메뉴 건너뛰기




Volumn 9, Issue 2, 2008, Pages 122-128

Bone marrow-derived mesenchymal stem cells for treatment of heart failure: Is it all paracrine actions and immunomodulation?

Author keywords

Heart failure; Immunomodulation; Mesenchymal stem cells; Paracrine actions

Indexed keywords

BONE MARROW; CELL THERAPY; EMBRYONIC STEM CELL; HEART FAILURE; HEART VENTRICLE FUNCTION; HUMAN; IMMUNE RESPONSE; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; ISCHEMIC HEART DISEASE; MESENCHYMAL STEM CELL; MUSCLE REGENERATION; NONHUMAN; PARACRINE SIGNALING; REVIEW; T LYMPHOCYTE;

EID: 38149132490     PISSN: 15582027     EISSN: None     Source Type: Journal    
DOI: 10.2459/JCM.0b013e32820588f0     Document Type: Review
Times cited : (41)

References (78)
  • 1
    • 0034988491 scopus 로고    scopus 로고
    • Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells
    • Jackson KA, Majka SM, Wang H, Pocius J, Hartley CJ, Majesky MW, et al. Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J Clin Invest 2001; 107:1395-1402.
    • (2001) J Clin Invest , vol.107 , pp. 1395-1402
    • Jackson, K.A.1    Majka, S.M.2    Wang, H.3    Pocius, J.4    Hartley, C.J.5    Majesky, M.W.6
  • 2
    • 0028949657 scopus 로고
    • Left ventricular remodeling after acute myocardial infarction
    • Pfeffer MA. Left ventricular remodeling after acute myocardial infarction. Annu Rev Med 1995; 46:455-466.
    • (1995) Annu Rev Med , vol.46 , pp. 455-466
    • Pfeffer, M.A.1
  • 4
    • 4444383358 scopus 로고    scopus 로고
    • Apoptosis: Pathophysiology and therapeutic implications for the cardiac surgeon
    • Khoynezhad A, Jalali Z, Tortolani AJ. Apoptosis: pathophysiology and therapeutic implications for the cardiac surgeon. Ann Thorac Surg 2004; 78:1109-1118.
    • (2004) Ann Thorac Surg , vol.78 , pp. 1109-1118
    • Khoynezhad, A.1    Jalali, Z.2    Tortolani, A.J.3
  • 5
    • 14644413468 scopus 로고    scopus 로고
    • Death begets failure in the heart
    • Foo RS, Mani K, Kitsis RN. Death begets failure in the heart. J Clin Invest 2005; 115:565-571.
    • (2005) J Clin Invest , vol.115 , pp. 565-571
    • Foo, R.S.1    Mani, K.2    Kitsis, R.N.3
  • 6
    • 6944245105 scopus 로고    scopus 로고
    • Role of apoptosis in remodeling after myocardial infarction
    • Takemura G, Fujiwara H. Role of apoptosis in remodeling after myocardial infarction. Pharmacol Ther 2004; 104:1-16.
    • (2004) Pharmacol Ther , vol.104 , pp. 1-16
    • Takemura, G.1    Fujiwara, H.2
  • 8
    • 0037336698 scopus 로고    scopus 로고
    • Improvement of cardiac function by bone marrow cell implantation in a rat hypoperfusion heart model
    • Nishida M, Li TS, Hirata K, Yano M, Matsuzaki M, Hamano K. Improvement of cardiac function by bone marrow cell implantation in a rat hypoperfusion heart model. Ann Thorac Surg 2003; 75:768-774.
    • (2003) Ann Thorac Surg , vol.75 , pp. 768-774
    • Nishida, M.1    Li, T.S.2    Hirata, K.3    Yano, M.4    Matsuzaki, M.5    Hamano, K.6
  • 9
    • 20644471364 scopus 로고    scopus 로고
    • Effects of mesenchymal stem cell transplantation on extracellular matrix after myocardial infarction in rats
    • Xu X, Xu Z, Xu Y, Cui G. Effects of mesenchymal stem cell transplantation on extracellular matrix after myocardial infarction in rats. Coron Artery Dis 2005; 16:245-255.
