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Volumn 18, Issue 4, 2004, Pages 235-268

The role of recombinant hirudins in the management of thrombotic disorders

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; ANTICOAGULANT AGENT; ARGATROBAN; CHROMOGENIC SUBSTRATE; DANAPAROID; DESULFATOHIRUDIN; ECARIN; HEPARIN; HIRUDIN ANTIBODY; HIRULOG; LEPIRUDIN; LOW MOLECULAR WEIGHT HEPARIN; RECOMBINANT HIRUDIN; THROMBIN INHIBITOR; UNCLASSIFIED DRUG;

EID: 3843090636     PISSN: 11738804     EISSN: None     Source Type: Journal    
DOI: 10.2165/00063030-200418040-00003     Document Type: Review
Times cited : (19)

References (137)
  • 1
    • 34447609147 scopus 로고
    • Über die Einwirkung eines Sekretes des officinellen Blutegels auf die Gerinnbarkeit des Bluts
    • Haycraft JB. Über die Einwirkung eines Sekretes des officinellen Blutegels auf die Gerinnbarkeit des Bluts. Naunyn Schmiedeberg's Arch Exp Pathol Pharmakol 1884; 18: 209-17
    • (1884) Naunyn Schmiedeberg's Arch Exp Pathol Pharmakol , vol.18 , pp. 209-217
    • Haycraft, J.B.1
  • 2
    • 0036800881 scopus 로고    scopus 로고
    • Pharmacology of recombinant hirudin
    • Nowak G. Pharmacology of recombinant hirudin. Semin Thromb Hemost 2002; 28: 415-24
    • (2002) Semin Thromb Hemost , vol.28 , pp. 415-424
    • Nowak, G.1
  • 3
    • 0031685806 scopus 로고    scopus 로고
    • Lepirudin: A review of its potential place in the management of thrombotic disorders
    • Adkins JC, Wilde MI. Lepirudin: a review of its potential place in the management of thrombotic disorders. Biodrugs 1998; 10: 227-55
    • (1998) Biodrugs , vol.10 , pp. 227-255
    • Adkins, J.C.1    Wilde, M.I.2
  • 4
    • 0033769928 scopus 로고    scopus 로고
    • Desirudin: A review of its use in the management of thrombotic disorders
    • Matheson AJ, Goa KL. Desirudin: a review of its use in the management of thrombotic disorders. Drugs 2000; 60: 679-700
    • (2000) Drugs , vol.60 , pp. 679-700
    • Matheson, A.J.1    Goa, K.L.2
  • 5
    • 0011094998 scopus 로고    scopus 로고
    • Pharmakologie der Hirudine und Hirudin-Derivate
    • Greinacher A, editor. Bremen: Uni-Med
    • Nowak G. Pharmakologie der Hirudine und Hirudin-Derivate [in German]. In: Greinacher A, editor. Hirudin in der vaskulären Medizin. Bremen: Uni-Med, 2001: 20-7
    • (2001) Hirudin in der Vaskulären Medizin , pp. 20-27
    • Nowak, G.1
  • 6
    • 0025817404 scopus 로고
    • Past, present and future of hirudin
    • Markwardt F. Past, present and future of hirudin. Haemostasis 1991; 21: 11-26
    • (1991) Haemostasis , vol.21 , pp. 11-26
    • Markwardt, F.1
  • 7
    • 0003929654 scopus 로고    scopus 로고
    • New Jersey, USA: Hoechst Marion Roussel
    • Hoechst Marion Roussel. Refludan-lepirudin: scientific monograph. New Jersey, USA: Hoechst Marion Roussel, 1997
    • (1997) Refludan-lepirudin: Scientific Monograph
  • 8
    • 0034921205 scopus 로고    scopus 로고
    • Protease-activated receptors in vascular biology
    • Coughlin SR. Protease-activated receptors in vascular biology. Thromb Haemost 2001; 86: 298-307
    • (2001) Thromb Haemost , vol.86 , pp. 298-307
    • Coughlin, S.R.1
  • 9
    • 0036262319 scopus 로고    scopus 로고
    • International Union of Pharmacology. XXVIII. Proteinase-activated receptors
    • Hollenberg MD, Compton SJ. International Union of Pharmacology. XXVIII. Proteinase-activated receptors. Pharmacol Rev 2002; 54: 203-17
    • (2002) Pharmacol Rev , vol.54 , pp. 203-217
    • Hollenberg, M.D.1    Compton, S.J.2
  • 10
    • 0000885094 scopus 로고    scopus 로고
    • Recombinant hirudin for the treatment of heparin-induced thrombocytopenia
    • Warkentin TE, Greinacher A, editors. New York: Dekker
    • Greinacher A. Recombinant hirudin for the treatment of heparin-induced thrombocytopenia. In: Warkentin TE, Greinacher A, editors. Heparin-induced thrombocytopenia. New York: Dekker, 2001: 349-80
    • (2001) Heparin-induced Thrombocytopenia , pp. 349-380
    • Greinacher, A.1
  • 11
    • 0022521744 scopus 로고
    • Kinetics of the inhibition of thrombin by hirudin
    • Stone SR, Hofsteenge J. Kinetics of the inhibition of thrombin by hirudin. Biochemistry 1986; 25: 4622-8
    • (1986) Biochemistry , vol.25 , pp. 4622-4628
    • Stone, S.R.1    Hofsteenge, J.2
  • 12
    • 0025146426 scopus 로고
    • Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors
    • Weitz JI, Hudoba M, Massel D, et al. Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors. J Clin Invest 1990; 86: 385-91
    • (1990) J Clin Invest , vol.86 , pp. 385-391
    • Weitz, J.I.1    Hudoba, M.2    Massel, D.3
  • 13
    • 12644267274 scopus 로고    scopus 로고
    • Effect of renal impairment on the pharmacokinetics and pharmacodynamics of desirudin
    • Levèvre G, Duval M, Gauron S, et al. Effect of renal impairment on the pharmacokinetics and pharmacodynamics of desirudin. Clin Pharmacol Ther 1997; 62: 50-9
    • (1997) Clin Pharmacol Ther , vol.62 , pp. 50-59
    • Levèvre, G.1    Duval, M.2    Gauron, S.3
  • 14
    • 0030932656 scopus 로고    scopus 로고
    • Pharmacokinetics of recombinant hirudin in hemodialyzed end-stage renal failure patients
    • Vanholder RC, Camez A, Veys N, et al. Pharmacokinetics of recombinant hirudin in hemodialyzed end-stage renal failure patients. Thromb Haemost 1997; 77: 650-5
    • (1997) Thromb Haemost , vol.77 , pp. 650-655
    • Vanholder, R.C.1    Camez, A.2    Veys, N.3
  • 15
    • 0025087055 scopus 로고
    • The pharmacology of recombinant hirudin, a new anticoagulant
    • Meyer BH, Luus HG, Müller FO, et al. The pharmacology of recombinant hirudin, a new anticoagulant. S Afr Med J 1990; 78: 268-70
    • (1990) S Afr Med J , vol.78 , pp. 268-270
    • Meyer, B.H.1    Luus, H.G.2    Müller, F.O.3
  • 16
    • 0036800833 scopus 로고    scopus 로고
    • Hirudin in renal insufficiency
    • Fischer KG. Hirudin in renal insufficiency. Semin Thromb Hemost 2002; 28: 467-82
    • (2002) Semin Thromb Hemost , vol.28 , pp. 467-482
    • Fischer, K.G.1
  • 17
    • 0033015812 scopus 로고    scopus 로고
    • R-hirudin as anticoagulant in regular hemodialysis therapy: Finding of therapeutic r-hirudin blood/plasma concentrations and respective dosages
    • Bucha E, Nowak G, Czerwinski R, et al. R-hirudin as anticoagulant in regular hemodialysis therapy: finding of therapeutic r-hirudin blood/plasma concentrations and respective dosages. Clin Appl Thromb Hemost 1999; 5: 164-70
    • (1999) Clin Appl Thromb Hemost , vol.5 , pp. 164-170
    • Bucha, E.1    Nowak, G.2    Czerwinski, R.3
  • 18
    • 0028365454 scopus 로고
    • Recombinant hirudin: A specific thrombin inhibiting anticoagulant for hemodialysis
    • Vanholder RC, Camez AA, Veys NM, et al. Recombinant hirudin: a specific thrombin inhibiting anticoagulant for hemodialysis. Kidney Int 1994; 45: 1754-9
    • (1994) Kidney Int , vol.45 , pp. 1754-1759
    • Vanholder, R.C.1    Camez, A.A.2    Veys, N.M.3
  • 19
    • 0029165489 scopus 로고
    • A comparison between the use of recombinant hirudin and heparin during hemodialysis
    • Van Wyk V, Badenhorst PN. Luus HG, et al. A comparison between the use of recombinant hirudin and heparin during hemodialysis. Kidney Int 1995; 48: 1338-43
    • (1995) Kidney Int , vol.48 , pp. 1338-1343
    • Van Wyk, V.1    Badenhorst, P.N.2    Luus, H.G.3
  • 20
    • 0026773307 scopus 로고
    • Pharmacology of r-hirudin in renal impairment
    • Nowak G, Bucha E, Gööck TH, et al. Pharmacology of r-hirudin in renal impairment. Thromb Res 1992; 66: 707-15
