Nonhormonal drugs for contraception in men: A systematic review

Obstetrical and Gynecological Survey

Volumn 60, Issue 11, 2005, Pages 746-752

  Lopez, Laureen M ^a,c   Grimes, David A ^a   Schulz, Kenneth F ^b  

^a FHI360   (United States)

^b Quantitative Sciences   (United States)

^c FAMILY HEALTH INTERNATIONAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZADIRACHTA INDICA EXTRACT; CONTRACEPTIVE VACCINE; FOLLITROPIN; GOSSYPOL; LUTEINIZING HORMONE; MALE CONTRACEPTIVE AGENT; POTASSIUM; SPERMICIDAL AGENT; STYRENE MALEIC ANHYDRIDE COPOLYMER; TESTOSTERONE; TRIPTERYGIUM HYPOGLAUCUM EXTRACT; TRIPTERYGIUM WILFORDII EXTRACT; TRIPTOLIDE; UNCLASSIFIED DRUG;

ARTHRITIS; AZOOSPERMIA; BLOOD PRESSURE; CHINESE MEDICINE; CONTINUING EDUCATION; CONTRACEPTION; COTTON; DRUG EFFICACY; FATIGUE; FOLLOW UP; HUMAN; INJECTION SITE; LIBIDO DISORDER; MALE; OLIGOSPERMIA; PLANT; POTASSIUM BLOOD LEVEL; REVIEW; SPERMATOZOON COUNT; SPERMATOZOON DENSITY; SPERMATOZOON MOTILITY; SYSTEMATIC REVIEW; TESTOSTERONE BLOOD LEVEL; TRADITIONAL MEDICINE; TREATMENT OUTCOME; TRIPTERYGIUM; VAS DEFERENS;

CONTRACEPTIVE AGENTS, MALE; GOSSYPOL; HUMANS; MALE; MEDICINE, CHINESE TRADITIONAL; PLANT PREPARATIONS; POTASSIUM; RANDOMIZED CONTROLLED TRIALS; TRIPTERYGIUM;

EID: 27544465448     PISSN: 00297828     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ogx.0000182905.71077.13     Document Type: Review

References (37)

