Effects of HBV X gene and arsenic trioxide on the expression of p53 in cultured HepG2 cells

Chinese Medical Journal

Volumn 120, Issue 24, 2007, Pages 2181-2184

  Lei, Jian Hua ^a   He, Xing E ^a   Yang, Xu ^a   Zhang, Min ^a   Lian, Jun ^a   Luo, Hong Yu ^a   Wang, Wen Long ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Arsenic trioxide; Gene X; Hepatitis B virus; RNA interference; Tumor suppressor protein p53

Indexed keywords

ARSENIC TRIOXIDE; HEPATITIS B VIRUS X PROTEIN; PROTEIN P53; SMALL INTERFERING RNA;

ARTICLE; CELL CULTURE; CELL LYSATE; CELL STRAIN HEPG2; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPRESSION VECTOR; GENE SEQUENCE; GENETIC TRANSFECTION; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; MOLECULAR CLONING; NONHUMAN; PROTEIN EXPRESSION; RNA INTERFERENCE; UPREGULATION;

EID: 38349130478     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00029330-200712020-00004     Document Type: Article

References (26)

1. Nakamura Y. Isolation of p53-target genes and their functional analysis. Cancer Sci 2004; 95: 7-11.
2. Farid NR. p53 and other cell cycle regulators. Cancer Treat Res 2004; 122: 149-164.
3. Mills AA. p53: link to the past, bridge to the future. Genes Dev 2005; 19: 2091-2099.
4. Murakami S. Hepatitis B virus X protein: a multifunctional viral regulator. Gastroenterology 2001; 36: 651-660.
5. Seeger C, Mason WS. Hepatitis B virus biology. Microbiol Mol Biol Rev 2000; 64: 51-68.
6. Elmore LW, Hancock AR, Chang SF, Wang XW, Chang S, Callahan CP, et al. Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis. Proc Natl Acad Sci U S A 1997; 94: 14707-14712.
7. Huo TI, Wang XW, Forgues M, Wu CG, Spillare EA, Giannini C, et al. Hepatitis B virus X mutants derived from human hepatocellular carcinoma retain the ability to abrogate p53-induced apoptosis. Oncogene 2001; 20: 3620-3628.
8. Ogden SK, Lee KC, Barton MC. Hepatitis B viral transactivator HBx alleviates p53-mediated repression of α-fetoprotein gene expression. J Biol Chem 2000; 275: 27806-27814.
9. Lin Y, Nomura T, Yamashita T, Dorjsuren D, Tang H, Murakami S. The transactivation and p53-interaction functions of HBx are mutually interfering but distinct. Cancer Res 1997; 57: 5137-5142.
10. Lee SG, Rho HM. Transcriptional repression of the human p53 gene by hepatitis B viral X protein. Oncogene 2000, 19: 468-471.
11. Wang XW, Gibson MK, Vermeulen W, Yeh H, Forrester K, Sturzbecher HW, et al. Abrogation of p53-induced apoptosis by the hepatitis B virus X gene. Cancer Res 1995; 55: 6012-6016.
12. Lin J, Zhu MH, Zhu S, Qu JK,Li-FM, Ni CR. The role of hepatitis B virus X gene and p53 on hepatocellular carcinoma cell growth. Chin J Pathol (Chin) 2003; 32: 43-47.
13. Liu LX, Zhu AL, Chen W, Guo HX, Wang XQ, Liu ZH, et al. The effect and mechanism of arsenic trioxide on hepatocellular carcinoma. Chin J Surg (Chin) 2005; 43: 33-36.
14. Xiong H, Hou J, Gao, WR, Chen QB. Investigation of the effect of 2-methoxyestradiol and arsenic troxide on the apoptosis-associated gene expression profile of myeloma cells. Chin J Hematol (Chin) 2005; 26: 200-204.
15. 3 induces apoptosis of the human B lymphoma cell line MBC-1. J Biol Regul Homeost Agents 2000; 14: 116-119.
16. 3 on cell cycle progression and cyclins D1 and B1 expression in two glioblastoma cell lines differing in p53 status. Int J Oncol 2002; 21: 49-55.
17. Lu M, Xia L, Luo D, Waxman S, Jing Y. Dual effects of glutathione-S-transferase π on As2O3 action in prostate cancer cells: enhancement of growth inhibition and inhibition of apoptosis. Oncogene 2004; 23: 3945-3952.
18. 3) on human breast cancer cells. J Cell Biochem 2004; 93: 173-187.
19. Hannon GJ. RNA interference. Nature 2002; 418: 244-251.
20. Tuschl T. Expanding small RNA interference. Nat Biotechnol 2002; 20: 446-448.
21. Paul CP, Good PD, Winer I, Enqelke DR. Effective expression of small interfering RNA in human cells. Nat Biotechnol 2002; 20: 505-508.
22. Cheng TL, Chang WW, Su IJ, Lai MD, Huang W, Lei HY, et al. Therapeutic inhibition of hepatitis B virus surface antigen expression by RNA interference. Biochem Biophys Res Commun 2005; 336: 820-830.
23. Ren XR, Zhou LJ, Luo GB, Lin B, Xu A. Inhibition of hepatitis B virus replication in 2.2.15 cells by expressed shRNA. J Viral Hepat 2005; 12: 236-242.
24. Moore MD, McGarvey MJ, Russell RA, Cullen BR, McClure MO. Stable inhibition of hepatitis B virus proteins by small interfering RNA expressed from viral vectors. J Gene Med 2005; 7: 918-925.
25. Gong GZ, Jiang YF, Zhu YH, Su XS. Regulation mechanism of HCV NS5A on p53 protein transactivity. Chin J Hepatol (Chin) 2003; 11: 162-165.
26. Ohtani S, Kagawa S, Tango Y, Umeoka T, Tokunaga N, Tsunemitsu Y, et al. Quantitative analysis of p53-targeted gene expression and visualization of p53 transcriptional activity following intratumoral administration of adenoviral p53 in vivo. Mol Cancer Ther 2004; 3: 93-100.