    • (2005) Coron Artery Dis , vol.16 , pp. 245-255
    • Xu, X.1    Xu, Z.2    Xu, Y.3    Cui, G.4
  • 10
    • 0036945050 scopus 로고    scopus 로고
    • Stem cells for myocardial regeneration
    • Orlic D, Hill JM, Arai AE. Stem cells for myocardial regeneration. Circ Res 2002; 91:1092-1102.
    • (2002) Circ Res , vol.91 , pp. 1092-1102
    • Orlic, D.1    Hill, J.M.2    Arai, A.E.3
  • 11
    • 21244458428 scopus 로고    scopus 로고
    • Reduction of myocardial scar size after implantation of mesenchymal stem cells in rats: What is the mechanism?
    • Jaquet K, Krause KT, Denschel J, Faessler P, Nauerz M, Geidel S, et al. Reduction of myocardial scar size after implantation of mesenchymal stem cells in rats: what is the mechanism? Stem Cells Dev 2005; 14:299-309.
    • (2005) Stem Cells Dev , vol.14 , pp. 299-309
    • Jaquet, K.1    Krause, K.T.2    Denschel, J.3    Faessler, P.4    Nauerz, M.5    Geidel, S.6
  • 12
    • 1642276287 scopus 로고    scopus 로고
    • Cellular transplantation: Hurdles remaining before widespread clinical use
    • Menasche P. Cellular transplantation: hurdles remaining before widespread clinical use. Curr Opin Cardiol 2004; 19:154-161.
    • (2004) Curr Opin Cardiol , vol.19 , pp. 154-161
    • Menasche, P.1
  • 15
    • 0037420105 scopus 로고    scopus 로고
    • Autologous skeletal myoblasts transplanted to ischemia-damaged myocardium in humans. Histological analysis of cell survival and differentiation
    • Pagani FD, DerSimonian H, Zawadzka A, Wetzel K, Edge AS, Jacoby DB, et al. Autologous skeletal myoblasts transplanted to ischemia-damaged myocardium in humans. Histological analysis of cell survival and differentiation. J Am Coll Cardiol 2003; 41:879-888.
    • (2003) J Am Coll Cardiol , vol.41 , pp. 879-888
    • Pagani, F.D.1    DerSimonian, H.2    Zawadzka, A.3    Wetzel, K.4    Edge, A.S.5    Jacoby, D.B.6
  • 17
    • 0033375056 scopus 로고    scopus 로고
    • Autologous heart cell transplantation improves cardiac function after myocardial injury
    • Sakai T, Li RK, Weisel RD, Mickle DA, Kim EJ, Tomita S, et al. Autologous heart cell transplantation improves cardiac function after myocardial injury. Ann Thorac Surg 1999; 68:2074-2081.
    • (1999) Ann Thorac Surg , vol.68 , pp. 2074-2081
    • Sakai, T.1    Li, R.K.2    Weisel, R.D.3    Mickle, D.A.4    Kim, E.J.5    Tomita, S.6
  • 18
    • 0029767708 scopus 로고    scopus 로고
    • The biology and application of human bone marrow stromal cell precursors
    • Gronthos S, Simmons PJ. The biology and application of human bone marrow stromal cell precursors. J Hematother 1996; 5:15-23.
    • (1996) J Hematother , vol.5 , pp. 15-23
    • Gronthos, S.1    Simmons, P.J.2
  • 20
    • 0026578530 scopus 로고
    • Characterization of cells with osteogenic potential from human marrow
    • Haynesworth SE, Goshima J, Goldberg VM, Caplan AI. Characterization of cells with osteogenic potential from human marrow. Bone 1992; 13:81-88.
