Dioxin health risk to infants using simulated tissue concentrations

Environmental Toxicology and Pharmacology

Volumn 18, Issue 1, 2004, Pages 21-37

  Maruyama, Wakae ^a   Yoshida, Kikuo ^b   Aoki, Yasunobu ^a  

^a NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES   (Japan)

^b NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

Dioxin; Human; Infant; PBPK model; Risk

Indexed keywords

DIOXIN;

ANALYTIC METHOD; ARTICLE; ARTIFICIAL MILK; BREAST FEEDING; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; GENITAL SYSTEM; HEALTH HAZARD; HUMAN; INFANT; LIVER; LIVER CELL CARCINOMA; LIVER TOXICITY; MATHEMATICAL MODEL; MOLECULAR MODEL; PRIORITY JOURNAL; RISK ASSESSMENT; SIMULATION;

EID: 3843098244     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etap.2004.05.003     Document Type: Article

References (70)

1. Abraham K., Krowke R., Neubert D. Pharmacokinetics and biological activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Arch. Toxicol. 62:1988;359-368
2. Abraham K., Wiesmuller T., Brunner H., Krowke R., Hagenmaier H., Neubert D. Elimination of various polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDDs and PCDFs) in rat faeces. Arch. Toxicol. 63:1989;75-78
3. Abraham K., Hille A., Ende M., Helge H. Intake and fecal excretion of PCDDs, PCDFs, HCB and PCBs (138,153, 180) in a breast-fed and foprmula-fed infant. Chemosphere. 29:1994;2279-2286
4. Abraham K., Papke O., Gross A., Kordonouri O., Wiegand S., Wahn U., Helge H. Time course of PCDD/PCDF/PCB concentrations in breast-feeding mothers and their infants. Chemosphere. 37:1998;1731-1741
5. Andersen M.E., Mills J.J., Gargas M.L., Kedderis L., Birnbaum L.S., Neubert D., Greenlee W.F. Modeling receptor-mediated processes bwith dioxin: implications of pharmacokinetics and risk assessment. Risk Anal. 13:1993;25-36
6. Andersen M.E., Eklund C.R., Mills J.J., Barton H.A., Birnbaum L.S. A multicompartment geometric model of liver in relation to regional induction of cytochrome P450s. Toxicol. Appl. Pharmacol. 144:1997;135-144
7. Andersen M.E., Dennison J.E. Mode of action and tissue dosimetry in current and future risk assessments. Sci. Total Environ. 274:2001;3-14
8. Ayotte P., Carrier G., Dewailly E. Health risk assessment for inuit newborns exposed to dioxin-like compounds through breast feeding. Chemosphere. 32:1996;531-542
9. Beck H., Kleeman W.J., Mather W., Palavinskas R. PCDD and PCDF levels in different organs from infants II. Organohalogen Comp. 21:1994a;259-264
10. Beck H., Dross A., Mathar W. PCDD and PCDF exposure and levels in humans in Germany. Environ. Health Perspect. 102:1994b;173-185
11. Carrier G., Brunet R.C., Brodeur J. Modelings of the toxicokinetics of polychlorinated dibenzo-p-dioxins and dibenzofurans in mammalians, including humans. I. Nonlinear distribution of PCDD/PCDF body burden between liver and adipose tissues. Toxicol. Appl. Pharmacol. 131:1995a;253-266
12. Carrier G., Brunet R.C., Brodeur J. Modelings of the toxicokinetics of polychlorinated dibenzo-p-dioxins and dibenzofurans in mammalians, including humans. II. Kinetics of absorption and disposition of PCDDs/PCDFs. Toxicol. Appl. Pharmacol. 131:1995b;267-276
13. Crump K.S. Calculation of benchmark doses from continuous data. Risk Anal. 15:1995;79-89
14. Dahl P., Lindstrom G., Wiberg K., Rappe C. Absorption of PCBs, PCDDs, and PCDFs by breast-fed infants. Chemosphere. 30:1995;2297-2306
15. Environment Agency. Report of survey on the exposure of dioxins in human (2000). http://www.env.go.jp/press/press.php3?serial=3160 (in Japanese.)
16. Faqi A.S., Dalsenter P.R., Merker H.J., Chahoud I. Reproductive toxicity and tissue concentrations of low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin in male offspring rats exposed throughout pregnancy and lactation. Toxicol. Appl. Pharmacol. 150:1998;383-392
17. Fries G.F., Paustenbach D.J. Evaluation of potential transmission of 2,3,7,8-tetrachlorodibenzo-p-dioxin-contaminated incinerator emissions to humans via foods. J. Toxicol. Environ. Health. 29:1990;1-43
