Maternal exposure to a low dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) suppressed the development of reproductive organs of male rats: Dose-dependent increase of mRNA levels of 5α-reductase type 2 in contrast to decrease of androgen receptor in the pubertal ventral prostate

Toxicological Sciences

Volumn 60, Issue 1, 2001, Pages 132-143

  Ohsako, Seiichiroh ^a,b   Miyabara, Yuichi ^a,b   Nishimura, Noriko ^a,b   Kurosawa, Shuichi ^c   Sakaue, Motoharu ^a   Ishimura, Ryuta ^a,b   Sato, Mikio ^a   Takeda, Ken ^c   Aoki, Yasunobu ^a,b   Sone, Hideko ^a,b   Tohyama, Chiharu ^a,b   Yonemoto, Junzo ^a,b  

^a NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

5 alpha reductase; Androgen receptor; Male reproduction; TCDD; Ventral prostate

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ANDROGEN; ANDROGEN RECEPTOR; LUTEINIZING HORMONE; MESSENGER RNA; STEROID 5ALPHA REDUCTASE; TESTOSTERONE;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONCENTRATION RESPONSE; CONTROLLED STUDY; EPIDIDYMIS; FEMALE; GAS CHROMATOGRAPHY; GENITAL SYSTEM; GESTATIONAL AGE; HEALTH HAZARD; LUTEINIZING HORMONE BLOOD LEVEL; MALE; MALE GENITAL SYSTEM; MASS SPECTROMETRY; NONHUMAN; ORGANOGENESIS; PERINATAL PERIOD; PREGNANCY; PRENATAL EXPOSURE; PROGENY; PROSTATE; PUBERTY; RAT; RAT STRAIN; RELIABILITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; SPERMATOGENESIS; TESTIS DEVELOPMENT; TESTIS WEIGHT; TESTOSTERONE BLOOD LEVEL; TOXICITY; UROGENITAL SYSTEM;

ADIPOSE TISSUE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENVIRONMENTAL POLLUTANTS; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; MALE; MATERNAL EXPOSURE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PROSTATE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ANDROGEN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEXUAL MATURATION; SPERM COUNT; TESTIS; TESTOSTERONE 5-ALPHA-REDUCTASE; TETRACHLORODIBENZODIOXIN; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 17744400089     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/60.1.132     Document Type: Article

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