Chromosome 2q32 may harbor a QTL affecting BMD variation at different skeletal sites

Journal of Bone and Mineral Research

Volumn 22, Issue 11, 2007, Pages 1672-1678

  Wang, Liang ^a,b   Liu, Yong Jun ^b   Xiao, Peng ^c   Shen, Hui ^b   Deng, Hong Yi ^b   Papasian, Christopher J ^b   Drees, Betty M ^b   Hamilton, James J ^b   Recker, Robert R ^c   Deng, Hong Wen ^a,b,d  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b UNIVERSITY OF MISSOURI KANSAS CITY SCHOOL OF MEDICINE   (United States)

^c CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HUNAN NORMAL UNIVERSITY   (China)

Author keywords

BMD; Linkage; Pleiotropy; Principal component analysis; Quantitative trait loci

Indexed keywords

ADULT; ARTICLE; BONE DENSITY; CHROMOSOME 2Q; CORRELATION ANALYSIS; EUROPEAN AMERICAN; FEMALE; FOREARM; GENE MAPPING; GENETIC LINKAGE; GENOME; HERITABILITY; HUMAN; LINKAGE ANALYSIS; MALE; NORMAL HUMAN; PEDIGREE; PHENOTYPE; PLEIOTROPY; PRINCIPAL COMPONENT ANALYSIS; QUANTITATIVE TRAIT LOCUS; SPINE; UNITED STATES; BONE; CHROMOSOME 2; GENETIC MARKER; GENETICS; RADIOGRAPHY;

BONE AND BONES; BONE DENSITY; CHROMOSOMES, HUMAN, PAIR 2; GENETIC MARKERS; HUMANS; LINKAGE (GENETICS); PEDIGREE; QUANTITATIVE TRAIT LOCI;

EID: 38449090321     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.070722     Document Type: Article

References (44)

