Analysis of epstein-barr virus strains and variants in classical Hodgkin's lymphoma by laser microdissection

Histology and Histopathology

Volumn 23, Issue 2, 2008, Pages 209-217

  Bellas, Carmen ^b   García Cosío, Mónica ^a   Santón, Almudena ^a   Martín, Paloma ^b   Reguero, Maria Eugenia ^a   Cristóbal, Eva ^a  

^a HOSPITAL RAMÓN Y CAJAL   (Spain)

^b HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

Author keywords

EBNA 3C gene; Epstein barr virus; Hodgkin's lymphoma; Laser microdissection; LMP 1 gene

Indexed keywords

HUMAN HERPESVIRUS 4; HUMAN IMMUNODEFICIENCY VIRUS;

EBNA 3C, EPSTEIN BARR VIRUS; EBNA-3C, EPSTEIN-BARR VIRUS; EBV ASSOCIATED MEMBRANE ANTIGEN, EPSTEIN BARR VIRUS; EBV-ASSOCIATED MEMBRANE ANTIGEN, EPSTEIN-BARR VIRUS; MATRIX PROTEIN; RIBOSOME PROTEIN; RNA BINDING PROTEIN; RPL22 PROTEIN, HUMAN; UNCLASSIFIED DRUG; VIRUS ANTIGEN;

ARTICLE; CANCER STAGING; COMORBIDITY; EPSTEIN BARR VIRUS; GENETICS; HODGKIN DISEASE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IN SITU HYBRIDIZATION; ISOLATION AND PURIFICATION; LASER; METHODOLOGY; MICRODISSECTION; MORTALITY; PATHOGENICITY; PATHOLOGY; POLYMERASE CHAIN REACTION; SPAIN; SURVIVAL RATE; VIROLOGY; VIRUS INFECTION;

ANTIGENS, VIRAL; COMORBIDITY; EPSTEIN-BARR VIRUS INFECTIONS; HERPESVIRUS 4, HUMAN; HIV SEROPOSITIVITY; HODGKIN DISEASE; HUMANS; IN SITU HYBRIDIZATION; LASERS; MICRODISSECTION; NEOPLASM STAGING; POLYMERASE CHAIN REACTION; RIBOSOMAL PROTEINS; RNA-BINDING PROTEINS; SPAIN; SURVIVAL RATE; VIRAL MATRIX PROTEINS;

