-
1
-
-
0027257461
-
Structural organization of the human gene encoding nuclear lamin A and nuclear lamin C
-
Lin E., and Worman H.J. Structural organization of the human gene encoding nuclear lamin A and nuclear lamin C. J. Biol. Chem. 268 (1993) 16321-16326
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 16321-16326
-
-
Lin, E.1
Worman, H.J.2
-
2
-
-
0028237586
-
An antibody which specifically recognizes prelamin A but not mature lamin A: application to detection of blocks in farnesylation-dependent protein processing
-
Sinensky M., Fantle K., and Dalton M. An antibody which specifically recognizes prelamin A but not mature lamin A: application to detection of blocks in farnesylation-dependent protein processing. Cancer Res. 54 (1994) 3229-3232
-
(1994)
Cancer Res.
, vol.54
, pp. 3229-3232
-
-
Sinensky, M.1
Fantle, K.2
Dalton, M.3
-
3
-
-
17144398001
-
Prelamin A endoproteolytic processing in vitro by recombinant Zmpste24
-
Corrigan D.P., Kuszczak D., Rusinol A.E., Thewke D.P., Hrycyna C.A., Michaelis S., and Sinensky M.S. Prelamin A endoproteolytic processing in vitro by recombinant Zmpste24. Biochem. J. 387 (2005) 129-138
-
(2005)
Biochem. J.
, vol.387
, pp. 129-138
-
-
Corrigan, D.P.1
Kuszczak, D.2
Rusinol, A.E.3
Thewke, D.P.4
Hrycyna, C.A.5
Michaelis, S.6
Sinensky, M.S.7
-
4
-
-
0036791026
-
Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect
-
Bergo M.O., Gavino B., Ross J., Schmidt W.K., Hong C., Kendall L.V., Mohr A., Meta M., Genant H., Jiang Y., Wisner E.R., van Bruggen N., Carano R.A.D., Michaelis S., Griffey S.M., and Young S.G. Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 13049-13054
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 13049-13054
-
-
Bergo, M.O.1
Gavino, B.2
Ross, J.3
Schmidt, W.K.4
Hong, C.5
Kendall, L.V.6
Mohr, A.7
Meta, M.8
Genant, H.9
Jiang, Y.10
Wisner, E.R.11
van Bruggen, N.12
Carano, R.A.D.13
Michaelis, S.14
Griffey, S.M.15
Young, S.G.16
-
5
-
-
33748760066
-
Farnesylated lamins, progeroid syndromes and farnesyl transferase inhibitors
-
Rusinol A.E., and Sinensky M.S. Farnesylated lamins, progeroid syndromes and farnesyl transferase inhibitors. J. Cell Sci. 119 (2006) 3265-3272
-
(2006)
J. Cell Sci.
, vol.119
, pp. 3265-3272
-
-
Rusinol, A.E.1
Sinensky, M.S.2
-
6
-
-
0037673950
-
Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome
-
Eriksson M., Brown W.T., Gordon L.B., Glynn M.W., Singer J., Scott L., Erdos M.R., Robbins C.M., Moses T.Y., Berglund P., Dutra A., Pak E., Durkin S., Csoka A.B., Boehnke M., Glover T.W., and Collins F.S. Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature 423 (2003) 293-298
-
(2003)
Nature
, vol.423
, pp. 293-298
-
-
Eriksson, M.1
Brown, W.T.2
Gordon, L.B.3
Glynn, M.W.4
Singer, J.5
Scott, L.6
Erdos, M.R.7
Robbins, C.M.8
Moses, T.Y.9
Berglund, P.10
Dutra, A.11
Pak, E.12
Durkin, S.13
Csoka, A.B.14
Boehnke, M.15
Glover, T.W.16
Collins, F.S.17
-
7
-
-
20444449733
-
Altered prelamin A processing is a common mechanism leading to lipodystrophy
-
Capanni C., Mattioli E., Columbaro M., Lucarelli E., Parnaik V.K., Novelli G., Wehnert M., Cenni V., Maraldi N.M., Squarzoni S., and Lattanzi G. Altered prelamin A processing is a common mechanism leading to lipodystrophy. Hum. Mol. Genet. 14 (2005) 1489-1502
-
(2005)
Hum. Mol. Genet.