1. Duncan EL, Brown MA, Sinsheimer J, Bell J, Carr AJ, Words-worth BP, Wass JA 1999 Suggestive linkage of the parathyroid receptor type 1 to osteoporosis. J Bone Miner Res 14:1993-1999.
2. Black DM, Cummings SR, Melton LJ III 1992 Appendicular bone mineral and a woman's lifetime risk of hip fracture. J Bone Miner Res 7:639-646.
3. Hui SL, Slemenda CW, Johnston CC Jr 1989 Baseline measurement of bone mass predicts fracture in white women. Ann Intern Med 111:355-361.
4. Nevitt MC, Johnell O, Black DM, Ensrud K, Genant HK, Cummings SR 1994 Bone mineral density predicts non-spine fractures in very elderly women. Study of Osteoporotic Fractures Research Group. Osteoporos Int 4:325-331.
5. Smith DM, Nance WE, Kang KW, Christian JC, Johnston CC Jr 1973 Genetic factors in determining bone mass. J Clin Invest 52:2800-2808.
6. Dequeker J, Nijs J, Verstraeten A, Geusens P, Gevers G 1987 Genetic determinants of bone mineral content at the spine and radius: A twin study. Bone 8:207-209.
7. Pocock NA, Eisman JA, Hopper JL, Yeates MG, Sambrook PN, Eberl S 1987 Genetic determinants of bone mass in adults. A twin study. J Clin Invest 80:706-710.
8. Recker RR, Deng HW 2002 Role of genetics in osteoporosis. Endocrine 17:55-66.
9. Nguyen TV, Howard GM, Kelly PJ, Eisman JA 1998 Bone mass, lean mass, and fat mass: Same genes or same environments? Am J Epidemiol 147:3-16.
10. Yang TL, Zhao LJ, Liu YJ, Liu JF, Recker RR, Deng HW 2006 Genetic and environmental correlations of bone mineral density at different skeletal sites in females and males. Calcif Tissue Int 78:212-217.
11. Livshits G, Deng HW, Nguyen TV, Yakovenko K, Recker RR, Eisman JA 2004 Genetics of bone mineral density: Evidence for a major pleiotropic effect from an intercontinental study. J Bone Miner Res 19:914-923.
12. Livshits G, Karasik D, Pavlovsky O, Kobyliansky E 1999 Segregation analysis reveals a major gene effect in compact and cancellous bone mineral density in 2 populations. Hum Biol 71:155-172.
13. Deng HW, Stegman MR, Davies KM, Conway T, Recker RR 1999 Genetic determination of variation and covariation of peak bone mass at the hip and spine. J Clin Densitom 2:251-263.
14. Devoto M, Spotila LD, Stabley DL, Wharton GN, Rydbeck H, Korkko J, Kosich R, Prockop D, Tenenhouse A, Sol-Church K 2005 Univariate and bivariate variance component linkage analysis of a whole-genome scan for loci contributing to bone mineral density. Eur J Hum Genet 13:781-788.
15. Karasik D, Myers RH, Hannan MT, Gagnon D, McLean RR, Cupples LA, Kiel DP 2002 Mapping of quantitative ultrasound of the calcaneus bone to chromosome 1 by genome-wide linkage analysis. Osteoporos Int 13:796-802.
16. Karasik D, Myers RH, Cupples LA, Hannan MT, Gagnon DR, Herbert A, Kiel DP 2002 Genome screen for quantitative trait loci contributing to normal variation in bone mineral density: The Framingham Study. J Bone Miner Res 17:1718-1727.
17. Xiao P, Shen H, Guo YF, Xiong DH, Liu YZ, Liu YJ, Zhao LJ, Long JR, Guo Y, Recker RR, Deng HW 2006 Genomic regions identified for BMD in a large sample including epistatic interactions and gender-specific effects. J Bone Miner Res 21:1536-1544.
18. Deng HW, Xu FH, Huang QY, Shen H, Deng H, Conway T, Liu YJ, Liu YZ, Li JL, Zhang HT, Davies KM, Recker RR 2002 A whole-genome linkage scan suggests several genomic regions potentially containing quantitative trait Loci for osteoporosis. J Clin Endocrinol Metab 87:5151-5159.
19. Deng HW, Deng H, Liu YJ, Liu YZ, Xu FH, Shen H, Conway T, Li JL, Huang QY, Davies KM, Recker RR 2002 A genomewide linkage scan for quantitative-trait loci for obesity phenotypes. Am J Hum Genet 70:1138-1151.
20. Genant HK, Grampp S, Gluer CC, Faulkner KG, Jergas M, Engelke K, Hagiwara S, Van Kuijk C 1994 Universal standardization for dual x-ray absorptiometry: Patient and phantom cross-calibration results. J Bone Miner Res 9:1503-1514.
21. Almasy L, Blangero J 1998 Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62:1198-1211.
22. Self SGLK-Y 1987 Asymptotic Properties of Maximum Likelihood Estimators and Likelihood Ratio Tests Under Non-standard Conditions. J Am Stat Assoc 82:605-609.