18. Giesy J.P., Jude D.J., Tillit D.E., Gale R.W., Meadows J.C., Zajieck J.L., Peterman P.H., Verbrugge D.A., Sanderson J.T., Schwartz T.R., Tuchman M.L. Polychlorinated dibenzo-p-dioxins, dibenzofurans, biphenylles and 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents in fishes from Saginaw bay Michigan. Environ. Toxicol. Chem. 16:1997;713-724
19. Guo X., Longnecker M.P., Michalek J.E. Relation of serum tetrachlorodibenzo-p-dioxin concentration to diet among veterans in the Air Force Health Study with background-level exposure. J. Toxicol. Environ. Health A. 63:2001;159-172
20. Gray L.E. Jr., Kelce W.R., Monosson E., Ostby J.S., Birnbaum L.S. Exposure to TCDD during development permanently alters reproductive function in male Long Evans rats and hamsters: reduced ejaculated and epididymal sperm numbers and sex accessory gland weights in offspring with normal androgenic status. Toxicol. Appl. Pharmacol. 131:1995;108-118
21. Gray L.E., Ostby J.S., Kelce W.R. A dose-response analysis of the reproductive effects of a single gestational dose of 2,3,7,8- tetrachlorodibenzo- p-dioxin in male Long Evans hooded rat offspring. Toxicol. Appl. Pharmacol. 146:1997;11-20
22. Hoover S.M. Exposure to persistent organochlorines in Canadian breast milk: a probabilistic assessment. Risk Anal. 19:1999;527-545
23. House R.V., Lauer L.D., Murray M.J., Thomas P.T., Ehrlich J.P., Burleson G.R., Dean J.H. Examination of immune parameters and host resistance mechanisms in B6C3F1 mice following adult exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. J. Toxicol. Environ. Health. 31:1990;203-215
24. Hurst C.H., DeVito M.J., Setzer R.W., Birnbaum L.S. Acute administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in pregnant Long Evans rats: association of measured tissue concentrations with developmental effects. Toxicol. Sci. 53:2000;411-420
25. Iida T., Hirakawa H., Matsueda T., Takenaka S., Nagayama J. Polychlorinated dibenzo-p-dioxins and related compounds in breast milk or Japanese primiparas and multiparas. Chemosphere. 38:1999;2461-2466
26. Kirman C.R., Hays S.M., Kedderis G.L., Gargas M.L., Strother D.E. Improving cancer dose-response characterization by using physiologically based pharmacokinetic modelling: an analysis of pooled data for acrylonitrile-induced brain tumors to assess cancer potency in the rat. Risk Anal. 20:2000;135-151
27. Kitamura K., Sunaga M., Watanabe S., Yamada T., Hata J. Concentration of polychlorinated dibenzo-p-dioxins and their related compounds in the human bile in relation to those in the liver and blood. Organohalogen Comp. 44:1999;165-168
28. Kissel J.C., Robarge G.M. Assessing the elimination of 2,3,7,8-TCDD from humans with a physiologically based pharmacokinetic model. Chemosphere. 17:1988;2017-2027
29. Kociba R.J., Keyes D.G., Beyer J.E., Carreon R.M., Wade C.E., Dittenber D.A., Kalnins R.P., Frauson L.E., Park C.N., Barnard S.D., Hummel R.R.A., Humiston C.G. Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats. Toxicol. Appl. Pharmacol. 46:1978;279-303
30. Kohn M.C., Lucier G.W., Clark G.C., Sewall C., Trischer A.M., Portier C.J. A mechanistic model of effects of dioxin on gene expression in the rat liver. Toxicol. Appl. Pharmacol. 120:1993;138-154
31. Korner W., Dawidowsky N., Hagenmaier H. Fecal excretion of PCDDs and PCDFs in two breast-fed infants. Chemosphere. 27:1993;157-162
32. Kreuzer P.E., Csanady G.A., Baur C., Kessler W., Papke O., Greim H., Filser J.G. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and congeners in infants. A toxicokinetic model of human lifetime body burden by TCDD with special emphasis on its uptake by nutrition. Arch. Toxicol. 71:1997;383-400
33. Lakind J.S., Berlin C.M., Park C.N., Naiman D.Q., Gudka N.J. Methodology for chalacterizing distributions of incremental body burdens of 2,3,7,8-TCDD and DDE from breast milk in North American nursing infants. J. Toxicol. Environ. Health A. 59:2000;605-639
34. LaKind J.S., Berlin C.M., Naiman D.Q. Infant Exposure to Chemicals in Breast Milk in the United States: what we need to learn From a breast milk monitoring program. Environ. Health. Perspect. 109:2001;75-88
