Effect of glutamine synthesis inhibition with methionine sulfoximine on the nitric oxide-cyclic GMP pathway in the rat striatum treated acutely with ammonia: A microdialysis study

Neurochemical Research

Volumn 33, Issue 2, 2008, Pages 267-272

  Hilgier, Wojciech ^a   Węgrzynowicz, Michal ^a   Ma̧czewski, Michal ^b   Beręsewicz, Andrzej ^b   Oja, Simo S ^c   Saransaari, Pirjo ^d   Albrecht, Jan ^a  

^a MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

^b MEDICAL CENTER FOR POSTGRADUATE EDUCATION   (Poland)

^c TAMPERE UNIVERSITY HOSPITAL   (Finland)

^d UNIVERSITY OF TAMPERE MEDICAL SCHOOL   (Finland)

Author keywords

Ammonia; Cyclic GMP; Methionine sulfoximine; Microdialysis; Nitric oxide Glutamine; Rat; Striatum

Indexed keywords

AMMONIUM CHLORIDE; CYCLIC GMP; GLUTAMINE; METHIONINE SULFOXIMINE; N METHYL DEXTRO ASPARTIC ACID; NITRATE; NITRIC OXIDE; NITRITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORPUS STRIATUM; DIALYSATE; DRUG EFFECT; MALE; MICRODIALYSIS; MOLECULAR PROBE; NEUROTOXICITY; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT;

RATTUS;

EID: 38349161319     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-007-9455-1     Document Type: Article

References (47)