23. Amos C, de Andrade M, Zhu D 2001 Comparison of multivariate tests for genetic linkage. Hum Hered 51:133-144.
24. Almasy L, Dyer TD, Blangero J 1997 Bivariate quantitative trait linkage analysis: Pleiotropy versus co-incident linkages. Genet Epidemiol 14:953-958.
25. Williams FM, Spector TD 2006 Recent advances in the genetics of osteoporosis. J Musculoskelet Neuron Interact 6:27-35.
26. Livshits G, Otremski I, Kobyliansky E 1995 Genetics of human body size and shape: Complex segregation analysis. Ann Hum Biol 22:13-27.
27. Nguyen TV, Blangero J, Eisman JA 2000 Genetic epidemiological approaches to the search for osteoporosis genes. J Bone Miner Res 15:392-401.
28. Favus MJ 2006 Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 6th ed. American Society for Bone and Mineral Research, Washington, DC, USA.
29. Zambonin Zallone A, Teti A, Primavera MV 1984 Monocytes from circulating blood fuse in vitro with purified osteoclasts in primary culture. J Cell Sci 66:335-342.
30. Horton MA, Spragg JH, Bodary SC, Helfrich MH 1994 Recognition of cryptic sites in human and mouse laminins by rat osteoclasts is mediated by beta 3 and beta 1 integrins. Bone 15:639-646.
31. Parfitt AM 1998 Osteoclast precursors as leukocytes: Importance of the area code. Bone 23:491-494.
32. Wilson SG, Reed PW, Andrew T, Barber MJ, Lindersson M, Langdown M, Thompson D, Thompson E, Bailey M, Chiano M, Kleyn PW, Spector TD 2004 A genome-screen of a large twin cohort reveals linkage for quantitative ultrasound of the calcaneus to 2q33-37 and 4q12-21. J Bone Miner Res 19:270-277.
33. Knapp KM, Andrew T, MacGregor AJ, Blake GM, Fogelman I, Spector TD 2003 An investigation of unique and shared gene effects on speed of sound and bone density using axial transmission quantitative ultrasound and DXA in twins. J Bone Miner Res 18:1525-1530.
34. Wilson SG, Reed PW, Bansal A, Chiano M, Lindersson M, Langdown M, Prince RL, Thompson D, Thompson E, Bailey M, Kleyn PW, Sambrook P, Shi MM, Spector TD 2003 Comparison of genome screens for two independent cohorts provides replication of suggestive linkage of bone mineral density to 3p21 and 1p36. Am J Hum Genet 72:144-155.
35. Hsu YH, Xu X, Terwedow HA, Niu T, Hong X, Wu D, Wang L, Brain JD, Bouxsein ML, Cummings SR, Rosen CJ, Xu X 2007 Large-scale genome-wide linkage analysis for loci linked to BMD at different skeletal sites in extreme selected sibships. J Bone Miner Res 22:184-194.
36. Kammerer CM, Schneider JL, Cole SA, Hixson JE, Samollow PB, O'Connell JR, Perez R, Dyer TD, Almasy L, Blangero J, Bauer RL, Mitchell BD 2003 Quantitative trait loci on chromosomes 2p, 4p, and 13q influence bone mineral density of the forearm and hip in Mexican Americans. J Bone Miner Res 18:2245-2252.
37. Peacock M, Koller DL, Fishburn T, Krishnan S, Lai D, Hui S, Johnston CC, Foroud T, Econs MJ 2005 Sex-specific and non-sex-specific quantitative trait loci contribute to normal variation in bone mineral density in men. J Clin Endocrinol Metab 90:3060-3066.
38. McPherron AC, Lawler AM, Lee SJ 1997 Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature 387:83-90.
39. Hamrick MW, Pennington C, Byron CD 2003 Bone architecture and disc degeneration in the lumbar spine of mice lacking GDF-8 (myostatin). J Orthop Res 21:1025-1032.
40. Montgomery E, Pennington C, Isales CM, Hamrick MW 2005 Muscle-bone interactions in dystrophin-deficient and myostatin-deficient mice. Anat Rec A Discov Mol Cell Evol Biol 286:814-22.
41. Andreoli A, Monteleone M, Van Loan M, Promenzio L, Tarantino U, De Lorenzo A 2001 Effects of different sports on bone density and muscle mass in highly trained athletes. Med Sci Sports Exerc 33:507-511.
42. Witzke KA, Snow CM 1999 Lean body mass and leg power best predict bone mineral density in adolescent girls. Med Sci Sports Exerc 31:1558-1563.
43. Xiao L, Naganawa T, Obugunde E, Gronowicz G, Ornitz DM, Coffin JD, Hurley MM 2004 Statl controls postnatal bone formation by regulating fibroblast growth factor signaling in osteoblasts. J Biol Chem 279:27743-27752.
44. Kim S, Koga T, Isobe M, Kern BE, Yokochi T, Chin YE, Karsenty G, Taniguchi T, Takayanagi H 2003 Statl functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation. Genes Dev 17:1979-1991.