γ-glutamyl hydrolase: Kinetic characterization of isopeptide hydrolysis using fluorogenic substrates

Biochemistry

Volumn 47, Issue 4, 2008, Pages 1228-1239

  Alexander, Jessica P ^a,d   Ryan, Thomas J ^c   Ballou, David P ^b   Coward, James K ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c WADSWORTH CENTER   (United States)

^d MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFOLATE DRUGS; CYSTEINE PEPTIDASE; GLUTAMYL HYDROLASE; MICHAELIS-MENTEN KINETICS; SCISSILE ISOPEPTIDE BOND;

ACYLATION; CATALYSIS; DRUG PRODUCTS; HYDROLYSIS; REACTION KINETICS; SUBSTITUTION REACTIONS;

ENZYMES;

(4,4 DIFLUORO)GLUTAMYL GAMMA GLUTAMATE; FLUORINE; FOLIC ACID; FOLIC ACID ANTAGONIST; GAMMA GLUTAMYL HYDROLASE; GLUTAMIC ACID DERIVATIVE; GLUTAMYL GAMMA GLUTAMATE; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; CATALYSIS; CHEMICAL REACTION KINETICS; CONCENTRATION (PARAMETERS); DEACYLATION; FLUORESCENCE; HYDROLYSIS; MICHAELIS MENTEN KINETICS; PRIORITY JOURNAL; STEADY STATE;

CATALYSIS; FLUORESCENT DYES; GAMMA-GLUTAMYL HYDROLASE; HYDROLYSIS; KINETICS; MOLECULAR STRUCTURE; PEPTIDES; SUBSTRATE SPECIFICITY;

EID: 38549084117     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi701607v     Document Type: Article

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