, vol.14
, pp. 1489-1502
-
-
Capanni, C.1
Mattioli, E.2
Columbaro, M.3
Lucarelli, E.4
Parnaik, V.K.5
Novelli, G.6
Wehnert, M.7
Cenni, V.8
Maraldi, N.M.9
Squarzoni, S.10
Lattanzi, G.11
-
8
-
-
28344440157
-
Alterations of nuclear envelope and chromatin organization in mandibuloacral dysplasia, a rare form of laminopathy
-
Filesi I., Gullotta F., Lattanzi G., D'Apice M.R., Capanni C., Nardone A., Columbaro M., Scarano G., Mattioli E., Sabatelli P., Maraldi N.M., Biocca S., and Novelli G. Alterations of nuclear envelope and chromatin organization in mandibuloacral dysplasia, a rare form of laminopathy. Physiol. Genomics 23 (2005) 150-158
-
(2005)
Physiol. Genomics
, vol.23
, pp. 150-158
-
-
Filesi, I.1
Gullotta, F.2
Lattanzi, G.3
D'Apice, M.R.4
Capanni, C.5
Nardone, A.6
Columbaro, M.7
Scarano, G.8
Mattioli, E.9
Sabatelli, P.10
Maraldi, N.M.11
Biocca, S.12
Novelli, G.13
-
9
-
-
20444506041
-
Loss of ZMPSTE24 (FACE-1) causes autosomal recessive restrictive dermopathy and accumulation of Lamin A precursors
-
Navarro C.L., Cadinanos J., De Sandre-Giovannoli A., Bernard R., Courrier S., Boccaccio I., Boyer A., Kleijer W.J., Wagner A., Giuliano F., Beemer F.A., Freije J.M., Cau P., Hennekam R.C., Lopez-Otin C., Badens C., and Levy N. Loss of ZMPSTE24 (FACE-1) causes autosomal recessive restrictive dermopathy and accumulation of Lamin A precursors. Hum. Mol. Genet. 14 (2005) 1503-1513
-
(2005)
Hum. Mol. Genet.
, vol.14
, pp. 1503-1513
-
-
Navarro, C.L.1
Cadinanos, J.2
De Sandre-Giovannoli, A.3
Bernard, R.4
Courrier, S.5
Boccaccio, I.6
Boyer, A.7
Kleijer, W.J.8
Wagner, A.9
Giuliano, F.10
Beemer, F.A.11
Freije, J.M.12
Cau, P.13
Hennekam, R.C.14
Lopez-Otin, C.15
Badens, C.16
Levy, N.17
-
10
-
-
33745915850
-
Nuclear lamins: laminopathies and their role in premature ageing
-
Broers J.L.V., Ramaekers F.C.S., Bonne G., Yaou R.J., and Hutchison C.J. Nuclear lamins: laminopathies and their role in premature ageing. Physiol. Rev. 86 (2006) 967-1008
-
(2006)
Physiol. Rev.
, vol.86
, pp. 967-1008
-
-
Broers, J.L.V.1
Ramaekers, F.C.S.2
Bonne, G.3
Yaou, R.J.4
Hutchison, C.J.5
-
11
-
-
33646536969
-
Nuclear lamins, diseases and aging
-
Mattout A., Dechat T., Adam S.A., Goldman R.D., and Gruenbaum Y. Nuclear lamins, diseases and aging. Curr. Opin. Cell Biol. 18 (2006) 1-7
-
(2006)
Curr. Opin. Cell Biol.
, vol.18
, pp. 1-7
-
-
Mattout, A.1
Dechat, T.2
Adam, S.A.3
Goldman, R.D.4
Gruenbaum, Y.5
-
12
-
-
33845998966
-
Prelamin A farnesylation and progeroid syndromes
-
Young S.G., Meta M., Yang S.H., and Fong L.G. Prelamin A farnesylation and progeroid syndromes. J. Biol. Chem. 281 (2006) 39741-39745
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 39741-39745
-
-
Young, S.G.1
Meta, M.2
Yang, S.H.3
Fong, L.G.4
-
13
-
-
27544498316
-
Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition
-
Glynn M.W., and Glover T.W. Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition. Hum. Mol. Genet. 14 (2005) 2959-2969
-
(2005)
Hum. Mol. Genet.