    • (1992) Thromb Res , vol.66 , pp. 707-715
    • Nowak, G.1    Bucha, E.2    Gööck, T.H.3
  • 21
    • 0027765635 scopus 로고
    • Catabolism of hirudin and thrombin-hirudin complexes in the rat
    • Bichler J, Baynes JW, Thorpe SR. Catabolism of hirudin and thrombin-hirudin complexes in the rat. Biochem J 1993; 296: 771-6
    • (1993) Biochem J , vol.296 , pp. 771-776
    • Bichler, J.1    Baynes, J.W.2    Thorpe, S.R.3
  • 22
    • 0036800879 scopus 로고    scopus 로고
    • Methods for the monitoring of direct thrombin inhibitors
    • Hafner G, Roser M, Nauck M. Methods for the monitoring of direct thrombin inhibitors. Semin Thromb Hemost 2002; 28: 425-30
    • (2002) Semin Thromb Hemost , vol.28 , pp. 425-430
    • Hafner, G.1    Roser, M.2    Nauck, M.3
  • 23
    • 0028092111 scopus 로고
    • Hirudin in acute myocardial infarction: Safety report from the Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9A Trial
    • Antman EM. Hirudin in acute myocardial infarction: safety report from the Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9A Trial. Circulation 1994; 90: 1624-30
    • (1994) Circulation , vol.90 , pp. 1624-1630
    • Antman, E.M.1
  • 24
    • 0028037517 scopus 로고
    • Randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes
    • The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) IIa Investigators. Randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes. Circulation 1994; 90: 1631-7
    • (1994) Circulation , vol.90 , pp. 1631-1637
  • 25
    • 0028117846 scopus 로고
    • Safety observations from the pilot phase of the randomized r-Hirudin for Improvement of Thrombolysis (HIT-III) study: A study of the Arbeitsgemeinschaft Leitender Kardiologischer Krankenhausärzte (ALKK)
    • Neuhaus KL, Von Essen R, Tebbe U, et al. Safety observations from the pilot phase of the randomized r-Hirudin for Improvement of Thrombolysis (HIT-III) study: a study of the Arbeitsgemeinschaft Leitender Kardiologischer Krankenhausärzte (ALKK). Circulation 1994; 90: 1638-42
    • (1994) Circulation , vol.90 , pp. 1638-1642
    • Neuhaus, K.L.1    Von Essen, R.2    Tebbe, U.3
  • 26
    • 0029999678 scopus 로고    scopus 로고
    • Quantitative determination of hirudin in blood and body fluids
    • Nowak G, Bucha E. Quantitative determination of hirudin in blood and body fluids. Semin Thromb Hemost 1996; 22: 197-202
    • (1996) Semin Thromb Hemost , vol.22 , pp. 197-202
    • Nowak, G.1    Bucha, E.2
  • 27
    • 0027258015 scopus 로고
    • Effects of hirudin on activated partial thromboplastin time determined with ten different reagents
    • Tripodi A, Chantarangkul V, Arbini AA, et al. Effects of hirudin on activated partial thromboplastin time determined with ten different reagents. Thromb Haemost 1993; 70: 286-8
    • (1993) Thromb Haemost , vol.70 , pp. 286-288
    • Tripodi, A.1    Chantarangkul, V.2    Arbini, A.A.3
  • 28
    • 0027949358 scopus 로고
    • Monitoring anticoagulant therapy by activated partial thromboplastin time: Hirudin assessment
    • Nurmohamed MT, Berckmans RJ, Morriën-Salomons WM, et al. Monitoring anticoagulant therapy by activated partial thromboplastin time: hirudin assessment. Thromb Haemost 1994; 72: 685-92
    • (1994) Thromb Haemost , vol.72 , pp. 685-692
    • Nurmohamed, M.T.1    Berckmans, R.J.2    Morriën-Salomons, W.M.3
  • 29
    • 0034782040 scopus 로고    scopus 로고
    • Clinical monitoring of hirudin and direct thrombin inhibitors
    • Nowak G. Clinical monitoring of hirudin and direct thrombin inhibitors. Semin Thromb Hemost 2001; 27: 537-42
    • (2001) Semin Thromb Hemost , vol.27 , pp. 537-542
    • Nowak, G.1
  • 30
    • 9544240341 scopus 로고    scopus 로고
    • Recombinant hirudin as a periprocedural antithrombotic in coronary angioplasty for unstable angina pectoris
    • Hafner G, Rupprecht HJ, Luz M, et al. Recombinant hirudin as a periprocedural antithrombotic in coronary angioplasty for unstable angina pectoris. Eur Heart J 1996; 17: 1207-15
    • (1996) Eur Heart J , vol.17 , pp. 1207-1215
    • Hafner, G.1    Rupprecht, H.J.2    Luz, M.3
  • 31
    • 0034254793 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia with thromboembolic complications: Meta-analysis of 2 prospective trials to assess the value of parenteral treatment with lepirudin and its therapeutic aPTT range
    • Greinacher A, Eichler P, Lubenow N, et al. Heparin-induced thrombocytopenia with thromboembolic complications: meta-analysis of 2 prospective trials to assess the value of parenteral treatment with lepirudin and its therapeutic aPTT range. Blood 2000; 96: 846-51
    • (2000) Blood , vol.96 , pp. 846-851
    • Greinacher, A.1    Eichler, P.2    Lubenow, N.3
  • 32
    • 0343376125 scopus 로고    scopus 로고
    • Monitoring of recombinant hirudin: Assessment of a plasma-based ecarin clotting time assay
    • Pötzsch B, Hund S, Madlener K, et al. Monitoring of recombinant hirudin: assessment of a plasma-based ecarin clotting time assay. Thromb Res 1997; 86: 373-83
    • (1997) Thromb Res , vol.86 , pp. 373-383
    • Pötzsch, B.1    Hund, S.2    Madlener, K.3
  • 33
    • 0034306569 scopus 로고    scopus 로고
    • Hirudin determination in plasma can be strongly influenced by the prothrombin level
    • Lindhoff-Last E, Piechottka GP, Rabe F, et al. Hirudin determination in plasma can be strongly influenced by the prothrombin level. Thromb Res 2000; 100: 55-60
    • (2000) Thromb Res , vol.100 , pp. 55-60
    • Lindhoff-Last, E.1    Piechottka, G.P.2    Rabe, F.3
  • 34
    • 0029788104 scopus 로고    scopus 로고
    • Hirudin in acute myocardial infarction: Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9B trial
    • Antman EM. Hirudin in acute myocardial infarction: Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9B trial. Circulation 1996; 94: 911-21
    • (1996) Circulation , vol.94 , pp. 911-921
    • Antman, E.M.1
  • 35
    • 0029835392 scopus 로고    scopus 로고
    • A comparison of recombinant hirudin with heparin for the treatment of acute coronary syndromes
    • The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) IIb Investigators. A comparison of recombinant hirudin with heparin for the treatment of acute coronary syndromes. N Engl J Med 1996; 335: 775-82
    • (1996) N Engl J Med , vol.335 , pp. 775-782
  • 36
    • 0002353110 scopus 로고    scopus 로고
    • Clinical picture of heparin-induced thrombocytopenia
    • Warkentin TE, Greinacher A, editors. New York: Dekker
    • Warkentin TE. Clinical picture of heparin-induced thrombocytopenia. In: Warkentin TE, Greinacher A, editors. Heparin-induced thrombocytopenia. New York: Dekker, 2001: 43-86
    • (2001) Heparin-induced Thrombocytopenia , pp. 43-86
    • Warkentin, T.E.1
  • 37
    • 0033961010 scopus 로고    scopus 로고
    • Hirudin as anticoagulant for cardiopulmonary bypass: Importance of preoperative renal function
    • Koster A, Pasic M, Bauer M, et al. Hirudin as anticoagulant for cardiopulmonary bypass: importance of preoperative renal function. Ann Thorac Surg 2000; 69: 37-41
    • (2000) Ann Thorac Surg , vol.69 , pp. 37-41
    • Koster, A.1    Pasic, M.2    Bauer, M.3
  • 38
    • 0032748071 scopus 로고    scopus 로고
    • Recombinant hirudin (lepirudin) as anticoagulant in intensive care patients treated with continuous hemodialysis
    • Fischer KG, van de Loo A, Böhler J. Recombinant hirudin (lepirudin) as anticoagulant in intensive care patients treated with continuous hemodialysis. Kidney Int 1999; 56 Suppl. 72: S46-50
    • (1999) Kidney Int , vol.56 , Issue.72 SUPPL.
