ, Dolan RJ (2002). The neural basis of mood-congruent processing biases in depression. Archives of General Psychiatry 59, 597-604.
33. Faustman WO, Moses JA, Csernansky JG (1990). Limitations of the Mini-Mental State Examination in predicting neuropsychological functioning in a psychiatric sample. Acta Psychiatrica Scandinavica 81, 126-131.
34. Feil D, Razani J, Boone K, Lesser I (2003). Apathy and cognitive performance in older adults with depression. International Journal of Geriatric Psychiatry 18, 479-488.
35. Figiel GS, Krishnan KR, Doraiswamy PM, Rao VP, Nemeroff CB, Boyko OB (1991). Subcortical hyperintensities on brain magnetic resonance imaging: a comparison between late-age onset and early onset elderly depressed subjects. Neurobiology of Aging 26, 245-247.
36. Folstein M, Folstein S, Fanjiang G (2001). Mini-Mental State Examination: Clinical Guide and User's Guide. Psychological Assessment Resources: Lutz, FL.
37. Folstein S, Abbott MH, Chase GA, Jensen BA, Folstein MF (1983). The association of affective disorder with Huntington's disease in a case series and in families. Psychological Medicine 13, 537-542.
38. Frodl T, Meisenzahl EM, Zetzsche T, Hohne T, Banac S, Schorr C, Jager M, Leinsinger G, Bottlender R, Reiser M, Moller HJ (2004). Hippocampal and amygdala changes in patients with major depressive disorder and healthy controls during a 1-year follow-up. Journal of Clinical Psychiatry 65, 492-499.
39. Gallo JJ, Lebowitz BD (1999). The epidemiology of common late-life mental disorders in the community: themes for the new century. Psychiatric Services 50, 1158-1166.
40. Ganguli M, Dodge HH, Shen C, DeKosky ST (2004). Mild cognitive impairment, amnestic type: an epidemiologic study. Neurology 63, 115-121.
41. George MS, Ketter TA, Parekh PI, Rosinsky N, Ring HA, Pazzaglia PJ, Marangell LB, Callahan AM, Post RM (1997). Blunted left cingulate activation in mood disorder subjects during a response interference task (the Stroop). Journal of Neuropsychiatry and Clinical Neurosciences 9, 55-63.
42. Gilley DW, Wilson RS, Bienias JL, Bennett DA, Evans DA (2004). Predictors of depressive symptoms in persons with Alzheimer's disease. Journals of Gerontology. Series B, Psychological Sciences and Social Sciences 59, 75-83.
43. Goethals I, Audenaert K, Jacobs F, Van de Wiele C, Ham H, Pyck H, Vandierendonck A, Van Heeringen C, Dierckx R (2005). Blunted prefrontal perfusion in depressed patients performing the Tower of London task. Psychiatry Research 139, 31-40.
44. Graciani A, Banegas JR, Guallar-Castillon P, Dominguez-Rojas V, Rodriguez-Artalejo F (2006). Cognitive assessment of the non-demented elderly community dwellers in Spain. Dementia and Geriatric Cognitive Disorders 21, 104-112.
45. Green RC, Cupples LA, Kurz A, Auerbach S, Go R, Sadovnick D, Duara R, Kukull WA, Chui H, Edeki T, Griffith PA, Friedland RP, Bachman D, Farrer L (2003). Depression as a risk factor for Alzheimer disease: the MIRAGE study. Archives of Neurology 60, 753-759.
46. Hastings RS, Parsey RV, Oquendo MA, Arango V, Mann JJ (2004). Volumetric analysis of the prefrontal cortex, amygdala, and hippocampus in major depression. Neuropsychopharmacology 29, 952-959.
47. Hickie I, Naismith S, Ward PB, Turner K, Scott E, Mitchell P, Wilhelm K, Parker G (2005). Reduced hippocampal volumes and memory loss in patients with early- and late-onset depression. British Journal of Psychiatry 186, 197-202.