EID: 38449093956     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Baichwal V.R. and Sugden B. (1998). Transformation of Balb 3T3 cells by the BNLF-1 gene of Epstein-Barr virus. Oncogene 2, 461-4677.
2. Bellas C., Santon A., Manzanal A., Campo E., Martin C., Acevedo A., Varona C., Forteza J., Morente M. and Montalban C. (1996). Pathological, immunological, and molecular features of Hodgkin's disease associated with HIV infection. Comparison with ordinary Hodgkin's disease. Am. J. Surg. Pathol. 20, 1520-1524.
3. Boyle M.J., Vasak E., Tschuchnigg M., Turner J.J., Sculley T., Penny R., Cooper D.A., Tindall B. and Sewell W.A. (1993). Subtypes of Epstein-Barr virus (EBV) in Hodgkin's disease: association between B-type EBV and immunocompromise. Blood 81, 468-474.
4. Chen W.G., Chen Y.Y., Bacchi M.M., Bacchi C.E., Alvarenga M. and Weiss L.M. (1996). Genotyping of Epstein-Barr virus in Brazilian Burkitt's lymphoma and reactive lymphoid tissue. Type A with a high prevalence of deletions within the latent membrane protein gene. Am. J. Pathol. 148, 17-23.
5. Correa P. and O'Conor G. (1971). Epidemiologic patterns of Hodgkin's disease. Int. J. Cancer 8, 192-201.
6. De Re V., Boiocchi M., Dolcetti R., Gloghini A., Uccini S., Baroni C., Scarpa A., Cattoretti G. and Carbone A. (1993). Subtypes of Epstein-Barr virus in HIV-1-associated and HIV-1-unrelated Hodgkin's disease cases. Int. J. Cancer 54, 895-898.
7. Dirnhofer S., Angeles-Angeles A., Ortiz-Hidalgo C., Reyes E., Gredler E., Krugmann J., Fend F. and Quintanilla-Martinez L. (1999). High prevalence of a 30-base pair deletion in the Epstein-Barr virus (EBV) latent membrane protein 1 gene and of strain type B EBV in Mexican classical Hodgkin's disease and reactive lymphoid tissue. Hum. Pathol. 7, 781-787.
8. Dolcetti R., Zancai P., De R., Gloghini A., Bigoni B., Pivetta B., Carbone A. and Boiocchi M. (1997). Epstein-Barr virus strains with latent membrane protein-1 deletions: prevalence in the Italian population and high association with human immunodeficiency virus-related Hodgkin's disease. Blood 89, 1723-1731.
9. Faumont N., Al S.T., Brousset P., Offer C., Delsol G. and Meggetto F. (2001). Demonstration by single-cell PCR that Reed--Sternberg cells and bystander B lymphocytes are infected by different Epstein--Barr virus strains in Hodgkin's disease. J. Gen. Virol. 82, 1169-1174.
10. Faumont N., Trempat P., Brousset P., Delsol G. and Meggetto F. (2004). In Hodgkin's disease Reed-Sternberg cells and normal B-lymphocytes are infected by related Epstein-Barr virus strains. Virus Res. 101, 163-173.
11. Gan Y.J., Razzouk B.I., Su T. and Sixbey J.W. (2002). A defective, rearranged Epstein-Barr virus genome in EBER-negative and EBER-positive Hodgkin's disease. Am. J. Pathol. 160, 781-786.
12. Garcia-Cosio M., Santon A., Martin P., Camarasa N., Montalban C., Garcia J.F. and Bellas C. (2004). Analysis of transcription factor OCT.1, OCT.2 and BOB.1 expression using tissue arrays in classical Hodgkin's lymphoma. Mod. Pathol. 17, 1531-1538.
13. Gerard L., Galicier L., Boulanger E., Quint L., Lebrette M.G., Mortier E., Meignin V. and Oksenhendler E. (2003). Improved survival in HIV-related Hodgkin's lymphoma since the introduction of highly active antiretroviral therapy. AIDS 17, 81-87.
14. Guidoboni M., Ponzoni M., Caggiari L., Lettini A.A., Vago L., De R., Gloghini A., Zancai P., Carbone A., Boiocchi M. and Dolcetti R. (2005). Latent membrane protein 1 deletion mutants accumulate in reed-sternberg cells of human immunodeficiency virus-related Hodgkin's lymphoma. J. Virol. 79, 2643-2649.
15. Gulley M.L., Eagan P.A., Quintanilla-Martinez L., Picado A.L., Smir B.N., Childs C., Dunn C.D., Craig F.E., Williams J.W. and Banks P.M. (1994). Epstein-Barr virus DNA is abundant and monoclonal in the Reed-Sternberg cells of Hodgkin's disease: association with mixed cellularity subtype and Hispanic American ethnicity. Blood 83, 1595-1602.
16. Harris N.L., Jaffe E.S., Stein H., Banks P.M., Chan J.K., Cleary M.L., Delsol G., De Wolf-Peeters C., Falini B., Gatter K.C., Isaacson P.G., Knowles D.M., Mason D.Y., Muller-Hermelink H.K., Pileri S.A., Piris M.A., Ralfkiaer E. and Warnke R.A. (1994). A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 84, 1361-1392.
17. Herbst H., Niedobitek G., Kneba M., Hummel M., Finn T., Anagnostopoulos I., Bergholz M., Krieger G. and Stein H. (1990). High incidence of Epstein-Barr virus genomes in Hodgkin's disease Am. J. Pathol. 137, 13-18.
18. Hu L.F., Chen F., Zheng X., Ernberg I., Cao S.L., Christensson B., Klein G. and Winberg G. (1993). Clonability and tumorigenicity of human epithelial cells expressing the EBV encoded membrane protein LMP1. Oncogene 8, 1575-1583.
19. Hummel M., Anagnostopoulos I., Dallenbach F., Korbjuhn P., Dimmler C. and Stein H. (1992). EBV infection patterns in Hodgkin's disease and normal lymphoid tissue: expression and cellular localization of EBV gene products. Br. J. Haematol. 82, 689-694.
20. Kanzler H., Hansmann M.L., Kapp U., Wolf J., Diehl V., Rajewsky K. and Kuppers R. (1996). Molecular single cell analysis demonstrates the derivation of a peripheral blood-derived cell line (L1236) from the Hodgkin/Reed-Sternberg cells of a Hodgkin's lymphoma patient. Blood 87, 3429-3436.
21. Kanzler H., Kuppers R., Hansmann M.L. and Rajewsky K. (1996). Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells. J. Exp. Med. 184, 1495-1505.
