Hypermethylation status of APC inversely correlates with the presence of submucosal invasion in laterally spreading colorectal tumors

Molecular Carcinogenesis

Volumn 47, Issue 1, 2008, Pages 1-8

  Hashimoto, Kaszuo ^a   Shimizu, Yoshihisa ^a   Suehiro, Yutaka ^a   Okayama, Naoko ^b   Hashimoto, Shinichi ^a   Okada, Toshiyuki ^a   Hiura, Mikako ^a   Ueno, Koji ^a   Hazama, Shoichi ^a   Higaki, Shingo ^a   Hamanaka, Yuichiro ^a   Oka, Masaaki ^b   Sakaida, Isao ^a   Hinoda, Yuji ^a  

^a YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b YAMAGUCHI UNIVERSITY HOSPITAL   (Japan)

Author keywords

APC; Laterally spreading tumor; Methylation

Indexed keywords

ADULT; AGED; ARTICLE; CANCER INVASION; CLINICAL ARTICLE; CLINICAL FEATURE; COLORECTAL CANCER; CORRELATION ANALYSIS; CPG ISLAND; DNA METHYLATION; EPIGENETICS; FEMALE; GENE; HMLH1 GENE; HUMAN; HYPERMETHYLATION; MALE; MGMT GENE; MINT1 GENE; MINT2 GENE; MINT31 GENE; P16 GENE; PARAMETER; POLYMERASE CHAIN REACTION; PREDICTION; PRIORITY JOURNAL; SUBMUCOSA; TUMOR SUPPRESSOR GENE; ADENOMA; CELL DIVISION; COLORECTAL TUMOR; GENETICS; MIDDLE AGED; MUTATION; PATHOLOGY;

CYTIDYLYL 3' 5' GUANOSINE; CYTIDYLYL-3'-5'-GUANOSINE; DINUCLEOSIDE PHOSPHATE; DNA; PRIMER DNA; UNCLASSIFIED DRUG;

ADENOMA; AGED; CELL DIVISION; COLORECTAL NEOPLASMS; DINUCLEOSIDE PHOSPHATES; DNA METHYLATION; DNA PRIMERS; DNA, NEOPLASM; FEMALE; GENES, APC; HUMANS; MALE; MIDDLE AGED; MUTATION; NEOPLASM INVASIVENESS;

EID: 38349062262     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20363     Document Type: Article

References (47)