    • Fischer, K.G.1    Van De Loo, A.2    Böhler, J.3
  • 39
    • 0032707502 scopus 로고    scopus 로고
    • Bleeding after intermittent or continuous r-hirudin during CVVH
    • Kern H, Ziemer S, Kox WJ. Bleeding after intermittent or continuous r-hirudin during CVVH. Intensive Care Med 1999; 25: 1311-4
    • (1999) Intensive Care Med , vol.25 , pp. 1311-1314
    • Kern, H.1    Ziemer, S.2    Kox, W.J.3
  • 40
    • 0032989167 scopus 로고    scopus 로고
    • Treatment of hirudin overdosage in a patient with chronic renal failure
    • Bauersachs RM, Lindhoff-Last E, Ehrly AM, et al. Treatment of hirudin overdosage in a patient with chronic renal failure. Thromb Haemost 1999; 81: 323-4
    • (1999) Thromb Haemost , vol.81 , pp. 323-324
    • Bauersachs, R.M.1    Lindhoff-Last, E.2    Ehrly, A.M.3
  • 41
    • 0011148724 scopus 로고    scopus 로고
    • Treatment of hirudin overdose with hemofiltration
    • Fischer KG, Weiner SM, Benz K, et al. Treatment of hirudin overdose with hemofiltration. Blood Purif 2000; 18: 80-1
    • (2000) Blood Purif , vol.18 , pp. 80-81
    • Fischer, K.G.1    Weiner, S.M.2    Benz, K.3
  • 42
    • 0027361488 scopus 로고
    • Recombinant hirudin in patients with chronic, stable coronary artery disease: Safety, half-life, and effect on coagulation parameters
    • Zoldhelyi P, Webster MW, Fuster V, et al. Recombinant hirudin in patients with chronic, stable coronary artery disease: safety, half-life, and effect on coagulation parameters. Circulation 1993; 88: 2015-22
    • (1993) Circulation , vol.88 , pp. 2015-2022
    • Zoldhelyi, P.1    Webster, M.W.2    Fuster, V.3
  • 43
    • 0027496925 scopus 로고
    • Safety and efficacy of recombinant hirudin (CGP 39 393) versus heparin in patients with stable angina undergoing coronary angioplasty
    • Van den Bos AA, Deckers JW, Heyndrickx GR, et al. Safety and efficacy of recombinant hirudin (CGP 39 393) versus heparin in patients with stable angina undergoing coronary angioplasty. Circulation 1993; 88: 2058-66
    • (1993) Circulation , vol.88 , pp. 2058-2066
    • Van Den Bos, A.A.1    Deckers, J.W.2    Heyndrickx, G.R.3
  • 44
    • 0028346249 scopus 로고
    • Recombinant hirudin for unstable angina pectoris: A multicenter randomized angiographic trial
    • Topol EJ, Fuster V, Harrington RA, et al. Recombinant hirudin for unstable angina pectoris: a multicenter randomized angiographic trial. Circulation 1994; 89: 1557-66
    • (1994) Circulation , vol.89 , pp. 1557-1566
    • Topol, E.J.1    Fuster, V.2    Harrington, R.A.3
  • 45
    • 0029782577 scopus 로고    scopus 로고
    • Clinical trials of recombinant hirudin in acute coronary syndromes
    • Challapalli R, Lefkovits J, Topol EJ. Clinical trials of recombinant hirudin in acute coronary syndromes. Coron Artery Dis 1996; 7: 429-37
    • (1996) Coron Artery Dis , vol.7 , pp. 429-437
    • Challapalli, R.1    Lefkovits, J.2    Topol, E.J.3
  • 46
    • 0030916929 scopus 로고    scopus 로고
    • Subcutaneous recombinant hirudin (HBW 023) versus intravenous sodium heparin in treatment of established acute deep vein thrombosis of the legs: A multicentre prospective dose-ranging randomized trial
    • Schiele F, Lindgaerde F, Eriksson H, et al. Subcutaneous recombinant hirudin (HBW 023) versus intravenous sodium heparin in treatment of established acute deep vein thrombosis of the legs: a multicentre prospective dose-ranging randomized trial. Thromb Haemost 1997; 77: 834-8
    • (1997) Thromb Haemost , vol.77 , pp. 834-838
    • Schiele, F.1    Lindgaerde, F.2    Eriksson, H.3
  • 47
    • 0029915374 scopus 로고    scopus 로고
    • Prevention of deep-vein thrombosis after total hip replacement: Direct thrombin inhibition with recombinant hirudin, CGP 39393
    • Eriksson BI, Ekman S, Kälebo P, et al. Prevention of deep-vein thrombosis after total hip replacement: direct thrombin inhibition with recombinant hirudin, CGP 39393. Lancet 1996; 347: 635-9
    • (1996) Lancet , vol.347 , pp. 635-639
    • Eriksson, B.I.1    Ekman, S.2    Kälebo, P.3
  • 48
    • 0033527370 scopus 로고    scopus 로고
    • Generation of anti-hirudin antibodies in heparin-induced thrombocytopenic patients treated with r-hirudin
    • Song X, Huhle G, Wang L, et al. Generation of anti-hirudin antibodies in heparin-induced thrombocytopenic patients treated with r-hirudin. Circulation 1999; 100: 1528-32
    • (1999) Circulation , vol.100 , pp. 1528-1532
    • Song, X.1    Huhle, G.2    Wang, L.3
  • 49
    • 0032866224 scopus 로고    scopus 로고
    • Immunologic response to recombinant hirudin in HIT type II patients during long-term treatment
    • Huhle G, Hoffmann U, Song X, et al. Immunologic response to recombinant hirudin in HIT type II patients during long-term treatment. Br J Haematol 1999; 106: 195-201
    • (1999) Br J Haematol , vol.106 , pp. 195-201
    • Huhle, G.1    Hoffmann, U.2    Song, X.3
  • 50
    • 0034307370 scopus 로고    scopus 로고
    • Antihirudin antibodies in patients with heparin-induced thrombocytopenia treated with lepirudin: Incidence, effects on aPTT, and clinical relevance
    • Eichler P, Friesen HJ, Lubenow N, et al. Antihirudin antibodies in patients with heparin-induced thrombocytopenia treated with lepirudin: incidence, effects on aPTT, and clinical relevance. Blood 2000; 96: 2373-8
    • (2000) Blood , vol.96 , pp. 2373-2378
    • Eichler, P.1    Friesen, H.J.2    Lubenow, N.3
  • 51
    • 0345369740 scopus 로고    scopus 로고
    • Recombinant hirudin (lepirudin) provides safe and effective anticoagulation in patients with heparin-induced thrombocytopenia: A prospective study
    • Greinacher A, Völpel H, Janssens U, et al. Recombinant hirudin (lepirudin) provides safe and effective anticoagulation in patients with heparin-induced thrombocytopenia: a prospective study. Circulation 1999; 99: 73-80
    • (1999) Circulation , vol.99 , pp. 73-80
    • Greinacher, A.1    Völpel, H.2    Janssens, U.3
  • 52
    • 0033543081 scopus 로고    scopus 로고
    • Lepirudin (recombinant hirudin) for parenteral anticoagulation in patients with heparin-induced thrombocytopenia
    • Greinacher A, Janssens U, Berg G, et al. Lepirudin (recombinant hirudin) for parenteral anticoagulation in patients with heparin-induced thrombocytopenia. Circulation 1999; 100: 587-93
    • (1999) Circulation , vol.100 , pp. 587-593
    • Greinacher, A.1    Janssens, U.2    Berg, G.3
  • 53
    • 0037769831 scopus 로고    scopus 로고
    • Antihirudin antibodies following low-dose subcutaneous treatment with desirudin for thrombosis prophylaxis after hip-replacement surgery: Incidence and clinical relevance
    • Greinacher A, Eichler P, Albrecht D, et al. Antihirudin antibodies following low-dose subcutaneous treatment with desirudin for thrombosis prophylaxis after hip-replacement surgery: incidence and clinical relevance. Blood 2003; 101: 2617-9
    • (2003) Blood , vol.101 , pp. 2617-2619
    • Greinacher, A.1    Eichler, P.2    Albrecht, D.3
  • 54
    • 0036800789 scopus 로고    scopus 로고
    • Biological relevance of anti-recombinant hirudin antibodies: Results from in vitro and in vivo studies
