Molecular single-cell analysis of the clonal relaionship of small Epstein-Barr virus-infected cells and Epstein-Barr virus-harboring Hodgkin and Reed/Sternberg cells in Hodgkin disease

Blood

Volumn 96, Issue 9, 2000, Pages 3133-3138

  Spieker, T ^a   Kurth, J ^a   Kuppers, R ^a   Rajewsky, K ^a   Brauninger, A ^a   Hansmann, M L ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CLONAL ANERGY; EPSTEIN BARR VIRUS; GENE REARRANGEMENT; GERMINAL CENTER; HODGKIN DISEASE; HUMAN; HUMAN TISSUE; IMMUNOGLOBULIN GENE; IMMUNOHISTOCHEMISTRY; METASTASIS POTENTIAL; MOLECULAR CLONING; PRIORITY JOURNAL; REED STERNBERG CELL; SOMATIC MUTATION; TISSUE SECTION; VIRUS INFECTION;

EID: 0034331240     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.9.3133     Document Type: Article

References (39)

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2. Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells
3. Rare occurrence of classical Hodgkin's disease as a T cell lymphoma
4. Hodgkin and Reed-Sternberg cells represent an expansion of a single clone originating from a germinal center B-cell with functional immunoglobulin gene rearrangements but defective immunoglobulin transcription
5. Detection of Epstein-Barr viral genomes in Reed-Sternberg cells of Hodgkin's disease
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14. Hodgkin's disease in patients with previous infectious mononucleosis
15. Distribution and phenotype of Epstein-Barr virus-harboring cells in Hodgkin's disease
16. Presence of Epstein-Barr virus in Hodgkin's disease is not exclusive to Reed-Sternberg cells
17. Patterns of Epstein-Barr virus infection in non-neoplastic lymphoid tissue
18. Micromanipulation and PCR analysis of single cells from tissue sections
19. Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells
20. Molecular analysis of single B cells from T-cell-rich B-cell lymphoma shows the derivation of the tumor cells from mutating germinal center B cells and exemplifies means by which immunoglobulin genes are modified in germinal center B cells
21. A uniform deleting element mediates the loss of kappa genes in human B cells
22. The human CK gene segment and the kappa deleting element are closely linked
23. Molecular Ig gene analysis reveals that monocytoid B cell lymphoma is a malignancy of mature B cells carrying somatically mutated V region genes and suggests that rearrangement of the kappa-deleting element (resulting in deletion of Ig kappa enhancers) abolishes somatic hypermutation in the human
24. Frequent occurrence of deletions and duplications during somatic hypermutation: Implications for oncogene translocations and heavy chain disease
25. Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes
26. Somatic hypermutation in normal and transformed human B cells
27. Immunohistochemical detection of the Epstein-Barr virus-encoded latent membrane protein 2A in Hodgkin's disease and infectious mononucleosis
28. Chromosomal abnormalities in Hodgkin's disease are not restricted to Hodgkin/Reed-Sternberg cells
29. Morphologically normal, CD30-negative B-lymphocytes with chromosome aberrations in classical Hodgkin's disease: The progenitor cell of the malignant clone?
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34. An anti-CD30 single-chain Fv selected by phage display and fused to Pseudomonas exotoxin A (Ki-4(scFv)-ETA') is a potent immunotoxin against a Hodgkin-derived cell line
35. Isolation of viable Hodgkin and Reed-Sternberg cells from Hodgkin disease tissues
36. Detection of clonal Hodgkin and Reed-Sternberg cells with identical somatically mutated and rearranged V(H) genes in different biopsies in relapsed Hodgkin's disease
37. Identification of common germinal-center B-cell precursors in two patients with both Hodgkin's disease and non-Hodgkin's lymphoma
38. Clonal relapse in Hodgkin's disease
39. EBV persistence in memory B cells in vivo