Genetic polymorphisms of the human P2X7 receptor and relationship to function

Drug Development Research

Volumn 53, Issue 2-3, 2001, Pages 72-76

  Wiley, James S ^a,b   Gu, Ben J ^a   Zhang, Weiyi ^a   Worthington, Rebecca A ^a   Dao Ung, Phuong ^a   Shemon, Anne N ^a   Sluyter, Ronald ^a   Liang, Simon ^a   Barden, Julian A ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b NEPEAN HOSPITAL   (Australia)

Author keywords

Loss of function mutation; Non functional P2X77; P2X7 receptor; Polymorphisms of P2X7

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALANINE; COMPLEMENTARY DNA; ETHIDIUM; GLUTAMIC ACID; MONOCLONAL ANTIBODY; PURINE P2X RECEPTOR;

AMINO ACID SUBSTITUTION; ANTIGEN BINDING; APOPTOSIS; CHANNEL GATING; CHRONIC LYMPHATIC LEUKEMIA; CONFERENCE PAPER; CONTROLLED STUDY; EXTRACELLULAR SPACE; GENETIC CODE; GENETIC POLYMORPHISM; GERM LINE; HOMOZYGOSITY; HUMAN; HUMAN CELL; LYMPHOCYTE; MONOCYTE; PHARMACOGENETICS; POLYMORPHONUCLEAR CELL; PROTEIN EXPRESSION; RECEPTOR INTRINSIC ACTIVITY; THROMBOCYTE;

EID: 0034857738     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/ddr.1173     Document Type: Conference Paper

References (6)

1. Buell G, Michel AD, Lewis G, Collo G, Humphrey PP, Surprenant A. 1996. P2X1 receptor activation in HL60 cells. Blood 87:2659-2664.
2. Buell GN, Talabot F, Gos A, Lorenz J, Lai E, Morris MA, Antonarakis SE. 1998. Gene structure and chromosomal localization of the human P2X7 receptor. Receptors Channels 5:347-354.
3. Burnstock G. 1996. P2 purinoceptors: historical perspective and classification. Ciba Foundation Symposium 198:1-28.
4. Collins A, Lonjou G, Morton NE. 1999. Genetic epidemiology of single-nucleotide polymorphisms. Proc Natl Acad Sci USA 96:15173-15177.
5. Nicke A, Baumert HG, Rettinger J, Eichele A, Lambrecht G, Mutschler E, Schmalzing G. 1998. P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand-gated ion channels. EMBO J 17:3016-3028.
6. Nihei OK, de Carvalho AC, Savino W, Alves LA. 2000. Pharmacologic properties of P2Z/P2X7 receptor characterized in murine dendritic cells: role on the induction of apoptosis. Blood 96:996-1005.