    • Liebe V, Bruckmann M, Fischer KG, et al. Biological relevance of anti-recombinant hirudin antibodies: results from in vitro and in vivo studies. Semin Thromb Hemost 2002; 28: 483-90
    • (2002) Semin Thromb Hemost , vol.28 , pp. 483-490
    • Liebe, V.1    Bruckmann, M.2    Fischer, K.G.3
  • 55
    • 0038489335 scopus 로고    scopus 로고
    • Anti-hirudin antibodies alter pharmacokineticsand pharmacodynamics of recombinant hirudin
    • Fischer KG, Liebe V, Hudek R, et al. Anti-hirudin antibodies alter pharmacokineticsand pharmacodynamics of recombinant hirudin. Thromb Haemost 2003; 89: 973-82
    • (2003) Thromb Haemost , vol.89 , pp. 973-982
    • Fischer, K.G.1    Liebe, V.2    Hudek, R.3
  • 56
    • 0035002191 scopus 로고    scopus 로고
    • Anti-r-hirudin antibodies reveal clinical relevance through direct functional inactivation of r-hirudin or prolongation of r-hirudin's plasma halflife
    • Huhle G, Liebe V, Hudek R, et al. Anti-r-hirudin antibodies reveal clinical relevance through direct functional inactivation of r-hirudin or prolongation of r-hirudin's plasma halflife. Thromb Haemost 2001; 85: 936-8
    • (2001) Thromb Haemost , vol.85 , pp. 936-938
    • Huhle, G.1    Liebe, V.2    Hudek, R.3
  • 57
    • 0028603598 scopus 로고
    • Weak allergenicity of recombinant hirudin CGP 39393 (REVASC) in immunocompetent volunteers
    • The European Hirudin in Thrombosis Group (HIT Group)
    • Close P, Bichler J, Kerry R, et al. Weak allergenicity of recombinant hirudin CGP 39393 (REVASC) in immunocompetent volunteers. The European Hirudin in Thrombosis Group (HIT Group). Coron Artery Dis 1994; 5: 943-9
    • (1994) Coron Artery Dis , vol.5 , pp. 943-949
    • Close, P.1    Bichler, J.2    Kerry, R.3
  • 61
    • 0000252196 scopus 로고    scopus 로고
    • Frequency of heparin-induced thrombocytopenia
    • Warkentin TE, Greinacher A, editors. New York: Dekker
    • Lee DH, Warkentin TE. Frequency of heparin-induced thrombocytopenia. In: Warkentin TE, Greinacher A, editors. Heparin-induced thrombocytopenia. New York: Dekker, 2001: 87-121
    • (2001) Heparin-induced Thrombocytopenia , pp. 87-121
    • Lee, D.H.1    Warkentin, T.E.2
  • 62
    • 0029035681 scopus 로고
    • Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin
    • Warkentin TE, Levine MN, Hirsh J, et al. Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin. N Engl J Med 1995; 332: 1330-5
    • (1995) N Engl J Med , vol.332 , pp. 1330-1335
    • Warkentin, T.E.1    Levine, M.N.2    Hirsh, J.3
  • 63
    • 0035953702 scopus 로고    scopus 로고
    • Temporal aspects of heparin-induced thrombocytopenia
    • Warkentin TE, Kelton JG. Temporal aspects of heparin-induced thrombocytopenia. N Engl J Med 2001; 344: 1286-92
    • (2001) N Engl J Med , vol.344 , pp. 1286-1292
    • Warkentin, T.E.1    Kelton, J.G.2
  • 64
    • 0031795614 scopus 로고    scopus 로고
    • Clinical presentation of heparin-induced thrombocytopenia
    • Warkentin TE. Clinical presentation of heparin-induced thrombocytopenia. Semin Hematol 1998; 35: 9-16
    • (1998) Semin Hematol , vol.35 , pp. 9-16
    • Warkentin, T.E.1
  • 65
    • 0000070506 scopus 로고    scopus 로고
    • Nonimmune heparin-platelet interactions: Implications for the pathogenesis of heparin-induced thrombocytopenia
    • Warkentin TE, Greinacher A, editors. New York: Dekker
    • Horne MKI. Nonimmune heparin-platelet interactions: implications for the pathogenesis of heparin-induced thrombocytopenia, In: Warkentin TE, Greinacher A, editors. Heparin-induced thrombocytopenia. New York: Dekker, 2001: 123-36
    • (2001) Heparin-induced Thrombocytopenia , pp. 123-136
    • Horne, M.K.I.1
  • 66
    • 8644281747 scopus 로고    scopus 로고
    • Heparin-dependent antigens in heparin-induced thrombocytopenia
    • Warkentin TE, Greinacher A, editors. New York: Dekker
    • Amiral I, Meyer D. Heparin-dependent antigens in heparin-induced thrombocytopenia. In: Warkentin TE, Greinacher A, editors. Heparin-induced thrombocytopenia. New York: Dekker, 2001: 137-48
    • (2001) Heparin-induced Thrombocytopenia , pp. 137-148
    • Amiral, I.1    Meyer, D.2
  • 67
    • 0028009642 scopus 로고
    • Antibodies from patients with heparin-induced thrombocytopenia/thrombosis are specific for platelet factor 4 complexed with heparin or bound to endothelial cells
    • Visentin GP, Ford SE, Scott JP, et al. Antibodies from patients with heparin-induced thrombocytopenia/thrombosis are specific for platelet factor 4 complexed with heparin or bound to endothelial cells. J Clin Invest 1994; 93: 81-8
    • (1994) J Clin Invest , vol.93 , pp. 81-88
    • Visentin, G.P.1    Ford, S.E.2    Scott, J.P.3
  • 68
    • 0028014541 scopus 로고
    • Heparin-associated thrombocytopenia: Isolation of the antibody and characterization of a multimolecular PF4-heparin complex as the major antigen
    • Greinacher A, Pötzsch B, Amiral J, et al. Heparin-associated thrombocytopenia: isolation of the antibody and characterization of a multimolecular PF4-heparin complex as the major antigen. Thromb Haemost 1994; 71: 247-51
    • (1994) Thromb Haemost , vol.71 , pp. 247-251
    • Greinacher, A.1    Pötzsch, B.2    Amiral, J.3
  • 69
    • 8944247264 scopus 로고    scopus 로고
    • Presence of autoantibodies to interleukin-8 or neutrophil-activating peptide-2 in patients with heparin-associated thrombocytopenia
    • Amiral J, Marfaing-Koka A, Wolf M, et al. Presence of autoantibodies to interleukin-8 or neutrophil-activating peptide-2 in patients with heparin-associated thrombocytopenia. Blood 1996; 88: 410-6
    • (1996) Blood , vol.88 , pp. 410-416
    • Amiral, J.1    Marfaing-Koka, A.2    Wolf, M.3
  • 70
    • 0002205476 scopus 로고    scopus 로고
    • The platelet Fc receptor in heparin-induced thrombocytopenia
    • Warkentin TE, Greinacher A, editors. New York: Dekker
    • Denomme GA. The platelet Fc receptor in heparin-induced thrombocytopenia. In: Warkentin TE, Greinacher A, editors. Heparin-induced thrombocytopenia. New York: Dekker, 2001: 189-214
    • (2001) Heparin-induced Thrombocytopenia , pp. 189-214
    • Denomme, G.A.1
  • 71
    • 0023109003 scopus 로고
    • Immune endothelial-cell injury in heparin-associated thrombocytopenia
    • Cines DB, Tomaski A, Tannebaum S. Immune endothelial-cell injury in heparin-associated thrombocytopenia. N Engl J Med 1987; 316: 581-9
    • (1987) N Engl J Med , vol.316 , pp. 581-589
    • Cines, D.B.1    Tomaski, A.2    Tannebaum, S.3
  • 72
    • 0029161648 scopus 로고
    • Use of recombinant hirudin as antithrombotic treatment in patients with heparin-induced thrombocytopenia
    • Schiele F, Vuillemenot A, Kramarz P, et al. Use of recombinant hirudin as antithrombotic treatment in patients with heparin-induced thrombocytopenia. Am J Hematol 1995; 50: 20-5
    • (1995) Am J Hematol , vol.50 , pp. 20-25
    • Schiele, F.1    Vuillemenot, A.2    Kramarz, P.3
  • 73
    • 0030711717 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia with thromboembolic arterial occlusion treated with recombinant hirudin
    • Schmidt OH, Lang W. Heparin-induced thrombocytopenia with thromboembolic arterial occlusion treated with recombinant hirudin [letter]. N Engl J Med 1997; 337: 1389
