Differential hypothalamic-pituitary-adrenal activation of the neuroactive steroids pregnenolone sulfate and deoxycorticosterone in healthy controls and alcohol-dependent subjects

Psychoneuroendocrinology

Volumn 33, Issue 2, 2008, Pages 214-226

  Porcu, Patrizia ^a   O'Buckley, Todd K ^a   Leslie Morrow, A ^a   Adinoff, Bryon ^b,c  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c VA NORTH TEXAS HEALTH CARE SYSTEM   (United States)

Author keywords

Alcohol dependence; Deoxycorticosterone; Hypothalamic pituitary adrenal axis; Neuroactive steroids; Pregnenolone sulfate

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; DEOXYCORTICOSTERONE; DEXAMETHASONE; NALOXONE; PREGNENOLONE SULFATE; TETRACOSACTIDE;

ADRENAL GLAND; ADULT; ALCOHOLISM; ARTICLE; CIRCADIAN RHYTHM; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; PRIORITY JOURNAL; RADIOIMMUNOASSAY; TOBACCO DEPENDENCE;

ADULT; ALCOHOL-RELATED DISORDERS; ANALYSIS OF VARIANCE; ANIMALS; CASE-CONTROL STUDIES; CORTICOTROPIN-RELEASING HORMONE; COSYNTROPIN; DESOXYCORTICOSTERONE; DEXAMETHASONE; DRUG SYNERGISM; FEEDBACK, BIOCHEMICAL; HORMONES; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; MATCHED-PAIR ANALYSIS; MIDDLE AGED; NALOXONE; NARCOTIC ANTAGONISTS; PITUITARY-ADRENAL SYSTEM; PREGNENOLONE; REFERENCE VALUES; SHEEP; STIMULATION, CHEMICAL; TOBACCO USE DISORDER;

EID: 38349094180     PISSN: 03064530     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2007.11.003     Document Type: Article

References (52)