    • (1992) Bone , vol.13 , pp. 81-88
    • Haynesworth, S.E.1    Goshima, J.2    Goldberg, V.M.3    Caplan, A.I.4
  • 21
    • 0141890186 scopus 로고    scopus 로고
    • Biology and clinical applications of mesenchymal stem cells
    • Barry FP. Biology and clinical applications of mesenchymal stem cells. Birth Defects Res C Embryo Today 2003; 69:250-256.
    • (2003) Birth Defects Res C Embryo Today , vol.69 , pp. 250-256
    • Barry, F.P.1
  • 24
    • 0037809253 scopus 로고    scopus 로고
    • Engineering mesenchymal stem cells for immunotherapy
    • Jorgensen C, Djouad F, Apparailly F, Noel D. Engineering mesenchymal stem cells for immunotherapy. Gene Ther 2003; 10:928-931.
    • (2003) Gene Ther , vol.10 , pp. 928-931
    • Jorgensen, C.1    Djouad, F.2    Apparailly, F.3    Noel, D.4
  • 25
    • 1542286220 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Clinical applications and biological characterization
    • Barry FP, Murphy JM. Mesenchymal stem cells: clinical applications and biological characterization. Int J Biochem Cell Biol 2004; 36:568-584.
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 568-584
    • Barry, F.P.1    Murphy, J.M.2
  • 26
    • 17444379357 scopus 로고    scopus 로고
    • Immunobiology of human mesenchymal stem cells and future use in hematopoietic stem cell transplantation
    • Le Blanc K, Ringden O. Immunobiology of human mesenchymal stem cells and future use in hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2005; 11:321-334.
    • (2005) Biol Blood Marrow Transplant , vol.11 , pp. 321-334
    • Le Blanc, K.1    Ringden, O.2
  • 27
    • 17444410347 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Progress toward promise
    • Le Blanc K, Pittenger M. Mesenchymal stem cells: progress toward promise. Cytotherapy 2005; 7:36-45.
    • (2005) Cytotherapy , vol.7 , pp. 36-45
    • Le Blanc, K.1    Pittenger, M.2
  • 28
    • 0347600715 scopus 로고    scopus 로고
    • Immunomodulatory effects of fetal and adult mesenchymal stem cells
    • Le Blanc K. Immunomodulatory effects of fetal and adult mesenchymal stem cells. Cytotherapy 2003; 5:485-489.
    • (2003) Cytotherapy , vol.5 , pp. 485-489
    • Le Blanc, K.1
  • 34
    • 0037417501 scopus 로고    scopus 로고
    • Autologous bone-marrow stem-cell transplantation for myocardial regeneration
    • Stamm C, Westphal B, Kleine HD, Petzsch M, Kittner C, Klinge H, et al. Autologous bone-marrow stem-cell transplantation for myocardial regeneration. Lancet 2003; 361:45-46.
    • (2003) Lancet , vol.361 , pp. 45-46
    • Stamm, C.1    Westphal, B.2    Kleine, H.D.3    Petzsch, M.4    Kittner, C.5    Klinge, H.6
  • 35
    • 1342309727 scopus 로고    scopus 로고
    • Autotransplantation of unmanipulated bone marrow into scarred myocardium is safe and enhances cardiac function in humans
    • Galinanes M, Loubani M, Davies J, Chin D, Pasi J, Bell PR. Autotransplantation of unmanipulated bone marrow into scarred myocardium is safe and enhances cardiac function in humans. Cell Transplant 2004; 13:7-13.
    • (2004) Cell Transplant , vol.13 , pp. 7-13
    • Galinanes, M.1    Loubani, M.2    Davies, J.3    Chin, D.4    Pasi, J.5    Bell, P.R.6
  • 36
    • 5644236574 scopus 로고    scopus 로고
    • Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction: Final one-year results of the TOPCARE-AMI Trial
    • Schachinger V, Assmus B, Britten MB, Honold J, Lehmann R, Teupe C, et al. Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction: final one-year results of the TOPCARE-AMI Trial. J Am Coll Cardiol 2004; 44:1690-1699.