1. Fan P, Szerb JC (1993) Effects of ammonium ions on synaptic transmission and on responses to quisqualate and N-methyl-d-aspartate in hippocampal CA1 pyramidal neurons in vitro. Brain Res 632:225-231
2. Hermenegildo C, Monfort P, Felipo V (2000) Activation of NMDA receptors in rat brain in vivo following acute ammonia intoxication: characterization by in vivo brain microdialysis. Hepatology 31:709-715
3. Schliess F, Gorg B, Fischer R et al (2002) Ammonia induces MK-801-sensitive nitration and phosphorylation of protein tyrosine residues in rat astrocytes. FASEB J 16:739-741
4. Schliess F, Foster N, Gorg B et al (2004) Astrocyte swelling increases protein tyrosine nitration in cultured rat astrocytes. Glia 47:21-29
5. Murthy CR, Rama Rao KV, Bai G et al (2001) Ammonia-induced production of free radicals in primary cultures of rat astrocytes. J Neurosci Res 66:282-288
6. Hilgier W, Anderzhanova E, Oja SS et al (2003) Taurine reduces ammonia- and N-methyl-D-aspartate-induced accumulation of cyclic GMP and hydroxyl radicals in microdialysates of the rat striatum. Eur J Pharmacol 468:21-25
7. Kosenko E, Venediktova N, Kaminsky Y et al (2003) Sources of oxygen radicals in brain in acute ammonia intoxication in vivo. Brain Res 981:193-200
8. Haussinger D, Gorg B, Reinehr R et al (2005) Protein tyrosine nitration in hyperammonemia and hepatic encephalopathy. Metab Brain Dis 20:285-294
9. Swamy M, Zakaria AZ, Govindasamy C et al (2005) Effects of acute ammonia toxicity on nitric oxide (NO), citrulline-NO cycle enzymes, arginase and related metabolites in different regions of rat brain. Neurosci Res 53:116-122
10. Hilgier W, Oja SS, Saransaari P et al (2005) Taurine prevents ammonia-induced accumulation of cyclic GMP in rat striatum by interaction with GABAA and glycine receptors. Brain Res 1043:242-246
11. Albrecht J, Wegrzynowicz M (2007) Cyclic GMP in blood and minimal hepatic encephalopathy: fine-tuning of the diagnosis. J Mol Med 85:203-205
12. Hilgier W, Oja SS, Saransaari P et al (2004) A novel glycine site-specific N-methyl-D-aspartate receptor antagonist prevents activation of the NMDA/NO/CGMP pathway by ammonia. Brain Res 1015:186-188
13. Takahashi H, Koehler RC, Brusilow SW et al (1991) Inhibition of brain glutamine accumulation prevents cerebral edema in hyperammonemic rats. Am J Physiol 261:H825-H829
14. Willard-Mack CL, Koehler RC, Hirata T et al (1996) Inhibition of glutamine synthetase reduces ammonia induced astrocyte swelling in rat. Neuroscience 71:589-599
15. Tofteng F, Hauerberg J, Hansen BA et al (2006) Persistent arterial hyperammonemia increases the concentration of glutamine and alanine in the brain and correlates with intracranial pressure in patients with fulminant hepatic failure. J Cereb Blood Flow Metab 26:21-27
16. Albrecht J, Norenberg MD (2006) Glutamine: a Trojan horse in ammonia neurotoxicity. Hepatology 44:788-794
17. Ziemińska E, Dolińska M, Łazarewicz JW et al (2000) Induction of permeability transition and swelling of rat brain mitochondria by glutamine. Neurotoxicology 21:295-300
18. Rama Rao KV, Jayakumar AR, Norenberg MD (2003) Induction of the mitochondrial permeability transition in cultured astrocytes by glutamine. Neurochem Int 43:517-523
19. Jayakumar AR, Rama Rao KV, Schousboe A et al (2004) Glutamine-induced free radical production in cultured astrocytes. Glia 46:296-301
20. Suzuki K, Matsuo N, Moriguchi T et al (1992) Changes in brain ECF amino acids in rats with experimentally induced hyperammonemia. Metab Brain Dis 7:63-75
21. McArdle P, Penning DH, Dexter F et al (1996) Flumazenil does not affect the increase in rat hippocampal extracellular glutamate concentration produced during thioacetamide-induced hepatic encephalopathy. Metab Brain Dis 11:329-342
22. Rose C, Michalak A, Pannunzio M et al (2000) Mild hypothermia delays the onset of coma and prevents brain edema and extracellular brain glutamate accumulation in rats with acute liver failure. Hepatology 31:872-877
23. Paulsen RE, Odden E, Fonnum F (1988) Importance of glutamine for gamma-aminobutyric acid synthesis in rat neostriatum in vivo. J Neurochem 51:1294-1299
24. Fonnum F, Paulsen RE (1990) Comparison of transmitter amino acid levels in rat globus pallidus and neostriatum during hypoglycemia or after treatment with methionine sulfoximine or gamma-vinyl gamma-aminobutyric acid. J Neurochem 54:1253-1257
25. Paxinos G, Watson C (1982) The rat brain in stereotaxic coordinates. Academic Press, New York
26. Zielińska M, Hilgier W, Borkowska HD et al (2002) Ammonia-induced extracellular accumulation of taurine in the rat striatum in vivo: role of ionotropic glutamate receptors. Neurochem Res 27:37-42
27. Pye IF, Stonier C, McGale EHF (1978) Double-enzymatic assay for determination of glutamine and glutamic acid in cerebrospinal fluid and plasma. Anal Chem 50:951-953
28. 2+ exchange in rat heart. Eur J Pharmacol 461:139-147
29. Vogels BA, Maas MA, Daalhuisen J et al (1997) Memantine, a noncompetitive NMDA receptor antagonist improves hyperammonemia-induced encephalopathy and acute hepatic encephalopathy in rats. Hepatology 25:820-827
30. Master S, Gottstein J, Blei AT (1999) Cerebral blood flow and the development of ammonia-induced brain edema in rats after portacaval anastomosis. Hepatology 30:876-880
31. Kosenko E, Kaminski Y, Lopata O et al (1999) Blocking NMDA receptors prevents the oxidative stress induced by acute ammonia intoxication. Free Radic Biol Med 26:1369-1374
32. Dolińska M, Hilgier W, Albrecht J (1996) Ammonia stimulates glutamine uptake to the cerebral non-synaptic mitochondria of the rat. Neurosci Lett 213:45-48
33. de Knegt RJ, Schalm SW, van der Rijt CC et al (1994) Extracellular brain glutamate during acute liver failure and during acute hyperammonemia simulating acute liver failure: an experimental study based on in vivo brain dialysis. J Hepatol 20:19-26
34. Vogels BA, van Steynen B, Maas MA et al (1997) The effects of ammonia and portal-systemic shunting on brain metabolism, neurotransmission and intracranial hypertension in hyperammonaemia-induced encephalopathy. J Hepatol 26:387-395
35. Kanamori K, Ross BD (2005) Suppression of glial glutamine release to the extracellular fluid studied in vivo by NMR and microdialysis in hyperammonemic rat brain. J Neurochem 94:74-85
36. Hecker M, Mitchell JA, Swierkosz TA et al (1990) Inhibition by L-glutamine of the release of endothelium-derived relaxing factor from cultured endothelial cells. Br J Pharmacol 101:237-239
37. Arnal JF, Munzel T, Venema RC et al (1995) Interactions between L-arginine and L-glutamine change endothelial NO production. An effect independent of NO synthase substrate availability. J Clin Invest 95:2565-2572
38. Meininger CJ, Kelly KA, Li H et al (2000) Glucosamine inhibits inducible nitric oxide synthesis. Biochem Biophys Res Commun 279:234-239
39. Wu G, Haynes TE, Li H et al (2001) Glutamine metabolism to glucosamine is necessary for glutamine inhibition of endothelial nitric oxide synthesis. Biochem J 353:245-252
40. Shaw CA, Bains JS, Pasqualotto BA et al (1999) Methionine sulfoximine shows excitotoxic actions in rat cortical slices. Can J Physiol Pharmacol 77:871-877
41. Zielińska M, Stafiej A, Law RO et al (2004) Effects of methionine sulfoximine on the glutamine and glutamate content and cell volume in rat cerebral cortical slices: involvement of mechanisms not related to inhibition of glutamine synthesis. Neurotoxicology 25:443-449
42. Palekar AG, Tate SS, Meister A (1975) Decrease in glutathione levels of kidney and liver after injection of methionine sulfoximine into rats. Biochem Biophys Res Commun 62:651-657
43. Meister A, Griffith OW (1979) Effects of methionine sulfoximine analogs on the synthesis of glutamine and glutathione: possible chemotherapeutic implications. Cancer Treat Rep 63:1115-1121
44. Wȩgrzynowicz M, Hilgier W, Dybel A, et al (2007) Upregulation of cerebral cortical glutathione synthesis by ammonia in vivo and in cultured glial cells: the role of cystine uptake. Neurochem Int 50:883-889
45. Rodriguez-Diaz M, Alonso TJ, Perdomo-Diaz J et al (2005) Glial regulation of nonsynaptic extracellular glutamate in the substantia nigra. Glia 49:134-142
46. Bacci A, Sancini G, Verderio C et al (2002) Block of glutamate-glutamine cycle between astrocytes and neurons inhibits epileptiform activity in hippocampus. J Neurophysiol 88:2302-2310
47. Le Meur K, Galante M, Angulo MC, et al (2007) Tonic activation of NMDA receptors by ambient glutamate of non-synaptic origin in the rat hippocampus. J Physiol 580:373-383