    • (1997) N Engl J Med , vol.337 , pp. 1389
    • Schmidt, O.H.1    Lang, W.2
  • 74
    • 0030958446 scopus 로고    scopus 로고
    • Anticoagulation in patients with heparin-induced thrombocytopenia type II
    • Harenberg J, Huhle G, Piazolo L, et al. Anticoagulation in patients with heparin-induced thrombocytopenia type II. Semin Thromb Hemost 1997; 23: 189-96
    • (1997) Semin Thromb Hemost , vol.23 , pp. 189-196
    • Harenberg, J.1    Huhle, G.2    Piazolo, L.3
  • 75
    • 0033597268 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia as the cause of persistent bleeding after pacemaker implantation
    • Madei W, Klieser HP, Hoerauf K. Heparin-induced thrombocytopenia as the cause of persistent bleeding after pacemaker implantation [in German]. Dtsch Med Wochenschr 1999; 124: 487-90
    • (1999) Dtsch Med Wochenschr , vol.124 , pp. 487-490
    • Madei, W.1    Klieser, H.P.2    Hoerauf, K.3
  • 76
    • 0025951938 scopus 로고
    • A rapid and sensitive test for diagnosing heparin-associated thrombocytopenia
    • Greinacher A, Michels I, Kiefel V, et al. A rapid and sensitive test for diagnosing heparin-associated thrombocytopenia. Thromb Haemost 1991; 66: 734-6
    • (1991) Thromb Haemost , vol.66 , pp. 734-736
    • Greinacher, A.1    Michels, I.2    Kiefel, V.3
  • 77
    • 0028335456 scopus 로고
    • Laboratory diagnosis of heparin-associated thrombocytopenia and comparison of platelet aggregation test, heparin-induced platelet activation test, and platelet factor 4/heparin enzyme-linked immunosorbent assay
    • Greinacher A, Amiral J, Dummel V, et al. Laboratory diagnosis of heparin-associated thrombocytopenia and comparison of platelet aggregation test, heparin-induced platelet activation test, and platelet factor 4/heparin enzyme-linked immunosorbent assay. Transfusion 1994; 34: 381-5
    • (1994) Transfusion , vol.34 , pp. 381-385
    • Greinacher, A.1    Amiral, J.2    Dummel, V.3
  • 78
    • 0030281338 scopus 로고    scopus 로고
    • A 14-year study of heparin-induced thrombocytopenia
    • Warkentin TE, Kelton JG. A 14-year study of heparin-induced thrombocytopenia. Am J Med 1996; 101: 502-7
    • (1996) Am J Med , vol.101 , pp. 502-507
    • Warkentin, T.E.1    Kelton, J.G.2
  • 79
    • 0035853125 scopus 로고    scopus 로고
    • Recombinant hirudin in clinical practice: Focus on lepirudin
    • Greinacher A, Lubenow N. Recombinant hirudin in clinical practice: focus on lepirudin. Circulation 2001; 103: 1479-84
    • (2001) Circulation , vol.103 , pp. 1479-1484
    • Greinacher, A.1    Lubenow, N.2
  • 80
    • 0033832463 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia: Recommendations for optimal use of recombinant hirudin
    • Lubenow N, Greinacher A. Heparin-induced thrombocytopenia: recommendations for optimal use of recombinant hirudin. Biodrugs 2000; 14: 109-25
    • (2000) Biodrugs , vol.14 , pp. 109-125
    • Lubenow, N.1    Greinacher, A.2
  • 82
    • 0033519051 scopus 로고    scopus 로고
    • Venous thrombosis: A multicausal disease
    • Rosendaal FR. Venous thrombosis: a multicausal disease. Lancet 1999; 353: 1167-73
    • (1999) Lancet , vol.353 , pp. 1167-1173
    • Rosendaal, F.R.1
  • 83
    • 0027504813 scopus 로고
    • A comparison of subcutaneous low-molecular-weight heparin with warfarin sodium for prophylaxis against deep-vein thrombosis after hip or knee implantation
    • Hull R, Raskob G, Pineo G, et al. A comparison of subcutaneous low-molecular-weight heparin with warfarin sodium for prophylaxis against deep-vein thrombosis after hip or knee implantation. N Engl J Med 1993; 329: 1370-6
    • (1993) N Engl J Med , vol.329 , pp. 1370-1376
    • Hull, R.1    Raskob, G.2    Pineo, G.3
  • 84
    • 0027964241 scopus 로고
    • Direct thrombin inhibition with Rec-hirudin CGP 39393 as prophylaxis of thromboembolic complications after total hip replacement
    • Eriksson BI, Kälebo P, Ekman S, et al. Direct thrombin inhibition with Rec-hirudin CGP 39393 as prophylaxis of thromboembolic complications after total hip replacement. Thromb Haemost 1994; 72: 227-31
    • (1994) Thromb Haemost , vol.72 , pp. 227-231
    • Eriksson, B.I.1    Kälebo, P.2    Ekman, S.3
  • 85
    • 0030953595 scopus 로고    scopus 로고
    • Prevention of thromboembolism with use of recombinant hirudin: Results of a double-blind, multicenter trial comparing the efficacy of desirudin (Revasc) with that of unfractionated heparin in patients having a total hip replacement
    • Eriksson BI, Ekman S, Lindbratt S, et al. Prevention of thromboembolism with use of recombinant hirudin: results of a double-blind, multicenter trial comparing the efficacy of desirudin (Revasc) with that of unfractionated heparin in patients having a total hip replacement. J Bone Joint Surg 1997; 79: 326-33
    • (1997) J Bone Joint Surg , vol.79 , pp. 326-333
    • Eriksson, B.I.1    Ekman, S.2    Lindbratt, S.3
  • 86
    • 0030722727 scopus 로고    scopus 로고
    • A comparison of recombinant hirudin with a low-molecular-weight heparin to prevent thromboembolic complications after total hip replacement
    • Eriksson BI, Wille-Iorgensen P, Kälebo P, et al. A comparison of recombinant hirudin with a low-molecular-weight heparin to prevent thromboembolic complications after total hip replacement. N Engl J Med 1997; 337: 1329-35
    • (1997) N Engl J Med , vol.337 , pp. 1329-1335
    • Eriksson, B.I.1    Wille-Iorgensen, P.2    Kälebo, P.3
  • 87
    • 0034663076 scopus 로고    scopus 로고
    • A new therapeutic option by subcutaneous recombinant hirudin in patients with heparin-induced thrombocytopenia type II: A pilot study
    • Huhle G, Hoffmann U, Hoffmann I, et al. A new therapeutic option by subcutaneous recombinant hirudin in patients with heparin-induced thrombocytopenia type II: a pilot study. Thromb Res 2000; 99: 325-34
    • (2000) Thromb Res , vol.99 , pp. 325-334
    • Huhle, G.1    Hoffmann, U.2    Hoffmann, I.3
  • 88
    • 0027293280 scopus 로고
    • Treatment of severe venous thromboembolism with intravenous Hirudin (HBW 023): An open pilot study
    • Parent F, Bridey F, Dreyfus M, et al. Treatment of severe venous thromboembolism with intravenous Hirudin (HBW 023): an open pilot study. Thromb Haemost 1993; 70: 386-8
    • (1993) Thromb Haemost , vol.70 , pp. 386-388
    • Parent, F.1    Bridey, F.2    Dreyfus, M.3
  • 89
    • 0028273524 scopus 로고
    • A pilot study of subcutaneous recombinant hirudin (HBW 023) in the treatment of deep vein thrombosis
    • Schiele F, Vuillemenot A, Kramarz P, et al. A pilot study of subcutaneous recombinant hirudin (HBW 023) in the treatment of deep vein thrombosis. Thromb Haemost 1994; 71: 558-62
    • (1994) Thromb Haemost , vol.71 , pp. 558-562
    • Schiele, F.1    Vuillemenot, A.2    Kramarz, P.3
  • 90
    • 0033845449 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia: A critical risk/benefit analysis of patients in intensive care treated with r-hirudin
    • Schenk JF, Berg G, Morsdorf S, et al. Heparin-induced thrombocytopenia: a critical risk/benefit analysis of patients in intensive care treated with r-hirudin. Clin Appl Thromb Hemost 2000; 6: 151-6