    • (2004) J Am Coll Cardiol , vol.44 , pp. 1690-1699
    • Schachinger, V.1    Assmus, B.2    Britten, M.B.3    Honold, J.4    Lehmann, R.5    Teupe, C.6
  • 37
    • 0038376000 scopus 로고    scopus 로고
    • Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration
    • Rafii S, Lyden D. Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration. Nat Med 2003; 9:702-712.
    • (2003) Nat Med , vol.9 , pp. 702-712
    • Rafii, S.1    Lyden, D.2
  • 39
    • 0035044085 scopus 로고    scopus 로고
    • Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function
    • Kocher AA, Schuster MD, Szabolcs MJ, Takuma S, Burkhoff D, Wang J, et al. Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med 2001; 7: 430-436.
    • (2001) Nat Med , vol.7 , pp. 430-436
    • Kocher, A.A.1    Schuster, M.D.2    Szabolcs, M.J.3    Takuma, S.4    Burkhoff, D.5    Wang, J.6
  • 40
    • 18244421981 scopus 로고    scopus 로고
    • Young adult bone marrow-derived endothelial precursor cells restore aging-impaired cardiac angiogenic function
    • Edelberg JM, Tang L, Hattori K, Lyden D, Rafii S. Young adult bone marrow-derived endothelial precursor cells restore aging-impaired cardiac angiogenic function. Circ Res 2002; 90:E89-E93.
    • (2002) Circ Res , vol.90
    • Edelberg, J.M.1    Tang, L.2    Hattori, K.3    Lyden, D.4    Rafii, S.5
  • 41
    • 0242318367 scopus 로고    scopus 로고
    • Transdifferentiation of human peripheral blood CD34+-enriched cell population into cardiomyocytes, endothelial cells, and smooth muscle cells in vivo
    • Yeh ET, Zhang S, Wu HD, Korbling M, Willerson JT, Estrov Z. Transdifferentiation of human peripheral blood CD34+-enriched cell population into cardiomyocytes, endothelial cells, and smooth muscle cells in vivo. Circulation 2003; 108:2070-2073.
    • (2003) Circulation , vol.108 , pp. 2070-2073
    • Yeh, E.T.1    Zhang, S.2    Wu, H.D.3    Korbling, M.4    Willerson, J.T.5    Estrov, Z.6
  • 42
    • 11144356049 scopus 로고    scopus 로고
    • Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts
    • Murry CE, Soonpaa MH, Reinecke H, Nakajima H, Nakajima HO, Rubart M, et al. Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature 2004; 428:664-668.
    • (2004) Nature , vol.428 , pp. 664-668
    • Murry, C.E.1    Soonpaa, M.H.2    Reinecke, H.3    Nakajima, H.4    Nakajima, H.O.5    Rubart, M.6
  • 44
    • 0036266426 scopus 로고    scopus 로고
    • Mesenchymal stem cell implantation in a swine myocardial infarct model: Engraftment and functional effects
    • Shake JG, Gruber PJ, Baumgartner WA, Senechal G, Meyers J, Redmond JM, et al. Mesenchymal stem cell implantation in a swine myocardial infarct model: engraftment and functional effects. Ann Thorac Surg 2002; 73:1919-1925.
    • (2002) Ann Thorac Surg , vol.73 , pp. 1919-1925
    • Shake, J.G.1    Gruber, P.J.2    Baumgartner, W.A.3    Senechal, G.4    Meyers, J.5    Redmond, J.M.6
  • 45
    • 0344672626 scopus 로고    scopus 로고
    • Autologous transplantation of bone marrow cells improves damaged heart function
    • Tomita S, Li RK, Weisel RD, Mickle DA, Kim EJ, Sakai T, et al. Autologous transplantation of bone marrow cells improves damaged heart function. Circulation 1999; 100 (Suppl):II247-II256.
