Hirudin determination in plasma can be strongly influenced by the prothrombin level

Thrombosis Research

Volumn 100, Issue 1, 2000, Pages 55-60

  Lindhoff Last, Edelgard ^a   Piechottka, Gerd Paul ^b   Rabe, Fritz ^b   Bauersachs, Rupert ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b Haemochrom Diagnostica GmbH   (Germany)

Author keywords

Chromogenic substrate assay; Ecarin clotting time; Prothrombin; r Hirudin

Indexed keywords

CHROMOGENIC SUBSTRATE; ECARIN; HIRUDIN; LEPIRUDIN; PHENPROCOUMON; SNAKE VENOM; THROMBOPLASTIN;

ANTICOAGULATION; ARTICLE; BLOOD CLOTTING TIME; BLOOD SAMPLING; DEEP VEIN THROMBOSIS; DISEASE ASSOCIATION; HEART INFARCTION; HUMAN; PRIORITY JOURNAL; PROTHROMBIN DEFICIENCY; PROTHROMBIN TIME; THROMBOCYTOPENIA; UNSTABLE ANGINA PECTORIS;

ANTITHROMBINS; BLOOD COAGULATION TESTS; CHROMOGENIC COMPOUNDS; FALSE POSITIVE REACTIONS; HIRUDIN; HUMAN; PROTHROMBIN; RECOMBINANT PROTEINS; REPRODUCIBILITY OF RESULTS; THROMBOCYTOPENIA; TIME FACTORS;

EID: 0034306569     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(00)00303-0     Document Type: Article

References (14)

1. Hirudin: The promising antithrombotic
2. Platelet functions in recombinant hirudin-anticoagulated blood
3. Effects of recombinant hirudin (lepirudin) compared with heparin on death, myocardial infarction, refractory angina, and revasularisation procedures in patients with acute myocardial ischaemia without ST elevation: A randomised trial
4. Hirudin in acute myocardial infarction: Safety report from the thrombolysis and thrombin inhibition in myocardial infarction (TIMI) 9A trial
5. Recombinant hirudin (lepirudin) provides safe and effective anticoagulation in patients with heparin-induced thrombocytopenia
6. Subcutaneous recombinant hirudin (HBW 023) versus intravenous sodium heparin in treatment of established acute deep vein thrombosis of the legs: A multicentre prospective dose ranging randomized trial
7. Monitoring anticoagulant therapy by activated partial thromboplastin time: Hirudin assessment
8. Laboratory assays for the evaluation of recombinant hirudin
9. Monitoring of recombinant hirudin: Assessment of a plasma-based ecarin clotting time assay
10. Quantitative determination of hirudin in blood and body fluids
11. Mechanisms of alpha-thrombin and beta-thrombin-E formation: Use of ecarin for isolation of meizothrombin
12. Evaluation of an automated chromogenic substrate assay for the rapid determination of hirudin in plasma
13. A fast photometric assay for the determination of hirudin
14. Chromogenic substrate assay for automatic determination of high dose and low dose hirudin levels in plasma