35. Lawrence G.S., Gobas F.A.P.C. A pharmacokinetic analysis of interspecies extrapolation in dioxin risk assessment. Chemosphere. 35:1997;427-452
36. Leung H.W., Ku R.H., Paustenbach D.J., Andersen M.E. A physiologically based pharmacokinetic model for 2,3,7,8- tetrachlorodibenzo-p-dioxin in C57BL/6J and DBA/2J mice. Toxicol. Lett. 42:1988;15-28
37. Leung H.W., Paustenbach D.J., Andersen M.E. A physiologically based pharmacokinetic model for 2,3,7,8-tetrachlorodibenzodioxin. Chemosphere. 18:1989;659-664
38. Liem, A.K.D, Theelen, R.M.C., 1997. Dioxins: chemical analysis, exposure and risk assessment. Ph.D. Dissertation, National Institute of Public Health and the Environment, P.O.Box 3720 BA, Bilthoven, The Netherlands.
39. Luebke R.W., Copeland C.B., Diliberto J.J., Akubue P.I., Andrews D.L., Riddle M.M., Williams W.C., Birnbaum L.S. Assessment of host resistance to Trichinella spiralis in mice following preinfection exposure to 2,3,7,8-TCDD. Toxicol. Appl. Pharmacol. 125:1994;7-16
40. Maruyama W., Yoshida K., Tanaka T., Nakanishi J. Possible range of dioxin concentration in human tissues: simulation with a physiological based model. J. Toxicol. Environ. Health A. 65:2002;2053-2073
41. Maruyama W., Yoshida K., Tanaka T., Nakanishi J. Simulation of dioxin accumulation in human tissues and analysis of reproductive risk. Chemosphere. 53:2003;301-313
42. McLachlan M. Digestive tract absorption of PCDDs, PCDFs, and PCBs in a nursing infant. Toxicol. Appl. Pharmacol. 123:1993;68-72
43. McClelland D.B., McGrath J., Samson R.R. Antimicrobial factors in human milk. Studies of concentration and transfer to the infant during the early stages of lactation. Acta Paediatr. Scand. Suppl. 271:1978;1-20
44. National Nutrition Survey, Japan (J-NNS) 1998. http://www1.mhlw.go.jp/ toukei/k-eiyou_11/t0225-1.html.
45. Nagayama J., Okamura K., Iida T., Hirakawa H., Matsueda T., Tsuji H., Hasegawa M., Sato K., Ma H.Y., Yanagawa T., Igarashi H., Fukushige J., Watanabe T. Postnatal exposure to chlorinated dioxins and related chemicals on thyroid hormone status in Japanese breast-fed infants. Clearance of PCDD/Fs via gastrointestinal tract in occupationally exposed persons. Chemosphere. 37:1998;1789-1793
46. Neal R.A., Olson J.R., Gasiewicz T.A., Geiger L.E. The toxicokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in mammalian systems. Drug. Metab. Rev. 13:1982;355-385
47. Ogawa, Y., Tada, H., Nakamura, H., Nishida, H., 2000. New Neonatal Study, second ed. Medicus Shuppan, Osaka, pp. 233-234. (In Japanese).
48. Ohsako S., Miyabara Y., Nishimura N., Kurosawa S., Sakaue M., Ishimura R., Sato M., Takeda K., Aoki Y., Sone H., Tohyama C., Yonemoto J. Maternal exposure to a low dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) suppressed the development of reproductive organs of male rats: dose-dependent increase of mRNA levels of 5a-reductase type 2 in contrast to decrease of androgen receptor in the pubertal ventral prostate. Toxicol. Sci. 60:2001;132-143
49. Patandin S., Dagnelie P.C., Mulder P.G., Op de Coul E., van der Veen J.E., Weisglas-Kuperus N., Sauer P.J. Dietary exposure to polychlorinated biphenyls and dioxins from infancy until adulthood: a comparison between breast-feeding, toddler, and long-term exposure. Environ. Health Perspect. 107:1999;45-51
50. Paustenbach D.J. The practice of exposure assessment: a state-of-the-art review. J. Toxicol. Environ Health B Crit. Rev. 3:2000;179-291
51. Pitot H.C., Campbell H.A., Poland A. Quantitative evaluation of the promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin of hepatocarcinogenesis from diethylnitrosoamine. Cancer Res. 40:1980;3616-3620
52. Pluim H.J., Koppe J.G., Olie K., van der Slikke J.W., Slot P.C., van Boxtel C.J. Clinical laboratory manifestations of exposure to background levels of dioxins in the perinatal period. Acta Paediatr. 83:1994;583-587
53. Portier C.J., Sherman C.D., Kohn M., Edler L., Kopp-Schneider A., Maronpot R.M., Lucier G. Modeling the number and size of hepatic focal lesions following exposure to 2,3,7,8-TCDD. Toxicol. Appl. Pharmacol. 138:1996;20-30
