A mutation in the translation initiation codon of Gata-1 disrupts megakaryocyte maturation and causes thrombocytopenia

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 38, 2006, Pages 14146-14151

  Majewski, Ian J ^a,b   Metcalf, Donald ^a,c   Mielke, Lisa A ^a   Krebs, Danielle L ^a   Ellis, Sarah ^b   Carpinelli, Marina R ^a   Mifsud, Sandra ^a   Di Rago, Ladina ^a   Corbin, Jason ^a   Nicola, Nicos A ^a   Hilton, Douglas J ^a   Alexander, Warren S ^a  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c PETER MACCALLUM CANCER CENTRE   (Australia)

Author keywords

N ethyl N nitrosourea mutagenesis; Platelet

Indexed keywords

ETHYLNITROSOUREA; TRANSCRIPTION FACTOR GATA 1;

ACUTE MEGAKARYOCYTIC LEUKEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW; CELL MATURATION; CODON; COLONY FORMING CELL; CONTROLLED STUDY; DOWN SYNDROME; EMBRYO DEVELOPMENT; FEMALE; FETUS LIVER; GATA 1 GENE; GENE; GENE LOCUS; GENE MUTATION; HEMIZYGOSITY; MALE; MAST CELL; MEGAKARYOBLAST; MEGAKARYOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN; START CODON; THROMBOCYTOPENIA; TRANSLATION INITIATION; X CHROMOSOME INACTIVATION;

ALKYLATING AGENTS; ANIMALS; BONE MARROW CELLS; CELL DIFFERENTIATION; CODON; ETHYLNITROSOUREA; FEMALE; GATA1 TRANSCRIPTION FACTOR; HEMATOPOIETIC STEM CELLS; HUMANS; MALE; MEGAKARYOCYTES; MICE; MICE, INBRED STRAINS; MUTATION; PROTEIN BIOSYNTHESIS; PROTEIN ISOFORMS; SPLEEN; THROMBOCYTOPENIA; TRANSCRIPTION INITIATION SITE;

ANIMALIA;

EID: 33749021334     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0606439103     Document Type: Article

References (27)

1. Fujiwara Y, Browne CP, Cunniff K, Goff SC, Orkin SH (1996) Proc Natl Acad Sci USA 93:12355-12358.
2. Migliaccio AR, Rana RA, Sanchez M, Lorenzini R, Centurione L, Bianchi L, Vannucchi AM, Migliaccio G, Orkin SH (2003) J Exp Med 197:281-296.
3. Weiss MJ, Keller G, Orkin SH (1994) Genes Dev 8:1184-1197.
4. Yu C, Cantor AB, Yang H, Browne C, Wells RA, Fujiwara Y, Orkin SH (2002) J Exp Med 195:1387-1395.
5. Yamaguchi Y, Zon LI, Ackerman SJ, Yamamoto M, Suda T (1998) Blood 91:450-457.
6. Vyas P, Ault K, Jackson CW, Orkin SH, Shivdasani RA (1999) Blood 93:2867-2875.
7. Muntean AG, Crispino JD (2005) Blood 106:1223-1231.
8. Stachura DL, Chou ST, Weiss MJ (2006) Blood 107:87-97.
9. Shivdasani RA, Fujiwara Y, McDevitt MA, Orkin SH (1997) EMBO J 16:3965-3973.
10. Wechsler J, Greene M, McDevitt MA, Anastasi J, Karp JE, Le Beau MM, Crispino JD (2002) Nat Genet 32:148-152.
11. Xu G, Nagano M, Kanezaki R, Toki T, Hayashi Y, Taketani T, Taki T, Mitui T, Koike K, Kato K, et al. (2003) Blood 102:2960-2968.
12. Rainis L, Bercovich D, Strehl S, Teigler-Schlegel A, Stark B, Trka J, Amariglio N, Biondi A, Muler I, Rechavi G, et al. (2003) Blood 102:981-986.
13. Hirose Y, Kudo K, Kiyoi H, Hayashi Y, Naoe T, Kojima S (2003) Leukemia 17:2250-2252.
14. Martin DI, Orkin SH (1990) Genes Dev 4:1886-1898.
15. Visvader JE, Crossley M, Hill J, Orkin SH, Adams JM (1995) Mol Cell Biol 15:634-641.
16. Shimizu R, Takahashi S, Ohneda K, Engel JD, Yamamoto M (2001) EMBO J 20:5250-5260.
17. Li Z, Godinho FJ, Klusmann JH, Garriga-Canut M, Yu C, Orkin SH (2005) Nat Genet 37:613-619.
18. Hitzler JK, Zipursky A (2005) Nat Rev Cancer 5:11-20.
19. Balduini CL, Pecci A, Loffredo G, Izzo P, Noris P, Grosso M, Bergamaschi G, Rosti V, Magrini U, Ceresa IF, et al. (2004) Thromb Haemostasis 91:129-140.
20. Nichols KE, Crispino JD, Poncz M, White JG, Orkin SH, Maris JM, Weiss MJ (2000) Nat Genet 24:266-270.
21. Yu C, Niakan KK, Matsushita M, Stamatoyannopoulos G, Orkin SH, Raskind WH (2002) Blood 100:2040-2045.
22. Mehaffey MG, Newton AL, Gandhi MJ, Crossley M, Drachman JG (2001) Blood 98:2681-2688.
23. Calligaris R, Bottardi S, Cogoi S, Apezteguia I, Santoro C (1995) Proc Natl Acad Sci USA 92:11598-11602.
24. Ware J, Russell S, Ruggeri ZM (2000) Proc Natl Acad Sci USA 97:2803-2808.
25. Shivdasani RA, Rosenblatt MF, Zucker-Franklin D, Jackson CW, Hunt P, Saris CJ, Orkin SH (1995) Cell 81:695-704.
26. Hollanda LM, Lima CS, Cunha AF, Albuquerque DM, Vassallo J, Ozelo MC, Joazeiro PP, Saad ST, Costa FF (2006) Nat Genet 38:807-812.
27. Alexander WS, Roberts AW, Nicola NA, Li R, Metcalf D (1996) Blood 87:2162-2170.