    • (1999) Circulation , vol.100 , Issue.SUPPL.
    • Tomita, S.1    Li, R.K.2    Weisel, R.D.3    Mickle, D.A.4    Kim, E.J.5    Sakai, T.6
  • 46
    • 0035497343 scopus 로고    scopus 로고
    • The coronary delivery of marrow stromal cells for myocardial regeneration: Pathophysiologic and therapeutic implications
    • Wang JS, Shum-Tim D, Chedrawy E, Chiu RC. The coronary delivery of marrow stromal cells for myocardial regeneration: pathophysiologic and therapeutic implications. J Thorac Cardiovasc Surg 2001; 122:699-705.
    • (2001) J Thorac Cardiovasc Surg , vol.122 , pp. 699-705
    • Wang, J.S.1    Shum-Tim, D.2    Chedrawy, E.3    Chiu, R.C.4
  • 47
    • 20544450374 scopus 로고    scopus 로고
    • Paracrine action enhances the effects of autologous mesenchymal stem cell transplantation on vascular regeneration in rat model of myocardial infarction
    • Tang YL, Zhao Q, Qin X, Shen L, Cheng L, Ge J, et al. Paracrine action enhances the effects of autologous mesenchymal stem cell transplantation on vascular regeneration in rat model of myocardial infarction. Ann Thorac Surg 2005; 80:229-237.
    • (2005) Ann Thorac Surg , vol.80 , pp. 229-237
    • Tang, Y.L.1    Zhao, Q.2    Qin, X.3    Shen, L.4    Cheng, L.5    Ge, J.6
  • 48
    • 9944249035 scopus 로고    scopus 로고
    • Mobilizing of haematopoietic stem cells to ischemic myocardium by plasmid mediated stromal-cell-derived factor-1alpha (SDF-1alpha) treatment
    • Tang YL, Qian K, Zhang YC, Shen L, Phillips MI. Mobilizing of haematopoietic stem cells to ischemic myocardium by plasmid mediated stromal-cell-derived factor-1alpha (SDF-1alpha) treatment. Regul Pept 2005; 125:1-8.
    • (2005) Regul Pept , vol.125 , pp. 1-8
    • Tang, Y.L.1    Qian, K.2    Zhang, Y.C.3    Shen, L.4    Phillips, M.I.5
  • 49
    • 0035964391 scopus 로고    scopus 로고
    • Implantation of bone marrow mononuclear cells into ischemic myocardium enhances collateral perfusion and regional function via side supply of angioblasts, angiogenic ligands, and cytokines
    • Kamihata H, Matsubara H, Nishiue T, Fujiyama S, Tsutsumi Y, Ozono R, et al. Implantation of bone marrow mononuclear cells into ischemic myocardium enhances collateral perfusion and regional function via side supply of angioblasts, angiogenic ligands, and cytokines. Circulation 2001; 104:1046-1052.
    • (2001) Circulation , vol.104 , pp. 1046-1052
    • Kamihata, H.1    Matsubara, H.2    Nishiue, T.3    Fujiyama, S.4    Tsutsumi, Y.5    Ozono, R.6
  • 50
    • 0033934786 scopus 로고    scopus 로고
    • Effect of cytokines and growth factors on the macrophage colony-stimulating factor secretion by human bone marrow stromal cells
    • Besse A, Trimoreau F, Praloran V, Denizot Y. Effect of cytokines and growth factors on the macrophage colony-stimulating factor secretion by human bone marrow stromal cells. Cytokine 2000; 12:522-525.
