Functionalized congeners of tyrosine-based P2X7 receptor antagonists: Probing multiple sites for linking and dimerization

Bioconjugate Chemistry

Volumn 13, Issue 5, 2002, Pages 1100-1111

  Chen, Wangzhong ^a   Ravi, R Ghana ^a   Kertesy, Sylvia B ^b   Dubyak, George R ^b   Jacobson, Kenneth A ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; COPPER COMPOUNDS; DIMERS; SODIUM BOROHYDRIDE;

BIOLOGICAL POTENCY; BIOPHYSICAL STUDIES; CATION CHANNELS; DIMERIZATIONS; FUNCTIONALIZATIONS; FUNCTIONALIZED; HEK293 CELLS; ISOTHIOCYANATES; RECEPTOR ANTAGONISTS; SYNTHESISED;

AMINO ACIDS;

ADENOSINE TRIPHOSPHATE; CROSS LINKING REAGENT; DRUG DERIVATIVE; POTASSIUM; PURINE P2 RECEPTOR; PURINE P2X7 RECEPTOR; TYROSINE;

ARTICLE; BINDING SITE; CELL LINE; DIMERIZATION; DRUG ANTAGONISM; GENETIC TRANSFECTION; GENETICS; HUMAN; IC 50; METABOLISM; STRUCTURE ACTIVITY RELATION;

ADENOSINE TRIPHOSPHATE; BINDING SITES; CELL LINE; CROSS-LINKING REAGENTS; DIMERIZATION; HUMANS; INHIBITORY CONCENTRATION 50; POTASSIUM; RECEPTORS, PURINERGIC P2; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION; TYROSINE;

EID: 0036737034     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc020025i     Document Type: Article

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