Ammonia stimulates glutamine uptake to the cerebral non-synaptic mitochondria of the rat

Neuroscience Letters

Volumn 213, Issue 1, 1996, Pages 45-48

  Dolińska, Monika ^a   Hilgier, Wojciech ^a   Albrecht, Jan ^a  

^a MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

Author keywords

Ammonia neurotoxicity; Brain; Glutamine uptake; Hyperammonemia; Mitochondria

Indexed keywords

AMMONIA; GLUTAMINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; CONTROLLED STUDY; HYPERAMMONEMIA; MALE; MITOCHONDRION; NEUROTOXICITY; NEUROTRANSMITTER UPTAKE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030602843     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(96)12827-5     Document Type: Article

References (27)

1. [1] Albrecht, J., Astrocytes and ammonia neurotoxicity. In. M. Aschner and H.K. Kimelberg (Eds.), The Role of Glia in Neurotoxicity, CRC Press, Boca Raton, FL, 1996, pp. 129-145.
2. [2] Albrecht, J., Wysmyk-Cybula, U. and Rafalowska, U., Cerebral oxygen consumption in experimental hepatic encephalopathy: different responses in astrocytes, neurons and synaptosomes, Exp. Neurol., 97 (1987) 418-422.
3. [3] Cooper, A.J.L. and Plum, F., Biochemistry and physiology of brain ammonia, Physiol. Rev., 67 (1987) 440-519.
4. [4] DeJong, C.H.C., Deutz, N.E.P. and Soeters, P., Cerebral cortex ammonia and glutamine metabolism in two rat models of chronic liver insufficiency-induced hyperammonemia: influence of pair-feeding, J. Neurochem., 60 (1993) 1047-1057.
5. [5] Faff-Michalak, L. and Albrecht, J., Aspartate aminotransferase, malate dehydrogenase, and pyruvate carboxylase activities in rat cerebral synaptic and non-synaptic mitochondria: effects of in vitro treatment with ammonia, hyperammonemia and hepatic encephalopathy, Metabol. Brain Dis., 6 (1991) 187-197.
6. 15N-N.M.R. study of cerebral, hepatic and renal nitrogen metabolism in hyperamrnonemic rats, Biochem. J., 270 (1990) 473-481.
7. [7] Hawkins, R.A. and Jessy, J., Hyperammonemia does not impair brain function in the absence of net glutamine synthesis, Biochem. J., 277 (1991) 697-703.
8. [8] Hawkins, R.A., Jessy, J., Mans, A.M. and DeJoseph, M.R., Effect of reducing brain glutamine synthesis on metabolic symptoms of hepatic encephalopathy, J. Neurochem., 60 (1993) 1000-1006.
9. 3H]deoxyglucose, Acta Neurol. Scand., 83 (1991) 353-355.
10. [10] Hilgier, W. and Olson, J.E., Brain ion and amino acid contents during edema development in hepatic encephalopathy, J. Neurochem., 62 (1994) 197-204.
11. [11] Jessy, J., De Joseph, M.R. and Hawkins, R.A., Hyperammonemia depresses glucose consumption throughout brain, Biochem. J., 277 (1991) 693-696.
12. [12] Lai, J.C.K. and Clark, J.B., Preparation of synaptic and non-synaptic mitochondria from rat brain. In S. Fleischer and L. Packer (Eds.), Methods in Enzymology, Vol. 55, Academic Press, New York, 1970, pp. 51-60.
13. [13] Mena, E.E. and Cotman, C.W., Pathologic concentrations of ammonium ions block L-glutamate uptake, Exp. Neurol., 89 (1986) 259-263.
14. [14] Minn, A., Glutamine uptake by isolated rat brain mitochondria, Neuroscience, 11 (1982) 2859-2865.
15. [15] Norenberg, M.D. and Lapham, L.W., The astrocyte response in experimental portal-systemic encephalopathy: an electron microscopic study, J. Neuropathol. Exp. Neurol., 33 (1974) 422-435.
16. [16] Oppong, K.N.W., Bartlett, K., Record C.O. and Mardini, H.A., Synaptosomal glutamate transport in thioacetamide-induced hepatic encephalopathy in the rat, Hepatology, 22 (1995) 553-558.
17. [17] Pilbeam, C.M., Anderson, RM. and Bathal, P.S., The brain in experimental portal-systemic encephalopathy I. Morphological changes in three animal models, J. Pathol., 140 (1983) 331-345.
18. [18] Pluta, R. and Albrecht, J., Changes in arterial and cerebral vevous blood gases, cerebral blood flow, and cerebral oxygen consumption at different stages of thioacetamide-induced hepatogenic encephalopathy in rat, Resuscitation, 14 (1986) 135-139.
19. [19] Schrnidlin, A. and Wiesinger, H., Transport of L-arginine in cultured astrocytes, Glia, 11 (1994) 262-268.
20. [20] Shrode, L. and Putnam, R.W., Intracellular pH regulation in priary rat astrocytes and C6 glioma cells, Glia, 12 (1994) 196-210.
21. [21] Steib, A., Rendon, A., Mark, J. and Borg, J., Preferential glutamine uptake in rat brain synaptic mitochondria, FEBS Lett., 207 (1986) 63-68.
22. [22] Swain, M., Butterworth, R.F. and Blei, A.T., Ammonia and related amino acids in the pathogenesis of brain edema in acute ischemic failure in rats, Hepatology, 15 (1992) 449-453.
23. [23] Szerb, J.C. and Butterworth, R.F., Effect of ammonium ions on synaptic transmission in the mammalian central nervous system, Prog. Neurobiol., 39 (1992) 135-153.
24. [24] Takahashi, H., Koehler, R.C., Brusilow, S.W. and Traystman, R.J., Inhibition of glutamine accumulation prevents cerebral edema in hyperammonemic rats, Am. J. Physiol. 261 (1991) H825-H829.
25. [25] Waniewski, R.A., Physiological levels of ammonia regulate glutamine synthesis from extracellular glutamate in astrocyte cultures, J. Neurochem., 58 (1992) 167-174.
26. [26] Willard-Mack, C.I., Koehler, R.C., Hirata, T., Cork, L.C., Takahashi, H., Traystman, R.J. and Brusilow, S.W., Inhibition of glutamine synthetase reduces ammonia-induced astrocyte swelling in rat, Neuroscience, 71 (1996) 589-599.
27. [27] Westergaaard, N., Sonnewald, U. and Schousboe, A., Metabolic trafficking between neurons and astrocytes: the glutamate/glutamine cycle revisited, Dev. Neurosci., 17 (1995) 203-211.