    • (2000) Cytokine , vol.12 , pp. 522-525
    • Besse, A.1    Trimoreau, F.2    Praloran, V.3    Denizot, Y.4
  • 51
    • 8344232505 scopus 로고    scopus 로고
    • Partial restoration of myocardial function and perfusion by cell therapy following myocardial infarction
    • Bick-Forrester J, Lee MS, Makkar RR, Forrester JS. Partial restoration of myocardial function and perfusion by cell therapy following myocardial infarction. Curr Opin Cardiol 2004; 19:631-637.
    • (2004) Curr Opin Cardiol , vol.19 , pp. 631-637
    • Bick-Forrester, J.1    Lee, M.S.2    Makkar, R.R.3    Forrester, J.S.4
  • 52
    • 0042740515 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex
    • Le Blanc K, Tammik L, Sundberg B, Haynesworth SE, Ringden O. Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex. Scand J Immunol 2003; 57:11-20.
    • (2003) Scand J Immunol , vol.57 , pp. 11-20
    • Le Blanc, K.1    Tammik, L.2    Sundberg, B.3    Haynesworth, S.E.4    Ringden, O.5
  • 53
    • 23844520618 scopus 로고    scopus 로고
    • They are not stealthy in the heart: Embryonic stem cells trigger cell infiltration, humoral and T-lymphocyte-based host immune response
    • Kofidis T, deBruin JL, Tanaka M, Zwierzchoniewska M, Weissman I, Fedoseyeva E, et al. They are not stealthy in the heart: embryonic stem cells trigger cell infiltration, humoral and T-lymphocyte-based host immune response. Eur J Cardiothorac Surg 2005; 28:461-466.
    • (2005) Eur J Cardiothorac Surg , vol.28 , pp. 461-466
    • Kofidis, T.1    deBruin, J.L.2    Tanaka, M.3    Zwierzchoniewska, M.4    Weissman, I.5    Fedoseyeva, E.6
  • 54
    • 0001044185 scopus 로고    scopus 로고
    • Stromal cell modulation of the immune system. A potential role for mesenchymal stem cells
    • McIntosh K, Bartholomew A. Stromal cell modulation of the immune system. A potential role for mesenchymal stem cells. Graft 2000; 3:324-328.
    • (2000) Graft , vol.3 , pp. 324-328
    • McIntosh, K.1    Bartholomew, A.2
  • 56
    • 0037093058 scopus 로고    scopus 로고
    • Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
    • Di Nicola M, Carlo-Stella C, Magni M, Milanesi M, Longoni PD, Matteucci P, et al. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 2002; 99:3838-3843.
    • (2002) Blood , vol.99 , pp. 3838-3843
    • Di Nicola, M.1    Carlo-Stella, C.2    Magni, M.3    Milanesi, M.4    Longoni, P.D.5    Matteucci, P.6
  • 57
    • 0037442264 scopus 로고    scopus 로고
    • Suppression of allogeneic T-cell proliferation by human marrow stromal cells: Implications in transplantation
    • Tse WT, Pendleton JD, Beyer WM, Egalka MC, Guinan EC. Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation. Transplantation 2003; 75:389-397.
    • (2003) Transplantation , vol.75 , pp. 389-397
    • Tse, W.T.1    Pendleton, J.D.2    Beyer, W.M.3    Egalka, M.C.4    Guinan, E.C.5
  • 58
    • 0242410394 scopus 로고    scopus 로고
    • Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals
    • Djouad F, Plence P, Bony C, Tropel P, Apparailly F, Sany J, et al. Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals. Blood 2003; 102:3837-3844.
    • (2003) Blood , vol.102 , pp. 3837-3844
    • Djouad, F.1    Plence, P.2    Bony, C.3    Tropel, P.4    Apparailly, F.5    Sany, J.6
  • 59
    • 0036142769 scopus 로고    scopus 로고
    • Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo
    • Bartholomew A, Sturgeon C, Siatskas M, Ferrer K, McIntosh K, Patil S, et al. Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol 2002; 30:42-48.
