The synthesis of (2S)-4,4-difluoroglutamyl γ-peptides based on Garner's aldehyde and fluoro-reformatsky chemistry

Synthesis

Volumn , Issue 17, 2002, Pages 2616-2626

  Konas, David W ^a   Pankuch, Jessica J ^a   Coward, James K ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Fluorescence enzyme assay; Fluoroamino acids; Fluoropeptides; Stereoselective synthesis; glutamyl hydrolase

Indexed keywords

ALDEHYDES; AMINO ACIDS; FLUORINE; HYDROLYSIS; STEREOCHEMISTRY; SYNTHESIS (CHEMICAL);

REFORMATSKY REACTION;

PROTEINS;

4,4 DIFLUOROGLUTAMIC ACID; 4,4 DIFLUOROGLUTAMINE; 4,4 DIFLUOROGLUTAMYL GAMMA PEPTIDE; ALDEHYDE; AMINO ACID; ETHYL BROMODIFLUOROACETATE; FLUORINE; FLUOROACETIC ACID; GAMMA GLUTAMYL HYDROLASE; GLUTAMIC ACID DERIVATIVE; GLUTAMINE DERIVATIVE; ORGANOFLUORINE DERIVATIVE; PEPTIDE DERIVATIVE; SERINE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; ENZYME ASSAY; HYDROLYSIS; REACTION ANALYSIS; REFORMATSKY REACTION; STEREOCHEMISTRY; SYNTHESIS;

EID: 0036459076     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2002-35616     Document Type: Article

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