1. Robaire B. Advancing towards a male contraceptive: a novel approach from an unexpected direction. Trends Pharmacol Sci 2003;24:326-328.
2. Anderson RA. Hormonal contraception in the male. Br Med Bull 2000;56:717-728.
3. Nieschlag E, Henke A. Hopes for male contraception. Lancet 2005;365:554-556.
4. Grimes D, Gallo M, Grigorieva V, et al. Steroid hormones for contraception in men. Cochrane Database Syst Rev 2004;2.
5. Anawalt BD, Amory JK. Advances in male hormonal contraception. Ann Med 2001;33:587-595.
6. Kamischke A, Nieschlag E. Progress towards hormonal male contraception. Trends Pharmacol Sci 2004;25:49-57.
7. Anderson RA, Baird DT. Male contraception. Endocr Rev 2002;23:735-762.
8. Weber RF, Dohle GR. Male contraception: mechanical, hormonal and non-hormonal methods. World J Urol 2003;21: 338-340.
9. Jensen JT. Male contraception. Curr Womens Health Rep 2002;2:338-345.
10. Qian SZ, Hu YZ, Wang SM, et al. Effects of Tripterygium hypoglaucum (Levl.) Hutch on male fertility. Adv Contracept 1988;4:307-310.
11. Delves PJ. How far from a hormone-based contraceptive vaccine? J Reprod Immunol 2004;62:69-78.
12. Talwar GP. Fertility regulating and immunotherapeutic vaccines reaching human trials stage. Hum Reprod Update 1997; 3:301-310.
13. Delves PJ, Lund T, Roitt IM. Antifertility vaccines. Trends Immunol 2002;23:213-219.
14. Lohiya NK, Manivannan B, Mishra PK, et al. Vas deferens, a site of male contraception: an overview. Asian J Androl 2001; 3:87-95.
15. Chaki SP, Das HC, Misro MM. A short-term evaluation of semen and accessory sex gland function in phase III trial subjects receiving intravasal contraceptive RISUG. Contraception 2003;67:73-78.
16. Chaudhury K, Bhattacharyya AK, Guha SK. Studies on the membrane integrity of human sperm treated with a new injectable male contraceptive. Hum Reprod 2004;19:1826-1830.
17. World Health Organization. Task Force on Methods for the Regulation of Male Fertility. Contraceptive efficacy of testosterone-induced azoospermia and oligozoospermia in normal men. Fertil Steril 1996;65:821-829.
18. Liu GZ, Lyle KC, Cao J. Clinical trial of gossypol as a male contraceptive drug. Part I. Efficacy study. Fertil Steril 1987; 48:459-461.
19. Liu GZ, Lyle KC. Clinical trial of gossypol as a male contraceptive drug. Part II. Hypokalemia study. Fertil Steril 1987;48: 462-465.
20. Qian SZ, Zhong CQ, Xu N, et al. The antifertility effect of total glycosides of Tripterigium wilfordii Hook. f. (GTW) in men. Adv Contracept 1987;2:253-254.
21. Khillare B, Shrivastav TG. Spermicidal activity of Azadirachta indica (neem) leaf extract. Contraception 2003;68:225-229.
22. Raghuvanshi P, Bagga R, Malhotra D, et al. Spermicidal & contraceptive properties of Praneem polyherbal pessary. Indian J Med Res 2001;113:135-141.
23. Guha SK, Singh G, Anand S, et al. Phase I clinical trial of an injectable contraceptive for the male. Contraception 1993;48: 367-375.
24. Guha SK, Singh G, Ansari S, et al. Phase II clinical trial of a vas deferens injectable contraceptive for the male. Contraception 1997;56:245-250.
25. Coutinho EM, Athayde C, Atta G, et al. Gossypol blood levels and inhibition of spermatogenesis in men taking gossypol as a contraceptive. A multicenter, international, dose-finding study. Contraception 2000;61:61-67.
26. Meng GD, Zhu JC, Chen ZW, et al. Follow-up of men in the recovery period immediately after the cessation of gossypol treatment. Contraception 1988;37:119-128.
27. Zhong CQ, Lui QL, Tang YJ, et al. Study on sperm function in men long after cessation of gossypol treatment. Contraception 1990;41:617-622.
28. Waites GM, Wang C, Griffin PD. Gossypol: reasons for its failure to be accepted as a safe, reversible male antifertility drug. Int J Androl 1998;21:8-12.
29. Huynh PN, Hikim AP, Wang C, et al. Long-term effects of triptolide on spermatogenesis, epididymal sperm function, and fertility in male rats. J Androl 2000;21:689-699.
30. Shi YL, Bai JP, Wang WP. Ion-channels in human sperm membrane and contraceptive mechanisms of male antifertility compounds derived from Chinese traditional medicine. Acta Pharmacol Sin 2003;24:22-30.
31. Chen H, Chang X, Weng T, et al. A study of microemulsion systems for transdermal delivery of triptolide. J Control Release 2004;98:427-436.
32. Hair WM, Wu FC. Male contraception: prospects for the new millennium. Asian J Androl 2000;2:3-12.
33. Waites GM. Development of methods of male contraception: impact of the World Health Organization Task Force. Fertil Steril 2003;80:1-15.
34. Chaudhury K, Sharma U, Jagannathan NR, et al. Effect of a new injectable male contraceptive on the seminal plasma amino acids studied by proton NMR spectroscopy. Contraception 2002;66:199-204.
35. Suganuma R, Walden CM, Butters TD, et al. Alkylated imino sugars, reversible male infertility-inducing agents, do not affect the genetic integrity of male mouse germ cells during short-term treatment despite induction of sperm deformities. Biol Reprod 2005;72:805-813.
36. van der Spoel AC, Jeyakumar M, Butters TD, et al. Reversible infertility in male mice after oral administration of alkylated imino sugars: a nonhormonal approach to male contraception. Proc Natl Acad Sci U S A 2002;99:17173-17178.
37. Cheng CY, Mo M, Grima J, et al. Indazole carboxylic acids in male contraception. Contraception 2002;65:265-268.