, vol.14
, pp. 2959-2969
-
-
Glynn, M.W.1
Glover, T.W.2
-
14
-
-
33645060977
-
A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria
-
Fong L.G., Frost D., Meta M., Qiao X., Yang S.H., Coffinier C., and Young S.G. A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria. Science 311 (2006) 1621-1623
-
(2006)
Science
, vol.311
, pp. 1621-1623
-
-
Fong, L.G.1
Frost, D.2
Meta, M.3
Qiao, X.4
Yang, S.H.5
Coffinier, C.6
Young, S.G.7
-
15
-
-
28344445866
-
Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment
-
Columbaro M., Capanni C., Mattioli E., Novelli G., Parnaik V.K., Squarzoni S., Maraldi N.M., and Lattanzi G. Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment. Cell. Mol. Life Sci. 62 (2005) 2669-2678
-
(2005)
Cell. Mol. Life Sci.
, vol.62
, pp. 2669-2678
-
-
Columbaro, M.1
Capanni, C.2
Mattioli, E.3
Novelli, G.4
Parnaik, V.K.5
Squarzoni, S.6
Maraldi, N.M.7
Lattanzi, G.8
-
16
-
-
33745016642
-
Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging
-
Shumaker D.K., Dechat T., Kohlmaier A., Adam S.A., Bozovsky M.R., Erdos M.R., Eriksson M., Goldman A.E., Khuon S., Collins F.S., Jenuwein T., and Goldman R.D. Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 8703-8708
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 8703-8708
-
-
Shumaker, D.K.1
Dechat, T.2
Kohlmaier, A.3
Adam, S.A.4
Bozovsky, M.R.5
Erdos, M.R.6
Eriksson, M.7
Goldman, A.E.8
Khuon, S.9
Collins, F.S.10
Jenuwein, T.11
Goldman, R.D.12
-
17
-
-
17644373758
-
Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome
-
Scaffidi P., and Misteli T. Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome. Nat. Med. 11 (2005) 440-445
-
(2005)
Nat. Med.
, vol.11
, pp. 440-445
-
-
Scaffidi, P.1
Misteli, T.2
-
18
-
-
0034084316
-
Comparison of potential markers of farnesyltransferase inhibition
-
Adjei A.A., Davis J.N., Erlichman C., Svingen P.A., and Kaufmann S.H. Comparison of potential markers of farnesyltransferase inhibition. Clin. Cancer Res. 6 (2000) 2318-2325
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 2318-2325
-
-
Adjei, A.A.1
Davis, J.N.2
Erlichman, C.3
Svingen, P.A.4
Kaufmann, S.H.5
-
19
-
-
0031054691
-
In vitro assay and characterization of the farnesylation-dependent prelamin A endoprotease
-
Kilic F., Dalton M.B., Burrell S.K., Mayer J.P., Patterson S.D., and Sinensky M. In vitro assay and characterization of the farnesylation-dependent prelamin A endoprotease. J. Biol. Chem. 272 (1997) 5298-5304
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 5298-5304
-
-
Kilic, F.1
Dalton, M.B.2
Burrell, S.K.3
Mayer, J.P.4
Patterson, S.D.5
Sinensky, M.6
-
20
-
-
33748195107
-
A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules
-
Banaszynski L.A., Chen L.C., Maynard-Smith L.A., Ooi A.G., and Wandless T.J. A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules. Cell 126 (2006) 995-1004
-
(2006)
Cell
, vol.126
, pp. 995-1004
-
-
Banaszynski, L.A.1
Chen, L.C.2
Maynard-Smith, L.A.3
Ooi, A.G.4
Wandless, T.J.5
-
21
-
-
0034487785
-
Experimental condensation inhibition in constitutive and facultative heterochromatin of mammalian chromosomes
-
Haaf T., and Schmid M. Experimental condensation inhibition in constitutive and facultative heterochromatin of mammalian chromosomes. Cytogenet. Cell Genet. 91 (2000) 113-123
-
(2000)
Cytogenet. Cell Genet.
, vol.91
, pp. 113-123
-
-
Haaf, T.1
Schmid, M.2
-
22
-
-
0033013469
-
The putative nuclear receptor mediator TIF1alpha is tightly associated with euchromatin
-
Remboutsika E., Lutz Y., Gansmuller A., Vonesch J.L., Losson R., and Chambon P. The putative nuclear receptor mediator TIF1alpha is tightly associated with euchromatin. J. Cell Sci. 112 (1999) 1671-1683
-
(1999)
