Determination of how many immunoglobulin variable region heavy chain mutations are allowable in unmutated chronic lymphocytic leukaemia - Long-term follow up of patients with different percentages of mutations

British Journal of Haematology

Volumn 140, Issue 3, 2008, Pages 320-323

  Hamblin, Terry J ^a   Davis, Zadie A ^a   Oscier, David G ^a  

^a ROYAL BOURNEMOUTH HOSPITAL   (United Kingdom)

Author keywords

Chronic lymphocytic leukaemia; IGHV genes; Prognosis; Prognostic markers

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN;

ARTICLE; CANCER SURVIVAL; CHRONIC LYMPHATIC LEUKEMIA; DNA POLYMORPHISM; FOLLOW UP; GENE MUTATION; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS; SEQUENCE HOMOLOGY;

BASE SEQUENCE; DNA MUTATIONAL ANALYSIS; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; GENES, IMMUNOGLOBULIN HEAVY CHAIN; GENETIC MARKERS; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MOLECULAR SEQUENCE DATA; PROGNOSIS; RETROSPECTIVE STUDIES; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SURVIVAL RATE;

EID: 38349088322     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2007.06928.x     Document Type: Article

References (15)

1. Albesiano, E., Messmer, B.T., Damle, R.N., Allen, S.L., Rai, K.R. Chiorazzi, N. (2003) Activation-induced cytidine deaminase in chronic lymphocytic leukemia B cells: expression as multiple forms in a dynamic, variably sized fraction of the clone. Blood, 102, 3333 3339.
2. Damle, R.N., Wasil, T., Fais, F., Ghiotto, F., Valetto, A., Allen, S.L., Buchbinder, A., Budman, D., Dittmar, K., Kolitz, J., Lichtman, S.M., Schulman, P., Vinciguerra, V.P., Rai, K.R., Ferrarini, M. Chiorazzi, N. (1999) Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood, 94, 1840 1847.
3. Davis, Z.A., Orchard, J.A., Corcoran, M.M. Oscier, D.G. (2003) Divergence from the germ-line sequence in unmutated chronic lymphocytic leukemia is due to somatic mutation rather than polymorphisms. Blood, 102, 3075 3075.
4. Hamblin, T.J., Davis, Z., Gardiner, A., Oscier, D.G. Stevenson, F.K. (1999) Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood, 94, 1848 1854.
5. Hamblin, T.J., Orchard, J.A., Ibbotson, R.E., Davis, Z., Thomas, P.W., Stevenson, F.K. Oscier, D.G. (2002) CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease. Blood, 99, 1023 1029.
6. Klein, U., Tu, Y., Stolovitzky, G.A., Mattioli, M., Cattoretti, G., Husson, H., Freedman, A., Inghirami, G., Cro, L., Baldini, L., Neri, A., Califano, A. Dalla-Favera, R. (2001) Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells. Journal of Experimental Medicine, 194, 1625 1638.
7. Krober, A., Seiler, T., Benner, A., Bullinger, L., Bruckle, E., Lichter, P., Dohner, H. Stilgenbauer, S. (2002) V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia. Blood, 100, 1410 1416.
8. Lin, K., Sherrington, P.D., Dennis, M., Matrai, Z., Cawley, J.C. Pettitt, A.R. (2002) Relationship between p53 dysfunction, CD38 expression, and IgV(H) mutation in chronic lymphocytic leukemia. Blood, 100, 1404 1409.
9. Matsuda, F., Shin, E.K., Nagaoka, H., Matsumura, R., Haino, M., Fukita, Y., Taka-ishi, S., Imai, T., Riley, J.H., Anand, R., Soeda, E. Honjo, T. (1993) Structure and physical map of 64 variable segments in the 3'0.8-megabase region of the human immunoglobulin heavy-chain locus. Nature Genetics, 3, 88 94.
10. Rassenti, L.Z., Huynh, L., Toy, T.L., Chen, L., Keating, M.J., Gribben, J.G., Neuberg, D.S., Flinn, I.W., Rai, K.R., Byrd, J.C., Kay, N.E., Greaves, A., Weiss, A. Kipps, T.J. (2004) ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia. New England Journal of Medicine, 351, 893 901.
11. Reiniger, L., Bodor, C., Bognar, A., Balogh, Z., Csomor, J., Szepesi, A., Kopper, L. Matolcsy, A. (2006) Richter's and prolymphocytic transformation of chronic lymphocytic leukemia are associated with high mRNA expression of activation-induced cytidine deaminase and aberrant somatic hypermutation. Leukemia, 20, 1089 1095.
12. H gene mutation status in pathogenesis and clinical course. Leukemia, 16, 993 1007.
13. Tobin, G., Thunberg, U., Johnson, A., Thorn, I., Soderberg, O., Hultdin, M., Botling, J., Enblad, G., Sallstrom, J., Sundstrom, C., Roos, G. Rosenquist, R. (2002) Somatically mutated Ig V(H)3-21 genes characterize a new subset of chronic lymphocytic leukemia. Blood, 99, 2262 2264.
14. Van Dongen, J.J., Langerak, A.W., Bruggermann, M., Evans, P.A., Hummel, M., Lavender, F.L., Delabesse, E., Davi, F., Schuuring, E., Garcia-Sanz, R., Van Krieken, J.H., Droese, J., Gonzalez, D., Bastard, C., White, H.E., Spaargaren, M., Gonzalez, M., Parreira, A., Smith, J.L., Morgan, G.J., Kneba, M. Macintyre, E.A. (2003) Design and standardization of PCR primers ad protocols for detection of clonal immunoglobulina nd T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia, 17, 2257 2317.
15. Widhopf, G.F., Goldberg, C.J., Toy, T.L., Rassenti, L.Z., Wierda, W.G., Byrd, J.C., Keating, M.J., Gribben, J.G., Rai, K.R. Kipps, T.J. (2007) Non-stochastic pairing of immunoglobulin heavy and light chains expressed by chronic lymphocytic leukemia B cells is predicated on the heavy chain CDR3. Blood (prepublished online August 3, 2007; DOI.