    • (2000) Clin Appl Thromb Hemost , vol.6 , pp. 151-156
    • Schenk, J.F.1    Berg, G.2    Morsdorf, S.3
  • 91
    • 0017687268 scopus 로고
    • Quantitative venographic assessment of deep vein thrombosis in the evaluation of streptokinase and heparin therapy
    • Marder VJ, Soulen RL, Atichartakarn V, et al. Quantitative venographic assessment of deep vein thrombosis in the evaluation of streptokinase and heparin therapy. J Lab Clin Med 1977; 89: 1018-29
    • (1977) J Lab Clin Med , vol.89 , pp. 1018-1029
    • Marder, V.J.1    Soulen, R.L.2    Atichartakarn, V.3
  • 92
    • 0027125530 scopus 로고
    • The pathophysiology of coronary artery disease and the acute coronary syndromes (1)
    • Fuster V, Badimon L, Badimon JJ, et al. The pathophysiology of coronary artery disease and the acute coronary syndromes (1). N Engl J Med 1992; 326: 242-50
    • (1992) N Engl J Med , vol.326 , pp. 242-250
    • Fuster, V.1    Badimon, L.2    Badimon, J.J.3
  • 93
    • 0026541706 scopus 로고
    • The pathophysiology of coronary artery disease and the acute coronary syndromes (2)
    • Fuster V, Badimon L, Badimon JJ, et al. The pathophysiology of coronary artery disease and the acute coronary syndromes (2). N Engl J Med 1992; 326: 310-8
    • (1992) N Engl J Med , vol.326 , pp. 310-318
    • Fuster, V.1    Badimon, L.2    Badimon, J.J.3
  • 95
    • 0343580449 scopus 로고    scopus 로고
    • Comparison of the effects of two doses of recombinant hirudin compared with heparin in patients with acute myocardial ischemia without ST elevation: A pilot study
    • Organization to Assess Strategies for Ischemic Syndromes (OASIS) Investigators. Comparison of the effects of two doses of recombinant hirudin compared with heparin in patients with acute myocardial ischemia without ST elevation: a pilot study. Circulation 1997; 96: 769-77
    • (1997) Circulation , vol.96 , pp. 769-777
  • 96
    • 0033528281 scopus 로고    scopus 로고
    • Effects of recombinant hirudin (lepirudin) compared with heparin on death, myocardial infarction, refractory angina, and revascularisation procedures in patients with acute myocardial ischaemia without ST elevation: A randomised trial
    • Organisation to Assess Strategies for Ischemic Syndromes (OASIS-2) Investigators. Effects of recombinant hirudin (lepirudin) compared with heparin on death, myocardial infarction, refractory angina, and revascularisation procedures in patients with acute myocardial ischaemia without ST elevation: a randomised trial. Lancet 1999; 353: 429-38
    • (1999) Lancet , vol.353 , pp. 429-438
  • 97
    • 0033213674 scopus 로고    scopus 로고
    • Recombinant hirudin (lepirudin) for the improvement of thrombolysis with streptokinase in patients with acute myocardial infarction: Results of the HIT-4 trial
    • Neuhaus KL, Molhoek GP, Zeymer U, et al. Recombinant hirudin (lepirudin) for the improvement of thrombolysis with streptokinase in patients with acute myocardial infarction: results of the HIT-4 trial. J Am Coll Cardiol 1999; 34: 966-73
    • (1999) J Am Coll Cardiol , vol.34 , pp. 966-973
    • Neuhaus, K.L.1    Molhoek, G.P.2    Zeymer, U.3
  • 98
    • 0030908055 scopus 로고    scopus 로고
    • A clinical trial comparing primary coronary angioplasty with tissue plasminogen activator for acute myocardial infarction
    • The Global Use of Strategies to Open Occluded Coronary Arteries in Acute Coronary Syndromes (GUSTO IIb) Angioplasty Substudy Investigators. A clinical trial comparing primary coronary angioplasty with tissue plasminogen activator for acute myocardial infarction. N Engl J Med 1997; 336: 1621-8
    • (1997) N Engl J Med , vol.336 , pp. 1621-1628
  • 99
    • 0029101260 scopus 로고
    • A comparison of hirudin with heparin in the prevention of restenosis after coronary angioplasty: Helvetica Investigators
    • Serruys PW, Herrman JP, Simon R, et al. A comparison of hirudin with heparin in the prevention of restenosis after coronary angioplasty: Helvetica Investigators. N Engl J Med 1995; 333: 757-63
    • (1995) N Engl J Med , vol.333 , pp. 757-763
    • Serruys, P.W.1    Herrman, J.P.2    Simon, R.3
  • 100
    • 0032958887 scopus 로고    scopus 로고
    • Death and nonfatal reinfarction within the first 24 hours after presentation with an acute coronary syndrome: Experience from GUSTO-IIb: Global Utilization of Strategies for Total Occlusion
    • Kleiman NS, Granger CB, White HD, et al. Death and nonfatal reinfarction within the first 24 hours after presentation with an acute coronary syndrome: experience from GUSTO-IIb: Global Utilization of Strategies for Total Occlusion. Am Heart J 1999; 137: 12-23
    • (1999) Am Heart J , vol.137 , pp. 12-23
    • Kleiman, N.S.1    Granger, C.B.2    White, H.D.3
  • 101
    • 0035869325 scopus 로고    scopus 로고
    • Reactivation of ischemic events in acute coronary syndromes: Results from GUSTO-IIb: Global use of strategies to open occluded arteries in acute coronary syndromes
    • Bahit MC, Topol EJ, Califf RM, et al. Reactivation of ischemic events in acute coronary syndromes: results from GUSTO-IIb: Global use of strategies to open occluded arteries in acute coronary syndromes. J Am Coll Cardiol 2001; 37: 1001-7
    • (2001) J Am Coll Cardiol , vol.37 , pp. 1001-1007
    • Bahit, M.C.1    Topol, E.J.2    Califf, R.M.3
  • 102
    • 0029153842 scopus 로고
    • r-hirudin in unstable angina pectoris: Rationale and preliminary data from the APT pilot study
    • Fox KA. r-hirudin in unstable angina pectoris: rationale and preliminary data from the APT pilot study. Eur Heart J 1995; 16 Suppl. D: 28-32
    • (1995) Eur Heart J , vol.16 , Issue.SUPPL. D , pp. 28-32
    • Fox, K.A.1
  • 103
    • 0028296374 scopus 로고
    • A pilot trial of recombinant desulfatohirudin compared with heparin in conjunction with tissue-type plasminogen activator and aspirin for acute myocardial infarction: Results of the Thrombolysis in Myocardial Infarction (TIMI) 5 trial
    • Cannon CP, McCabe CH, Henry TD, et al. A pilot trial of recombinant desulfatohirudin compared with heparin in conjunction with tissue-type plasminogen activator and aspirin for acute myocardial infarction: results of the Thrombolysis in Myocardial Infarction (TIMI) 5 trial. J Am Coll Cardiol 1994; 23: 993-1003
    • (1994) J Am Coll Cardiol , vol.23 , pp. 993-1003
    • Cannon, C.P.1    McCabe, C.H.2    Henry, T.D.3
  • 104
    • 0028795568 scopus 로고
    • Initial experience with hirudin and streptokinase in acute myocardial infarction: Results of the Thrombolysis in Myocardial Infarction (TIMI) 6 trial
    • Lee LV, for the TIMI6 Investigators. Initial experience with hirudin and streptokinase in acute myocardial infarction: results of the Thrombolysis in Myocardial Infarction (TIMI) 6 trial. Am J Cardiol 1995; 75: 7-13
    • (1995) Am J Cardiol , vol.75 , pp. 7-13
    • Lee, L.V.1
  • 105
    • 0028844223 scopus 로고
    • Frequency of "optimal anticoagulation" for acute myocardial infarction after thrombolysis with front-loaded recombinant tissue-type plasminogen activator and conjunctive therapy with recombinant hirudin (HBW 023): ALKK Study Group