48. Hickie I, Scott E, Mitchell P, Wilhelm K, Austin MP, Bennett B (1995). Subcortical hyperintensities on magnetic resonance imaging: clinical correlates and prognostic significance in patients with severe depression. Biological Psychiatry 37, 151-160.
49. Houston WS, Bondi MW (2005). Potentially Reversible Cognitive Symptoms in Older Adults. Guilford: New York.
50. Jorm AF (2001). History of depression as a risk factor for dementia: an updated review. Australian and New Zealand Journal of Psychiatry 35, 776-781.
51. Kalayam B, Alexopoulos GS (1999). Prefrontal dysfunction and treatment response in geriatric depression. Archives of General Psychiatry 56, 713-718.
52. Keller MB, McCullough JP, Klein DN, Arnow B, Dunner DL, Gelenberg AJ, Markowitz JC, Nemeroff CB, Russell JM, Thase ME, Trivedi MH, Zajecka J (2000). A comparison of nefazodone, the cognitive behavioral-analysis system of psychotherapy, and their combination for the treatment of chronic depression. New England Journal of Medicine 342, 1462-1470.
53. Kiosses DN, Klimstra S, Murphy C, Alexopoulos GS (2001). Executive dysfunction and disability in elderly patients with major depression. American Journal of Geriatric Psychiatry 9, 269-274.
54. Kivela SL, Pahkala K, Laippala P (1988). Prevalence of depression in an elderly population in Finland. Acta Psychiatrica Scandinavica 78, 401-413.
55. Klatka LA, Louis ED, Schiffer RB (1996). Psychiatric features in diffuse Lewy body disease: a clinicopathologic study using Alzheimer's disease and Parkinson's disease comparison groups. Neurology 47, 1148-1152.
56. Koenig HG, Blazer DG (1992). Epidemiology of geriatric affective disorders. Clinics in Geriatric Medicine 8, 235-251.
57. Koenig HG, Blazer DG (2004). Mood disorders. In Textbook of Geriatric Psychiatry (ed. D. G. Blazer, D. C. Steffens and E. W. Busse), p. 241. American Psychiatric Publishing: Arlington, VA.
58. Kramer-Ginsberg E, Greenwald BS, Krishnan KRR, Christiansen B, Hu J, Ashtari M, Patel M, Pollack S (1999). Neuropsychological functioning and MRI signal hyperintensities in geriatric depression. American Journal of Psychiatry 156, 438-444.
59. Krishnan KR, Taylor WD, McQuoid DR, MacFall JR, Payne ME, Provenzale JM, Steffens DC (2004). Clinical characteristics of magnetic resonance imaging-defined subcortical ischemic depression. Biological Psychiatry 55, 390-397.
60. Krishnan KRR, Goli Z, Ellinwood EH, Franz RD, Blazer DG, Nemeroff CB (1988). Leukoencephalopathy in patients diagnosed as major depressive. Biological Psychiatry 23, 519-522.
61. Krishnan KRR, Hays JC, Blazer DG (1997). MRI-defined vascular depression. American Journal of Psychiatry 154, 497-501.
62. Kumar A, Bilker W, Jin Z, Udupa J, Gottleib G (1999). Age of onset of depression and quantitative neuroanatomic measures: absence of specific correlates. Psychiatry Research 91, 101-110.
63. Lai T-J, Payne M, Byrum CE, Steffens DC, Krishnan KRR (2000). Reduction of orbital frontal cortex volume in geriatric depression. Biological Psychiatry 48, 971-975.
64. Lee JS, Potter GG, Wagner HR, Welsh-Bohmer KA, Steffens DC (2007). Persistent mild cognitive impairment in geriatric depression. International Psychogeriatrics 19, 125-135.
65. Lee Y, Shinkai S (2005). Correlates of cognitive impairment and depressive symptoms among older adults in Korea and Japan. International Journal of Geriatric Psychiatry 20, 576-586.
