Sex-specific and non-sex-specific quantitative trait loci contribute to normal variation in bone mineral density in men

Journal of Clinical Endocrinology and Metabolism

Volumn 90, Issue 5, 2005, Pages 3060-3066

  Peacock, Munro ^a,b   Koller, Daniel L ^a   Fishburn, Tonya ^a   Krishnan, Subha ^a   Lai, Dongbing ^a   Hui, Siu ^a   Johnston, C Conrad ^a   Foroud, Tatiana ^a   Econs, Michael J ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Univ Hosp and Outpatient Ctr 5420   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BONE DENSITY; BONE MINERAL; CHROMOSOME 18; CHROMOSOME 1Q; CHROMOSOME 21; CHROMOSOME 2Q; CONTROLLED STUDY; FRACTURE; GENETIC ANALYSIS; GENETIC VARIABILITY; HIP; HUMAN; LINKAGE ANALYSIS; MALE; NORMAL HUMAN; OSTEOPOROSIS; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; SPINE;

ADOLESCENT; ADULT; BONE DENSITY; HUMANS; MALE; MIDDLE AGED; QUANTITATIVE TRAIT LOCI; SEX CHARACTERISTICS;

PIERINAE;

EID: 18844442011     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2004-2143     Document Type: Article

References (25)

1. Riis BJ, Hansen MA, Jensen AM, Overgaard K, Christiansen C 1996 Low bone mass and fast rate of bone loss at menopause: equal risk factors for future fracture: a 15-year follow-up study. Bone 19:9-12
2. Kellie SE, Brody JA 1990 Sex-specific and race-specific hip fracture rates. Am J Public Health 80:326-328
3. Silverman SL, Madison RE 1988 Decreased incidence of hip fracture in Hispanics, Asians, and Blacks: California Hospital Discharge Data. Am J Public Health 78:1482-1483
4. 2004 Bone health and osteoporosis: a report of the Surgeon General. Rockville, MD: Public Health Service Office of the Surgeon General; 1-404
5. Orwoll ES, Klein RF 1995 Osteoporosis in men. Endocr Rev 16:87-116
6. Bilezikian JP 1999 Osteoporosis in men. J Clin Endocrinol Metab 84:3431-3434
7. Peacock M, Turner CH, Econs MJ, Foroud T 2002 Genetics of osteoporosis. Endocr Rev 23:303-326
8. Orwoll ES, Belknap JK, Klein RF 2001 Gender specificity in the genetic determinants of peak bone mass. J Bone Miner Res 16:1962-1971
9. Turner CH, Sun Q, Schriefer J, Pitner N, Price R, Bouxsein ML, Rosen CJ, Donahue LR, Shultz KL, Beamer WG 2003 Congenic mice reveal sex-specific genetic regulation of femoral structure and strength. Calcif Tissue Int 73:297-303
10. Duncan EL, Cardon LR, Sinsheimer JS, Wass JA, Brown MA 2003 Site and gender specificity of inheritance of bone mineral density. J Bone Miner Res 18:1531-1538
11. Van Pottelbergh, I, Goemaere S, Zmierczak H, De Bacquer D, Kaufman JM 2003 Deficient acquisition of bone during maturation underlies idiopathic osteoporosis in men: evidence from a three-generation family study. J Bone Miner Res 18:303-311
12. Jones G, Nguyen TV 2000 Associations between maternal peak bone mass and bone mass in prepubertal male and female children. J Bone Miner Res 15: 1998-2004
13. Peacock M, Koller DL, Hui S, Johnston CC, Foroud T, Econs MJ 2004 Peak bone mineral density at the hip is linked to chromosomes 14q and 15q. Osteoporos Int 15:489-496
14. Goring HH, Ott J 1997 Relationship estimation in affected sib pair analysis of late-onset disease. Eur J Hum Genet 5:69-77
15. Boehnke M, Cox NJ 1997 Accurate inference of relationships in sib-pair linkage studies. Am J Hum Genet 61:423-429
16. Almasy L, Blangero J 1998 Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62:1198-1211
17. Sham P 1988 Statistics in human genetics. New York: Oxford University Press
18. Kruglyak L, Lander ES 1995 Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am J Hum Genet 57:439-454
19. Haseman JK, Elston RC 1972 The investigation of linkage between a quantitative trait and a marker locus. Behav Genet 2:3-19
20. Econs MJ, Koller DL, Hui S, Conneally PM, Johnston CC, Peacock M, Foroud T 2004 Confirmation linkage to chromosome 1q for peak vertebral bone mineral density in premenopausal white women. Am J Hum Genet 74:223-228
21. Lander ES, Kruglyak L 1995 Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11:241-247
22. Nguyen TV, Livshits G, Center JR, Yakovenko K, Eisman JA 2003 Genetic determination of bone mineral density: evidence for a major gene. J Clin Endocrinol Metab 88:3614-3620
23. Livshits G, Karaski D, Pavlovsky O, Kobyliansky E 1999 Segregation analysis reveals a major gene effect in compact and cancellous bone mineral density in 2 populations. Hum Biol 71:155-172
24. Kammerer CM, Schneider JL, Cole SA, Hixson JE, Samollow PB, O'Connell JR, Perez R, Dyer TD, Almasy L, Blangero J, Bauer RL, Mitchell BD 2003 Quantitative trait loci on chromosomes 2p, 4p, and 13q influence bone mineral density of the forearm and hip in Mexican Americans. J Bone Miner Res 18:2245-2252
25. Kwitek AE, Tonellato PJ, Chen D, Gullings-Handley J, Cheng YS, Twigger S, Scheetz TE, Casavant TL, Stoll M, Nobrega MA, Shiozawa M, Soares MB, Sheffield VC, Jacob HJ 2001 Automated construction of high-density comparative maps between rat, human, and mouse. Genome Res 11:1935-1943