    • Zeymer U, Von Essen R, Tebbe U, et al. Frequency of "optimal anticoagulation" for acute myocardial infarction after thrombolysis with front-loaded recombinant tissue-type plasminogen activator and conjunctive therapy with recombinant hirudin (HBW 023): ALKK Study Group. Am J Cardiol 1995; 76: 997-1001
    • (1995) Am J Cardiol , vol.76 , pp. 997-1001
    • Zeymer, U.1    Von Essen, R.2    Tebbe, U.3
  • 106
    • 7144253804 scopus 로고    scopus 로고
    • Randomized comparison of direct thrombin inhibition versus heparin in conjunction with fibrinolytic therapy for acute myocardial infarction: Results from the GUSTO-IIb Trial
    • Global Use of Strategies to Open Occluded Coronary Arteries in Acute Coronary Syndromes (GUSTO-IIb) Investigators
    • Metz BK, White HD, Granger CB, et al. Randomized comparison of direct thrombin inhibition versus heparin in conjunction with fibrinolytic therapy for acute myocardial infarction: results from the GUSTO-IIb Trial. Global Use of Strategies to Open Occluded Coronary Arteries in Acute Coronary Syndromes (GUSTO-IIb) Investigators. J Am Coll Cardiol 1998; 31: 1493-8
    • (1998) J Am Coll Cardiol , vol.31 , pp. 1493-1498
    • Metz, B.K.1    White, H.D.2    Granger, C.B.3
  • 107
    • 0028858265 scopus 로고
    • Recombinant hirudin (HBW 023) prevents troponin T release after coronary angioplasty in patients with unstable angina
    • Rupprecht HJ, Terres W, Ozbek C, et al. Recombinant hirudin (HBW 023) prevents troponin T release after coronary angioplasty in patients with unstable angina. J Am Coll Cardiol 1995; 26: 1637-42
    • (1995) J Am Coll Cardiol , vol.26 , pp. 1637-1642
    • Rupprecht, H.J.1    Terres, W.2    Ozbek, C.3
  • 108
    • 0036399443 scopus 로고    scopus 로고
    • Efficacy of hirudin in reducing cardiovascular events in patients with acute coronary syndrome undergoing early percutaneous coronary intervention
    • Mehta SR, Eikelboom JW, Rupprecht HJ, et al. Efficacy of hirudin in reducing cardiovascular events in patients with acute coronary syndrome undergoing early percutaneous coronary intervention. Eur Heart J 2002; 23: 117-23
    • (2002) Eur Heart J , vol.23 , pp. 117-123
    • Mehta, S.R.1    Eikelboom, J.W.2    Rupprecht, H.J.3
  • 109
    • 0001799065 scopus 로고    scopus 로고
    • Danaparoid for the treatment of heparin-induced thrombocytopenia
    • Warkentin TE, Greinacher A, editors. New York: Dekker
    • Chong BH, Magnani HN. Danaparoid for the treatment of heparin-induced thrombocytopenia. In: Warkentin TE, Greinacher A, editors. Heparin-induced thrombocytopenia. New York: Dekker, 2001: 323-47
    • (2001) Heparin-induced Thrombocytopenia , pp. 323-347
    • Chong, B.H.1    Magnani, H.N.2
  • 110
    • 0030715080 scopus 로고    scopus 로고
    • Danaparoid: A review of its pharmacology and clinical use in the management of heparin-induced thrombocytopenia
    • Wilde MI, Markham A. Danaparoid: a review of its pharmacology and clinical use in the management of heparin-induced thrombocytopenia. Drugs 1997; 54: 903-24
    • (1997) Drugs , vol.54 , pp. 903-924
    • Wilde, M.I.1    Markham, A.2
  • 111
    • 0034966778 scopus 로고    scopus 로고
    • A comparison of danaparoid and lepirudin in heparin-induced thrombocytopenia
    • Farner B, Eichler P, Kroll H, et al. A comparison of danaparoid and lepirudin in heparin-induced thrombocytopenia. Thromb Haemost 2001; 85: 950-7
    • (2001) Thromb Haemost , vol.85 , pp. 950-957
    • Farner, B.1    Eichler, P.2    Kroll, H.3
  • 112
    • 0001571413 scopus 로고    scopus 로고
    • Argatroban therapy in heparin-induced thrombocytopenia
    • Warkentin TE, Greinacher A, editors. New York: Dekker
    • Lewis BE, Hursting MJ. Argatroban therapy in heparin-induced thrombocytopenia. In: Warkentin TE, Greinacher A, editors. Heparin-induced thrombocytopenia. New York: Dekker, 2001: 381-407
    • (2001) Heparin-induced Thrombocytopenia , pp. 381-407
    • Lewis, B.E.1    Hursting, M.J.2
  • 113
    • 0035836541 scopus 로고    scopus 로고
    • Argatroban anticoagulant therapy in patients with heparin-induced thrombocytopenia
    • Lewis BE, Wallis DE, Berkowitz SD, et al. Argatroban anticoagulant therapy in patients with heparin-induced thrombocytopenia. Circulation 2001; 103: 1838-43
    • (2001) Circulation , vol.103 , pp. 1838-1843
    • Lewis, B.E.1    Wallis, D.E.2    Berkowitz, S.D.3
  • 114
    • 0034049121 scopus 로고    scopus 로고
    • The pharmacokinetics and pharmacodynamics of argatroban: Effects of age, gender, and hepatic or renal dysfunction
    • Swan SK, Hursting MJ. The pharmacokinetics and pharmacodynamics of argatroban: effects of age, gender, and hepatic or renal dysfunction. Pharmacotherapy 2000; 20: 318-29
    • (2000) Pharmacotherapy , vol.20 , pp. 318-329
    • Swan, S.K.1    Hursting, M.J.2
  • 115
    • 33748233635 scopus 로고
    • The unique antithrombin III binding domain of heparin: A lead to new synthetic antithrombotics
    • van Boeckel CAA, Petitou M. The unique antithrombin III binding domain of heparin: a lead to new synthetic antithrombotics. Angew Chem Int Ed Engl 1993; 32: 1671-90
    • (1993) Angew Chem Int Ed Engl , vol.32 , pp. 1671-1690
    • Van Boeckel, C.A.A.1    Petitou, M.2
  • 116
    • 0026690347 scopus 로고
    • Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin-proteinase reactions: Resolution of the antithrombin conformational change contribution to heparin rate enhancement
    • Olson ST, Bjork I, Sheffer R, et al. Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin-proteinase reactions: resolution of the antithrombin conformational change contribution to heparin rate enhancement. J Biol Chem 1992; 267: 12528-38
    • (1992) J Biol Chem , vol.267 , pp. 12528-12538
    • Olson, S.T.1    Bjork, I.2    Sheffer, R.3
  • 117
    • 0029563321 scopus 로고
    • The effect of the synthetic pentasaccharide SR 90107/ORG 31540 on thrombin generation ex vivo is uniquely due to ATIII-mediated neutralization of factor Xa
    • Lormeau JC, Herault JP. The effect of the synthetic pentasaccharide SR 90107/ORG 31540 on thrombin generation ex vivo is uniquely due to ATIII-mediated neutralization of factor Xa. Thromb Haemost 1995; 74: 1474-7
    • (1995) Thromb Haemost , vol.74 , pp. 1474-1477
    • Lormeau, J.C.1    Herault, J.P.2
  • 118
    • 0030980765 scopus 로고    scopus 로고
    • Absence of cross-reactivity of SR90107A/ORG31540 pentasaccharide with antibodies to heparin-PF4 complexes developed in heparin-induced thrombocytopenia
    • Amiral J, Lormeau JC, Marfaing-Koka A, et al. Absence of cross-reactivity of SR90107A/ORG31540 pentasaccharide with antibodies to heparin-PF4 complexes developed in heparin-induced thrombocytopenia. Blood Coagul Fibrinolysis 1997; 8: 114-7
    • (1997) Blood Coagul Fibrinolysis , vol.8 , pp. 114-117
    • Amiral, J.1    Lormeau, J.C.2    Marfaing-Koka, A.3
  • 119
    • 0035283092 scopus 로고    scopus 로고
    • A synthetic pentasaccharide for the prevention of deep-vein thrombosis after total hip replacement