66. Lenze EJ, Dew MA, Mazumdar S, Begley AE, Cornes C, Miller MD, Imber SD, Frank E, Kupfer DJ, Reynolds CF (2002). Combined pharmacotherapy and psychotherapy as maintenance treatment for late-life depression: effects on social adjustment. American Journal of Psychiatry 159, 466-468.
67. Levy ML, Cummings JL, Fairbanks LA, Masterman D, Miller BL, Craig AH, Paulsen JS, Litvan I (1998). Apathy is not depression. Journal of Neuropsychiatry and Clinical Neurosciences 10, 314-319.
68. Levy RM, Steffens DC, McQuoid DR, Provenzale JM, MacFall JR, Krishnan KRR (2003). MRI lesion severity and mortality in geriatric depression. American Journal of Geriatric Psychiatry 11, 678-682.
69. London ED, Simon SL, Berman SM, Mandelkern MA, Lichtman AM, Bramen J, Shinn AK, Miotto K, Learn J, Dong Y, Matochik JA, Kurian V, Newton T, Woods R, Rawson R, Ling W (2004). Mood disturbances and regional cerebral metabolic abnormalities in recently abstinent methamphetamine abusers. Archives of General Psychiatry 61, 73-84.
70. Lopez OL, Becker JT, Sweet RA, Klunk W, Kaufer DI, Saxton J, Habeych M, DeKosky ST (2003a). Psychiatric symptoms vary with the severity of dementia in probable Alzheimer's disease. Journal of Neuropsychiatry and Clinical Neurosciences 15, 346-353.
71. Lopez OL, Jagust WJ, DeKosky ST, Becker JT, Fitzpatrick A, Dulberg C, Breitner J, Lyketsos C, Jones B, Kawas C, Carlson M, Kuller LH (2003b). Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study Cognition Study: Part 1. Archives of Neurology 60, 1385-1389.
72. Lupien SJ, Nair NP, Briere S, Maheu F, Tu MT, Lemay M, McEwen BS, Meaney MJ (1999). Increased cortisol levels and impaired cognition in human aging: implication for depression and dementia in later life. Reviews in Neurosciences 10, 117-139.
73. Lyketsos CG, Lopez O, Jones B, Fitzpatrick AL, Breitner J, DeKosky S (2002). Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study. Journal of the American Medical Association 288, 1475-1483.
74. Lynch TR, Cheavens JS, Cukrowicz KC, Thorp SR, Bronner L, Beyer J (2007). Treatment of older adults with co-morbid personality disorder and depression: a dialectical behavior therapy approach. International Journal of Geriatric Psychiatry 22, 131-143.
75. Lyness SA, Zarow C, Chui HC (2003). Neuron loss in key cholinergic and aminergic nuclei in Alzheimer disease: a meta-analysis. Neurobiology of Aging 24, 1-23.
76. MacFall JR, Payne ME, Provenzale JM, Krishnan KRR (2001). Medial orbital frontal lesions in late-onset depression. Biological Psychiatry 49, 803-806.
77. MacQueen GM, Campbell S, McEwen BS, Macdonald K, Amano S, Joffe RT, Nahmias C, Young LT (2003). Course of illness, hippocampal function, and hippocampal volume in major depression. Proceedings of the National Academy of Sciences USA 100, 1387-1392.
78. Mast BT, Yochim B, MacNeill SE, Lichtenberg PA (2004). Risk factors for geriatric depression: the importance of executive functioning within the vascular depression hypothesis. Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 59, 1290-1294.
79. Mehta KM, Yaffe K, Langa KM, Sands L, Whooley MA, Covinsky KE (2003). Additive effects of cognitive function and depressive symptoms on mortality in elderly community-living adults. Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 58, M461-M467.
80. Michael N, Erfurth A, Ohrmann P, Arolt V, Heindel W, Pfleiderer B (2003). Metabolic changes within the left dorsolateral prefrontal cortex occurring with electroconvulsive therapy in patients with treatment resistant unipolar depression. Psychological Medicine 33, 1277-1284.