J. Cell Sci.
, vol.112
, pp. 1671-1683
-
-
Remboutsika, E.1
Lutz, Y.2
Gansmuller, A.3
Vonesch, J.L.4
Losson, R.5
Chambon, P.6
-
23
-
-
33750743459
-
Characterization of the functional activities of the bovine papillomavirus type 1 E2 protein single-chain heterodimers
-
Kurg R., Tekkel H., Abroi A., and Ustav M. Characterization of the functional activities of the bovine papillomavirus type 1 E2 protein single-chain heterodimers. J. Virol. 80 (2006) 11218-11225
-
(2006)
J. Virol.
, vol.80
, pp. 11218-11225
-
-
Kurg, R.1
Tekkel, H.2
Abroi, A.3
Ustav, M.4
-
24
-
-
0036578920
-
Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice
-
Pendas A.M., Zhou Z., Cadinanos J., Freije J.M., Wang J., Hultenby K.K., Astudillo A., Wernerson A., Rodriguez F., Tryggvason K., and Lopez-Otin C. Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice. Nat. Genet. 31 (2002) 94-99
-
(2002)
Nat. Genet.
, vol.31
, pp. 94-99
-
-
Pendas, A.M.1
Zhou, Z.2
Cadinanos, J.3
Freije, J.M.4
Wang, J.5
Hultenby, K.K.6
Astudillo, A.7
Wernerson, A.8
Rodriguez, F.9
Tryggvason, K.10
Lopez-Otin, C.11
-
25
-
-
4143103828
-
A phosphorylation cluster in the chromatin-binding region regulates chromosome association of LAP2alpha
-
Gajewski A., Csaszar E., and Foisner R. A phosphorylation cluster in the chromatin-binding region regulates chromosome association of LAP2alpha. J. Biol. Chem. 279 (2004) 35813-35821
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 35813-35821
-
-
Gajewski, A.1
Csaszar, E.2
Foisner, R.3
-
26
-
-
0033763071
-
Lamina-associated polypeptide 2alpha binds intranuclear A-type lamins
-
Dechat T., Korbei B., Vaughan O.A., Vlcek S., Hutchison C.J., and Foisner R. Lamina-associated polypeptide 2alpha binds intranuclear A-type lamins. J. Cell Sci. 113 (2000) 3473-3484
-
(2000)
J. Cell Sci.
, vol.113
, pp. 3473-3484
-
-
Dechat, T.1
Korbei, B.2
Vaughan, O.A.3
Vlcek, S.4
Hutchison, C.J.5
Foisner, R.6
-
27
-
-
34347362571
-
Pre-Lamin A processing is linked to heterochromatin organization
-
Lattanzi G., Columbaro M., Mattioli E., Cenni V., Camozzi D., Wehnert M., Santi S., Riccio M., Del Coco R., Maraldi N.M., Squarzoni S., Foisner R., and Capanni C. Pre-Lamin A processing is linked to heterochromatin organization. J. Cell. Biochem. 102 (2007) 1149-1159
-
(2007)
J. Cell. Biochem.
, vol.102
, pp. 1149-1159
-
-
Lattanzi, G.1
Columbaro, M.2
Mattioli, E.3
Cenni, V.4
Camozzi, D.5
Wehnert, M.6
Santi, S.7
Riccio, M.8
Del Coco, R.9
Maraldi, N.M.10
Squarzoni, S.11
Foisner, R.12
Capanni, C.13
-
28
-
-
28844466695
-
Familial Cardiomyopathy Registry Research Group, Thymopoietin (lamina-associated polypeptide 2) gene mutation associated with dilated cardiomyopathy
-
Taylor M.R., Slavov D., Gajewski A., Vlcek S., Ku L., Fain P.R., Carniel E., Di Lenarda A., Sinagra G., Boucek M.M., Cavanaugh J., Graw S.L., Ruegg P., Feiger J., Zhu X., Ferguson D.A., Bristow M.R., Gotzmann J., Foisner R., and Mestroni L. Familial Cardiomyopathy Registry Research Group, Thymopoietin (lamina-associated polypeptide 2) gene mutation associated with dilated cardiomyopathy. Hum. Mutat. 26 (2005) 566-574
-
(2005)
Hum. Mutat.
, vol.26
, pp. 566-574
-
-
Taylor, M.R.1
Slavov, D.2
Gajewski, A.3
Vlcek, S.4
Ku, L.5
Fain, P.R.6
Carniel, E.7
Di Lenarda, A.8
Sinagra, G.9
Boucek, M.M.10
Cavanaugh, J.11
Graw, S.L.12
Ruegg, P.13
Feiger, J.14
Zhu, X.15
Ferguson, D.A.16
Bristow, M.R.17
Gotzmann, J.18
Foisner, R.19
Mestroni, L.20
more..
