Association between lung cancer risk and single nucleotide polymorphisms in the first intron and codon 178 of the DNA repair gene, O6- alkylguanine-DNA alkyltransferase

International Journal of Cancer

Volumn 122, Issue 4, 2008, Pages 791-795

  Crosbie, Philip A J ^a,b,c   McGown, Gail ^a   Thorncroft, Mary R ^a   O'Donnell, Paul N S ^b   Barber, Philip V ^b   Lewis, Sarah J ^c   Harrison, Kathryn L ^c   Agius, Raymond M ^c   Santibáñez Koref, Mauro F ^d   Margison, Geoffrey P ^a   Povey, Andrew C ^c  

^a CHRISTIE HOSPITAL   (United Kingdom)

^b WYTHENSHAWE HOSPITAL   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

^d NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

AGT; DNA alkylation; Lung cancer; MGMT; Polymorphisms; Tobacco smoke

Indexed keywords

6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE;

ADULT; AGED; ALLELE; ARTICLE; CANCER RISK; CODON; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; INTRON; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; META ANALYSIS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; ADENOCARCINOMA; CASE CONTROL STUDY; CLINICAL TRIAL; COMPARATIVE STUDY; DNA REPAIR; ENZYMOLOGY; GENETIC PREDISPOSITION; GENETICS; LUNG TUMOR; MIDDLE AGED; MULTICENTER STUDY; RISK FACTOR; SMALL CELL CARCINOMA; SQUAMOUS CELL CARCINOMA;

ADENOCARCINOMA; AGED; CARCINOMA, SMALL CELL; CARCINOMA, SQUAMOUS CELL; CASE-CONTROL STUDIES; CODON; DNA REPAIR; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INTRONS; LUNG NEOPLASMS; MALE; MIDDLE AGED; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; SMOKING;

EID: 38349049186     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.23059     Document Type: Article

References (31)

1. Alberg AJ, Samet JM. Epidemiology of lung cancer. Chest 2003;123(1 Suppl):21S-49S.
2. Smith CJ, Perfetti TA, Garg R, Hansch C. IARC carcinogens reported in cigarette mainstream smoke and their calculated log P values. Food Chem Toxicol 2003;41:807-17.
3. Hecht SS. Cigarette smoking and lung cancer: chemical mechanisms and approaches to prevention. Lancet Oncol 2002;3:461-9.
4. Hecht SS, Hoffmann D. Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke. Carcinogenesis 1988;9:875-84.
5. 6-methylguanine formation in Clara cells and induction of pulmonary neoplasia in the rat by 4-(methylnitrosamino)-1-(3- pyridyl)-1-butanone. Cancer Res 1990;50:3772-80.
6. 6-methylguanine is a critical determinant of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone tumorigenesis in A/J mouse lung. Cancer Res 1991;51:5557-64.
7. 6-pyridyloxo-butylguanine adducts contribute to the mutagenic properties of pyridyloxobutylating agents. Chem Res Toxicol 2005;18:619-25.
8. 6-methylguanine. Mutagenesis 2002;17:483-7.
9. 6-[4-oxo-4-(3-pyridyl)butyl]-guanine in Escherichia coli and human cells. Chem Res Toxicol 2002;15:165-9.
10. Olivier M, Hussain SP, Caron de Fromentel C, Hainaut P, Harris CC. p53 mutations TP53 mutation spectra and load: a tool for generating hypotheses on the etiology of cancer. IARC Sci Publ 2004;157:247-70.
11. 6-alkylguanine-DNA alkyltransferase: role in carcinogenesis and chemotherapy Bioessays 2002;24:255-66.
12. Gerson SL. MGMT: its role in cancer aetiology and cancer therapeutics. Nat Rev Cancer 2004;4:296-307.
13. 6-alkylguanine by alkyltransferases. Mutat Res 2000;462:83-100.
14. 6-alkylguanine-DNA alkyltransferase. Carcinogenesis 2003;24:625-35.
15. 6-methylguanine repair in fibroblast cultures from patients with lung cancer. Cancer Res 1989;49:5623-6.
16. 6-alkylguanine-DNA alkyltransferase activity in peripheral blood mononuclear cells. Carcinogenesis 2005;26:1473-80.
17. 6-alkylguanine-DNA alkyltransferases. Cancer Res 2006;66:4968-74.
18. 6-methylguanine- DNA methyltransferase (MGMT) gene increase human sensitivity to the genotoxic effects of the tobacco-specific nitrosamine carcinogen NNK. Pharmacogenet Genomics 2005;15:571-8.
19. 6-alkylguanine DNA alkyltransferase gene and lung cancer risk in non-smokers exposed to second-hand smoke. Cancer Epidemiol Biomarkers Prev 2004;13:320-3.
20. 6- alkylguanine DNA alkyltransferase gene in lung cancer risk. Cancer Epidemiol Biomarkers Prev 2000;9:339-42.
21. Krzesniak M, Butkiewicz D, Samojedny A, Chorazy M, Rusin M. Polymorphisms in TDG and MGMT genes - epidemiological and functional study in lung cancer patients from Poland. Ann Hum Genet 2004;68:300-12.
22. Zienolddiny S, Campa D, Lind H, Ryberg D, Skaug V, Stangeland L, Phillips DH, Canzian F, Haugen A. Polymorphisms of DNA repair genes and risk of non-small cell lung cancer. Carcinogenesis 2006;27:560-7.
23. 6- methylguanine-DNA methyltransferase-codon 178 genetic polymorphism. Lung Cancer 2004;44:281-6.
24. Margison GP, Povey AC, Santibáñez-Koref M. Genetic variation at the human MGMT locus and its biological consequences. Curr Pharmacogenomics 2006;4:133-44.
25. Lewis SJ, Cherry NM, McLNiven R, Barber PV, Povey AC. Polymorphisms in the NAD(P)H: quinone oxidoreductase gene and small cell lung cancer risk in a UK population. Lung Cancer 2001;34:177-83.
26. 6-alkylguanine- DNA alkyltransferase activity in bronchial epithelial cells. Int J Cancer 2006;119:463-6.
27. Hu Z, Wang H, Shao M, Jin G, Sun W, Wang Y, Liu H, Wang Y, Ma H, Qian J, Jin Ll, Wei Q, et al. Genetic variants in MGMT and risk of lung cancer in Southeastern Chinese: a haplotype-based analysis. Hum Mutat 2007;28:431-40.
28. 6-methylguanine-DNA methyltransferase with risk of lung cancer in non-Hispanic Whites. Cancer Epidemiol Biomarkers Prev 2006;15:2364-9.
29. 6-methylguanine-DNA methyltransferase SNPs: a frequency comparison of patients with familial melanoma and healthy individuals in Sweden. Hum Mutat 2002;20:408-9.
30. 6-methylguanine DNA methyltransferase and endometrial cancer risk. Carcinogenesis 2006;27:2281-5.
31. 6-methylguanine-DNA methyltransferase Leu84Phe and Ile143Val polymorphisms and risk of colorectal cancer in the Nurses' Health Study and Physicians' Health Study (United States). Cancer Causes Control 2006;17:721-3.