81. Mitchell AJ, Dening TR (1996). Depression-related cognitive impairment: possibilities for its pharmacological treatment. Journal of Affective Disorders 36, 79-87.
82. Moscovitch M, Rosenbaum RS, Gilboa A, Addis DR, Westmacott R, Grady C, McAndrews MP, Levine B, Black S, Winocur G, Nadel L (2005). Functional neuroanatomy of remote episodic, semantic and spatial memory: a unified account based on multiple trace theory. Journal of Anatomy 204, 35-66.
83. Murphy CF, Alexopoulos GS (2004). Longitudinal association of initiation/perseveration and severity of geriatric depression. American Journal of Geriatric Psychiatry 12, 50-56.
84. Murphy FC, Michael A, Robbins TW, Sahakian BJ (2003). Neuropsychological impairment in patients with major depressive disorder: the effects of feedback on task performance. Psychological Medicine 33, 455-467.
85. Nebes RD, Butters MA, Mulsant BH, Pollock BG, Zmuda MD, Houck PR, Reynolds CF (2000). Decreased working memory and processing speed mediate cognitive impairment in geriatric depression. Psychological Medicine 30, 679-691.
86. Nebes RD, Pollock BG, Houck PR, Butters MA, Mulsant BH, Zmuda MD, Reynolds 3rd CF (2003). Persistence of cognitive impairment in geriatric patients following antidepressant treatment: a randomized, double-blind clinical trial with nortriptyline and paroxetine. Journal of Psychiatric Research 37, 99-108.
87. Nemeth G, Hegedus K, Molnar L (1988). Akinetic mutism associated with bicingular lesions: clinicopathological and functional anatomical correlates. European Archives of Psychiatry and Clinical Neuroscience 237, 218-222.
88. O'Brien JT, Lloyd A, McKeith I, Gholkar A, Ferrier N (2004). A longitudinal study of hippocampal volume, cortisol levels, and cognition in older depressed subjects. American Journal of Psychiatry 161, 2081-2090.
89. Olin JT, Katz IR, Meyers BS, Schneider LS, Lebowitz BD (2002a). Provisional diagnostic criteria for depression of Alzheimer disease: rationale and background. American Journal of Geriatric Psychiatry 10, 129-141.
90. Olin JT, Schneider LS, Katz IR, Meyers BS, Alexopoulos GS, Breitner JC, Bruce ML, Caine ED, Cummings JL, Devanand DP, Krishnan KRR, Lyketsos CG, Lyness JM, Rabins PV, Reynolds III CF, Rovner BW, Steffens DC, Tariot PN, Lebowitz BD (2002b). Provisional diagnostic criteria for depression of Alzheimer disease. American Journal of Geriatric Psychiatry 10, 125-128.
91. Owen AM, Herrod NJ, Menon DK, Clark JC, Downey SP, Carpenter TA, Minhas PS, Turkheimer FE, Williams EJ, Robbins TW, Sahakian BJ, Petrides M, Pickard JD (1999). Redefining the functional organization of working memory processes within human lateral prefrontal cortex. European Journal of Neuroscience 11, 567-574.
92. Palmer BW, Boone KB, Lesser IM, Wohl MA, Berman N, Miller BL (1996). Neuropsychological deficits among older depressed patients with predominantly psychological or vegetative symptoms. Journal of Affective Disorders 41, 17-24.
93. Papka M, Rubio A, Schiffer RB (1998). A review of Lewy body disease, an emerging concept of cortical dementia. Journal of Neuropsychiatry and Clinical Neurosciences 10, 267-279.
94. Park JH, Lee SB, Lee TJ, Lee DY, Jhoo JH, Youn JC, Choo IH, Choi EA, Jeong JW, Choe JY, Woo JI, Kim KW (2007). Depression in vascular dementia is quantitatively and qualitatively different from depression in Alzheimer's disease. Dementia and Geriatric Cognitive Disorders 23, 67-73.