-
29
-
-
23044465584
-
Characterization of a human carcinoma cell line selected for resistance to the farnesyl transferase inhibitor 4-(2-(4-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-(5,6)-cyclohepta(1,2-b)-pyridin-11(R)-yl)-1-piperidinyl)-2-oxo-ethyl)-1-piperidinecarboxamide (SCH66336)
-
Bruzek L.M., Poynter J.N., Kaufmann S.H., and Adjei A.A. Characterization of a human carcinoma cell line selected for resistance to the farnesyl transferase inhibitor 4-(2-(4-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-(5,6)-cyclohepta(1,2-b)-pyridin-11(R)-yl)-1-piperidinyl)-2-oxo-ethyl)-1-piperidinecarboxamide (SCH66336). Mol. Pharmacol. 68 (2005) 477-486
-
(2005)
Mol. Pharmacol.
, vol.68
, pp. 477-486
-
-
Bruzek, L.M.1
Poynter, J.N.2
Kaufmann, S.H.3
Adjei, A.A.4
-
30
-
-
0028973293
-
Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes
-
Lerner E.C., Qian Y., Blaskovich M.A., Fossum R.D., Vogt A., Sun J., Cox A.D., Der C.J., Hamilton A.D., and Sebti S.M. Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes. J. Biol. Chem. 270 (1995) 26802-26806
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 26802-26806
-
-
Lerner, E.C.1
Qian, Y.2
Blaskovich, M.A.3
Fossum, R.D.4
Vogt, A.5
Sun, J.6
Cox, A.D.7
Der, C.J.8
Hamilton, A.D.9
Sebti, S.M.10
-
31
-
-
33846813827
-
Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter
-
Delarue F.L., Adnane J., Joshi B., Blaskovich M.A., Wang D.A., Hawker J., Bizouarn F., Ohkanda J., Zhu K., Hamilton A.D., Chellappan S., and Sebti S.M. Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter. Oncogene 26 (2007) 633-640
-
(2007)
Oncogene
, vol.26
, pp. 633-640
-
-
Delarue, F.L.1
Adnane, J.2
Joshi, B.3
Blaskovich, M.A.4
Wang, D.A.5
Hawker, J.6
Bizouarn, F.7
Ohkanda, J.8
Zhu, K.9
Hamilton, A.D.10
Chellappan, S.11
Sebti, S.M.12
-
32
-
-
33749594205
-
DNA methyltransferase 1 knockdown activates a replication stress checkpoint
-
Unterberger A., Andrews S.D., Weaver I.C.G., and Szyf M. DNA methyltransferase 1 knockdown activates a replication stress checkpoint. Mol. Cell. Biol. (2006) 7575-7586
-
(2006)
Mol. Cell. Biol.
, pp. 7575-7586
-
-
Unterberger, A.1
Andrews, S.D.2
Weaver, I.C.G.3
Szyf, M.4
-
33
-
-
2942643923
-
Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome
-
Goldman R.D., Shumaker D.K., Erdos M.R., Eriksson M., Goldman A.E., Gordon L.B., Gruenbaum Y., Khuon S., Mendez M., Varga R., and Collins F.S. Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 8963-8968
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 8963-8968
-
-
Goldman, R.D.1
Shumaker, D.K.2
Erdos, M.R.3
Eriksson, M.4
Goldman, A.E.5
Gordon, L.B.6
Gruenbaum, Y.7
Khuon, S.8
Mendez, M.9
Varga, R.10
Collins, F.S.11
-
34
-
-
16344392142
-
Laminopathies: Involvement of structural nuclear proteins in the pathogenesis of an increasing number of human diseases
-
Maraldi N.M., Squarzoni S., Sabatelli P., Capanni C., Mattioli E., Ognibene A., and Lattanzi G. Laminopathies: Involvement of structural nuclear proteins in the pathogenesis of an increasing number of human diseases. J. Cell. Physiol. 203 (2005) 319-327
-
(2005)
J. Cell. Physiol.
, vol.203
, pp. 319-327
-
-
Maraldi, N.M.1
Squarzoni, S.2
Sabatelli, P.3
Capanni, C.4
Mattioli, E.5
Ognibene, A.6
Lattanzi, G.7
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