22. Khan G., Coates P.J., Gupta R.K., Kangro H.O. and Slavin G. (1992). Presence of Epstein-Barr virus in Hodgkin's disease is not exclusive to Reed-Sternberg cells. Am. J. Pathol. 140, 757-762.
23. Khanim F., Yao Q.Y., Niedobitek G., Sihota S., Rickinson A.B. and Young L.S. (1996). Analysis of Epstein-Barr virus gene polymorphisms in normal donors and in virus-associated tumors from different geographic locations. Blood 88, 3491-501.
24. Kim L.H., Peh S.C. and Poppema S. (2003). Dual variant of Epstein-Barr virus in Hodgkin/Reed-Sternberg cells: single-cell PCR study on latent membrane protein-1 gene. Int. J. Cancer 107, 250-255.
25. Knecht H., Bachmann E., Brousset P., Sandvej K., Nadal D., Bachmann F., Odermatt B.F., Delsol G. and Pallesen G. (1993). Deletions within the LMP1 oncogene of Epstein-Barr virus are clustered in Hodgkin's disease and identical to those observed in nasopharyngeal carcinoma. Blood 82, 2937-2942.
26. Lister T.A., Crowther D., Sutcliffe S.B., Glatstein E., Canellos G.P., Young R.C., Rosenberg S.A., Coltman C.A. and Tubiana M. (1989). Report of a committee convened to discuss the evaluation and staging of patients with Hodgkin's disease: Cotswolds meeting. J. Clin. Oncol. 7, 1630-1636.
27. Luftig M., Yasui T., Soni V., Kang M.S., Jacobson N., Cahir-McFarland E., Seed B. and Kieff E. (2004). Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKK alpha-dependent noncanonical NF-kappaB activation. Proc. Natl. Acad. Sci. USA 101, 141-146.
28. Marafioti T., Hummel M., Foss H. D., Laumen H., Korbjuhn P., Anagnostopoulos I., Lammert H., Demel G., Theil J., Wirth T. and Stein H. (2000). Hodgkin and Reed-Sternberg cells represent an expansion of a single clone originating from a germinal center B-cell with functional immunoglobulin gene rearrangements but defective immunoglobulin transcription. Blood 95, 1443-1450.
29. Miller G. (1990). The switch between latency and replication of Epstein-Barr virus. J. Infect. Dis. 161, 833-844.
30. Sample J., Young L., Martin B., Chatman T., Kieff E., Rickinson A. and Kieff E. (1990). Epstein-Barr virus types 1 and 2 differ in their EBNA-3A, EBNA-3B, and EBNA-3C genes. J. Virol. 64, 4084-4092.
31. Sandvej K., Peh S.C., Andresen B.S. and Pallesen G. (1994). Identification of potential hot spots in the carboxy-terminal part of the Epstein-Barr virus (EBV) BNLF-1 gene in both malignant and benign EBV-associated diseases: high frequency of a 30-bp deletion in Malaysian and Danish peripheral T-cell lymphomas. Blood 84, 4053-4060.
32. Santon A. and Bellas C. (2001). Deletions within the Epstein-Barr virus latent membrane protein-1 oncogene in adult ordinary, HIV-associated and paediatric Hodgkin's disease. Leuk. Lymphoma 40, 235-242.
33. Santon A., Martin C., Manzanal A.I., Preciado M.V. and Bellas C. (1998). Paediatric Hodgkin's disease in Spain: association with Epstein-Barr virus strains carrying latent membrane protein-1 oncogene deletions and high frequency of dual infections. Br. J. Haematol. 103, 129-136.
34. Spieker T., Kurth J., Kuppers R., Rajewsky K., Brauninger A. and Hansmann M.L. (2000). Molecular single-cell analysis of the clonal relationship of small Epstein-Barr virus-infected cells and Epstein-Barr virus-harboring Hodgkin and Reed/Sternberg cells in Hodgkin disease. Blood 96, 3133-3138.
35. Vaccher E., Spina M. and Tirelli U. (2001). Clinical aspects and management of Hodgkin's disease and other tumours in HIV-infected individuals. Eur. J. Cancer 37, 1306-1315.
36. Walling D.M. and Raab-Traub N. (1994). Epstein-Barr virus intrastrain recombination in oral hairy leukoplakia. J. Virol. 68, 7909-7917.
37. Walling D.M., Brown A.L., Etienne W., Keitel W.A. and Ling P.D. (2003). Multiple Epstein-Barr virus infections in healthy individuals. J. Virol. 77, 6546-6550.
38. Wang D., Liebowitz D. and Kieff E. (1985). An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells. Cell 43, 831-840.
39. Weinreb M., Day P.J., Niggli F., Green E.K., Nyong'o A.O., Othieno-Abinya N.A., Riyat M.S., Raafat F. and Mann J.R. (1996a). The consistent association between Epstein-Barr virus and Hodgkin's disease in children in Kenya. Blood 87, 3828-3836.
40. Weinreb M., Day P.J., Niggli F., Powell J.E., Raafat F., Hesseling P.B., Schneider J.W., Hartley P.S., Tzortzatou-Stathopoulou F., Khalek E.R., Mangoud A., El-Safy U.R., Madanat F., Al S.M., Mpofu C., Revesz T., Rafii R., Tiedemann K., Waters K.D., Barrantes J.C., Nyongo A., Riyat M.S. and Mann J.R. (1996b). The role of Epstein-Barr virus in Hodgkin's disease from different geographical areas. Arch. Dis. Child. 74, 27-31.
41. Weiss L.M., Movahed L.A., Warnke R.A. and Sklar J. (1989). Detection of Epstein-Barr viral genomes in Reed-Sternberg cells of Hodgkin's disease. N. Engl. J. Med. 320, 502-506.
42. Weiss L.M., Chen Y.Y., Liu X.F. and Shibata D. (1991). Epstein-Barr virus and Hodgkin's disease. A correlative in situ hybridization and polymerase chain reaction study. Am. J. Pathol. 139, 1259-1265.
43. Wlodarska I., Nooyen P., Maes B., Martin-Subero J.I., Siebert R., Pauwels P., De Wolf-Peeters C. and Hagemeijer A. (2003). Frequent occurrence of BCL6 rearrangements in nodular lymphocyte predominance Hodgkin lymphoma but not in classical Hodgkin lymphoma. Blood 101, 706-710.