    • Turpie AG, Gallus AS, Hoek JA. A synthetic pentasaccharide for the prevention of deep-vein thrombosis after total hip replacement. N Engl J Med 2001; 344: 619-25
    • (2001) N Engl J Med , vol.344 , pp. 619-625
    • Turpie, A.G.1    Gallus, A.S.2    Hoek, J.A.3
  • 120
    • 0035522302 scopus 로고    scopus 로고
    • Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after hip-fracture surgery
    • Eriksson BI, Bauer KA, Lassen MR, et al. Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after hip-fracture surgery. N Engl J Med 2001; 345: 1298-304
    • (2001) N Engl J Med , vol.345 , pp. 1298-1304
    • Eriksson, B.I.1    Bauer, K.A.2    Lassen, M.R.3
  • 121
    • 0035522304 scopus 로고    scopus 로고
    • Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after elective major knee surgery
    • Bauer KA, Eriksson BI, Lassen MR, et al. Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after elective major knee surgery. N Engl J Med 2001; 345: 1305-10
    • (2001) N Engl J Med , vol.345 , pp. 1305-1310
    • Bauer, K.A.1    Eriksson, B.I.2    Lassen, M.R.3
  • 122
    • 0037176941 scopus 로고    scopus 로고
    • Direct thrombin inhibitors in acute coronary syndromes: Present and future
    • Weitz JI, Buller HR. Direct thrombin inhibitors in acute coronary syndromes: present and future. Circulation 2002; 105: 1004-11
    • (2002) Circulation , vol.105 , pp. 1004-1011
    • Weitz, J.I.1    Buller, H.R.2
  • 123
    • 0036247598 scopus 로고    scopus 로고
    • Bivalirudin: A review of its potential place in the management of acute coronary syndromes
    • Carswell CI, Plosker GL. Bivalirudin: a review of its potential place in the management of acute coronary syndromes. Drugs 2002; 62: 841-70
    • (2002) Drugs , vol.62 , pp. 841-870
    • Carswell, C.I.1    Plosker, G.L.2
  • 124
    • 0034567414 scopus 로고    scopus 로고
    • The use of bivalirudin in patients with renal impairment
    • Robson R. The use of bivalirudin in patients with renal impairment. J Invasive Cardiol 2000; 12 Suppl. F: 33F-6
    • (2000) J Invasive Cardiol , vol.12 , Issue.SUPPL. F
    • Robson, R.1
  • 125
    • 0035983918 scopus 로고    scopus 로고
    • Bivalirudin pharmacokinetics and pharmacodynamics: Effect of renal function, dose, and gender
    • Robson R, White H, Aylward P, et al. Bivalirudin pharmacokinetics and pharmacodynamics: effect of renal function, dose, and gender. Clin Pharmacol Ther 2002; 71: 433-9
    • (2002) Clin Pharmacol Ther , vol.71 , pp. 433-439
    • Robson, R.1    White, H.2    Aylward, P.3
  • 126
    • 0141594931 scopus 로고    scopus 로고
    • Bivalirudin provides increasing benefit with decreasing renal function: A meta-analysis of randomized trials
    • Chew DP, Bhatt DL, Kimball W, et al. Bivalirudin provides increasing benefit with decreasing renal function: a meta-analysis of randomized trials. Am J Cardiol 2003; 92: 919-23
    • (2003) Am J Cardiol , vol.92 , pp. 919-923
    • Chew, D.P.1    Bhatt, D.L.2    Kimball, W.3
  • 127
    • 0029103184 scopus 로고
    • Treatment with bivalirudin (Hirulog) as compared with heparin during coronary angioplasty for unstable or postinfarction angina: Hirulog Angioplasty Study Investigators
    • Bittl JA, Strony J, Brinker JA, et al. Treatment with bivalirudin (Hirulog) as compared with heparin during coronary angioplasty for unstable or postinfarction angina: Hirulog Angioplasty Study Investigators. N Engl J Med 1995; 333: 764-9
    • (1995) N Engl J Med , vol.333 , pp. 764-769
    • Bittl, J.A.1    Strony, J.2    Brinker, J.A.3
  • 128
    • 0035206428 scopus 로고    scopus 로고
    • Bivalirudin versus heparin during coronary angioplasty for unstable or postinfarction angina: Final report reanalysis of the Bivalirudin Angioplasty Study
    • Bittl JA, Chaitman BR, Feit F, et al. Bivalirudin versus heparin during coronary angioplasty for unstable or postinfarction angina: Final report reanalysis of the Bivalirudin Angioplasty Study. Am Heart J 2001; 142: 952-9
    • (2001) Am Heart J , vol.142 , pp. 952-959
    • Bittl, J.A.1    Chaitman, B.R.2    Feit, F.3
  • 129
    • 0036014076 scopus 로고    scopus 로고
    • Pharmacology and clinical use of bivalirudin
    • Sciulli TM, Mauro VF. Pharmacology and clinical use of bivalirudin. Ann Pharmacother 2002; 36: 1028-41
    • (2002) Ann Pharmacother , vol.36 , pp. 1028-1041
    • Sciulli, T.M.1    Mauro, V.F.2
  • 130
    • 0035651983 scopus 로고    scopus 로고
    • Thrombin-specific anticoagulation with bivalirudin versus heparin in patients receiving fibrinolytic therapy for acute myocardial infarction: The HERO-2 randomised trial
    • White H. Thrombin-specific anticoagulation with bivalirudin versus heparin in patients receiving fibrinolytic therapy for acute myocardial infarction: the HERO-2 randomised trial. Lancet 2001; 358: 1855-63
    • (2001) Lancet , vol.358 , pp. 1855-1863
    • White, H.1
  • 131
    • 0036481555 scopus 로고    scopus 로고
    • Improved efficacy and less bleeding: Further evidence of a unique uncoupling of benefit and risk with bivalirudin
    • White HD. Improved efficacy and less bleeding: further evidence of a unique uncoupling of benefit and risk with bivalirudin. Am Heart J 2002; 143: 189-92
    • (2002) Am Heart J , vol.143 , pp. 189-192
    • White, H.D.1
  • 132
    • 0037176525 scopus 로고    scopus 로고
    • Direct thrombin inhibitors in acute coronary syndromes: Principal results of a meta-analysis based on individual patients' data
    • Yusuf S, The Direct Thrombin Inhibitor Trialists' Collaborative Group. Direct thrombin inhibitors in acute coronary syndromes: principal results of a meta-analysis based on individual patients' data. Lancet 2002; 359: 294-302
    • (2002) Lancet , vol.359 , pp. 294-302
    • Yusuf, S.1
  • 133
    • 0033599835 scopus 로고    scopus 로고
    • New antithrombotic agents
    • Hirsh J, Weitz JI. New antithrombotic agents. Lancet 1999; 353: 1431-6
    • (1999) Lancet , vol.353 , pp. 1431-1436
    • Hirsh, J.1    Weitz, J.I.2
  • 134
  • 135
    • 0037132843 scopus 로고    scopus 로고
    • Platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes: A meta-analysis of all major randomized clinical trials
    • Boersma E, Harrington RA, Moliterno DJ, et al. Platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes: a meta-analysis of all major randomized clinical trials. Lancet 2002; 359: 189-98
    • (2002) Lancet , vol.359 , pp. 189-198
    • Boersma, E.1    Harrington, R.A.2    Moliterno, D.J.3
  • 136
    • 0032572295 scopus 로고    scopus 로고
    • Intracoronary stenting
    • Goy JJ, Eeckhout E. Intracoronary stenting. Lancet 1998; 351: 1943-9
    • (1998) Lancet , vol.351 , pp. 1943-1949
    • Goy, J.J.1    Eeckhout, E.2
  • 137
    • 0035869324 scopus 로고    scopus 로고
    • Stenting versus thrombolysis in acute myocardial infarction trial (STAT)
    • Le May MR, Labinaz M, Davies RF, et al. Stenting versus thrombolysis in acute myocardial infarction trial (STAT). J Am Coll Cardiol 2001; 37: 985-91
    • (2001) J Am Coll Cardiol , vol.37 , pp. 985-991
    • Le May, M.R.1    Labinaz, M.2    Davies, R.F.3


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