1. Bird AP. CpG-rich islands and the function of DNA methylation. Nature 1986;321:209-213.
2. Latham KE. X chromosome imprinting and inactivation in the early mammalian embryo. Trends Genet 1996;12:134-138.
3. Hansen RS, Gartler SM, Scott CR, Chen SH, Laird CD. Methylation analysis of CGG sites in the CpG island of the human FMR1 gene. Hum Mol Genet 1992;1:571-578.
4. Issa JP, Ottaviano YL, Celano P, Hamilton SR, Davidson NE, Baylin SB. Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat Genet 1994;7:536-540.
5. Baylin SB, Herman JG, Graff JR, Vertino PM, Issa JP. Alterations in DNA methylation: A fundamental aspect of neoplasia. Adv Cancer Res 1998;72:141-196.
6. Jones PA. DNA methylation errors and cancer. Cancer Res 1996;56:2463-2467.
7. Herman JG, Merlo A, Mao L, et al. Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res 1995;55:4525-4530.
8. Esteller M, Hamilton SR, Burger PC, Baylin SB, Herman JG. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res 1999;59:793-797.
9. Kane MF, Loda M, Gaida GM, et al. Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res 1997;57:808-811.
10. Esteller M, Sparks A, Toyota M, et al. Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer. Cancer Res 2000;60:4366-4371.
11. Herman JG, Umar A, Polyak K, et al. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci USA 1998;95:6870-6875.
12. Cunningham JM, Christensen ER, Tester DJ, et al. Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability. Cancer Res 1998;58:3455-3460.
13. Hawkins N, Norrie M, Cheong K, et al. CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability. Gastroenterology 2002;122:1376-1387.
14. Kudo S. Endoscopic mucosal resection of flat and depressed types of early colorectal cancer. Endoscopy 1993;25:455-461.
15. Yoshikane H, Hidano H, Sakakibara A, et al. Endoscopic resection of laterally spreading tumours of the large intestine using a distal attachment. Endoscopy 1999;31:426-430.
16. Tanimoto T, Tanaka S, Haruma K, et al. Growth patterns in various macroscopic types of noninvasive intramucosal colorectal carcinoma with special reference to apoptosis and cell proliferation. Dis Colon Rectum 1998;41:1376-1384.
17. Hurlstone DP, Sanders DS, Cross SS, et al. Colonoscopic resection of lateral spreading tumours: a prospective analysis of endoscopic mucosal resection. Gut 2004;53:1334-1339.
18. Noro A, Sugai T, Habano W, Nakamura S. Analysis of Ki-ras and p53 gene mutations in laterally spreading tumors of the colorectum. Pathol Int 2003;53:828-836.
19. Tanimoto T, Tanaka S, Haruma K, et al. MUC1 expression in intramucosal colorectal neoplasms. Possible involvement in histogenesis and progression. Oncology 1999;56:223-231.
20. Kuwai T, Tanaka S, Kaio E, et al. Clinical significance of Fhit expression in development of colorectal carcinoma of various macroscopic types. Int J Mol Med 2003;12:437-442.
21. Yamashita K, Arimura Y, Shimizu H, et al. Increased cyclooxygenase-2 expression in large flat colorectal tumors (laterally spreading tumors). J Gastroenterol 2003;38:69-73.
22. Hiraoka S, Kato J, Tatsukawa M, et al. Laterally spreading type of colorectal adenoma exhibits a unique methylation phenotype and K-ras mutations. Gastroenterology 2006;131:379-389.
23. Higaki S, Hashimoto S, Harada K, et al. Long-term follow-up of large flat colorectal tumors resected endoscopically. Endoscopy 2003;35:845-849.
24. Takahashi T, Nosho K, Yamamoto H, et al. Flat-type colorectal advanced adenomas (laterally spreading tumors) have different genetic and epigenetic alterations from protruded-type advanced adenomas. Mod Pathol 2006.
25. Suehiro Y, Umayahara K, Ogata H, et al. Genetic aberrations detected by comparative genomic hybridization predict outcome in patients with endometrioid carcinoma. Genes Chromosomes Cancer 2000;29:75-82.
26. Chan AO, Broaddus RR, Houlihan PS, Issa JP, Hamilton SR, Rashid A. CpG island methylation in aberrant crypt foci of the colorectum. Am J Pathol 2002;160:1823-1830.
27. Kondo Y, Shen L, Issa JP. Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer. Mol Cell Biol 2003;23:206-215.
28. Esteller M, Toyota M, Sanchez-Cespedes M, et al. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis. Cancer Res 2000;60:2368-2371.
29. Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 1996;93:9821-9826.
30. Toyota M, Ohe-Toyota M, Ahuja N, Issa JP. Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype. Proc Natl Acad Sci USA 2000;97:710-715.
31. Rashid A, Shen L, Morris JS, Issa JP, Hamilton SR. CpG island methylation in colorectal adenomas. Am J Pathol 2001;159:1129-1135.
32. Park SJ, Rashid A, Lee JH, Kim SG, Hamilton SR, Wu TT. Frequent CpG island methylation in serrated adenomas of the colorectum. Am J Pathol 2003;162:815-822.
33. Miyoshi Y, Nagase H, Ando H, et al. Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum Mol Genet 1992;1:229-233.
34. Abe S, Terai T, Sakamoto N, et al. Clinicopathological features of nonpolypoid colorectal tumors as viewed from the patients' background. J Gastroenterol 2006;41;325-331.
35. Shannon BA, Iacopetta BJ. Methylation of the hMLH1, p16, and MDR1 genes in colorectal carcinoma: associations with clinicopathological features. Cancer Lett 2001;167:91-97.
36. van Rijnsoever M, Grieu F, Elsaleh H, Joseph D, Iacopetta B. Characterisation of colorectal cancers showing hypermethylation at multiple CpG islands. Gut 2002;51:797-802.
37. Chirieac LR, Shen L, Catalano PJ, Issa JP, Hamilton SR. Phenotype of microsatellite-stable colorectal carcinomas with CpG island methylation. Am J Surg Pathol 2005;29:429-436.
38. Behrens J. The role of the Wnt signalling pathway in colorectal tumorigenesis. Biochem Soc Trans 2005;33:672-675.
39. Jaiswal AS, Balusu R, Narayan S. Involvement of adenomatous polyposis coli in colorectal tumorigenesis. Front Biosci 2005;10:1118-1134.
40. Doucas H, Garcea G, Neal CP, Manson MM, Berry DP. Changes in the Wnt signalling pathway in gastrointestinal cancers and their prognostic significance. Eur J Cancer 2005;41:365-379.
41. Nathke IS. The adenomatous polyposis coli protein: The Achilles heel of the gut epithelium. Annu Rev Cell Dev Biol 2004;20:337-366.
42. Lind GE, Thorstensen L, Lovig T, et al. A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines. Mol Cancer 2004;3:28.
43. Giovannucci E, Stampfer MJ, Colditz GA, et al. Folate, methionine, and alcohol intake and risk of colorectal adenoma. J Natl Cancer Inst 1993;85:875-884.
44. de Vogel S, van Engeland M, Luchtenborg M, et al. Dietary folate and apc mutations in sporadic colorectal cancer. J Nutr 2006;136:3015-3021.
45. Kondo Y, Issa JP. Epigenetic changes in colorectal cancer. Cancer Metastasis Rev 2004;23:29-39.
46. Safar AM, Spencer H III, Su X, et al. Methylation profiling of archived non-small cell lung cancer: A promising prognostic system. Clin Cancer Res 2005;11:4400-4405.
47. Uraoka T, Saito Y, Matsuda T, et al. Endoscopic indications for endoscopic mucosal resection of laterally spreading tumours in the colorectum. Gut 2006;55:1592-1597.