    • (2002) Exp Hematol , vol.30 , pp. 42-48
    • Bartholomew, A.1    Sturgeon, C.2    Siatskas, M.3    Ferrer, K.4    McIntosh, K.5    Patil, S.6
  • 60
    • 15044348816 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit lymphocyte proliferation by mitogens and alloantigens by different mechanisms
    • Rasmusson I, Ringden O, Sundberg B, Le Blanc K. Mesenchymal stem cells inhibit lymphocyte proliferation by mitogens and alloantigens by different mechanisms. Exp Cell Res 2005; 305:33-41.
    • (2005) Exp Cell Res , vol.305 , pp. 33-41
    • Rasmusson, I.1    Ringden, O.2    Sundberg, B.3    Le Blanc, K.4
  • 61
    • 0242300602 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells
    • Rasmusson I, Ringden O, Sundberg B, Le Blanc K. Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells. Transplantation 2003; 76:1208-1213.
    • (2003) Transplantation , vol.76 , pp. 1208-1213
    • Rasmusson, I.1    Ringden, O.2    Sundberg, B.3    Le Blanc, K.4
  • 62
    • 0141886188 scopus 로고    scopus 로고
    • Veto-like activity of mesenchymal stem cells: Functional discrimination between cellular responses to alloantigens and recall antigens
    • Potian JA, Aviv H, Ponzio NM, Harrison JS, Rameshwar P. Veto-like activity of mesenchymal stem cells: functional discrimination between cellular responses to alloantigens and recall antigens. J Immunol 2003; 171:3426-3434.
    • (2003) J Immunol , vol.171 , pp. 3426-3434
    • Potian, J.A.1    Aviv, H.2    Ponzio, N.M.3    Harrison, J.S.4    Rameshwar, P.5
  • 63
    • 0038204193 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide
    • Krampera M, Glennie S, Dyson J, Scott D, Laylor R, Simpson E, et al. Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide. Blood 2003; 101:3722-3729.
    • (2003) Blood , vol.101 , pp. 3722-3729
    • Krampera, M.1    Glennie, S.2    Dyson, J.3    Scott, D.4    Laylor, R.5    Simpson, E.6
  • 64
    • 2342482526 scopus 로고    scopus 로고
    • Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells
    • Le Blanc K, Rasmusson I, Sundberg B, Gotherstrom C, Hassan M, Uzunel M, et al. Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet 2004; 363:1439-1441.
    • (2004) Lancet , vol.363 , pp. 1439-1441
    • Le Blanc, K.1    Rasmusson, I.2    Sundberg, B.3    Gotherstrom, C.4    Hassan, M.5    Uzunel, M.6
  • 65
    • 13544249606 scopus 로고    scopus 로고
    • Human mesenchymal stem cells modulate allogeneic immune cell responses
    • Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 2005; 105:1815-1822.
    • (2005) Blood , vol.105 , pp. 1815-1822
    • Aggarwal, S.1    Pittenger, M.F.2
  • 67
    • 0031932868 scopus 로고    scopus 로고
    • Immune evasion by tumours: Involvement of the CD95 (APO-1/Fas) system and its clinical implications
    • Strand S, Galle PR. Immune evasion by tumours: involvement of the CD95 (APO-1/Fas) system and its clinical implications. Mol Med Today 1998; 4:63-68.
    • (1998) Mol Med Today , vol.4 , pp. 63-68
    • Strand, S.1    Galle, P.R.2
  • 69
    • 20244381685 scopus 로고    scopus 로고
    • Immunomodulatory effect of human adipose tissue-derived adult stem cells: Comparison with bone marrow mesenchymal stem cells
    • Puissant B, Barreau C, Bourin P, Clavel C, Corre J, Bousquet C, et al. Immunomodulatory effect of human adipose tissue-derived adult stem cells: comparison with bone marrow mesenchymal stem cells. Br J Haematol 2005; 129:118-129.