95. Patten SB, Love EJ (1994). Drug-induced depression. Incidence, avoidance and management. Drug Safety 10, 203-219.
96. Paus T, Petrides M, Evans AC, Meyer E (1993). Role of the human anterior cingulate cortex in the control of oculomotor, manual, and speech responses: a positron emission tomography study. Journal of Neurophysiology 70, 453-469.
97. Phillips ML, Drevets WC, Rauch SL, Lane R (2003). Neurobiology of emotion perception. I: The neural basis of normal emotion perception. Biological Psychiatry 54, 504-514.
98. Potter GG, Kittinger JD, Wagner HR, Steffens DC, Krishnan KR (2004). Prefrontal neuropsychological predictors of treatment remission in late-life depression. Neuropsychopharmacology 29, 2266-2271.
99. Potter GG, Steffens DC (2007). Contribution of depression to cognitive impairment and dementia in older adults. The Neurologist 13, 105-117.
100. Rait G, Fletcher A, Smeeth L, Brayne C, Stirling S, Nunes M, Breeze E, Ng ES, Bulpitt CJ, Jones D, Tulloch AJ (2005). Prevalence of cognitive impairment: results from the MRC trial of assessment and management of older people in the community. Age and Aging 34, 242-248.
101. Rapp MA, Dahlman K, Sano M, Grossman HT, Haroutunian V, Gorman JM (2005). Neuropsychological differences between late-onset and recurrent geriatric major depression. American Journal of Psychiatry 162, 691-698.
102. Reischies FM, Neu P (2000). Comorbidity of mild cognitive disorder and depression - a neuropsychological analysis. European Archives of Psychiatry and Clinical Neuroscience 50, 186-193.
103. Robert PH, Schuck S, Dubois B, Olie JP, Lepine JP, Gallarda T, Goni S, Troy S (2003). Screening for Alzheimer's disease with the short cognitive evaluation battery. Dementia and Geriatric Cognitive Disorders 15, 92-98.
104. Rugg MD, Fletcher PC, Chua PM, Dolan RJ (1999). The role of the prefrontal cortex in recognition memory and memory for source: an fMRI study. Neuroimage 10, 520-529.
105. Salloway S, Malloy P, Kohn R, Gillard E, Duffy J, Rogg J, Tung G, Richardson E, Thomas C, Westlake R (1996). MRI and neuropsychological differences in early- and late-life-onset geriatric depression. Neurology 46, 1567-1574.
106. Shah PJ, Ebmeier KP, Glabus MF, Godwin GM (1998). Cortical grey matter reductions associated with treatment-resistant chronic unipolar depression. British Journal of Psychiatry 172, 527-532.
107. Sheline YI, Barch DM, Garcia K, Gersing K, Pieper C, Welsh-Bohmer K, Steffens DC, Doraiswamy PM (2006). Cognitive function in late life depression: relationships to depression severity, cerebrovascular risk factors and processing speed. Biological Psychiatry 60, 58-65.
108. Sheline YI, Gado MH, Kraemer HC (2003). Untreated depression and hippocampal volume loss. American Journal of Psychiatry 160, 1516-1518.
109. Sheline YI, Sanghavi M, Mintun MA, Gado MH (1999). Depression duration but not age predicts hippocampal volume loss in medically healthy women with recurrent major depression. Journal of Neuroscience 19, 5034-5043.
110. Sheline YI, Wang PW, Gado MH, Csernansky JG, Vannier MW (1996). Hippocampal atrophy in recurrent major depression. Proceedings of the National Academy of Sciences USA 93, 3908-3913.
111. Simpson SW, Jackson A, Baldwin RC, Burns A (1997). 1997 IPA/Bayer Research Awards in Psychogeriatrics. Subcortical hyperintensities in late-life depression: acute response to treatment and neuropsychological impairment. International Psychogeriatrics 9, 257-275.