54. Rohde S., Moser A., Papke O., McLachlan M.S. Chemosphere. 38:1999;3397-3410
55. Rogan W.J., Blanton P.J., Portier C.J., Stallard E. Should the presence of carcinogens in breast milk discourage breast feeding? Regul. Toxicol. Pharmacol. 13:1991;228-240
56. Sato, M., Araga, N., Suzuki, J., Hattori, R., Yagihashi, M., 1999. Child Health: Its Theory and Practice, fifth ed. Jusonbo Press, Tokyo, pp. 92-94. (In Japanese).
57. Schecter A.J., Papke O., Lis A., Olson J.R. Chlorinated dioxin, dibenzofuran and PCB levels in human fetal tissue at 8-18 weeks gestational age, compared with placental, newborn and adult tissue level. Organohalogen Comp. 25:1995;167-171
58. Schecter A., Ryan J.J., Papke O. Decrease in levels and body burden of dioxins, dibenzofurans, PCBs, DDE, and HCB in blood and milk in a mother nursing twins over a thirty-eight month period. Chemosphere. 37:1998;1807-1816
59. Schrey P., Wittsiepe J., Mackrodt P., Selenka F. Human fecal PCDD/F-excretion exceeds the dietary intake. Chemosphere. 37:1998;1825-1831
60. Snyder, W.S., Cook, M.J., Nasset, E.S., Karhausen, L.R., Howell, G.P., Tipton, I.H., 1974. Report of the task group on reference man. ICRP publication 23. The International Commission on Radiological Protection (ICRP). Pergamon, Elsevier Science, U.K., pp. 8-234.
61. Tada H., Oda S., Kitajima T., Morita M., Nakamura K. Intake of PCDDs, PCDFs and CoPCBs in breast fed infants of Japan. Organohalogen Comp. 44:1999;271-273
62. Teeguarden J.G., Dragan Y.P., Singh J., Vaughan J., Xu Y.H., Goldsworthy T., Pitot H.C. Quantitative analysis of dose- and time-dependent promotion of four phenotypes of altered hepatic foci by 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Sprague-Dawley rats. Toxicol. Sci. 51:1999;211-223
63. Toyoda, M., Iida, T., Uchibe, H., Yanagi, T., Kono, Y., Hori, T., 1999. Total diet study report of daily intake of dioxins from food materials. Ministry of Health and Welfare of Japan. (In Japanese).
64. Tritscher A.M., Goldstein J.A., Portier C.J., McCoy Z., Clark G.C., Lucier G.W. Dose-response relationships for chronic exposure to 2,3,7,8- tetrachlorodibenzo- p-dioxin in a rat tumor promotion model - quantification and immunolocalization of CYP1A1 and CYP1A2 in the liver. Cancer Res. 52:1992;3436-3442
65. US Environmental Protection Agency (US EPA). 2000. Exposure and human health reassessment of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds. Part III: Integrated summary and risk characterization for 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds. EPA/600/P-00/001Bg.
66. US Environmental Protection Agency (US EPA). 2001. Dioxin reassessment - an SAB review of the office of research and development's reassessment of dioxin. Review of the revised sections (dose response modeling, integrated summary, risk characterization, and toxicity equivalency factors) of the EPA's reassessment of dioxin by the dioxin reassessment review subcommittee of the EPA science advisory board (SAB). EPA-SAB-EC-01-006
67. Van den Berg M., Birnbaum L., Bosveld A.T.C., Brunstrom B., Cook P., Feeley M., Giesy J.P., Hanberg A., Hasegawa R., Kennedy S.W., Kubiak T., Larsen J.C., Rolaf van Leeuwen F.X., Liem A.K.D., Nolt C., Peterson R.E., Poellinger L., Safe S., Schrenk D., Tillitt D., Tysklind M., Younes M., Waern F., Zacharewski T. Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. Environ. Health Perspect. 106:1998;775-792
68. Yang Y.G., Lebrec H., Burleson G.R. Effect of 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) on pulmonary influenza virus titer and natural killer (NK) activity in rats. Fundam. Appl. Toxicol. 23:1994;125-131
69. Wang X., Santostefano M.J., Evans M.V., Richardson V.M., Diliberto J.J., Birnbaum L.S. Determination of parameters responsible for pharmacokinetic behavior of TCDD in female Sprague-Dawley ratrs. Toxicol. Appl. Pharmacol. 147:1997;151-168
70. Weisglas-Kuperus N., Patandin S., Berbers G.A., Sas T.C., Mulder P.G., Sauer P.J., Hooijkaas H. Immunologic effects of background exposure to polychlorinated biphenyls and dioxins in Dutch preschool children. Environ. Health Perspect. 108:2000;1203-1207