    • (2005) Br J Haematol , vol.129 , pp. 118-129
    • Puissant, B.1    Barreau, C.2    Bourin, P.3    Clavel, C.4    Corre, J.5    Bousquet, C.6
  • 70
    • 1842483153 scopus 로고    scopus 로고
    • Human mesenchymal stem cells support unrelated donor hematopoietic stem cells and suppress T-cell activation
    • Maitra B, Szekely E, Gjini K, Laughlin MJ, Dennis J, Haynesworth SE, et al. Human mesenchymal stem cells support unrelated donor hematopoietic stem cells and suppress T-cell activation. Bone Marrow Transplant 2004; 33:597-604.
    • (2004) Bone Marrow Transplant , vol.33 , pp. 597-604
    • Maitra, B.1    Szekely, E.2    Gjini, K.3    Laughlin, M.J.4    Dennis, J.5    Haynesworth, S.E.6
  • 71
    • 2942595706 scopus 로고    scopus 로고
    • Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation
    • Meisel R, Zibert A, Laryea M, Gobel U, Daubener W, Dilloo D. Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation. Blood 2004; 103:4619-4621.
    • (2004) Blood , vol.103 , pp. 4619-4621
    • Meisel, R.1    Zibert, A.2    Laryea, M.3    Gobel, U.4    Daubener, W.5    Dilloo, D.6
  • 72
    • 2942562525 scopus 로고    scopus 로고
    • Effects of mesenchymal stem cells on differentiation, maturation, and function of human monocyte-derived dendritic cells
    • Zhang W, Ge W, Li C, You S, Liao L, Han Q, et al. Effects of mesenchymal stem cells on differentiation, maturation, and function of human monocyte-derived dendritic cells. Stem Cells Dev 2004; 13:263-271.
    • (2004) Stem Cells Dev , vol.13 , pp. 263-271
    • Zhang, W.1    Ge, W.2    Li, C.3    You, S.4    Liao, L.5    Han, Q.6
  • 73
    • 18544371666 scopus 로고    scopus 로고
    • Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells
    • Jiang XX, Zhang Y, Liu B, Zhang SX, Wu Y, Yu XD, et al. Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells. Blood 2005; 105:4120-4126.
    • (2005) Blood , vol.105 , pp. 4120-4126
    • Jiang, X.X.1    Zhang, Y.2    Liu, B.3    Zhang, S.X.4    Wu, Y.5    Yu, X.D.6
  • 76
    • 33745266607 scopus 로고    scopus 로고
    • Characterization of the optimal culture conditions for clinical scale production of human mesenchymal stem cells
    • Sotiropoulou PA, Perez SA, Salagianni M, Baxevanis CN, Papamichail M. Characterization of the optimal culture conditions for clinical scale production of human mesenchymal stem cells. Stem Cells 2006; 24:462-471.
    • (2006) Stem Cells , vol.24 , pp. 462-471
    • Sotiropoulou, P.A.1    Perez, S.A.2    Salagianni, M.3    Baxevanis, C.N.4    Papamichail, M.5
  • 78
    • 0042239361 scopus 로고    scopus 로고
    • Expanded mesenchymal stem cells (MSC), co-infused with HLA identical hematopoietic stem cell transplants, reduce acute and chronic graft versus host disease: A matched pair analysis [abstract]
    • Frassoni F, Labopin M, Bacigalupo A, Gluckman E, Rocha V, Bruno B, et al. Expanded mesenchymal stem cells (MSC), co-infused with HLA identical hematopoietic stem cell transplants, reduce acute and chronic graft versus host disease: a matched pair analysis [abstract]. Bone Marrow Transplant 2002; 29 (Suppl 2):S2.
    • (2002) Bone Marrow Transplant , vol.29 , Issue.SUPPL. 2
    • Frassoni, F.1    Labopin, M.2    Bacigalupo, A.3    Gluckman, E.4    Rocha, V.5    Bruno, B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.