1. Adinoff B., Martin P.R., Bone G.H., Eckardt M.J., Roehrich L., George D.T., Moss H.B., Eskay R., Linnoila M., and Gold P.W. Hypothalamic-pituitary-adrenal axis functioning and cerebrospinal fluid corticotropin releasing hormone and corticotropin levels in alcoholics after recent and long-term abstinence. Arch. Gen. Psychiatr. 47 (1990) 325-330
2. Adinoff B., Krebaum S.R., Chandler P.A., Ye W., Brown M.B., and Williams M.J. Dissection of hypothalamic-pituitary-adrenal axis pathology in 1-month-abstinent alcohol-dependent men, part 1: adrenocortical and pituitary glucocorticoid responsiveness. Alcohol Clin. Exp. Res. 29 (2005) 517-527
3. Adinoff B., Krebaum S.R., Chandler P.A., Ye W., Brown M.B., and Williams M.J. Dissection of hypothalamic-pituitary-adrenal axis pathology in 1-month-abstinent alcohol-dependent men, part 2: response to ovine corticotropin-releasing factor and naloxone. Alcohol Clin. Exp. Res. 29 (2005) 528-537
4. Anthenelli R.M., Maxwell R.A., Geracioti T.D.J., and Hauger R. Stress hormone dysregulation at rest and after serotonergic stimulation among alcohol-dependent men with extended abstinence and controls. Alcohol Clin. Exp. Res. 25 (2001) 692-703
5. Barbaccia M.L., Affricano D., Trabucchi M., Purdy R.H., Colombo G., Agabio R., and Gessa G.L. Ethanol markedly increases "GABAergic'' neurosteroids in alcohol-preferring rats. Eur. J. Pharmacol. 384 (1999) R1-R2
6. Bates M.E., Bowden S.C., and Barry D. Neurocognitive impairment associated with alcohol use disorders: implications for treatment. Exp. Clin. Psychopharmacol. 10 (2002) 193-212
7. Baulieu E.E. Neurosteroids: a novel function of the brain. Psychoneuroendocrinology 23 (1998) 963-987
8. Beck A.T., Ward C.H., Mendelson M., Mock J., and Erbaugh J. An inventory for measuring depression. Arch. Gen. Psychiatr. 4 (1979) 561-571
9. Boizel R., De Peretti E., Cathiard A., Halimi S., Bost M., Berthezene F., and Saez J. Pattern of plasma levels of cortisol, dehydroepiandrosterone and pregnenolone sulphate in normal subjects and in patients with homozygous familial hypercholesterolaemia during ACTH infusion. Clin. Endocrinol. (Oxf) 25 (1986) 363-371
10. Brown R.D., and Strott C.A. Plasma deoxycorticosterone in man. J. Clin. Endocr. 32 (1971) 744-750
11. Caldeira J.C., Wu Y., Mameli M., Purdy R.H., Li P.-K., Akwa Y., Savage D.D., Engen J.R., and Valenzuela C.F. Fetal alcohol exposure alters neurosteroid levels in the developing rat brain. J. Neurochem. 90 (2004) 1530-1539
12. Costa A., Bono G., Martignoni E., Merlo P., Sances G., and Nappi G. An assessment of hypothalamo-pituitary-adrenal axis functioning in nondepressed early abstinent alcoholics. Psychoneuroendocrinology 21 (1996) 263-275
13. Craig C.R. Anticonvulsant activity of steroids: separability of anticonvulsant from hormonal effects. J. Pharmacol. Exp. Ther. 153 (1966) 337-343
14. Davies E., and MacKenzie S.M. Extra-adrenal production of corticosteroids. Clin. Exp. Pharmacol. Physiol. 30 (2003) 437-445
15. De Peretti E., and Mappus E. Pattern of plasma pregnenolone sulfate levels in humans from birth to adulthood. J. Clin. Endocrinol. Metab. 57 (1983) 550-556
16. Ehrenreich H., Schuck J., Stender N., Pilz J., Gefeller O., Schilling L., Poser W., and Kaw S. Endocrine and hemodynamic effects of stress versus systemic CRF in alcoholics during early and medium term abstinence. Alcohol Clin. Exp. Res. 21 (1997) 1285-1293
17. Flood J.F., Morley J.E., and Roberts E. Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it. Proc. Natl. Acad. Sci. USA 89 (1992) 1567-1571
18. Flood J.F., Morley J.E., and Roberts E. Pregnenolone sulfate enhances post-training memory processes when injected in very low doses into limbic system structures: the amygdala is by far the most sensitive. Proc. Natl. Acad. Sci. USA 92 (1995) 10806-10810
19. Genazzani A.R., Petraglia F., Bernardi F., Casarosa E., Salvestroni C., Tonetti A., Nappi R.E., Luisi S., Palumbo M., Purdy R.H., and Luisi M. Circulating levels of allopregnanolone in humans: gender, age, and endocrine influences. J. Clin. Endocrinol. Metab. 83 6 (1998) 2099-2103
20. Higashi T., Sugitani H., Yagi T., and Shimada K. Studies on neurosteroids XVI. Levels of pregnenolone sulfate in rat brains determined by enzyme-linked immunosorbent assay not requiring solvolysis. Biol. Pharm. Bull. 26 (2003) 709-711
21. Hill M., Popov P., Havlikova H., Kancheva L., Vrbikova J., Kancheva R., Pouzar V., Cerny I., and Starka L. Altered profiles of serum neuroactive steroids in premenopausal women treated for alcohol addiction. Steroids 70 (2005) 515-524
22. Inder W.J., Joyce P.R., Ellis M.J., Evans M.J., Livesey J.H., and Donald R.A. The effects of alcoholism on the hypothalamic-pituitary-adrenal axis: interaction with endogenous opioid peptides. Clin. Endocrinol. (Oxf) 43 (1995) 283-290
23. Kater C.E., Irony I., Biglieri E.G., and Faiçal S. Continuous adrenocorticotropin administration in hypopituitarism produces asynchronous increases of deoxycorticosterone and 11-deoxycortisol relative to other reduced zona fasciculata steroids. J. Clin. Endocrinol. Metab. 71 (1990) 305-310
24. Khisti R.T., Boyd K.N., Kumar S., and Morrow A.L. Systemic ethanol administration elevates deoxycorticosterone levels and chronic ethanol exposure attenuates this response. Brain Res. 1049 (2005) 104-111
