Total ghrelin levels during acute insulin infusion in patients with polycystic ovary syndrome

Journal of Endocrinological Investigation

Volumn 30, Issue 10, 2007, Pages 820-827

  Micic, D ^a   Sumarac Dumanovic, M ^a   Kendereski, A ^a   Cvijovic, G ^a   Zoric, S ^a   Pejkovic, D ^a   Micic, J ^b   Milic, N ^c   Dieguez, C ^d   Casanueva, F F ^d  

^a INSTITUTE OF ENDOCRINOLOGY   (Serbia)

^b CLINICAL CENTER OF SERBIA   (Serbia)

^c UNIVERSITY OF BELGRADE   (Serbia)

^d UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Euglycemic clamp; Ghrelin; Insulin; PCOS; SHBG

Indexed keywords

ANDROGEN; GHRELIN; GLUCOSE; HUMAN INSULIN; ANTIDIABETIC AGENT; INSULIN; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERINSULINEMIA; INSULIN INFUSION; INSULIN RESISTANCE; INSULIN SENSITIVITY; OBESITY; OVARY POLYCYSTIC DISEASE; ACUTE DISEASE; BLOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; GLUCOSE CLAMP TECHNIQUE; HYPERINSULINISM; METABOLISM;

ACUTE DISEASE; ADULT; BODY MASS INDEX; FASTING; FEMALE; GHRELIN; GLUCOSE CLAMP TECHNIQUE; HUMANS; HYPERINSULINISM; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; OBESITY; OVERWEIGHT; POLYCYSTIC OVARY SYNDROME; SEX HORMONE-BINDING GLOBULIN; TESTOSTERONE;

EID: 38449091761     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03349222     Document Type: Article

References (44)

1. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999, 402: 656-60.
2. Wren AM, Seal LJ, Cohen MA, et al. Ghrelin enhances appetite and increase food intake in humans. J Clin Endocrinol Metab 2001, 86: 5992-5.
3. Horvath IL, Diano S, Sotonyi P, Heiman M, Tschöp M. Mini-review: ghrelin and the regulation of energy balance - A hypothalamic perspective. Endocrinology 2001, 142: 163-9.
4. Tschöp M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nature 2000, 407: 908-13.
5. Shiiya T, Nakazato M, Mizuta M, et al. Plasma ghrelin levels in lean and obese humans and the effects of glucose on ghrelin secretion. J Clin Endocrinol Metab 2002, 87: 240-4.
6. Schöfl C, Horn R, Schill T, Schlösser HW, Müller MJ, Brabant G. Circulating ghrelin levels in patients with polycystic ovary syndrome. J Clin Endocrinol Metab 2002, 87: 4607-10.
7. Pagotto U, Gambineri A, Vicennati V, Heiman ML, Tschöp M, Pasquali R. Plasma ghrelin, obesity, and the polycystic ovary syndrome: correlation with insulin resistance and androgen levels. J Clin Endocrinol Metab 2002, 87: 5625-9.
8. Moran LJ, Noakes M, Clifton PM, et al. Ghrelin and measures of satiety are altered in polycystic ovary syndrome but not differentially affected by diet composition. J Clin Endocrinol Metab 2004, 89: 3337-44.
9. Panidis D, Farmakiotis D, Koliakos G, et al. Comparative study of plasma ghrelin levels in women with polycystic ovary syndrome, in hyperandrogenic women and in normal controls. Human Reprod 2005, 20: 2127-32.
10. Orio F Jr, Lucidi P, Palomba S, et al. Circulating ghrelin concentrations in the polycystic ovary syndrome. J Clin Endocrinol Metab 2003, 88: 942-5.
11. Wasko R, Komarowska H, Warenik-Szymankiewicz A, Sowinski J. Elevated ghrelin plasma levels in patients with polycystic ovary syndrome. Horm Metab Res 2004, 36: 170-3.
12. Dunaif A. Insulin resistance and the polycystic ovary syndrome: mechanism and implication for pathogenesis. Endocrine Rev 1997, 18: 774-800.
13. Schaller G, Schmidt A, Pleiner J, Woloszczuk W, Wolzt M, Luger A. Plasma ghrelin concentrations are not regulated by glucose or insulin: a double blind, placebo-controlled crossover clamp study. Diabetes 2003, 52: 16-20.
14. Leonetti F, Iacobellis G, Riabaudo MC, et al. Acute insulin infusion decreases plasma ghrelin levels in uncomplicated obesity. Reg Pept 2004, 122: 179-83.
15. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004, 81: 19-25.
16. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 2000, 23, (Suppl 1): S4-19.
17. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979, 237: E214-23.
18. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function frm fasting glucose and insulin concentration in man. Diabetologia 1985, 28: 412-9.
19. Stanczyk FZ. Diagnosis of hyperandrogenism: biochemical criteria. Best Pract Res Clin Endocrinol Metab 2006, 20: 177-91.
20. Glintborg D, Andersen H, Hagen C, et al. Evaluation of metabolic risk markers in polycystic ovary syndrome (PCOS). Adiponectin, ghrelin, leptin and body composition in hirsute PCOS patients and controls. Eur J Endocrinol 2006, 155: 337-45.
21. Flanagan DE, Evans ML, Monsod TP, et al. The influence of insulin on circulating ghrelin. Am J Physiol Endocrinol Metab 2003, 284: E313-6.
22. Saad MF, Bernaba B, Hwu CM, et al. Insulin regulates plasma ghrelin concentration. J Clin Endocrinol Metab 2002, 87: 3997-4000.
23. Ikezaki A, Hosoda H, Ito K, et al. Fasting plasma ghrelin levels are negatively correlated with insulin resistance and PAI-1, but not with leptin, in obese children and adolescents. Diabetes 2002, 51: 3408-11.
24. le Roux CW, Patterson M, Vincent RP, Hunt C, Ghatei MA, Bloom SR. Postprandial plasma ghrelin is suppressed proportional to meal calorie content in normal weight but not obese subjects. J Clin Endocrinol Metab 2005, 90: 1068-71.
25. Mohlig M, Spranger J, Otto B, Ristow M, Tschöp M, Pfeiffer AF. Euglycemic hyperinsulinemia, but not lipid infusion, decreases circulating ghrelin levels in humans. J Endocrinol Invest 2002, 25: RC36-8.
26. McLaughlin T, Abbasi F, Lamendola C, Frayo RS, Cummings DE. Plasma ghrelin concentrations are decreased in insulin-resistant obese adults relative to equally obese inulin-sensitive controls. J Clin Endocrinol Metab 2004, 89: 1630-5.
27. van der Lely AJ, Tschöp M, Heiman ML, Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 2004, 25: 426-57.
28. St-Pierre DH, Karelis AD, Coderre L, et al. Association of acylated and nonacylated Ghrelin with insulin sensitivity in overweight and obese postmenopausal women. J Clin Endocrinol Metab 2007, 92: 264-9.
29. Welt CK, Gudmundsson JA, Arason G, et al. Characterizing discrete subsets of polycystic ovary syndrome as defined by the Rotterdam criteria: the impact of weight on phenotype and metabolic features. J Clin Endocrinol Metab 2006, 91: 4842-8.
30. Porte D Jr, Baskin DG, Schwartz MW. Insulin signaling in the central nervous system: a critical role in metabolic homeostasis and disease from C. elegans to humans. Diabetes 2005, 54: 1264-76.
31. Plum L, Schubert M, Brüning JC. The role of insulin receptor signaling in the brain. Trends Endocrinol Metab 2005, 16: 59-65.
32. Pliquett RU, Führer D, Falk S, Zysset S, von Cramon DY, Stumvoll M. The effects of insulin on the central nervous system-focus on appetite regulation. Horm Metab Res 2006, 38: 442-6.
33. Ueno M, Carvalheira JB, Oliveira RL, Velloso LA, Saad MJ. Circulating ghrelin concentrations are lowered by intracerebroventricular insulin. Diabetologia 2006, 49: 2449-52.
34. Wierup N, Svensson H, Mulder H, Sundler F. The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas. Regul Pept 2002, 107: 63-9.
35. Caixas A, Bashore C, Nash W, PI-Sunyer FX, Laferrere B. Insulin, unlike food intake, does not suppress ghrelin in human subjects. J Clin Endocrinol Metab 2002, 87: 1902-6.
36. Ott V, Fasshauer M, Dalski A, et al. Direct peripheral effects of ghrelin includes suppression of adiponectin expression. Horm Metab Res 2002, 34: 640-5.
37. Ravussin E, Tschöp M, Morales S, Bouchard C, Heiman ML. Plasma ghrelin concentration and energy balance: over-feeding and negative energy balance studies in twins. J Clin Endocrinol Metab 2001, 86: 4547-51.
38. Kalra SP, Ueno N, Kalra PS. Stimulation of appetite by ghrelin is regulated by leptin restraint: peripheral and central sites of action. J Nutr 2005, 135: 1331-5.
39. Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 1998, 395: 763-70.
40. Bagnasco M, Kalra PS, Kalra SP. Ghrelin and leptin pulse discharge in fed and fasted rats. Endocrinology 2002, 143: 726-9.
41. Tschöp M, Weyer C, Tataranni A, Devanarayan V, Ravussin E, Heiman ML. Circulating ghrelin levels are decreased in human obesity. Diabetes 2001, 50: 707-9.
42. Gambineri A, Pagotto U, Tschöp M, et al. Anti-androgen treatment increases circulating ghrelin levels in obese women with polycystic ovary syndrome. J Endocrinol Invest 2003, 26: 629-34.
43. Tena-Sempere M, Barreiro MI, Gonzáles IC, et al. Novel expression and functional role of ghrelin in rat testis. Endocrinology 2002, 143: 717-25.
44. Dahan MH, Goldstein J. Serum sex-hormone binding globulin levels show too much variability to be used effectively as a screening marker for insulin resistance in women with polycystic ovary syndrome. Fertil Steril 2006, 86: 934-41.