Polymorphisms in the NAD(P)H: quinone oxidoreductase gene and small cell lung cancer risk in a UK population

Lung Cancer

Volumn 34, Issue 2, 2001, Pages 177-183

  Lewis, Sarah J ^a   Cherry, Nicola M ^a   Niven, Robert McL ^b   Barber, Phillip V ^b   Povey, Andrew C ^a,c  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b WYTHENSHAWE HOSPITAL   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Cancer; Cell; Genotype

Indexed keywords

CARCINOGEN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE);

ADULT; AGED; ALLELE; ARTICLE; BRONCHOSCOPY; CANCER EPIDEMIOLOGY; CANCER RISK; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; DETOXIFICATION; DISEASE ASSOCIATION; DISEASE COURSE; ENZYME ACTIVITY; ENZYME POLYMORPHISM; FEMALE; GENOTYPE; HUMAN; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; MALIGNANT NEOPLASTIC DISEASE; PRIORITY JOURNAL; PROTEIN VARIANT; SMOKING; TRACHEOBRONCHIAL TOILET; UNITED KINGDOM;

EID: 0034781801     PISSN: 01695002     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-5002(01)00243-4     Document Type: Article

References (20)

1. Molecular mechanisms of quinone cytotoxicity
2. NAD(P)H: quinone oxidoreductase 1 (DT-diaphorase) specifically prevents the formation of benzo(a)pyrene adducts generated by cytochrome p4501A1 and p450 reductase
3. Bioreductive activation of mitomycin C by DT-diaphorase
4. Immunohistochemical detection of NAD(P)H: quinone oxidoreductase in human lung and lung tumours
5. Cytosolic NAD(P)H: (quinone-acceptor) oxido reductase in human normal and tumour tissue: Effects of cigarette smoking and alcohol
6. Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis
7. DT-diaphorase activity in NSCLC and SCLC cell lines: A role for fos/jun regulation
8. Characterization of a polymorphism in NAD(P)H: quinone oxidoreductase (DT-diaphorase)
9. Lung cancer in Mexican-Americans and African-Americans is associated with the wild-type genotype of the NAD(P)H: quinone oxidoreductase polymorphism
10. Association of the NAD(P): quinone oxidoreductase 609C→T polymorphism with a decreased lung cancer risk
11. NAD(P)H: quinone oxidoreductase polymorphism and lung cancer in Taiwan
12. Identification of an NAD(P)H:quinone oxidoreductase polymorphism and its association with lung cancer and smoking
13. Human FAD-dependent NAD(P)H diaphorase
14. NAD(P)H: quinone oxidoreductase 1 reduces the mutagenicity of DNA caused by NADPH:P450 reductase activated metabolites of benzo(a)pyrene quinones
15. Presence of a heterozygous substitution and its relationship to DT-diaphorase activity
16. Ethnic variation in the prevalence of a common NAD(P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy
17. Increased frequency of a null-allele for NAD(P)H: quinone oxidoreductase in patients with urological malignancies
18. NAD(P)H: quinone oxidoreductase: Polymorphisms and allele frequencies in Caucasian, Chinese and Canadian Native Indian and Inuit populations
19. Genotype-phenotype relationships in studies of a polymorphism in NAD(P)H: quinone oxidoreductase 1