112. Starkstein SE, Petracca G, Chemerinski E, Kremer J (2001). Syndromic validity of apathy in Alzheimer's disease. American Journal of Psychiatry 158, 872-877.
113. Steffens DC, Bosworth HB, Provenzale JM, MacFall JR (2002). Subcortical white matter lesions and functional impairment in geriatric depression. Depression and Anxiety 15, 23-28.
114. Steffens DC, Conway CR, Dombeck CB, Wagner HR, Tupler LA, Weiner RD (2001). Severity of subcortical gray matter hyperintensity predicts ECT response in geriatric depression. Journal of ECT 17, 45-49.
115. Steffens DC, Krishnan KRR (1998). Structural neuroimaging and mood disorders: recent findings, implications for classification, and future directions. Biological Psychiatry 43, 705-712.
116. Steffens DC, Pieper CF, Bosworth HB, MacFall JR, Provenzale JM, Payne ME, Carroll BJ, George LK, Krishnan KR (2005). Biological and social predictors of long-term geriatric depression outcome. International Psychogeriatrics 17, 41-56.
117. Steffens DC, Plassman BL, Helms MJ, Welsh-Bohmer KA, Saunders AM, Breitner JC (1997). A twin study of late-onset depression and apolipoprotein E epsilon 4 as risk factors for Alzheimer's disease. Biological Psychiatry 41, 851-856.
118. Steffens DC, Skoog I, Norton MC, Hart AD, Tschanz JT, Plassman BL, Wyse BW, Welsh-Bohmer KA, Breitner JC (2000). Prevalence of depression and its treatment in an elderly population: the Cache County study. Archives of General Psychiatry 57, 601-607.
119. Sultzer DL, Levin HS, Mahler ME, High WM, Cummings JL (1993). A comparison of psychiatric symptoms in vascular dementia and Alzheimer's disease. American Journal of Psychiatry 150, 1806-1812.
120. Tandberg E, Larsen JP, Aarsland D, Cummings JL (1996). The occurrence of depression in Parkinson's disease. A community-based study. Archives of Neurology 53, 175-179.
121. Taylor WD, MacFall JR, Payne ME, McQuoid DR, Provenzale JM, Steffens DC, Krishnan KR (2004). Late-life depression and microstructural abnormalities in dorsolateral prefrontal cortex white matter. American Journal of Psychiatry 161, 1293-1296.
122. Taylor WD, Steffens DC, Krishnan KR (2006). Psychiatric disease in the twenty-first century: the case for subcortical ischemic depression. Biological Psychiatry 60, 1299-1303.
123. Tombaugh TN, McIntyre NJ (1992). The Mini-Mental State Examination: a comprehensive review. Journal of the American Geriatrics Society 40, 922-935.
124. Veiel HOF (1997). A preliminary profile of neuropsychological deficits associated with major depression. Journal of Clinical and Experimental Neuropsychology 19, 587-603.
125. Weintraub D, Stern MB (2005). Psychiatric complications in Parkinson disease. American Journal of Geriatric Psychiatry 13, 844-851.
126. Yanai I, Fujikawa T, Horiguchi J, Yamawaki S, Touhouda Y (1998). The 3-year course and outcome of patients with major depression and silent cerebral infarction. Journal of Affective Disorders 47, 25-30.
127. Zakzanis KK, Leach L, Kaplan E (1998). On the nature and pattern of neurocognitive function in major depressive disorder. Neuropsychiatry, Neuropsychology, and Behavioral Neurology 3, 111-119.
128. Zubenko GS, Zubenko WN, McPherson S, Spoor E, Marin DB, Farlow MR, Smith GE, Geda YE, Cummings JL, Petersen RC, Sunderland T (2003). A collaborative study of the emergence and clinical features of the major depressive syndrome of Alzheimer's disease. American Journal of Psychiatry 160, 857-866.