25. Laatikainen T., and Vihko R. Diurnal variation in the concentrations of solvolyzable steroids in human plasma. J. Clin. Endocr. 28 (1968) 1356-1360
26. Liere P., Pianos A., Eychenne B., Cambourg A., Liu S., Griffiths W., Schumacher M., Sjovall J., and Baulieu E.E. Novel lipoidal derivatives of pregnenolone and dehydroepiandrosterone and absence of their sulfated counterparts in rodent brain. J. Lipid Res. 45 (2004) 2287-2302
27. Liu S., Griffiths W.J., and Sjovall J. Capillary liquid chromatography/electrospray mass spectrometry for analysis of steroid sulfates in biological samples. Anal. Chem. 75 (2003) 791-797
28. Majewska M.D., Mienville J.M., and Vicini S. Neurosteroid pregnenolone sulfate antagonizes electrophysiological responses to GABA in neurons. Neurosci. Lett. 90 (1988) 279-284
29. Mameli M., and Valenzuela C.F. Alcohol increases efficacy of immature synapses in a neurosteroid-dependent manner. Eur. J. Neurosci. 23 (2006) 835-839
30. Marx C.E., Trost W.T., Shampine L., Behm F.M., Giordano L.A., Massing M.W., and Rose J.E. Neuroactive steroids, negative affect, and nicotine dependence severity in male smokers. Psychopharmacology 186 (2006) 462-472
31. Melchior C.L., and Ritzmann R.F. Neurosteroids block the memory-impairing effects of ethanol in mice. Pharmacol. Biochem. Behav. 53 (1996) 51-56
32. Morrow A.L., VanDoren M.J., Penland S.N., and Matthews D.B. The role of GABAergic neuroactive steroids in ethanol action, tolerance and dependence. Brain Res. Brain Res. Rev. 37 (2001) 98-109
33. Morrow A.L., Porcu P., Boyd K.N., and Grant K.A. Hypothalamic-pituitary-adrenal axis modulation of GABAergic neuroactive steroids influences ethanol sensitivity and drinking behavior. Dialog. Clin. Neurosci. 8 (2006) 463-477
34. Mtchedlishvili Z., and Kapur J. A presynaptic action of the neurosteroid pregnenolone sulfate on GABAergic synaptic transmission. Mol. Pharmacol. 64 (2003) 857-864
35. Owens M.J., Ritchie J.C., and Nemeroff C.B. 5α-Pregnane-3α,21-diol-20-one (THDOC) attenuates mild stress-induced increases in plasma corticosterone via a non-glucocorticoid mechanism: comparison with alprazolam. Brain Res. 573 (1992) 353-355
36. Patchev V.K., Shoaib M., Holsboer F., and Almeida O.F.X. The neurosteroid tetrahydroprogesterone counteracts corticotropin-releasing hormone-induced anxiety and alters the release and gene expression of corticotropin-releasing hormone in the rat hypothalamus. Neuroscience 62 (1994) 265-271
37. Patchev V.K., Hassan A.H.S., Holsboer F., and Almeida O.F.X. The neurosteroid tetrahydroprogesterone attenuates the endocrine response to stress and exerts glucocorticoid-like effects on vasopressin gene transcription in the rat hypothalamus. Neuropsychopharmacology 15 (1996) 533-540
38. Paul S.M., and Purdy R.H. Neuroactive steroids. FASEB J. 6 (1992) 2311-2322
39. Porcu P., Sogliano C., Cinus M., Purdy R.H., Biggio G., and Concas A. Nicotine-induced changes in cerebrocortical neuroactive steroids and plasma corticosterone concentrations in the rat. Pharmacol. Biochem. Behav. 74 (2003) 683-690
40. Porcu P., Grant K.A., Green H.L., Rogers L.S., and Morrow A.L. Hypothalamic-pituitary-adrenal axis and ethanol modulation of deoxycorticosterone levels in cynomolgus monkeys. Psychopharmacology 186 (2006) 293-301
41. Porcu, P., Grant, K.A., Morrow, A.L., 2006b. Long-term voluntary alcohol consumption increases plasma deoxycorticosterone levels and alters hypothalamic-pituitary-adrenal axis modulation in cynomolgus monkeys. 2006 Neuroscience Meeting Planner. Society for Neuroscience, Atlanta, GA. Online Program No. 192.3.
42. Porcu P., Rogers L.S.M., Morrow A.L., and Grant K.A. Plasma pregnenolone levels in cynomolgus monkeys following pharmacological challenges of the hypothalamic-pituitary-adrenal axis. Pharmacol. Biochem. Behav. 84 (2006) 618-627
43. Raffin-Sanson M.L., de Keyzer Y., and Bertagna X. Proopiomelanocortin, a polypeptide precursor with multiple functions: from physiology to pathological conditions. Eur. J. Endocrinol. 149 (2003) 79-90
44. A receptor function and seizure susceptibility. J. Neurosci. 22 (2002) 3795-3805
45. Selye H. The antagonism between anesthetic steroid hormones and pentamethylenetetrazol. J. Lab. Clin. Med. 27 (1942) 1051-1053
46. Spencer R.L., and McEwen B.S. Adaptation of the hypothalamic-pituitary-adrenal axis to chronic ethanol stress. Neuroendocrinology 52 (1990) 481-489
47. Stoffel-Wagner B. Neurosteroid metabolism in the human brain. Eur. J. Endocrinol. 145 (2001) 669-679
48. Tan S.Y., and Mulrow P.J. The contribution of the zona fasciculata and glomerulosa to plasma 11-deoxycorticosterone levels in man. J. Clin. Endocrinol. Metab. 41 (1975) 126-130
49. Torres J.M., and Ortega E. DHEA, PREG and their sulphate derivatives on plasma and brain after CRH and ACTH administration. Neurochem. Res. 28 (2003) 1187-1191
50. Vallee M., Mayo W., and Le Moal M. Role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive aging. Brain Res. Brain Res. Rev. 37 (2001) 301-312
51. Wand G.S., and Dobs A.S. Alterations in the hypothalamic-pituitary-adrenal axis in actively drinking alcoholics. J. Clin. Endocrinol. Metab. 72 (1991) 1290-1295
52. Wu F.-S., Gibbs T.T., and Farb D.H. Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-d-aspartate receptor. Mol. Pharmacol. 40 (1991) 333-336